# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	19	1.246659e-49	8.634097779473685e-47	2.600491	318	0.01795697	700	0.024022732025714286	1.25668	79	113	0.007562703	
GO Biological Process	regulation of DNA-templated transcription in response to stress	22	1.603899e-45	9.593503154999999e-43	2.414612	334	0.01886047	611	0.012107578670540098	1.268845	84	119	0.008041356	
GO Biological Process	endoplasmic reticulum unfolded protein response	29	1.89169e-43	8.583706451724137e-41	2.522113	293	0.01654526	362	0.00032010514333425413	1.356032	86	114	0.008232816	
GO Biological Process	IRE1-mediated unfolded protein response	37	4.198876e-41	1.4933245752432434e-38	3.394562	173	0.009769044	818	0.04514922073227384	1.332652	43	58	0.004116408	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	39	2.890193e-40	9.751807612051282e-38	2.117709	389	0.02196623	536	0.005524388793656716	1.252473	108	155	0.01033889	
GO Biological Process	cellular response to topologically incorrect protein	41	2.472436e-39	7.935313493658537e-37	2.264882	327	0.01846519	368	0.00039885965986413046	1.319051	102	139	0.009764503	
GO Biological Process	response to topologically incorrect protein	44	2.763676e-38	8.265275564545453e-36	2.056195	396	0.02236151	306	0.00006116311800653595	1.308203	131	180	0.01254069	
GO Biological Process	cellular response to unfolded protein	46	2.394552e-37	6.849980384347826e-35	2.299875	300	0.01694054	379	0.0005110219529287598	1.337006	90	121	0.008615738	
GO Biological Process	liver regeneration	50	1.544551e-35	4.0649493218e-33	3.190236	162	0.009147891	791	0.038812379002528444	1.438024	28	35	0.002680452	
GO Biological Process	response to unfolded protein	54	3.01314e-35	7.34257578888889e-33	2.0524	365	0.02061099	309	0.00006536858877993528	1.325678	118	160	0.01129619	
GO Biological Process	nuclear-transcribed mRNA catabolic process	55	3.741064e-35	8.950665668363636e-33	2.002444	387	0.02185329	259	0.00001075637998918919	1.316373	145	198	0.01388091	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	67	1.284115e-31	2.522040191791045e-29	2.510237	212	0.01197131	461	0.002128650649154013	1.382716	60	78	0.005743825	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	69	1.449958e-31	2.7652170031884056e-29	2.398291	231	0.01304421	247	0.000005902903643724696	1.416697	93	118	0.008902929	
GO Biological Process	regulation of cellular amino acid metabolic process	77	2.789559e-30	4.767247646883117e-28	3.110001	142	0.008018522	613	0.012548793771451874	1.378106	46	60	0.004403599	
GO Biological Process	multi-organism metabolic process	90	8.27137e-29	1.2093661981111112e-26	2.07071	289	0.01631939	206	5.042164052961166e-7	1.406231	115	147	0.011009	
GO Biological Process	viral gene expression	113	6.448599e-26	7.509479136371681e-24	2.172051	231	0.01304421	249	0.000006272266416064257	1.401224	99	127	0.009477312	
GO Biological Process	protein targeting to ER	121	4.380152e-25	4.763505799008265e-23	2.311373	195	0.01101135	215	9.254596170232558e-7	1.477178	83	101	0.007945625	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	137	7.577154e-24	7.277939378540146e-22	2.303549	186	0.01050313	577	0.008568912741074523	1.525177	28	33	0.002680452	
GO Biological Process	viral transcription	139	8.906118e-24	8.431338615971224e-22	2.161375	213	0.01202778	238	0.000003933016104117646	1.431661	90	113	0.008615738	
GO Biological Process	response to epidermal growth factor	143	1.638142e-23	1.5074343061538462e-21	2.269656	189	0.01067254	348	0.0002432863523649425	1.583538	37	42	0.003542026	
