# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA metabolic process	8	8.62877e-14	1.419324805375e-10	2.116969	121	0.02829086	124	0.0002841868578064516	1.571774	88	259	0.02168022	
GO Biological Process	rRNA processing	9	1.134077e-13	1.6581465825555554e-10	2.131214	118	0.02758943	138	0.0005182557723913044	1.560363	85	252	0.02094112	
GO Biological Process	DNA-templated transcription, termination	21	4.702462e-12	2.946652259904762e-9	2.729998	63	0.01472995	246	0.005362340642682927	1.740061	41	109	0.01010101	
GO Biological Process	termination of RNA polymerase II transcription	28	3.939134e-11	1.8512522966428572e-8	3.30336	43	0.01005378	350	0.02703936134114286	1.81018	27	69	0.006651885	
GO Biological Process	DNA-dependent DNA replication	32	1.306144e-10	5.3711090300000004e-8	2.228123	80	0.0187047	105	0.00011359553119809525	1.930859	48	115	0.01182557	
GO Biological Process	mitochondrial translational termination	34	2.283283e-10	8.83697676382353e-8	2.937379	47	0.01098901	363	0.031468443475206616	1.701523	32	87	0.007883715	
GO Biological Process	ribonucleoprotein complex export from nucleus	36	3.475736e-10	1.2704780562222222e-7	2.408482	65	0.01519757	174	0.0010763540177586208	1.77639	48	125	0.01182557	
GO Biological Process	telomere organization	37	3.675903e-10	1.3073299345135136e-7	2.444177	63	0.01472995	165	0.0008287737578787878	1.818776	46	117	0.01133284	
GO Biological Process	mitochondrial translational elongation	38	4.117026e-10	1.4256827666842105e-7	2.922544	46	0.0107552	391	0.04101209326598465	1.687135	31	85	0.007637349	
GO Biological Process	cellular protein complex disassembly	39	4.658551e-10	1.5718428874102563e-7	2.288457	71	0.01660042	276	0.009246204724275363	1.652149	45	126	0.01108647	
GO Biological Process	nucleoside triphosphate biosynthetic process	40	4.857916e-10	1.5981329161000001e-7	2.906893	46	0.0107552	341	0.021212010861290324	1.836801	27	68	0.006651885	
GO Biological Process	translational termination	47	1.11315e-9	3.116583159574468e-7	2.659868	51	0.01192425	283	0.01014038584770318	1.753017	36	95	0.00886918	
GO Biological Process	ribonucleoprotein complex localization	49	1.387341e-9	3.7257184120408164e-7	2.323314	65	0.01519757	189	0.0016153111133333335	1.748416	48	127	0.01182557	
GO Biological Process	nucleoside monophosphate biosynthetic process	50	1.675788e-9	4.4103388584e-7	2.448487	58	0.01356091	201	0.0024072027117412937	1.90483	35	85	0.008622814	
GO Biological Process	translational elongation	51	1.800902e-9	4.6466802780392155e-7	2.465872	57	0.0133271	323	0.017411446958823528	1.652149	40	112	0.009854644	
GO Biological Process	purine ribonucleoside monophosphate biosynthetic process	59	3.002495e-9	6.696581644915255e-7	2.894976	42	0.009819967	383	0.039440271616187995	1.807038	25	64	0.006159153	
GO Biological Process	RNA 3'-end processing	60	3.217024e-9	7.055469802666667e-7	2.470473	55	0.01285948	402	0.04456887832338309	1.59965	37	107	0.009115546	
GO Biological Process	mitochondrial translation	62	3.759645e-9	7.979543315322582e-7	2.507961	53	0.01239186	347	0.025214536317291068	1.642884	38	107	0.009361912	
GO Biological Process	regulation of ubiquitin protein ligase activity	72	9.33747e-9	0.0000017065523295833332	2.462871	52	0.01215805	141	0.0005522978822198582	1.961029	39	92	0.009608278	
GO Biological Process	negative regulation of ubiquitin protein ligase activity	74	1.586468e-8	0.000002821126001621622	2.618838	45	0.01052139	187	0.0016128578159893049	1.982578	33	77	0.008130081	
GO Cellular Component	mitochondrial ribosome	26	9.579414e-13	6.366625920000001e-11	3.470781	47	0.01098901	92	0.02288873113043478	1.687135	31	85	0.007637349	
GO Cellular Component	ribosomal subunit	34	7.814226e-10	3.9714654494117647e-8	2.140387	80	0.0187047	85	0.014613238588235294	1.475324	59	185	0.0145356	
GO Cellular Component	nuclear ubiquitin ligase complex	38	8.245379e-9	3.749477608421053e-7	3.610849	29	0.006780454	44	0.00015888370909090908	2.544309	22	40	0.005420054	
GO Cellular Component	chromosome, telomeric region	39	1.08074e-8	4.788509538461539e-7	2.077799	74	0.01730185	81	0.0096005312	1.523538	55	167	0.01355014	
