# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	histone methylation	27	5.96988e-88	2.9095426266666667e-85	2.645157	555	0.02348014	614	0.006775393360912052	1.313837	66	87	0.006087438	
GO Biological Process	protein methylation	33	5.404496e-71	2.155083723151515e-68	2.16014	667	0.02821847	366	0.00012490871549453552	1.328206	102	133	0.009407858	
GO Biological Process	protein folding	38	2.478059e-66	8.58125746868421e-64	2.06066	695	0.02940305	221	1.2099450419457012e-7	1.325728	173	226	0.01595647	
GO Biological Process	positive regulation of nuclease activity	86	9.380461e-35	1.435319608127907e-32	4.523469	103	0.004357575	597	0.005803872832160804	1.731876	15	15	0.001383509	
GO Biological Process	endoplasmic reticulum unfolded protein response	102	4.418329e-31	5.700077579509804e-29	2.057261	319	0.01349579	446	0.0007383647670179373	1.321695	87	114	0.00802435	
GO Biological Process	regulation of nuclease activity	145	6.582385e-25	5.973627876896552e-23	3.063709	118	0.004992173	710	0.01404726400746479	1.532044	23	26	0.00212138	
GO Biological Process	termination of RNA polymerase II transcription	152	3.81452e-24	3.302320307894737e-22	2.404808	173	0.007319034	600	0.006101815141	1.355381	54	69	0.004980631	
GO Biological Process	cotranslational protein targeting to membrane	161	2.877814e-23	2.3521213929192547e-21	2.09581	224	0.009476668	197	6.036579699086294e-9	1.51981	86	98	0.007932116	
GO Biological Process	protein targeting to ER	176	3.473237e-22	2.5968366865340907e-20	2.033633	229	0.009688201	185	1.7877518655135134e-9	1.526109	89	101	0.008208818	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	187	1.216359e-21	8.559394695721925e-20	2.087934	209	0.00884207	203	1.433846126502463e-8	1.524804	81	92	0.007470946	
GO Biological Process	IRE1-mediated unfolded protein response	205	4.499981e-20	2.8885487794634146e-18	2.293316	156	0.006599822	903	0.04523602250609081	1.313837	44	58	0.004058292	
GO Biological Process	positive regulation of gene expression, epigenetic	231	2.225335e-17	1.2676702712121212e-15	2.016957	179	0.007572873	635	0.008623934047086614	1.320555	61	80	0.005626268	
GO Biological Process	protein refolding	260	1.383939e-15	7.004328192692308e-14	3.910026	51	0.002157634	555	0.0037783685654054055	1.649406	20	21	0.001844678	
GO Biological Process	maintenance of protein localization in organelle	282	2.679035e-14	1.2501213320921986e-12	2.532717	88	0.003722977	818	0.03013653910635697	1.452541	26	31	0.002398082	
GO Biological Process	regulation of spindle organization	318	9.253213e-13	3.829026096446541e-11	2.170846	106	0.004484495	699	0.013136379321316166	1.451031	31	37	0.002859251	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	347	1.025487e-11	3.888871306340058e-10	2.013856	115	0.004865254	485	0.0015680793473195878	1.656577	22	23	0.002029146	
GO Biological Process	regulation of mitotic spindle organization	349	1.028966e-11	3.8797030355300863e-10	2.171235	96	0.004061429	625	0.00805011615296	1.484465	30	35	0.002767017	
GO Biological Process	mitochondrial DNA metabolic process	627	3.939803e-7	0.000008268559438118023	2.764416	33	0.001396116	858	0.03640150551282051	1.731876	11	11	0.001014573	
