# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process	5	4.379306e-46	1.1525457530799999e-42	2.007526	511	0.02190876	199	2.5744287437688446e-13	1.383678	175	198	0.01459063	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	7	8.477704e-45	1.593687241942857e-41	2.475201	314	0.01346253	348	8.547950272413793e-8	1.379792	104	118	0.008671002	
GO Biological Process	viral gene expression	16	3.319849e-40	2.7303683119375e-37	2.305959	323	0.0138484	249	2.4611547221686747e-10	1.417608	115	127	0.009588127	
GO Biological Process	viral transcription	30	2.266866e-34	9.943229898e-32	2.241994	291	0.01247642	268	1.104886105858209e-9	1.42699	103	113	0.008587627	
GO Biological Process	multi-organism metabolic process	32	5.411262e-34	2.2252123955625e-31	2.012862	370	0.01586349	232	3.3056599116379305e-11	1.405785	132	147	0.0110055	
GO Biological Process	translational initiation	36	1.700757e-32	6.2167392675000006e-30	2.014916	352	0.01509175	323	2.9639543447678018e-8	1.357525	124	143	0.0103385	
GO Biological Process	cotranslational protein targeting to membrane	37	4.324273e-32	1.5379218488378378e-29	2.342017	247	0.01058995	393	7.074753865139949e-7	1.38981	87	98	0.007253627	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	38	1.507369e-31	5.219860176578948e-29	2.379183	235	0.01007546	402	0.0000011544629656965175	1.395366	82	92	0.006836752	
GO Biological Process	protein targeting to ER	40	1.076355e-30	3.5409388612500005e-28	2.267916	252	0.01080432	366	2.766894033169399e-7	1.395029	90	101	0.007503752	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	58	7.887133e-25	1.7894272956379312e-22	2.035179	258	0.01106157	370	3.203017252756757e-7	1.386615	93	105	0.007753877	
GO Biological Process	mitochondrial translational termination	79	1.086365e-21	1.8095540550632914e-19	2.177469	190	0.008146116	585	0.00022054672949743591	1.331603	74	87	0.006169752	
GO Biological Process	mitochondrial translational elongation	93	1.034918e-19	1.464353329247312e-17	2.120366	182	0.007803121	610	0.0003795340352131147	1.326098	72	85	0.006003002	
GO Biological Process	regulation of pri-miRNA transcription from RNA polymerase II promoter	103	7.326213e-19	9.359770569611651e-17	2.068467	184	0.00788887	811	0.005364794494821208	1.457565	27	29	0.002251126	
GO Biological Process	regulation of cellular amino acid metabolic process	129	3.005371e-17	3.0657113944961238e-15	2.261529	136	0.005830904	1055	0.026353685212322276	1.278518	49	60	0.004085376	
GO Biological Process	cytoplasmic sequestering of protein	132	7.607086e-17	7.583457929848485e-15	2.656857	97	0.004158806	951	0.015308192637223977	1.364823	34	39	0.002834751	
GO Biological Process	IRE1-mediated unfolded protein response	134	1.117604e-16	1.0975038086567164e-14	2.160213	145	0.006216772	839	0.007135081135756853	1.322605	49	58	0.004085376	
GO Biological Process	positive regulation of pri-miRNA transcription from RNA polymerase II promoter	141	3.947418e-16	3.683976841276596e-14	2.418627	110	0.004716172	1003	0.020563882859421734	1.487256	19	20	0.001584125	
GO Biological Process	termination of RNA polymerase II transcription	176	1.720449e-14	1.2863288858522728e-12	2.028552	144	0.006173898	536	0.00009856584462499999	1.384022	61	69	0.005085876	
GO Biological Process	DNA replication checkpoint	240	1.652375e-12	9.059834427083333e-11	3.812649	41	0.001757846	905	0.011127791300331494	1.565533	16	16	0.001334	
