# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mitochondrial transport	13	5.162476e-36	5.225617052615384e-33	2.051876	371	0.03154225	171	7.64957525888889e-9	1.501044	147	239	0.0191058	
GO Biological Process	macromolecular complex disassembly	20	3.410545e-30	2.24396808275e-27	2.100412	292	0.02482571	118	2.9314939946610166e-11	1.6355	128	191	0.01663634	
GO Biological Process	mitochondrial translation	23	8.473487e-29	4.8479398014347823e-26	2.770313	161	0.01368815	154	1.6848920316883115e-9	1.779036	78	107	0.01013777	
GO Biological Process	mitochondrial translational elongation	33	4.283876e-26	1.7082280086060608e-23	2.980238	129	0.01096752	159	2.2773627488050314e-9	1.866244	65	85	0.008448141	
GO Biological Process	mitochondrial translational termination	34	5.914303e-26	2.2890092110882354e-23	2.954361	130	0.01105254	163	2.9229085647239263e-9	1.851393	66	87	0.008578113	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	37	2.493364e-24	8.867615371891891e-22	2.040934	249	0.02116987	327	0.0004949079779204893	1.417049	90	155	0.01169743	
GO Biological Process	translational elongation	39	4.886371e-24	1.6487116920256412e-21	2.501214	159	0.01351811	165	4.769385443212121e-9	1.743195	80	112	0.01039771	
GO Biological Process	protein complex disassembly	43	7.991423e-24	2.445561285046512e-21	2.067219	236	0.02006461	131	1.6415400473282444e-10	1.673029	109	159	0.01416688	
GO Biological Process	translational termination	44	1.316919e-23	3.938485709318182e-21	2.65507	140	0.01190274	155	1.896621951419355e-9	1.823933	71	95	0.00922797	
GO Biological Process	mitochondrial membrane organization	47	6.593627e-23	1.84607527006383e-20	2.075981	224	0.01904438	213	0.0000021950299316431923	1.59418	81	124	0.01052768	
GO Biological Process	mRNA transport	62	3.843742e-21	8.158032415806452e-19	2.022664	219	0.01861928	197	2.1814288831979696e-7	1.587979	95	146	0.01234728	
GO Biological Process	multi-organism metabolic process	64	9.72183e-21	1.99889939015625e-18	2.103628	195	0.01657881	193	1.382759992642487e-7	1.593778	96	147	0.01247726	
GO Biological Process	viral gene expression	69	3.936398e-20	7.507110330724638e-18	2.265119	160	0.01360313	210	0.0000014655034177619046	1.594955	83	127	0.01078763	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	71	6.84639e-20	1.2688964226760562e-17	2.329105	149	0.01266791	349	0.0007255340961318051	1.46842	71	118	0.00922797	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	83	9.527876e-19	1.5105701239036145e-16	2.117725	172	0.01462336	637	0.021480569811616956	1.360618	63	113	0.008188199	
GO Biological Process	cellular protein complex disassembly	88	4.422017e-18	6.612422920795455e-16	2.062791	176	0.01496344	174	1.1943970541379308e-8	1.685089	87	126	0.01130751	
GO Biological Process	viral transcription	94	1.311565e-17	1.8360514718085106e-15	2.215294	145	0.01232784	238	0.000017760099639915967	1.576589	73	113	0.009487913	
GO Biological Process	mitochondrial transmembrane transport	95	1.38064e-17	1.912404395789474e-15	2.348635	128	0.0108825	448	0.003826152549330357	1.499568	51	83	0.006628542	
GO Biological Process	mRNA export from nucleus	102	4.040376e-17	5.212481155294118e-15	2.219397	140	0.01190274	246	0.000023427417031707318	1.58861	69	106	0.008968027	
GO Biological Process	regulation of mitochondrial membrane permeability	104	5.818834e-17	7.362503519807693e-15	2.194926	142	0.01207278	340	0.0006279203879411765	1.604695	48	73	0.006238628	
GO Cellular Component	ribosomal subunit	32	7.586502e-31	4.09671108e-29	2.325189	239	0.02031967	46	1.9327495930434782e-10	1.609393	122	185	0.01585651	
GO Cellular Component	mitochondrial ribosome	36	3.781113e-26	1.81493424e-24	3.168615	118	0.01003231	54	2.66550912e-7	1.751398	61	85	0.007928256	
GO Cellular Component	large ribosomal subunit	41	7.356398e-22	3.1004526204878054e-20	2.435596	151	0.01283795	73	0.00005249178739726027	1.527948	72	115	0.009357941	
GO Cellular Component	mitochondrial large ribosomal subunit	42	2.154876e-20	8.865775542857143e-19	3.523899	78	0.006631525	93	0.0011063215277419354	1.674834	35	51	0.004548999	
