# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	22	1.290418e-108	7.718459300909091e-106	2.104124	1101	0.02182532	696	0.0050192358574712645	1.130295	141	155	0.009330334	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	25	9.144987e-107	4.81355535732e-104	2.379853	829	0.01643341	346	0.0000029508239816473994	1.209535	110	113	0.007278984	
GO Biological Process	endoplasmic reticulum unfolded protein response	26	1.168602e-106	5.914474506923077e-104	2.420454	801	0.01587836	455	0.00007325681818021979	1.188026	109	114	0.007212811	
GO Biological Process	cellular response to topologically incorrect protein	30	5.315471e-100	2.3315427629666665e-97	2.207755	908	0.01799944	365	0.000005787140729315068	1.188888	133	139	0.008800953	
GO Biological Process	cellular response to unfolded protein	35	3.870045e-93	1.4550263472857143e-90	2.228336	828	0.01641359	469	0.00010154435551599146	1.18091	115	121	0.007609846	
GO Biological Process	regulation of DNA-templated transcription in response to stress	36	4.505783e-92	1.6469888471388888e-89	2.180024	859	0.01702811	323	9.909130325386996e-7	1.211198	116	119	0.007676019	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	41	2.34724e-90	7.533495404878049e-88	2.292073	756	0.01498632	947	0.03840393704751848	1.136776	86	94	0.005690842	
GO Biological Process	IRE1-mediated unfolded protein response	53	1.204258e-82	2.9899681173584907e-80	2.975697	432	0.008563613	731	0.006755079942954856	1.199677	56	58	0.003705664	
GO Biological Process	liver regeneration	88	1.186485e-69	1.774199558522727e-67	2.785994	403	0.00798874	751	0.008701450952996004	1.242522	35	35	0.00231604	
GO Biological Process	positive regulation of mRNA metabolic process	103	1.295982e-62	1.6557113726213592e-60	2.370919	485	0.009614241	834	0.0178347682206235	1.194733	50	52	0.003308629	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	105	1.880674e-62	2.3569323015238094e-60	2.15764	592	0.01173532	376	0.00000754764542712766	1.200403	114	118	0.007543674	
GO Biological Process	regulation of mitochondrial membrane permeability	121	1.375334e-58	1.4957041409917354e-56	2.108346	585	0.01159656	546	0.0005315621431318682	1.208481	71	73	0.004698253	
GO Biological Process	regulation of necrotic cell death	124	5.708318e-58	6.0577223033870965e-56	3.91221	207	0.004103398	957	0.03891571433646813	1.242522	27	27	0.00178666	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	132	5.667159e-57	5.649556460681818e-55	2.182255	525	0.01040717	589	0.001230721725976231	1.194733	75	78	0.004962943	
GO Biological Process	regulation of mitophagy	174	8.350414e-51	6.315120564712644e-49	2.472744	360	0.007136344	951	0.0385174446130389	1.189649	45	47	0.002977766	
GO Biological Process	cotranslational protein targeting to membrane	183	1.798803e-49	1.2934671408196722e-47	2.121851	484	0.009594418	367	0.000005950230883106268	1.217165	96	98	0.006352567	
GO Biological Process	mitochondrial transmembrane transport	185	5.049038e-49	3.5913670833513517e-47	2.100591	491	0.00973318	464	0.00009028321836206896	1.212582	81	83	0.005359979	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	198	1.61351e-47	1.0723322267676769e-45	2.124226	463	0.009178131	492	0.00021626795103252034	1.223977	66	67	0.00436739	
GO Biological Process	protein targeting to ER	214	1.271588e-45	7.8190778e-44	2.038914	490	0.009713357	350	0.0000034350810037714287	1.217918	99	101	0.006551085	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	236	8.947351e-43	4.988906432584746e-41	2.06899	442	0.008761844	400	0.000017909030547999996	1.215511	90	92	0.005955532	
GO Cellular Component	cleavage furrow	57	8.221316e-43	2.492356850526316e-41	2.073616	440	0.008722198	120	0.000176639472	1.242522	52	52	0.003440974	
GO Cellular Component	mitochondrial ribosome	64	2.745224e-40	7.4121048e-39	2.216385	354	0.007017405	92	0.000003757104	1.227905	84	85	0.005558497	
GO Cellular Component	PcG protein complex	69	7.63409e-39	1.9118416695652174e-37	2.024086	422	0.008365381	180	0.005302000320000001	1.215511	45	46	0.002977766	
GO Cellular Component	mitochondrial large ribosomal subunit	86	1.676522e-31	3.368639553488372e-30	2.41223	229	0.004539508	126	0.00020916521142857144	1.242522	51	51	0.003374801	
GO Cellular Component	nuclear ubiquitin ligase complex	97	1.350275e-28	2.405438350515464e-27	2.333007	221	0.004380922	199	0.015580299256281408	1.211459	39	40	0.002580731	
GO Cellular Component	MLL1 complex	124	1.078437e-23	1.5028541419354837e-22	2.369453	175	0.003469056	200	0.01582742592	1.242522	29	29	0.001919005	
GO Cellular Component	ESCRT complex	220	2.319558e-13	1.8219073745454545e-12	2.008141	135	0.002676129	206	0.01910005374757282	1.242522	28	28	0.001852832	
GO Molecular Function	unfolded protein binding	16	1.515128e-64	3.99804401e-62	2.259417	553	0.01096222	95	0.00045269039515789475	1.183913	101	106	0.00668343	
GO Molecular Function	rRNA binding	24	1.386711e-38	2.4394557675e-36	2.550541	255	0.00505491	87	0.0001041816352413793	1.242522	60	60	0.003970355	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	32	2.40994e-31	3.1796145875000004e-29	2.32676	245	0.004856678	179	0.04320775930726257	1.242522	29	29	0.001919005	
Human Phenotype	Aplasia/hypoplasia of the femur	15	5.075344e-41	2.2578513674666666e-38	2.438539	296	0.00586766	396	0.012930632711616161	1.242522	33	33	0.002183695	
Human Phenotype	Aplasia/Hypoplasia involving the femoral head and neck	17	2.673148e-39	1.049289212e-36	2.83054	217	0.004301629	534	0.043958637425093636	1.242522	26	26	0.001720487	
Human Phenotype	Abnormal shape of the occiput	18	2.808603e-39	1.0412115455e-36	2.411907	289	0.005728898	543	0.04787200368692449	1.208008	35	36	0.00231604	
Human Phenotype	Abnormality of transition element cation homeostasis	148	2.291474e-19	1.0331760812162162e-17	2.426648	134	0.002656306	468	0.026119918576923078	1.242522	29	29	0.001919005	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	369	3.604682e-22	9.339936206504065e-21	2.192919	192	0.00380605	440	0.03202430874545455	1.242522	30	30	0.001985177