GO Cellular Component	ribosomal subunit	38	1.007108e-29	4.579691115789474e-28	2.028977	314	0.0177311	62	0.00000960139230967742	1.321428	136	185	0.01301934	
GO Cellular Component	large ribosomal subunit	41	7.594297e-26	3.2007183453658534e-24	2.260466	211	0.01191485	90	0.0016408030079999999	1.312979	84	115	0.008041356	
GO Cellular Component	mitochondrial ribosome	42	1.003643e-23	4.1292740571428576e-22	2.603919	146	0.008244396	102	0.005522095058823529	1.332287	63	85	0.006031017	
GO Cellular Component	nuclear ubiquitin ligase complex	45	2.614575e-23	1.0039968e-21	3.157518	105	0.005929189	159	0.03737990037735849	1.393086	31	40	0.002967643	
GO Cellular Component	mitochondrial large ribosomal subunit	51	2.940925e-21	9.96454588235294e-20	3.030661	101	0.005703315	166	0.043889461590361445	1.339336	38	51	0.003637756	
GO Cellular Component	endopeptidase complex	52	6.219227e-21	2.0666969723076925e-19	2.373268	152	0.008583206	87	0.001468288353103448	1.406763	54	69	0.005169443	
GO Cellular Component	proteasome complex	56	7.990823e-20	2.465739668571429e-18	2.327742	149	0.008413801	94	0.0019309885276595747	1.401016	53	68	0.005073712	
GO Cellular Component	pre-autophagosomal structure membrane	80	1.076802e-12	2.3258923199999998e-11	3.179902	53	0.002992829	129	0.015457254697674418	1.685185	15	16	0.001435956	
GO Cellular Component	ESCRT complex	142	4.062248e-9	4.943355312676056e-8	2.415283	57	0.003218702	155	0.03436892779354839	1.476543	23	28	0.0022018	
GO Cellular Component	pre-autophagosomal structure	143	4.120328e-9	4.978969779020979e-8	2.056375	81	0.004573945	116	0.00861772071724138	1.516666	27	32	0.002584721	
GO Cellular Component	mitochondrial nucleoid	149	1.26029e-8	1.4615980671140938e-7	2.032608	78	0.00440454	111	0.008209545859459459	1.455143	34	42	0.003254834	
GO Molecular Function	thyroid hormone receptor binding	105	3.424023e-9	1.3767833434285714e-7	2.213375	69	0.003896324	113	0.028006424031858403	1.54074	24	28	0.00229753	
GO Molecular Function	mannosyltransferase activity	269	0.00001423575	0.00022343247769516727	2.061915	43	0.002428144	119	0.033290129401680676	1.572839	21	24	0.002010339	
Human Phenotype	Increased serum lactate	12	1.299651e-20	7.2271426025e-18	2.08741	198	0.01118076	43	0.0010726687658372091	1.384098	77	100	0.007371243	
Human Phenotype	Aplasia/hypoplasia of the femur	28	1.964132e-14	4.680947441428572e-12	2.370239	101	0.005703315	93	0.026959809733333336	1.525177	28	33	0.002680452	
Mouse Phenotype Single KO	increased skin tumor incidence	95	5.78818e-16	5.579196237894736e-14	2.33095	117	0.00660681	137	0.004131117720948905	1.511559	37	44	0.003542026	
Mouse Phenotype	extramedullary hematopoiesis	4	1.981889e-49	4.737210182249999e-46	2.008304	546	0.03083178	265	0.005913900627169811	1.242864	121	175	0.01158338	
Mouse Phenotype	pancytopenia	107	2.471517e-18	2.208427480093458e-16	2.556804	114	0.006437405	446	0.043875664809417035	1.487611	24	29	0.00229753	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	296	1.544248e-10	4.988025381081081e-9	2.342537	72	0.004065729	303	0.00962684468217822	1.557859	26	30	0.002488991	
Mouse Phenotype	abnormal vertebral transverse process morphology	513	2.059245e-7	0.0000038379028157894735	2.193799	54	0.003049297	425	0.035453672767058825	1.79753	11	11	0.001053035	
Mouse Phenotype	decreased type II pneumocyte number	642	0.000002948161	0.00004390555657476635	2.082276	49	0.002766955	368	0.02276790808125	1.79753	12	12	0.001148765