GO Cellular Component	proteasome complex	41	4.809216e-8	0.000002026908597073171	2.652084	41	0.009586159	82	0.011583591102439025	1.836801	27	68	0.006651885	
GO Cellular Component	endopeptidase complex	42	4.880884e-8	0.0000020081351314285715	2.650586	41	0.009586159	86	0.014450633079069769	1.81018	27	69	0.006651885	
GO Cellular Component	PRC1 complex	43	7.707166e-8	0.000003097205313488372	7.089804	13	0.003039514	88	0.01974564	3.084011	8	12	0.001970929	
GO Cellular Component	nuclear nucleosome	44	9.255602e-8	0.000003634927330909091	4.563064	19	0.004442366	101	0.0411069984950495	1.966057	17	40	0.004188224	
GO Cellular Component	nuclear chromosome, telomeric region	46	2.820607e-7	0.000010595671513043479	2.099358	58	0.01356091	66	0.0040255383272727275	1.647142	47	132	0.01157921	
GO Cellular Component	peptidase complex	47	3.208646e-7	0.000011796894229787232	2.275853	48	0.01122282	89	0.021070261213483144	1.682188	32	88	0.007883715	
GO Cellular Component	large ribosomal subunit	48	3.873443e-7	0.0000139443948	2.217891	50	0.01169044	79	0.008317642693670886	1.649275	41	115	0.01010101	
GO Cellular Component	small-subunit processome	52	0.000001005208	0.000033403835076923076	3.33987	23	0.005377601	93	0.023558177032258064	2.11475	16	35	0.003941858	
GO Cellular Component	preribosome	54	0.000001359121	0.000043491872	2.35095	40	0.00935235	96	0.031018212	1.704322	28	76	0.006898251	
GO Cellular Component	nucleosome	59	0.000002783273	0.00008151687701694916	2.402191	36	0.008417115	60	0.001067590368	1.806349	41	105	0.01010101	
GO Cellular Component	endoribonuclease complex	63	0.000006048419	0.00016589949257142858	3.179694	21	0.004909984	94	0.024210640340425534	2.233249	14	29	0.003449125	
GO Cellular Component	PcG protein complex	64	0.000007699146	0.000207876942	2.206321	39	0.009118541	71	0.005791713261971831	2.111877	21	46	0.005173688	
GO Cellular Component	DNA packaging complex	66	0.000008906792	0.00023319600872727272	2.167068	40	0.00935235	52	0.0005447742646153847	1.817364	44	112	0.01084011	
GO Cellular Component	cytoplasmic stress granule	96	0.00008374063	0.00150733134	2.200913	30	0.007014262	54	0.0006064048	2.366799	22	43	0.005420054	
GO Cellular Component	U1 snRNP	101	0.00009931866	0.0016992341037623763	3.238914	15	0.003507131	84	0.012873359314285713	2.67822	11	19	0.002710027	
GO Cellular Component	anaphase-promoting complex	104	0.0001506292	0.0025027620923076927	3.457934	13	0.003039514	98	0.033406718693877555	2.423151	11	21	0.002710027	
GO Molecular Function	snRNA binding	11	3.230806e-10	1.2400420847272728e-7	4.470889	27	0.006312836	36	0.012257322127777779	2.313008	19	38	0.004680956	
GO Molecular Function	ribonucleoprotein complex binding	28	4.800057e-8	0.000007237800233571429	2.184463	60	0.01402852	44	0.01711203467272727	1.689502	42	115	0.01034738	
GO Molecular Function	ribonuclease activity	31	1.048918e-7	0.000014285586438709677	2.23716	54	0.01262567	51	0.04544042570196078	1.682188	36	99	0.00886918	
GO Molecular Function	ubiquitin ligase inhibitor activity	67	0.00003248085	0.00204677833880597	8.142618	7	0.001636661	48	0.0414383230875	4.626016	5	5	0.001231831	
GO Molecular Function	ubiquitin-protein transferase regulator activity	74	0.0000816841	0.004660409056756757	2.648489	21	0.004909984	42	0.015910074223809523	2.993305	11	17	0.002710027	
GO Molecular Function	tRNA-specific ribonuclease activity	111	0.0004854128	0.018463178753153155	3.052336	13	0.003039514	50	0.040608226168	2.89126	10	16	0.002463661	
Human Phenotype	Progressive external ophthalmoplegia	5	5.333487e-12	7.118071750200001e-9	6.497576	23	0.005377601	9	0.02003035892888889	3.392412	11	15	0.002710027	
Mouse Phenotype Single KO	pale liver	6	1.540541e-7	0.00023511223228333332	2.190926	55	0.01285948	60	0.008876035769	1.908232	33	80	0.008130081	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	39	0.0001344307	0.031563638971794865	2.055365	33	0.007715689	57	0.0070953769550877194	2.081707	27	60	0.006651885	
Mouse Phenotype	abnormal amino acid metabolism	1	3.977827e-12	3.8032003947e-8	11.13957	16	0.00374094	132	0.042038253877272724	3.965157	6	7	0.001478197