# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of gene expression, epigenetic	14	8.68362e-112	8.161982541428571e-109	2.062163	1183	0.03158541	568	0.00023471555396126762	1.163529	207	248	0.01536748	
GO Biological Process	mRNA catabolic process	33	2.005832e-82	7.998407056969696e-80	2.02204	914	0.02440327	116	8.415571866810344e-20	1.348175	206	213	0.01529324	
GO Biological Process	nuclear-transcribed mRNA catabolic process	34	9.1653e-82	3.547240667647059e-79	2.077078	849	0.02266781	120	6.781192379333333e-19	1.351745	192	198	0.0142539	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	38	1.509458e-78	5.2270941636842106e-76	2.560004	527	0.01407059	1046	0.041172774917782026	1.1596	94	113	0.006978471	
GO Biological Process	gene silencing	41	8.928919e-72	2.8657474419756094e-69	2.05106	767	0.02047845	921	0.019382364023887075	1.138422	147	180	0.01091314	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	42	2.825186e-68	8.851576803333332e-66	2.444641	498	0.01329631	248	9.104934954032259e-11	1.346733	114	118	0.008463252	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	48	1.166777e-65	3.1986705297916665e-63	2.231002	577	0.01540556	522	0.00011604521279885058	1.245953	101	113	0.007498144	
GO Biological Process	cotranslational protein targeting to membrane	52	7.664455e-64	1.9395492950961538e-61	2.544927	431	0.01150745	227	1.5248712966079293e-11	1.379762	97	98	0.007201188	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	56	6.083483e-63	1.429509871375e-60	3.816749	232	0.006194265	1073	0.04404762473998136	1.335904	23	24	0.001707498	
GO Biological Process	regulation of DNA-templated transcription in response to stress	57	6.677214e-63	1.5414992811578948e-60	2.11928	620	0.01655364	512	0.00010140225165429686	1.241702	106	119	0.007869339	
GO Biological Process	viral gene expression	69	2.306263e-57	4.398277509710145e-55	2.231812	502	0.01340311	220	6.767889029090909e-12	1.350082	123	127	0.009131403	
GO Biological Process	multi-organism metabolic process	71	1.759164e-56	3.260399869859155e-54	2.046229	604	0.01612645	208	1.7610265828365385e-12	1.337089	141	147	0.01046771	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	75	3.414346e-55	5.990583868533333e-53	2.471444	392	0.01046617	251	9.62535239123506e-11	1.378835	91	92	0.006755754	
GO Biological Process	protein targeting to ER	80	2.126498e-53	3.49782339775e-51	2.348255	419	0.01118706	219	5.9728598852511415e-12	1.380185	100	101	0.007423905	
GO Biological Process	translational initiation	85	7.303603e-52	1.1306836691411764e-49	2.024732	568	0.01516527	271	1.463253122398524e-9	1.306253	134	143	0.009948033	
GO Biological Process	endoplasmic reticulum unfolded protein response	89	3.427264e-51	5.067344604044944e-49	2.096042	515	0.0137502	328	9.54884840945122e-8	1.308391	107	114	0.007943578	
GO Biological Process	protein localization to endoplasmic reticulum	106	8.893346e-47	1.1040333963584906e-44	2.041837	500	0.01334971	206	1.4593049933980584e-12	1.360261	121	124	0.008982925	
GO Biological Process	viral transcription	107	1.109796e-46	1.364841641495327e-44	2.13984	446	0.01190794	238	3.800119050504201e-11	1.356978	110	113	0.008166295	
GO Biological Process	regulation of megakaryocyte differentiation	118	4.680692e-44	5.219764917627119e-42	2.139849	420	0.01121376	927	0.02028971588888889	1.210567	66	76	0.004899777	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	120	8.996059e-44	9.864928365083332e-42	2.112303	430	0.01148075	236	3.198756630169491e-11	1.367435	103	105	0.007646622	