GO Cellular Component	catalytic step 2 spliceosome	45	1.067872e-18	4.100628479999999e-17	2.262325	148	0.01258289	69	0.000022508331965217392	1.60156	63	96	0.008188199	
GO Cellular Component	small ribosomal subunit	65	5.283533e-12	1.4046069267692308e-10	2.228217	93	0.007906819	60	0.000002138284512	1.762564	52	72	0.006758513	
GO Cellular Component	spliceosomal snRNP complex	67	7.14976e-12	1.8439978029850747e-10	2.395645	79	0.006716545	91	0.0010348369160439559	1.613861	41	62	0.005328828	
GO Cellular Component	small nuclear ribonucleoprotein complex	83	2.382223e-9	4.959616077108434e-8	2.071064	82	0.006971603	111	0.004288368259459459	1.520875	43	69	0.00558877	
GO Cellular Component	mitochondrial small ribosomal subunit	85	3.403916e-9	6.919960997647059e-8	2.97944	40	0.003400782	81	0.00021080546133333332	2.004674	23	28	0.002989342	
GO Cellular Component	U12-type spliceosomal complex	93	8.468558e-9	1.5735127122580643e-7	2.880024	40	0.003400782	127	0.012523024176377951	1.783423	19	26	0.002469457	
GO Cellular Component	spliceosomal tri-snRNP complex	120	2.344063e-7	0.0000033754507199999997	2.566926	39	0.003315763	115	0.009044419617391303	1.767239	21	29	0.0027294	
GO Cellular Component	prespliceosome	171	0.00001674387	0.00016920121263157894	2.502555	28	0.002380548	131	0.014966115664122136	1.859408	16	21	0.002079543	
GO Cellular Component	Lewy body	232	0.000283924	0.0021147442758620693	2.71379	17	0.001445332	121	0.011324860720661157	2.440473	8	8	0.001039771	
GO Cellular Component	eukaryotic translation initiation factor 4F complex	236	0.0003035461	0.002222574833898305	2.798481	16	0.001360313	167	0.046967598754491025	2.169309	8	9	0.001039771	
GO Cellular Component	methylosome	251	0.0004847242	0.0033370654087649405	2.908025	14	0.001190274	160	0.0374628456	2.033728	10	12	0.001299714	
GO Cellular Component	death-inducing signaling complex	264	0.000697052	0.0045625221818181814	2.586508	16	0.001360313	167	0.046967598754491025	2.169309	8	9	0.001039771	
GO Molecular Function	unfolded protein binding	8	9.162056e-25	4.835275053999999e-22	2.628501	150	0.01275293	63	0.0012166222425396825	1.496517	65	106	0.008448141	
GO Molecular Function	structural constituent of ribosome	9	1.098205e-24	5.151801677777779e-22	2.215817	209	0.01776909	24	1.2148986194166668e-7	1.581788	105	162	0.013647	
GO Molecular Function	rRNA binding	10	1.461906e-23	6.1721671320000005e-21	3.689233	86	0.007311682	48	0.00044131598458333333	1.708331	42	60	0.005458799	
GO Molecular Function	ribonucleoprotein complex binding	14	2.682658e-15	8.090130054285714e-13	2.02555	153	0.01300799	36	0.00003958771200555556	1.570391	74	115	0.009617884	
GO Molecular Function	NF-kappaB binding	77	2.528696e-7	0.00001386513572987013	2.299892	48	0.004080939	95	0.012026598098947369	1.830355	21	28	0.0027294	
GO Molecular Function	apolipoprotein binding	153	0.00001284862	0.00035455472967320265	2.183741	38	0.003230743	128	0.04038375984375	1.982884	13	16	0.001689628	
GO Molecular Function	ribosomal small subunit binding	205	0.00006372342	0.0013123916060487806	2.238659	30	0.002550587	116	0.028634513913793104	2.091834	12	14	0.001559657	
GO Molecular Function	non-membrane spanning protein tyrosine phosphatase activity	246	0.0001301021	0.0022328905130081303	2.712598	19	0.001615372	117	0.028615864382905982	2.440473	8	8	0.001039771	
GO Molecular Function	dynactin binding	249	0.0001383502	0.0023458415437751005	2.283818	26	0.002210508	121	0.032040004320661154	2.218612	10	11	0.001299714	
Human Phenotype	Increased serum lactate	2	7.960591e-25	2.65605118715e-21	2.539659	160	0.01360313	18	2.8812067708333335e-8	1.781545	73	100	0.009487913	
Human Phenotype	Abnormal CSF metabolite level	3	1.245162e-21	2.7696553420000005e-18	3.007091	104	0.008842034	59	0.0003730383438644068	1.704457	44	63	0.005718742	
Human Phenotype	Increased CSF lactate	7	3.830072e-20	3.651152922285714e-17	3.033158	95	0.008076858	62	0.00047104319535483873	1.725162	41	58	0.005328828	