GO Biological Process	intra-S DNA damage checkpoint	308	3.792039e-11	1.6201117273051948e-9	3.211011	45	0.001929343	905	0.011127791300331494	1.565533	16	16	0.001334	
GO Cellular Component	ribosomal subunit	22	9.478786e-38	7.44515554909091e-36	2.016417	411	0.01762133	69	1.2531693913043478e-8	1.320125	156	185	0.0130065	
GO Cellular Component	large ribosomal subunit	30	1.289242e-28	7.42603392e-27	2.147387	264	0.01131881	83	4.918096192771085e-7	1.361333	100	115	0.008337502	
GO Cellular Component	mitochondrial ribosome	35	5.369377e-23	2.6509381302857145e-21	2.342673	173	0.007417253	148	0.0006240634637837838	1.30768	71	85	0.005919626	
GO Cellular Component	cytosolic large ribosomal subunit	48	1.059364e-16	3.8137104e-15	2.067807	161	0.006902761	149	0.0006222939704697987	1.360217	53	61	0.004418876	
GO Cellular Component	PRC1 complex	51	2.134905e-15	7.233560470588234e-14	4.400275	44	0.001886469	246	0.03234438790243902	1.565533	12	12	0.0010005	
GO Cellular Component	nuclear ubiquitin ligase complex	52	3.105634e-15	1.0320260676923077e-13	2.39738	105	0.004501801	102	0.000006410542870588235	1.526394	39	40	0.003251626	
GO Cellular Component	spliceosomal snRNP complex	53	7.180582e-15	2.3411406973584907e-13	2.095048	137	0.005873778	120	0.000029180519999999998	1.41403	56	62	0.004669001	
GO Cellular Component	mitochondrial large ribosomal subunit	55	8.574284e-15	2.6938841367272725e-13	2.36941	104	0.004458926	160	0.0009458368919999999	1.381352	45	51	0.003751876	
GO Cellular Component	COPI-coated vesicle	58	5.357927e-14	1.5962927337931036e-12	2.634395	80	0.003429943	237	0.022962028556962027	1.429399	21	23	0.001750875	
GO Cellular Component	MLL1 complex	86	8.775479e-11	1.76325903627907e-9	2.284169	78	0.003344195	145	0.0004647001953103449	1.511549	28	29	0.002334501	
GO Cellular Component	COPI vesicle coat	96	5.75274e-10	1.0354931999999999e-8	2.508501	59	0.002529583	235	0.021619566842553194	1.565533	13	13	0.001083875	
GO Cellular Component	proteasome accessory complex	106	7.375892e-9	1.202409563773585e-7	2.314684	60	0.002572458	225	0.01672992768	1.435072	22	24	0.00183425	
GO Cellular Component	centriolar satellite	111	9.798383e-9	1.525369894054054e-7	2.127428	71	0.003044075	208	0.008580475384615384	1.445107	24	26	0.002001001	
GO Cellular Component	spliceosomal tri-snRNP complex	113	1.084696e-8	1.6587209628318582e-7	2.190639	66	0.002829703	221	0.014213581900452488	1.403581	26	29	0.002167751	
GO Cellular Component	BLOC complex	119	2.633652e-8	3.8243282823529406e-7	2.181876	63	0.00270108	237	0.022962028556962027	1.429399	21	23	0.001750875	
GO Cellular Component	proton-transporting two-sector ATPase complex, catalytic domain	129	4.37325e-8	5.858120930232557e-7	2.447473	48	0.002057966	251	0.03574699831075698	1.473443	16	17	0.001334	
GO Cellular Component	pre-autophagosomal structure membrane	140	1.948461e-7	0.0000024049575771428568	2.277713	50	0.002143715	200	0.006612236928	1.565533	16	16	0.001334	
GO Cellular Component	proteasome regulatory particle	146	3.472088e-7	0.000004109430180821917	2.139167	55	0.002358086	255	0.04414639510588235	1.416434	19	21	0.001584125	
GO Cellular Component	anaphase-promoting complex	149	3.703511e-7	0.000004295078528859061	2.29249	47	0.002015092	155	0.0009048096743225808	1.565533	21	21	0.001750875	
GO Cellular Component	exon-exon junction complex	161	7.598954e-7	0.000008155895970186334	2.099766	54	0.002315212	211	0.008571608872037914	1.490984	20	21	0.0016675	