GO Biological Process	mitochondrial calcium ion transport	654	7.102397e-7	0.00001429058748058104	2.015861	60	0.002538393	813	0.02914723355719557	1.515392	21	24	0.001936912	
GO Biological Process	nucleotide-excision repair, DNA damage recognition	693	0.000001646452	0.00003126358133910534	2.014663	56	0.002369167	883	0.04106871740883353	1.505979	20	23	0.001844678	
GO Cellular Component	integral component of organelle membrane	21	3.955211e-67	3.254573622857143e-65	2.12818	652	0.02758387	86	0.00002472810195348837	1.304001	128	170	0.01180594	
GO Cellular Component	intrinsic component of organelle membrane	24	1.224227e-61	8.8144344e-60	2.035198	665	0.02813386	98	0.000059394145959183664	1.280082	136	184	0.01254381	
GO Cellular Component	endopeptidase complex	39	1.488513e-20	6.5952576e-19	2.152399	184	0.007784406	119	0.0004695372423529412	1.405581	56	69	0.005165099	
GO Cellular Component	proteasome complex	43	3.056632e-20	1.2283395572093024e-18	2.141911	183	0.007742099	127	0.0006238094966929134	1.400782	55	68	0.005072865	
GO Cellular Component	endoribonuclease complex	66	2.376772e-14	6.222821236363636e-13	2.493184	91	0.003849896	143	0.002424097611188811	1.552716	26	29	0.002398082	
GO Cellular Component	PRC1 complex	71	6.310445e-14	1.535837881690141e-12	4.144643	42	0.001776875	184	0.012864903652173914	1.731876	12	12	0.001106807	
GO Cellular Component	MLL1 complex	78	8.745897e-13	1.9375525661538464e-11	2.427301	84	0.00355375	143	0.002424097611188811	1.552716	26	29	0.002398082	
GO Cellular Component	COPI-coated vesicle	83	4.600559e-12	9.57803126746988e-11	2.469535	76	0.003215298	133	0.0007508946045112782	1.656577	22	23	0.002029146	
GO Cellular Component	nuclear ubiquitin ligase complex	88	2.756177e-11	5.412129381818181e-10	2.140335	95	0.004019123	128	0.000645964065	1.515392	35	40	0.003228187	
GO Cellular Component	pre-autophagosomal structure membrane	122	5.173596e-8	7.327847449180329e-7	2.337453	52	0.002199941	195	0.017135920246153846	1.623634	15	16	0.001383509	
GO Molecular Function	unfolded protein binding	12	1.086283e-101	3.8219056883333335e-99	3.575111	410	0.01734569	85	0.00033054738355294114	1.356092	83	106	0.007655414	
GO Molecular Function	protein methyltransferase activity	14	2.680099e-94	8.082412841428571e-92	2.710616	571	0.02415704	143	0.016331965552447553	1.298907	66	88	0.006087438	
GO Molecular Function	histone binding	18	1.14125e-73	2.6768652777777774e-71	2.041887	790	0.03342218	69	0.000024691810185507246	1.294534	148	198	0.01365062	
GO Molecular Function	S-adenosylmethionine-dependent methyltransferase activity	19	6.134504e-71	1.3631513625263156e-68	2.187516	648	0.02741465	78	0.00008530881182051282	1.318978	115	151	0.0106069	
GO Molecular Function	chaperone binding	20	1.492584e-70	3.1508448240000003e-68	2.821537	398	0.01683801	156	0.025363004635897437	1.284313	66	89	0.006087438	
GO Molecular Function	DNA polymerase binding	69	1.700343e-11	1.0404127747826086e-9	3.404758	43	0.001819182	174	0.046921002885057475	1.623634	15	16	0.001383509	
GO Molecular Function	snRNA binding	104	9.819228e-9	3.9862289053846155e-7	2.127333	71	0.003003765	116	0.004042401215517241	1.503998	33	38	0.003043719	
GO Molecular Function	K63-linked polyubiquitin binding	118	7.83382e-8	0.000002802914240677966	2.013054	71	0.003003765	166	0.03195293531325301	1.566935	19	21	0.001752444	
