# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	59	7.717464e-77	1.7212560809491525e-74	2.25037	666	0.0147626	400	0.00000510042511025	1.22499	109	114	0.007437227	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	69	3.946919e-74	7.527174945072463e-72	2.18925	682	0.01511726	357	0.000001096333791512605	1.23583	109	113	0.007437227	
GO Biological Process	cellular response to topologically incorrect protein	84	2.153412e-69	3.373422441428571e-67	2.041834	751	0.01664672	355	0.000001084808314169014	1.216662	132	139	0.00900655	
GO Biological Process	regulation of DNA-templated transcription in response to stress	85	3.119558e-69	4.829442790823529e-67	2.065927	728	0.0161369	319	3.36759641645768e-7	1.238117	115	119	0.007846616	
GO Biological Process	cellular response to unfolded protein	97	1.448723e-64	1.9653346347422678e-62	2.058362	684	0.01516159	406	0.000006676727507881773	1.217652	115	121	0.007846616	
GO Biological Process	IRE1-mediated unfolded protein response	100	2.656046e-63	3.4950909314000005e-61	2.795934	363	0.008046283	669	0.0016402723004484306	1.237003	56	58	0.003820961	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	105	3.976671e-62	4.983715589428571e-60	2.229256	547	0.01212484	376	0.000002372077387260638	1.226894	113	118	0.007710153	
GO Biological Process	cotranslational protein targeting to membrane	121	3.845031e-54	4.181550655289256e-52	2.259882	461	0.01021856	286	3.503059690524475e-8	1.268108	97	98	0.00661845	
GO Biological Process	cellular response to epidermal growth factor stimulus	122	6.009261e-54	6.481628319590164e-52	2.284089	449	0.009952565	912	0.013616637411074562	1.247466	37	38	0.002524563	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	126	4.678297e-53	4.8858500176984124e-51	2.010373	593	0.01314448	964	0.01841400023858921	1.158515	85	94	0.005799672	
GO Biological Process	response to epidermal growth factor	134	7.218706e-52	7.088877033880596e-50	2.201394	467	0.01035155	805	0.006263615344347826	1.250677	41	42	0.002797489	
GO Biological Process	protein targeting to ER	158	9.936056e-49	8.275225373670886e-47	2.149612	462	0.01024072	277	1.7631573080505414e-8	1.268497	100	101	0.006823144	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	160	2.019814e-48	1.661170776625e-46	2.224542	425	0.009420579	300	1.4010040779666669e-7	1.267256	91	92	0.006209061	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	207	2.060995e-42	1.3101755171497584e-40	2.059042	443	0.009819568	382	0.0000030659360785863877	1.264756	77	78	0.005253821	
GO Biological Process	mitochondrial transmembrane transport	238	3.058393e-39	1.6909829196218487e-37	2.028343	424	0.009398413	784	0.004823755389668368	1.188566	77	83	0.005253821	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	261	6.668285e-37	3.3619908932950197e-35	2.031563	396	0.008777763	563	0.00027366255756660745	1.242938	65	67	0.004435044	
GO Biological Process	snRNA metabolic process	263	1.613724e-36	8.074142249429658e-35	2.056499	380	0.008423106	403	0.000005462682935483871	1.251387	84	86	0.005731441	
GO Biological Process	positive regulation of mRNA metabolic process	292	1.308402e-33	5.896322574657534e-32	2.011584	368	0.008157113	980	0.020608027921428573	1.207267	49	52	0.003343341	
GO Biological Process	regulation of cellular amino acid metabolic process	293	1.771807e-33	7.957408980546075e-32	2.304038	268	0.005940506	644	0.001105273858416149	1.238476	58	60	0.003957424	
GO Biological Process	mitochondrial translational termination	316	1.332692e-31	5.5496500088607596e-30	2.020433	341	0.007558629	278	1.9436936427697842e-8	1.281182	87	87	0.005936135	
GO Cellular Component	mitochondrial ribosome	71	2.233466e-36	5.43581584225352e-35	2.219303	317	0.007026644	74	3.950978594594594e-7	1.266109	84	85	0.005731441	
GO Cellular Component	mitochondrial large ribosomal subunit	115	1.091419e-24	1.63997568e-23	2.296853	195	0.004322383	125	0.0006782614272000001	1.256061	50	51	0.003411572	
GO Cellular Component	endoribonuclease complex	119	3.436498e-23	4.990141633613446e-22	2.397234	167	0.003701733	164	0.007931305053658537	1.281182	29	29	0.001978712	
GO Cellular Component	nuclear ubiquitin ligase complex	142	3.158694e-20	3.8438191774647887e-19	2.148377	182	0.004034224	214	0.029400547289719622	1.217123	38	40	0.002592795	
GO Cellular Component	mitochondrial small ribosomal subunit	239	8.35986e-11	6.044283715481171e-10	2.019658	104	0.002305271	168	0.00992367257142857	1.281182	28	28	0.00191048	
GO Molecular Function	rRNA binding	22	4.257937e-35	8.171368188181818e-33	2.561197	229	0.00507603	134	0.009951777023880596	1.217123	57	60	0.003889192	
GO Molecular Function	snRNA binding	61	1.814433e-21	1.2558255944262295e-19	2.40187	153	0.003391408	111	0.003064840325765766	1.281182	38	38	0.002592795	
Human Phenotype	CNS hypomyelination	143	2.218855e-14	1.0354139451048952e-12	2.057944	138	0.003058917	277	0.014147721201083032	1.281182	30	30	0.002046943	
Mouse Phenotype Single KO	spontaneous skin ulceration	96	7.832224e-35	7.470799496666666e-33	2.470732	243	0.005386355	407	0.045702204520884526	1.281182	25	25	0.001705786	
Mouse Phenotype	increased liver adenoma incidence	146	1.131412e-33	7.409198720547945e-32	2.622786	210	0.004654874	449	0.02054447024832962	1.281182	28	28	0.00191048