GO Molecular Function	rRNA binding	5	1.001583e-30	8.457366852000001e-28	3.115145	144	0.006173898	112	0.0007039125730357143	1.382887	53	60	0.004418876	
GO Molecular Function	snRNA binding	13	1.418288e-15	4.606163027692307e-13	2.672077	88	0.003772938	126	0.0023500342263492067	1.441938	35	38	0.002918126	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	14	2.424493e-15	7.311578175714285e-13	2.321067	113	0.004844795	120	0.0013719367890000001	1.511549	28	29	0.002334501	
GO Molecular Function	DNA polymerase binding	34	1.337709e-10	1.6611198229411763e-8	3.289963	41	0.001757846	195	0.01656983874051282	1.565533	16	16	0.001334	
GO Molecular Function	NF-kappaB binding	44	8.903468e-10	8.543282249090909e-8	2.077987	86	0.003687189	238	0.04564572725210084	1.397797	25	28	0.002084376	
GO Molecular Function	mRNA 5'-UTR binding	101	4.905375e-7	0.000020505438861386137	2.000665	63	0.00270108	190	0.015500008611578946	1.494372	21	22	0.001750875	
GO Molecular Function	death receptor binding	116	0.000001156723	0.0000421007285	2.02466	57	0.002443835	179	0.0115246613150838	1.565533	17	17	0.001417375	
Human Phenotype	Abnormal CSF metabolite level	13	2.716563e-15	1.3944326845384615e-12	2.085103	143	0.006131024	113	0.000014753524669911503	1.441284	58	63	0.004835751	
Human Phenotype	Increased CSF lactate	26	3.342292e-13	8.578120967692308e-11	2.044812	127	0.005445035	111	0.000014767884042342341	1.457565	54	58	0.004502251	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	88	1.841281e-7	0.000013962350128409092	2.523369	41	0.001757846	281	0.0074078635313167265	1.565533	18	18	0.00150075	
Human Phenotype	Abnormal mitochondria in muscle tissue	100	3.265235e-7	0.000021788913155	2.143529	55	0.002358086	425	0.04944780926588235	1.429399	21	23	0.001750875	
Human Phenotype	Progressive macrocephaly	129	0.000001656353	0.0000856809578992248	2.043748	54	0.002315212	398	0.03652337449246231	1.435072	22	24	0.00183425	
Human Phenotype	Progressive external ophthalmoplegia	136	0.00000228121	0.00011193025242647059	2.227554	43	0.001843595	356	0.022467991	1.565533	15	15	0.001250625	
Human Phenotype	Increased muscle lipid content	158	0.000004166176	0.0001759550154936709	2.220004	41	0.001757846	406	0.03849724374630542	1.483136	18	19	0.00150075	
Human Phenotype	Acute necrotizing encephalopathy	165	0.000005111556	0.00020672371629090912	2.039173	49	0.00210084	373	0.028041126745308315	1.487256	19	20	0.001584125	
Mouse Phenotype Single KO	absent hypoglossal nerve	37	1.049739e-10	2.5979621683783784e-8	2.707689	56	0.00240096	330	0.03326077686060606	1.565533	15	15	0.001250625	
Mouse Phenotype Single KO	increased mammary adenocarcinoma incidence	80	2.086236e-8	0.0000023879578815	2.38437	53	0.002272338	291	0.02194964682027491	1.494372	21	22	0.001750875	
Mouse Phenotype Single KO	increased incidence of tumors by ionizing radiation induction	161	0.000001692206	0.00009624553007453416	2.27992	42	0.00180072	330	0.03326077686060606	1.565533	15	15	0.001250625	
Mouse Phenotype	absent hypoglossal nerve	49	1.049739e-10	2.0482764446938774e-8	2.707689	56	0.00240096	527	0.021746322148007587	1.565533	15	15	0.001250625	
Mouse Phenotype	abnormal hematopoietic stem cell proliferation	96	3.692755e-8	0.0000036777531828125002	2.958776	35	0.0015006	620	0.045340127937096776	1.565533	13	13	0.001083875	
Mouse Phenotype	increased incidence of tumors by UV-induction	100	4.78254e-8	0.000004572586494	2.981818	34	0.001457726	620	0.045340127937096776	1.565533	13	13	0.001083875