Human Phenotype	Abnormal CSF metabolite level	37	7.990446e-17	1.441087734e-14	2.14382	149	0.006303676	132	0.00008363897757575757	1.484465	54	63	0.004980631	
Human Phenotype	Progressive macrocephaly	110	7.226236e-10	4.383697529818182e-8	2.390145	64	0.002707619	266	0.007819343631954887	1.587553	22	24	0.002029146	
Human Phenotype	Acute necrotizing encephalopathy	200	7.447138e-7	0.000024847375937	2.135364	52	0.002199941	258	0.006823812386434108	1.645282	19	20	0.001752444	
Human Phenotype	Abnormal mitochondria in muscle tissue	215	0.00000104737	0.00003250744190697674	2.076687	54	0.002284554	290	0.011455320501724138	1.581278	21	23	0.001936912	
Human Phenotype	Glioma	231	0.000002861151	0.0000826513446883117	2.20696	43	0.001819182	256	0.006863576709374999	1.731876	15	15	0.001383509	
Human Phenotype	Progressive external ophthalmoplegia	332	0.00003308953	0.0006650796195481926	2.044704	40	0.001692262	256	0.006863576709374999	1.731876	15	15	0.001383509	
Mouse Phenotype Single KO	early cellular replicative senescence	4	6.181153e-188	1.4150204505249999e-184	5.81507	455	0.01924948	72	0.00018406422109722224	1.532044	46	52	0.00424276	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	5	2.013173e-178	3.6869250322e-175	5.296874	470	0.01988408	55	0.00004113219510727273	1.529824	53	60	0.004888397	
Mouse Phenotype Single KO	decreased fibroblast proliferation	9	2.066316e-143	2.1023617346666666e-140	3.244915	660	0.02792233	29	5.673140410344828e-8	1.498739	90	104	0.008301051	
Mouse Phenotype Single KO	abnormal fibroblast proliferation	10	3.623653e-134	3.3181790521e-131	2.689812	824	0.0348606	28	7.297595931785715e-9	1.451361	119	142	0.01097583	
Mouse Phenotype Single KO	abnormal fibroblast physiology	13	6.589528e-97	4.6415621458461536e-94	2.049507	1030	0.04357575	25	2.1374727249999997e-11	1.418489	172	210	0.01586423	
Mouse Phenotype Single KO	abnormal placenta labyrinth size	64	3.513245e-22	5.02668507265625e-20	2.047917	225	0.009518974	235	0.03930640301702128	1.393031	37	46	0.003412654	
Mouse Phenotype Single KO	increased B cell derived lymphoma incidence	65	1.807975e-21	2.54701955e-19	2.101579	204	0.008630537	197	0.023273719389847715	1.407149	39	48	0.003597122	
Mouse Phenotype	abnormal lysosome physiology	7	1.388345e-203	1.896280935e-200	5.609998	509	0.02153404	208	0.003124922296298077	1.454776	42	50	0.003873824	
Mouse Phenotype	early cellular replicative senescence	14	2.816692e-154	1.9235994437142857e-151	4.257709	507	0.02144942	83	0.0000147173855313253	1.494633	63	73	0.005810736	
Mouse Phenotype	abnormal cellular replicative senescence	16	8.902359e-146	5.3197158999375e-143	3.915753	527	0.02229555	82	0.000014475727112195123	1.463848	71	84	0.006548607	
Mouse Phenotype	decreased fibroblast proliferation	17	2.90641e-141	1.6345991770588234e-138	3.037917	715	0.03024919	43	8.210946777209302e-9	1.465434	110	130	0.01014573	
Mouse Phenotype	abnormal fibroblast proliferation	19	6.171656e-134	3.105642264e-131	2.577129	886	0.03748361	28	5.520944815714286e-10	1.436438	141	170	0.01300498	
Mouse Phenotype	shiny skin	159	2.458164e-16	1.4781450316981132e-14	2.392377	114	0.004822947	315	0.017384098547619048	1.477188	29	34	0.002674783