# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 66 1.167149e-40 2.3270475289393935e-38 2.300701 328 0.01588685 353 0.000025894477771388102 1.333725 95 113 0.00802636 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 77 9.368642e-37 1.6010644165974025e-34 2.404428 270 0.01307759 454 0.0003289413778854626 1.290656 96 118 0.008110848 GO Biological Process regulation of DNA-templated transcription in response to stress 79 5.71989e-35 9.527599051898734e-33 2.108326 340 0.01646808 328 0.000014850083951829267 1.333135 100 119 0.0084488 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 97 1.631669e-28 2.2135188011340206e-26 2.390415 209 0.01012303 862 0.018929358890951275 1.241555 72 92 0.006083136 GO Biological Process cotranslational protein targeting to membrane 98 2.223366e-28 2.985436040204082e-26 2.335161 218 0.01055895 675 0.005836127620444445 1.26267 78 98 0.006590064 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to hypoxia 99 5.025654e-28 6.680058685454545e-26 2.285175 225 0.01089799 567 0.001657448691393298 1.322026 65 78 0.00549172 GO Biological Process viral gene expression 101 8.53682e-27 1.1122377661386137e-24 2.096957 260 0.01259324 478 0.0004958671833682009 1.274142 102 127 0.008617776 GO Biological Process protein targeting to ER 109 6.231282e-26 7.522700902568808e-24 2.226577 219 0.01060738 1001 0.042110614127872134 1.209457 77 101 0.006505576 GO Biological Process viral transcription 122 1.108112e-23 1.1952168695081968e-21 2.062799 237 0.01147922 655 0.004619707026412214 1.24949 89 113 0.007519432 GO Biological Process establishment of protein localization to endoplasmic reticulum 126 5.128659e-23 5.356192363571429e-21 2.058553 231 0.01118861 880 0.020702262169318184 1.223818 81 105 0.006843528 GO Biological Process gene silencing by miRNA 137 1.880553e-21 1.8062917464963504e-19 2.382521 155 0.007507508 740 0.010180280747432434 1.3701 38 44 0.003210544 GO Biological Process posttranscriptional gene silencing 172 1.698868e-18 1.2997327913953488e-16 2.140178 166 0.008040298 905 0.024438487670718233 1.311857 43 52 0.003632984 GO Biological Process posttranscriptional gene silencing by RNA 177 2.531244e-18 1.8818440562711864e-16 2.141823 164 0.007943427 951 0.03085550270767613 1.306473 42 51 0.003548496 GO Biological Process heterochromatin organization 224 2.142308e-16 1.25851031125e-14 3.269411 68 0.003293616 964 0.03377621816078838 1.586431 13 13 0.001098344 GO Biological Process adherens junction assembly 263 7.042162e-15 3.523490865323194e-13 2.00873 152 0.007362201 831 0.016630474048134777 1.399792 30 34 0.00253464 GO Biological Process regulation of receptor biosynthetic process 296 8.647181e-14 3.844197796587838e-12 2.926607 66 0.003196745 863 0.018951003228273464 1.50711 19 20 0.001605272 GO Biological Process spliceosomal tri-snRNP complex assembly 552 7.364597e-10 1.7556292015036233e-8 3.926855 30 0.001453066 1038 0.04978228449421965 1.586431 12 12 0.001013856 GO Biological Process cellular response to misfolded protein 615 5.451363e-9 1.166414401902439e-7 2.394794 57 0.002760825 968 0.033734632622933886 1.448481 21 23 0.001774248 GO Biological Process negative regulation of cyclin-dependent protein serine/threonine kinase activity 618 5.69686e-9 1.213025578317152e-7 2.051351 80 0.003874843 657 0.004643306371232877 1.52033 23 24 0.001943224 GO Biological Process mismatch repair 778 1.606839e-7 0.000002717788483419023 2.069366 63 0.003051439 922 0.028024730863340563 1.416456 25 28 0.0021122 GO Cellular Component PRC1 complex 48 3.029968e-17 1.0907884800000002e-15 4.971036 44 0.002131163 180 0.037698192 1.586431 12 12 0.001013856 GO Cellular Component cytoplasmic stress granule 51 2.423517e-16 8.211445835294119e-15 2.158109 142 0.006877846 113 0.003060174838938053 1.401962 38 43 0.003210544 GO Cellular Component spliceosomal snRNP complex 86 1.109304e-11 2.2289271069767442e-10 2.004004 116 0.005618522 164 0.022409915707317075 1.27938 50 62 0.0042244 GO Cellular Component precatalytic spliceosome 97 1.658225e-10 2.9540338144329897e-9 2.571122 60 0.002906132 161 