GO Cellular Component	ribosomal subunit	28	4.786164e-67	2.953746925714286e-65	2.089775	684	0.0182624	44	1.3172807127272728e-16	1.341241	178	185	0.01321455	
GO Cellular Component	large ribosomal subunit	53	7.243795e-41	2.3617505207547172e-39	2.086933	412	0.01100016	61	1.0507106832786887e-11	1.357622	112	115	0.008314774	
GO Cellular Component	mitochondrial ribosome	70	2.614179e-33	6.453287588571428e-32	2.285281	271	0.007235542	93	5.344863793548388e-7	1.328387	81	85	0.006013363	
GO Cellular Component	cytoplasmic stress granule	72	3.718664e-32	8.9247936e-31	2.25359	269	0.007182143	152	0.00012574019368421054	1.361568	42	43	0.00311804	
GO Cellular Component	small ribosomal subunit	81	2.818924e-28	6.013704533333334e-27	2.091714	278	0.007422438	143	0.00007777610786013986	1.297182	67	72	0.004974016	
GO Cellular Component	cytosolic large ribosomal subunit	89	6.87169e-26	1.3341888e-24	2.071518	259	0.006915149	83	3.176665677108434e-8	1.393987	61	61	0.004528582	
GO Cellular Component	COPI-coated vesicle	99	4.242535e-22	7.405151999999999e-21	2.665871	130	0.003470924	243	0.03427616	1.333379	22	23	0.001633259	
GO Cellular Component	outer mitochondrial membrane protein complex	105	3.935979e-21	6.477496868571429e-20	3.499417	82	0.002189352	264	0.04478197745454545	1.393987	15	15	0.001113586	
GO Cellular Component	intrinsic component of mitochondrial outer membrane	108	6.183103e-20	9.8929648e-19	2.630016	119	0.003177231	243	0.03427616	1.333379	22	23	0.001633259	
GO Cellular Component	nuclear ubiquitin ligase complex	110	7.709026e-20	1.2110179025454544e-18	2.260734	159	0.004245207	159	0.00030487853886792453	1.359137	39	40	0.002895323	
GO Cellular Component	integral component of mitochondrial outer membrane	112	8.375172e-20	1.2921693942857144e-18	2.644468	117	0.003123832	259	0.04309020861776062	1.330624	21	22	0.00155902	
GO Cellular Component	mitochondrial small ribosomal subunit	128	1.119852e-16	1.5118002e-15	2.502888	107	0.002856838	257	0.04323844631906615	1.294416	26	28	0.001930215	
GO Cellular Component	mitochondrial large ribosomal subunit	130	1.202229e-16	1.5980397784615385e-15	2.128154	150	0.004004913	172	0.0006477419051162791	1.311987	48	51	0.003563474	
GO Cellular Component	endoribonuclease complex	165	2.836609e-13	2.9707032436363635e-12	2.092148	121	0.00323063	209	0.006688710981818181	1.345918	28	29	0.002078693	
GO Cellular Component	small-subunit processome	171	9.39013e-13	9.488973473684211e-12	2.039613	123	0.003284028	241	0.032296011684647304	1.274502	32	35	0.00237565	
GO Cellular Component	anaphase-promoting complex	173	1.155181e-12	1.153845530635838e-11	2.460364	81	0.002162653	210	0.007655583908571429	1.393987	21	21	0.00155902	
GO Cellular Component	MLL1 complex	175	1.95401e-12	1.929445302857143e-11	2.078947	114	0.003043734	173	0.0006490732578034683	1.393987	29	29	0.002152932	
GO Cellular Component	BLOC complex	208	5.782598e-11	4.804004492307692e-10	2.092021	97	0.002589844	203	0.004071851538916256	1.393987	23	23	0.001707498	
GO Cellular Component	BLOC-1 complex	210	7.190478e-11	5.916736182857143e-10	2.33898	75	0.002002456	229	0.0190396095720524	1.393987	18	18	0.001336303	
GO Cellular Component	Seh1-associated complex	260	2.647357e-8	1.7594741907692308e-7	2.110981	68	0.00181556	264	0.04478197745454545	1.393987	15	15	0.001113586	
GO Molecular Function	unfolded protein binding	8	1.860329e-54	9.8178862975e-52	2.349782	427	0.01140065	61	2.452678846557377e-7	1.315082	100	106	0.007423905	
