# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	negative regulation of gene expression, epigenetic	9	1.536261e-24	2.246184277666667e-21	3.517845	95	0.01904953	236	0.011394272158898305	1.604102	47	114	0.009738914	
GO Biological Process	protein-DNA complex subunit organization	17	2.153035e-19	1.666575739117647e-16	2.07889	184	0.03689593	71	0.000004736283655774648	1.618573	104	250	0.02154994	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	22	2.447056e-18	1.4636731774545456e-15	3.064561	84	0.01684379	261	0.016882553324904216	1.583865	46	113	0.009531703	
GO Biological Process	regulation of gene expression, epigenetic	23	2.463499e-18	1.4094427539565218e-15	2.133952	163	0.03268498	206	0.004993464893592234	1.427673	91	248	0.0188562	
GO Biological Process	nucleosome organization	24	7.842351e-18	4.2998957003749995e-15	2.384748	125	0.02506517	118	0.00010170169565932203	1.660985	73	171	0.0151264	
GO Biological Process	protein-DNA complex assembly	29	5.756824e-17	2.6122085177931036e-14	2.069055	161	0.03228394	96	0.000027064060470833334	1.616725	91	219	0.0188562	
GO Biological Process	nucleosome assembly	37	5.208456e-16	1.852380337945946e-13	2.43063	107	0.02145579	146	0.000490620246130137	1.6714	61	142	0.01263987	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	38	6.987681e-16	2.4197603757631577e-13	2.642557	91	0.01824744	357	0.04909777711764706	1.515002	44	113	0.009117281	
GO Biological Process	regulation of gene silencing	40	1.259791e-15	4.1443974422499994e-13	2.496779	99	0.01985161	300	0.025566221943666666	1.514739	51	131	0.01056776	
GO Biological Process	gene silencing	45	3.23018e-15	9.445764137777777e-13	2.289531	114	0.02285943	277	0.019332485468231048	1.448242	67	180	0.01388313	
GO Biological Process	chromatin assembly or disassembly	50	1.8418e-14	4.8472492399999995e-12	2.169306	121	0.02426308	134	0.0002516082307238806	1.617524	74	178	0.01533361	
GO Biological Process	cardiac vascular smooth muscle cell differentiation	53	2.008174e-14	4.985955031320754e-12	7.635909	25	0.005013034	250	0.015137218788	3.8908	6	6	0.001243266	
GO Biological Process	regulation of hematopoietic stem cell differentiation	58	2.475872e-14	5.61724131862069e-12	2.888759	70	0.01403649	344	0.04439093017732558	1.548765	41	103	0.008495649	
GO Biological Process	mRNA catabolic process	59	2.849981e-14	6.3564237252542375e-12	2.110114	127	0.02546621	173	0.0019093153735838151	1.497867	82	213	0.0169913	
GO Biological Process	regulation of DNA-templated transcription in response to stress	64	4.487635e-14	9.22699827578125e-12	2.413145	94	0.01884901	306	0.027887619281045748	1.536702	47	119	0.009738914	
GO Biological Process	RNA catabolic process	65	4.647196e-14	9.408069563692308e-12	2.006748	141	0.02827351	169	0.001757800243254438	1.46914	91	241	0.0188562	
GO Biological Process	chromatin assembly	66	4.875804e-14	9.721318914545454e-12	2.231575	110	0.02205735	179	0.0023004519691620113	1.57602	64	158	0.0132615	
GO Biological Process	nuclear-transcribed mRNA catabolic process	67	8.839695e-14	1.7361424851492536e-11	2.14976	117	0.023461	209	0.0063384069722488045	1.473788	75	198	0.01554082	
GO Biological Process	multi-organism metabolic process	74	4.343007e-13	7.722922853108107e-11	2.340798	92	0.01844796	260	0.016418595645384615	1.508677	57	147	0.01181102	
GO Biological Process	stress-activated MAPK cascade	78	1.196205e-12	2.0180591788461537e-10	2.134069	108	0.02165631	221	0.009513165078280544	1.656479	43	101	0.00891007	
GO Cellular Component	nucleosome	30	7.286472e-18	4.197007872e-16	3.662561	64	0.01283337	39	0.00012164575015384614	1.815707	49	105	0.01015334	
GO Cellular Component	vesicle coat	32	1.336333e-15	7.2161982e-14	3.200049	66	0.01323441	74	0.0484393894054054	1.754674	23	51	0.004765852	
GO Cellular Component	DNA packaging complex	33	2.9436e-15	1.5413760000000002e-13	3.113058	67	0.01343493	42	0.0004265802514285714	1.736964	50	112	0.01036055	
GO Cellular Component	mitochondrial nucleoid	123	0.00002369471	0.0003328817795121951	2.498489	27	0.005414077	71	0.04343527571830986	1.852762	20	42	0.004144219	
GO Cellular Component	cytoplasmic stress granule	140	0.00005130619	0.0006332649737142858	2.139245	34	0.006817726	61	0.025972347068852458	1.900158	21	43	0.00435143	
