# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	14	1.871306e-114	1.7588939752857145e-111	2.644804	729	0.01735012	309	6.236561129126213e-7	1.256364	109	114	0.007627712	
GO Biological Process	cellular response to topologically incorrect protein	17	4.056174e-105	3.139717274470588e-102	2.379164	815	0.01939691	283	8.447036439575972e-8	1.247823	132	139	0.009237229	
GO Biological Process	IRE1-mediated unfolded protein response	18	1.273835e-101	9.312441536111111e-99	3.498219	423	0.01006735	545	0.0005701961300183487	1.268686	56	58	0.003918824	
GO Biological Process	cellular response to unfolded protein	20	3.53008e-99	2.322616136e-96	2.41364	747	0.01777852	291	1.2987657158419243e-7	1.259698	116	121	0.008117565	
GO Biological Process	response to topologically incorrect protein	22	1.057329e-94	6.324269232272728e-92	2.10092	960	0.02284789	266	3.777839076766918e-8	1.226396	168	180	0.01175647	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	26	7.382282e-90	3.736286493769231e-87	2.385082	692	0.01646952	444	0.00007017899197972974	1.22097	105	113	0.007347796	
GO Biological Process	response to unfolded protein	27	2.337741e-87	1.1393456969999998e-84	2.09977	886	0.0210867	260	2.587323592230769e-8	1.240084	151	160	0.01056683	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	35	8.493804e-82	3.193427623885714e-79	2.039799	889	0.0211581	784	0.007670119262755101	1.144448	135	155	0.009447166	
GO Biological Process	regulation of DNA-templated transcription in response to stress	37	1.220092e-79	4.33924071027027e-77	2.202968	723	0.01720732	398	0.00002276834652487437	1.22566	111	119	0.00776767	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	41	1.872771e-76	6.010681363170732e-74	2.300517	632	0.01504153	649	0.0020391908218798153	1.202166	86	94	0.006018195	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	95	1.036782e-54	1.4361067724210524e-52	2.187907	500	0.01189995	362	0.000006774769381767956	1.236047	111	118	0.00776767	
GO Biological Process	positive regulation of mRNA metabolic process	99	1.218621e-53	1.6197811857575757e-51	2.388752	407	0.009686555	809	0.009099046735723114	1.238188	49	52	0.003428971	
GO Biological Process	cotranslational protein targeting to membrane	103	1.344758e-52	1.7180262642718448e-50	2.289604	435	0.01035295	306	5.030376076470589e-7	1.273771	95	98	0.006648006	
GO Biological Process	protein targeting to ER	111	3.185591e-50	3.776503780990991e-48	2.218132	444	0.01056715	298	2.476113133221476e-7	1.274966	98	101	0.006857943	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	113	9.209458e-50	1.072453609044248e-47	2.210811	443	0.01054335	698	0.0033847870127507165	1.212919	72	78	0.005038488	
GO Biological Process	response to cadmium ion	119	4.044795e-48	4.47272751302521e-46	2.454082	345	0.008210962	677	0.0028749635477104876	1.246031	55	58	0.003848845	
GO Biological Process	regulation of mitochondrial membrane permeability	120	2.01444e-47	2.20900133e-45	2.085618	482	0.01147155	552	0.0006535217104347825	1.241996	69	73	0.004828551	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	132	2.371158e-46	2.363793039545455e-44	2.242388	399	0.009496156	339	0.0000019590470954277284	1.271148	89	92	0.006228132	
GO Biological Process	viral gene expression	133	3.582707e-46	3.544724918270676e-44	2.017181	509	0.01211414	235	4.900707817489362e-9	1.27261	123	127	0.008607418	