GO Molecular Function	rRNA binding	10	4.063415e-46	1.7155738129999998e-43	3.058063	227	0.006060768	102	0.00021338882070588236	1.324287	57	60	0.004231626	
GO Molecular Function	protein transmembrane transporter activity	19	5.434839e-26	1.2076784346315788e-23	2.950083	131	0.003497624	227	0.046929092325991184	1.393987	18	18	0.001336303	
GO Molecular Function	snRNA binding	40	4.425438e-20	4.671049809e-18	2.496003	132	0.003524323	168	0.010264388179761904	1.320619	36	38	0.002672606	
GO Molecular Function	polyubiquitin binding	48	1.917889e-19	1.6869431995833336e-17	2.012821	204	0.005446681	131	0.0017647879427480917	1.332032	43	45	0.003192279	
GO Molecular Function	telomeric DNA binding	62	3.699814e-16	2.51945398516129e-14	2.059321	157	0.004191809	152	0.004931532098684211	1.352987	33	34	0.002449889	
GO Molecular Function	SUMO transferase activity	69	1.450804e-15	8.877238388405798e-14	2.3826	109	0.002910237	214	0.035696970542056075	1.393987	19	19	0.001410542	
GO Molecular Function	K63-linked polyubiquitin binding	107	1.3934e-12	5.498069906542056e-11	2.075627	116	0.003097132	194	0.02024745192886598	1.393987	21	21	0.00155902	
GO Molecular Function	proton-transporting ATP synthase activity, rotational mechanism	293	1.171197e-7	0.0000016876429126279862	2.037628	67	0.001788861	227	0.046929092325991184	1.393987	18	18	0.001336303	
Human Phenotype	Abnormal CSF metabolite level	9	2.912272e-24	2.159287895111111e-21	2.10661	232	0.006194265	157	0.00009295017214649681	1.327606	60	63	0.004454343	
Human Phenotype	Increased CSF lactate	21	9.234302e-23	2.934309392666667e-20	2.125643	212	0.005660277	146	0.00005359483937671233	1.345918	56	58	0.004157387	
Human Phenotype	Progressive macrocephaly	173	2.956322e-11	1.1403200408092484e-9	2.168334	92	0.002456346	285	0.008030674531578947	1.393987	24	24	0.001781737	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	333	4.986548e-8	9.992563004204203e-7	2.22295	58	0.001548566	383	0.04396146265535248	1.393987	18	18	0.001336303	
Human Phenotype	Increased muscle lipid content	375	1.443402e-7	0.0000025684857456	2.090578	62	0.001655364	360	0.03353864628888889	1.393987	19	19	0.001410542	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	2	4.802108e-75	2.1986451478e-71	3.031178	380	0.01014578	250	0.034773945582	1.31433	33	35	0.002449889	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	7	3.698689e-56	4.838413596142858e-53	2.135936	542	0.01447108	144	0.0023544007831944446	1.315082	50	53	0.003711952	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	203	1.58648e-14	7.156353379310345e-13	2.194623	120	0.00320393	204	0.01539567756617647	1.393987	24	24	0.001781737	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	8	4.623841e-68	5.526067975125e-65	2.752516	401	0.01070647	312	0.009424222540384615	1.3225	37	39	0.002746845	
Mouse Phenotype	pancytopenia	66	4.248173e-33	6.154057886818182e-31	2.460234	232	0.006194265	240	0.002588738351875	1.393987	29	29	0.002152932	
Mouse Phenotype	decreased circulating total protein level	69	1.580405e-32	2.1898916239130435e-30	2.007465	357	0.009531692	441	0.04829425870068028	1.228598	52	59	0.003860431	
Mouse Phenotype	enlarged liver sinusoidal spaces	90	3.03324e-29	3.2223119599999996e-27	2.030228	310	0.00827682	375	0.0244799818504	1.291988	38	41	0.002821084	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	181	1.42942e-19	7.550654486187846e-18	2.307497	150	0.004004913	232	0.0019199419373275863	1.393987	30	30	0.002227171