Human Phenotype	Lactic acidosis	8	9.517321e-20	7.938635379125e-17	2.01638	205	0.01742901	43	0.000012359867163720931	1.549789	87	137	0.01130751	
Human Phenotype	Abnormality of transition element cation homeostasis	21	2.000349e-16	6.356347084285714e-14	4.038786	52	0.004421017	144	0.006691651961805555	1.851393	22	29	0.002859371	
Human Phenotype	Abnormality of iron homeostasis	25	3.33084e-14	8.890678128e-12	3.904058	46	0.0039109	198	0.025505220430808082	1.830355	18	24	0.002339485	
Human Phenotype	Increased serum ferritin	28	1.679573e-13	4.0027823675e-11	4.289253	39	0.003315763	174	0.016752601015517243	1.952378	16	20	0.002079543	
Human Phenotype	Abnormality of mitochondrial metabolism	31	3.449053e-12	7.424364731935484e-10	2.127908	105	0.008927053	84	0.0011193711234523808	1.626982	46	69	0.005978685	
Human Phenotype	Abnormality of the mitochondrion	37	1.267362e-11	2.2857044935135138e-9	2.079176	105	0.008927053	106	0.002679394581320755	1.581152	46	71	0.005978685	
Human Phenotype	Leukodystrophy	53	1.783399e-10	2.2454002881132076e-8	2.232777	79	0.006716545	73	0.0007847588772876713	1.757141	36	50	0.004678971	
Human Phenotype	Progressive macrocephaly	72	8.441003e-9	7.823168474861111e-7	2.926982	39	0.003315763	198	0.025505220430808082	1.830355	18	24	0.002339485	
Human Phenotype	11 pairs of ribs	74	1.230781e-8	0.000001109865082837838	2.614728	46	0.0039109	249	0.04452498951807229	2.065016	11	13	0.001429685	
Human Phenotype	Abnormality of glycolysis	85	4.617926e-8	0.000003625343552705883	3.419381	28	0.002380548	210	0.029178404286666664	2.218612	10	11	0.001299714	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	44	4.060636e-12	8.450737239090908e-10	2.196872	97	0.008246897	104	0.004464268185961538	1.626982	40	60	0.005198856	
Mouse Phenotype Single KO	absent hypoglossal nerve	51	3.682679e-11	6.6122140398039215e-9	3.643479	38	0.003230743	97	0.0032686657276288656	2.277775	14	15	0.0018196	
Mouse Phenotype Single KO	early cellular replicative senescence	73	2.445002e-9	3.0669703169863017e-7	2.080366	81	0.006886584	193	0.0414002678134715	1.548762	33	52	0.004289056	
Mouse Phenotype Single KO	absent hypoglossal canal	81	4.180175e-9	4.725662033950617e-7	4.783506	22	0.00187043	189	0.03842075649100529	2.440473	8	8	0.001039771	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	84	5.246593e-9	5.719410964404762e-7	2.843282	42	0.003570821	61	0.0004245467415737705	2.304891	17	18	0.002209514	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	15	1.576779e-19	1.0050389346000001e-16	3.575936	73	0.006206427	336	0.03507222361607143	1.708331	21	30	0.0027294	
Mouse Phenotype	abnormal cellular replicative senescence	20	1.672879e-17	7.9971980595e-15	2.194993	147	0.01249787	71	0.000023659327411267604	1.685089	58	84	0.007538342	
Mouse Phenotype	early cellular replicative senescence	30	1.19034e-15	3.79361358e-13	2.193929	130	0.01105254	99	0.00017315676003030304	1.671557	50	73	0.00649857	
Mouse Phenotype	abnormal brown fat cell number	62	3.653104e-11	5.633439894193549e-9	4.212277	32	0.002720626	375	0.049368950136000005	2.440473	7	7	0.0009097998	
Mouse Phenotype	absent hypoglossal nerve	63	3.682679e-11	5.588903796666666e-9	3.643479	38	0.003230743	158	0.0020952471603797465	2.277775	14	15	0.0018196	
Mouse Phenotype	absent hypoglossal canal	97	4.180175e-9	4.120273523195877e-7	4.783506	22	0.00187043	297	0.02552826917979798	2.440473	8	8	0.001039771	
Mouse Phenotype	abnormal hypoglossal nerve topology	100	5.246593e-9	5.0162675673e-7	2.843282	42	0.003570821	106	0.00025509361347169816	2.304891	17	18	0.002209514	
Mouse Phenotype	abnormal level of surface class I molecules	169	7.691038e-7	0.000043511251075739644	3.792147	20	0.001700391	295	0.02549827951525424	2.091834	12	14	0.001559657	
Mouse Phenotype	abnormal hair medulla	249	0.00001235859	0.00047454007626506026	2.412446	31	0.002635606	361	0.044002582354570635	2.065016	11	13	0.001429685	
Mouse Phenotype	small intestinal villus atrophy	583	0.001381431	0.022654994495711837	3.231222	10	0.0008501955	375	0.049368950136000005	2.440473	7	7	0.0009097998