# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process	24	2.028218e-55	1.1120550275833331e-52	2.03241	600	0.02218033	111	6.388184736936938e-21	1.40043	191	198	0.01476728	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	25	1.315314e-54	6.9232867704e-52	2.328779	435	0.01608074	387	0.000001939276512635659	1.310434	102	113	0.007886191	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	33	1.393446e-50	5.55647148909091e-48	2.448197	364	0.01345606	905	0.012957136577900553	1.194807	93	113	0.007190351	
GO Biological Process	regulation of DNA-templated transcription in response to stress	36	9.280416e-50	3.392249837333333e-47	2.172322	459	0.01696795	347	4.076385160230548e-7	1.317559	108	119	0.008350085	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	56	1.523918e-40	3.580935171785714e-38	2.276908	335	0.01238402	238	1.3991041358403363e-11	1.39024	113	118	0.008736663	
GO Biological Process	viral gene expression	68	1.262211e-35	2.4425639042647056e-33	2.117519	344	0.01271672	169	5.887563962603551e-15	1.417462	124	127	0.009587135	
GO Biological Process	cotranslational protein targeting to membrane	71	1.573498e-34	2.9162901664788733e-32	2.289132	280	0.01035082	197	3.701358176243655e-13	1.436941	97	98	0.007499613	
GO Biological Process	endoplasmic reticulum unfolded protein response	77	2.181439e-33	3.72799425987013e-31	2.023029	359	0.01327123	517	0.000055136566336557066	1.273469	100	114	0.00773156	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	80	1.193673e-32	1.963442875875e-30	2.209197	285	0.01053565	580	0.0002766092132586207	1.302857	70	78	0.005412092	
GO Biological Process	regulation of hematopoietic stem cell differentiation	83	2.078606e-32	3.2954670306024096e-30	2.191098	288	0.01064656	954	0.017148204644654087	1.19805	85	103	0.006571826	
GO Biological Process	erythrocyte differentiation	95	1.776164e-29	2.4602675869473684e-27	2.000115	324	0.01197738	642	0.000729965804517134	1.304476	62	69	0.004793567	
GO Biological Process	IRE1-mediated unfolded protein response	96	1.885428e-29	2.5844111512499998e-27	2.517703	196	0.007245573	857	0.009896077776896151	1.276543	51	58	0.003943096	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	97	3.730776e-29	5.06116302927835e-27	2.208514	253	0.009352704	221	2.942662618959276e-12	1.435975	91	92	0.00703572	
GO Biological Process	translational elongation	107	3.50503e-28	4.3105317542056074e-26	2.031459	297	0.01097926	362	6.290045620994476e-7	1.322134	102	112	0.007886191	
GO Biological Process	viral transcription	108	4.261788e-28	5.19267299e-26	2.012815	303	0.01120106	202	6.678329301485149e-13	1.413213	110	113	0.008504716	
GO Biological Process	mitochondrial transmembrane transport	109	4.622167e-28	5.580100509449542e-26	2.122194	266	0.009833278	464	0.000019622040014008623	1.329318	76	83	0.005875986	
GO Biological Process	protein refolding	116	4.347212e-27	4.931462302413793e-25	4.890366	73	0.002698606	1149	0.04766501309834639	1.382624	20	21	0.001546312	
GO Biological Process	protein targeting to ER	120	1.092023e-26	1.1974942214166668e-24	2.071846	267	0.009870245	188	1.2965156730851064e-13	1.437381	100	101	0.00773156	
GO Biological Process	mitochondrial translational termination	145	4.582162e-24	4.1583910177931038e-22	2.154143	218	0.008058852	422	0.000006718268203317536	1.334947	80	87	0.006185248	
GO Biological Process	mitochondrial translational elongation	152	1.499059e-23	1.2977708803289475e-21	2.149676	214	0.007910983	442	0.000011517408795701358	1.332199	78	85	0.006030617	
GO Cellular Component	ribosomal subunit	23	3.902241e-45	2.9317706295652174e-43	2.038944	482	0.0178182	55	1.8976811170909091e-13	1.341893	171	185	0.01322097	
GO Cellular Component	large ribosomal subunit	37	7.954431e-32	3.7149342616216215e-30	2.125048	303	0.01120106	74	6.248265859459459e-9	1.350763	107	115	0.008272769	
GO Cellular Component	mitochondrial ribosome	46	3.842622e-26	1.443489307826087e-24	2.335153	200	0.007393442	123	0.000024954230634146345	1.315119	77	85	0.005953301	
GO Cellular Component	PcG protein complex	49	3.980021e-25	1.4035665893877552e-23	2.119866	237	0.008761229	116	0.000011341553710344826	1.420195	45	46	0.003479202	