GO Biological Process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	198	4.25399e-38	2.827184566161616e-36	2.415075	279	0.006640169	1018	0.03708113130451867	1.270196	29	30	0.002029391	
GO Cellular Component	cleavage furrow	47	1.725215e-43	6.342918127659575e-42	2.201035	389	0.009258157	103	0.000011172986283495146	1.313996	52	52	0.003638908	
GO Cellular Component	mitochondrial ribosome	49	1.393447e-41	4.914033502040817e-40	2.375367	316	0.007520765	98	0.000004820196048979592	1.267619	82	85	0.005738279	
GO Cellular Component	nuclear ubiquitin ligase complex	62	9.626051e-31	2.6828735690322577e-29	2.547543	201	0.004783778	199	0.014054058452261308	1.248296	38	40	0.002659202	
GO Cellular Component	DNA-directed RNA polymerase III complex	64	4.044792e-30	1.09209384e-28	4.203288	96	0.002284789	234	0.04109599753846154	1.313996	19	19	0.001329601	
GO Cellular Component	mitochondrial large ribosomal subunit	89	9.651492e-25	1.8739076602247193e-23	2.352328	186	0.00442678	154	0.0014114898701298702	1.262467	49	51	0.003428971	
GO Cellular Component	ESCRT complex	135	1.192291e-16	1.5261324800000002e-15	2.285978	128	0.003046386	174	0.004716445903448276	1.313996	28	28	0.001959412	
GO Cellular Component	endoribonuclease complex	138	1.932259e-16	2.4195243130434786e-15	2.173199	141	0.003355785	214	0.02953209330841122	1.268686	28	29	0.001959412	
GO Cellular Component	spliceosomal tri-snRNP complex	145	8.381229e-16	9.988112904827587e-15	2.266261	123	0.002927387	214	0.02953209330841122	1.268686	28	29	0.001959412	
GO Cellular Component	mitochondrial small ribosomal subunit	228	7.490398e-11	5.676933221052632e-10	2.064267	99	0.002356189	227	0.03546026516299559	1.267067	27	28	0.001889433	
GO Cellular Component	INO80-type complex	279	5.283368e-9	3.272279535483871e-8	2.136411	73	0.001737392	204	0.015791124705882353	1.313996	23	23	0.001609517	
GO Cellular Component	anaphase-promoting complex	299	5.148431e-8	2.97541430367893e-7	2.003638	74	0.001761192	213	0.026131489352112677	1.313996	21	21	0.001469559	
GO Molecular Function	unfolded protein binding	15	1.318548e-47	3.711273104e-45	2.168179	442	0.01051955	164	0.021988266103658536	1.165242	94	106	0.006578027	
GO Molecular Function	rRNA binding	22	2.727886e-32	5.2350612236363636e-30	2.545831	212	0.005045577	123	0.0032361921764227637	1.248296	57	60	0.003988803	
Human Phenotype	Abnormal CSF metabolite level	28	1.413376e-29	3.3683778742857146e-27	2.169223	268	0.006378371	181	0.000025146724910497233	1.293139	62	63	0.004338698	
Human Phenotype	Exercise intolerance	47	3.249914e-25	4.6141864089361706e-23	2.002884	274	0.00652117	200	0.000042149971135	1.276453	68	70	0.004758572	
Human Phenotype	Abnormality of reticulocytes	69	1.399652e-22	1.3536054776811594e-20	2.291032	178	0.004236381	449	0.02046308889309577	1.274178	32	33	0.002239328	
Human Phenotype	Abnormality of transition element cation homeostasis	72	5.64357e-22	5.2304920291666663e-20	2.717776	125	0.002974986	361	0.006677848553739612	1.313996	29	29	0.002029391	
Human Phenotype	Abnormality of iron homeostasis	86	5.749122e-21	4.460917570465116e-19	2.755957	116	0.002760787	453	0.020891085973509933	1.313996	24	24	0.001679496	
Mouse Phenotype	absent segment of posterior cerebral artery	63	3.143723e-49	4.770973905238096e-47	3.29606	218	0.005188376	597	0.03924483010552764	1.313996	22	22	0.001539538