0.02107498852173913 1.416456 25 28 0.0021122 GO Molecular Function mRNA 5'-UTR binding 54 2.229662e-12 1.7432653637037035e-10 2.583054 72 0.003487358 125 0.0181962322976 1.514321 21 22 0.001774248 GO Molecular Function snRNA binding 69 1.615135e-11 9.882753579710145e-10 2.469824 72 0.003487358 143 0.03222906510489511 1.37769 33 38 0.002788104 GO Molecular Function K63-linked polyubiquitin binding 139 2.383515e-7 0.0000072397124676259 2.045004 63 0.003051439 137 0.025241938884671532 1.510887 20 21 0.00168976 Human Phenotype Lipomatous tumor 411 0.0000890919 0.0014464969554744526 2.031539 36 0.001743679 265 0.03925932385283019 1.586431 14 14 0.001182832 Mouse Phenotype Single KO abnormal cellular replicative senescence 51 1.478156e-16 2.65401460627451e-14 2.064421 160 0.007749685 346 0.004130338952890174 1.348467 51 60 0.004308888 Mouse Phenotype Single KO abnormal thymus involution 52 1.609421e-16 2.8341284801923077e-14 2.900218 82 0.003971714 618 0.036663161101941746 1.586431 13 13 0.001098344 Mouse Phenotype Single KO early cellular replicative senescence 68 4.345091e-15 5.85117621867647e-13 2.077726 142 0.006877846 441 0.011436717168480725 1.342365 44 52 0.003717472 Mouse Phenotype Single KO thick ventricular wall 70 1.781295e-14 2.3301883307142857e-12 2.056252 139 0.006732539 587 0.03195758680749574 1.348467 34 40 0.002872592 Mouse Phenotype Single KO abnormal transitional stage T2 B cell morphology 122 7.463921e-12 5.60222332762295e-10 2.572513 69 0.003342052 454 0.012483276216079297 1.586431 16 16 0.001351808 Mouse Phenotype Single KO decreased spongiotrophoblast size 149 5.424973e-11 3.3339917960402684e-9 2.454449 69 0.003342052 639 0.04073444876838811 1.498296 17 18 0.001436296 Mouse Phenotype Single KO increased embryonic neuroepithelium apoptosis 166 1.643335e-10 9.065071442771084e-9 2.339452 72 0.003487358 414 0.008624730574396135 1.586431 17 17 0.001436296 Mouse Phenotype abnormal cellular replicative senescence 43 2.112928e-23 4.698070839069768e-21 2.041608 240 0.01162453 381 0.0003049123353543307 1.340912 71 84 0.005998648 Mouse Phenotype early cellular replicative senescence 49 2.197592e-22 4.287995328979592e-20 2.086336 217 0.01051051 362 0.00024040857178176796 1.369112 63 73 0.005322744 Mouse Phenotype abnormal thymus involution 58 1.345676e-20 2.2182772820689656e-18 2.809994 110 0.005327909 912 0.026015785023026317 1.448481 21 23 0.001774248 Mouse Phenotype abnormal rib development 103 4.047703e-15 3.757290134271845e-13 2.15938 130 0.006296619 1103 0.04738326715049864 1.346063 28 33 0.002365664 Mouse Phenotype decreased spongiotrophoblast size 143 1.603876e-13 1.0723537367832168e-11 2.652086 76 0.0036811 863 0.020848319979142528 1.502935 18 19 0.001520784 Mouse Phenotype lethality during fetal growth through weaning, incomplete penetrance 157 1.200192e-12 7.308939943949044e-11 2.706091 68 0.003293616 1033 0.03963782349757987 1.493112 16 17 0.001351808 Mouse Phenotype absent stapedial artery 166 1.742398e-12 1.0035582697590361e-10 2.379485 85 0.00411702 863 0.020848319979142528 1.502935 18 19 0.001520784 Mouse Phenotype decreased classified tumor incidence 178 3.188583e-12 1.7126989923033707e-10 2.160003 102 0.004940424 871 0.02155433596326062 1.416456 25 28 0.0021122 Mouse Phenotype increased embryonic neuroepithelium apoptosis 191 6.690405e-12 3.3490556128272253e-10 2.253943 90 0.004359198 367 0.0002519024165149864 1.586431 25 25 0.0021122 Mouse Phenotype increased kidney tumor incidence 324 1.833567e-9 5.410720397222222e-8 2.544689 54 0.002615519 711 0.008322713337974684 1.586431 16 16 0.001351808 Mouse Phenotype increased incidence of corneal inflammation 506 1.426348e-7 0.000002695121191304348 2.002057 69 0.003342052 746 0.010497588382841823 1.510887 20 21 0.00168976 Mouse Phenotype decreased transitional stage T1 B cell number 553 3.848944e-7 0.000006654566651717902 2.184781 52 0.002518648 1033 0.03963782349757987 1.493112 16 17 0.001351808 Mouse Phenotype increased hamartoma incidence 597 8.708038e-7 0.000013945988495477388 2.242773 46 0.002228034 1008 0.0372470665625 1.586431 12 12 0.001013856