GO Cellular Component	cytoplasmic stress granule	56	7.067405e-22	2.180799257142857e-20	2.192297	189	0.006986803	149	0.0002553963124832215	1.384232	41	43	0.00316994	
GO Cellular Component	cytosolic large ribosomal subunit	72	1.532649e-18	3.6783576e-17	2.048686	185	0.006838934	96	9.303651e-7	1.404157	59	61	0.004561621	
GO Cellular Component	intrinsic component of mitochondrial outer membrane	77	1.218401e-16	2.734281724675325e-15	2.754031	90	0.003327049	224	0.01653159085714286	1.388635	22	23	0.001700943	
GO Cellular Component	integral component of mitochondrial outer membrane	82	2.627483e-16	5.536939785365854e-15	2.753911	88	0.003253114	232	0.022263306206896552	1.385766	21	22	0.001623628	
GO Cellular Component	mitochondrial large ribosomal subunit	91	1.561127e-15	2.964425775824176e-14	2.298331	117	0.004325164	209	0.00949624466985646	1.28096	45	51	0.003479202	
GO Cellular Component	COPI-coated vesicle	93	3.265989e-15	6.068418270967742e-14	2.583759	91	0.003364016	178	0.001823604026966292	1.451755	23	23	0.001778259	
GO Cellular Component	nuclear ubiquitin ligase complex	97	1.651052e-14	2.941255521649485e-13	2.244254	114	0.004214262	133	0.00008154404715789474	1.415461	39	40	0.003015308	
GO Cellular Component	MLL1 complex	121	5.231525e-11	7.471136528925619e-10	2.19671	87	0.003216147	147	0.0002350021224489796	1.451755	29	29	0.002242152	
GO Cellular Component	sex chromosome	137	6.941164e-10	8.754986417518248e-9	2.041783	91	0.003364016	162	0.0006537354666666668	1.451755	26	26	0.002010206	
GO Cellular Component	COPI-coated vesicle membrane	151	4.835801e-9	5.533949753642384e-8	2.271528	64	0.002365901	227	0.019497084898678414	1.451755	16	16	0.00123705	
GO Cellular Component	exon-exon junction complex	176	1.734564e-7	0.0000017030264727272728	2.078684	62	0.002291967	244	0.02947479344262295	1.382624	20	21	0.001546312	
GO Cellular Component	TOR complex	177	1.7767e-7	0.0000017345410169491527	2.025104	66	0.002439836	238	0.02700652719327731	1.451755	15	15	0.001159734	
GO Cellular Component	anaphase-promoting complex	184	3.758295e-7	0.000003529529217391304	2.186919	52	0.001922295	191	0.0035855339560209427	1.451755	21	21	0.001623628	
GO Molecular Function	unfolded protein binding	9	5.636915e-39	2.644339458888889e-36	2.331504	306	0.01131197	78	0.000005070075305128205	1.314797	96	106	0.007422298	
GO Molecular Function	rRNA binding	12	9.589605e-24	3.3739426925e-21	2.648646	142	0.005249344	142	0.0031119470028169016	1.30658	54	60	0.004175043	
GO Molecular Function	snRNA binding	27	3.003717e-15	4.696923397777778e-13	2.513375	96	0.003548852	143	0.003324013076923077	1.375347	36	38	0.002783362	
GO Molecular Function	protein binding involved in protein folding	56	5.039976e-11	3.799781905714286e-9	2.209887	86	0.00317918	130	0.0013701961883076923	1.451755	27	27	0.002087521	
GO Molecular Function	O-methyltransferase activity	68	4.010155e-10	2.4898344720588236e-8	2.246981	75	0.002772541	172	0.009728217031395349	1.451755	21	21	0.001623628	
Human Phenotype	CNS hypomyelination	64	2.312544e-9	2.411188455e-7	2.064242	83	0.003068278	314	0.0042647143	1.403363	29	30	0.002242152	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	102	8.367038e-15	7.511467349607842e-13	2.456209	97	0.003585819	205	0.005776597413170732	1.451755	24	24	0.001855574	
Mouse Phenotype Single KO	increased hemangiosarcoma incidence	137	1.434501e-12	9.588120917518248e-11	2.112538	111	0.00410336	317	0.044310231930599374	1.391265	23	24	0.001778259	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	18	4.07425e-42	2.1641057916666667e-39	2.585052	272	0.01005508	513	0.039828311748538014	1.302857	35	39	0.002706046	
Mouse Phenotype	pancytopenia	25	6.518928e-34	2.49309882432e-31	2.789696	190	0.00702377	359	0.007522730624791086	1.401695	28	29	0.002164837	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	114	2.23829e-16	1.8772184815789477e-14	2.406818	113	0.004177295	231	0.0005695603590909091	1.451755	30	30	0.002319468	
Mouse Phenotype	increased acute lymphoblastic leukemia incidence	250	2.124939e-10	8.126616711600001e-9	2.578265	59	0.002181065	529	0.046291307540642715	1.451755	16	16	0.00123705	
Mouse Phenotype	increased adrenal gland tumor incidence	407	1.596514e-7	0.000003750434976412776	2.112827	60	0.002218033	486	0.03469429185802469	1.451755	17	17	0.001314365