GO Molecular Function	nucleosome binding	13	1.322575e-12	4.2953166538461535e-10	2.81761	63	0.01263285	92	0.04450898942391304	1.709594	29	66	0.006009117	
GO Molecular Function	ribonucleoprotein complex binding	19	3.255566e-10	7.234210343157895e-8	2.279377	73	0.01463806	95	0.046628567957894745	1.522487	45	115	0.009324492	
GO Molecular Function	nucleosomal DNA binding	21	1.270833e-9	2.554979488571428e-7	3.033555	41	0.008221376	57	0.00813222381754386	2.029983	24	46	0.004973063	
GO Molecular Function	protein serine/threonine kinase inhibitor activity	25	1.067352e-8	0.0000018025440575999998	2.656572	45	0.009023461	52	0.0019196484049999998	2.358061	20	33	0.004144219	
GO Molecular Function	O-methyltransferase activity	44	5.752878e-7	0.00005520147935454546	3.575237	22	0.00441147	79	0.026416995212658227	2.40859	13	21	0.002693742	
GO Molecular Function	SNAP receptor activity	110	0.00006446818	0.0024744059632727275	2.170336	32	0.006416683	76	0.0225807337	1.992849	21	41	0.00435143	
GO Molecular Function	NAD-dependent protein deacetylase activity	188	0.0009265289	0.020807473488297874	2.434082	17	0.003408863	59	0.009484601349152542	2.746447	12	17	0.002486531	
Human Phenotype	Limb hypertonia	117	0.0001607093	0.009165924435042735	2.40052	23	0.004611991	56	0.015793775560714284	2.746447	12	17	0.002486531	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	18	9.426154e-14	4.795294009888889e-11	3.294954	55	0.01102867	111	0.023921045588288288	2.112148	19	35	0.003937008	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	72	6.368339e-8	0.00000809928891986111	2.042193	69	0.01383597	131	0.04191890061984732	1.835283	25	53	0.005180274	
Mouse Phenotype Single KO	decreased erythroid progenitor cell number	77	8.981355e-8	0.00001068081399155844	2.034809	68	0.01363545	34	0.0006062634241176471	2.212416	29	51	0.006009117	
Mouse Phenotype Single KO	scoliosis	97	4.11251e-7	0.00003882294234020619	2.194336	51	0.01022659	35	0.0010248336492571428	2.445646	22	35	0.004558641	
Mouse Phenotype Single KO	decreased circulating tumor necrosis factor level	173	0.00001239556	0.0006561048723699421	2.335046	33	0.006617205	112	0.024832843772321426	1.990642	22	43	0.004558641	
Mouse Phenotype	decreased classified tumor incidence	27	1.007121e-14	3.566327363333333e-12	4.032817	46	0.009223982	210	0.01838157794857143	2.223314	16	28	0.003315375	
Mouse Phenotype	abnormal circulating tumor necrosis factor level	39	1.535048e-12	3.7632292123076925e-10	2.160464	104	0.02085422	222	0.02154448176756757	1.492362	56	146	0.01160381	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	41	3.046834e-12	7.10506826195122e-10	2.938456	57	0.01142972	229	0.022730271298689955	1.995282	20	39	0.004144219	
Mouse Phenotype	decreased erythroid progenitor cell number	55	3.350227e-11	5.823912790363636e-9	2.123844	95	0.01904953	20	0.00000127146910695	2.252568	44	76	0.009117281	
Mouse Phenotype	increased B cell derived lymphoma incidence	70	3.732576e-10	5.098165590857143e-8	2.257404	74	0.01483858	157	0.004502622628089171	1.795754	36	78	0.007459594	
Mouse Phenotype	abnormal mesangial cell morphology	149	7.411352e-7	0.00004755700434362416	2.208434	48	0.009625025	292	0.049095964202054795	1.789768	23	50	0.004765852	
Mouse Phenotype	decreased circulating tumor necrosis factor level	186	0.000004567771	0.00023479816414516131	2.348418	36	0.007218769	231	0.02309766660909091	1.867584	24	50	0.004973063	
Mouse Phenotype	increased keratinocyte apoptosis	187	0.000004818255	0.00024634939066844923	4.000563	16	0.003208342	275	0.04254422489454546	2.693631	9	13	0.001864898	
Mouse Phenotype	lethality during fetal growth through weaning, incomplete penetrance	324	0.0001973274	0.005822985405555555	2.80078	17	0.003408863	174	0.007282943389655172	2.746447	12	17	0.002486531	
Mouse Phenotype	decreased abdominal adipose tissue amount	350	0.0002985443	0.008155377292285713	2.533771	19	0.003809906	274	0.04260681689781022	2.178848	14	25	0.002900953	
Mouse Phenotype	decreased DN2 thymocyte number	395	0.0005963183	0.014433922193164557	2.139432	24	0.004812513	288	0.047905788874999994	2.829673	8	11	0.001657688