# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process formation of primary germ layer 44 1.586495e-10 4.744701751136364e-8 2.367024 69 0.03898305 209 0.0014325964045454546 2.113634 32 115 0.01294498 GO Biological Process positive regulation of cell-substrate adhesion 46 2.210484e-10 6.32342586e-8 2.461659 63 0.03559322 449 0.03657662744766147 1.845726 26 107 0.0105178 GO Biological Process gastrulation 50 9.578132e-10 2.52077277976e-7 2.104067 81 0.04576271 157 0.00039301549460509557 2.019156 42 158 0.01699029 GO Biological Process regulation of smooth muscle cell differentiation 208 0.0001432346 0.009061654333653846 2.773592 18 0.01016949 167 0.0005307311518922156 3.797937 13 26 0.0052589 GO Biological Process chorio-allantoic fusion 238 0.0003218141 0.01779307454579832 3.617328 11 0.006214689 226 0.0018731504613716814 6.510749 6 7 0.002427184 GO Biological Process labyrinthine layer morphogenesis 276 0.0007988832 0.03808878271304348 2.547161 16 0.009039548 403 0.025223083037965263 3.255374 9 21 0.003640777 Human Phenotype Vertigo 62 0.00008240945 0.008869649352419354 3.674705 13 0.007344633 16 0.043733507399999996 4.021345 9 17 0.003640777 Mouse Phenotype Single KO absent limb buds 13 8.162019e-23 5.749200614076922e-20 8.875397 37 0.02090395 378 0.032003375851851854 4.143204 6 11 0.002427184 Mouse Phenotype Single KO abnormal chorioallantoic fusion 15 6.629283e-21 4.0469562954e-18 4.029284 67 0.03785311 91 0.00025278301005494507 2.637456 25 72 0.01011327 Mouse Phenotype Single KO kinked neural tube 16 1.043148e-20 5.9700663975e-18 5.195646 51 0.02881356 312 0.01722767163173077 2.383019 16 51 0.006472492 Mouse Phenotype Single KO failure of chorioallantoic fusion 19 2.451643e-19 1.1815628921578946e-16 4.125168 60 0.03389831 117 0.0005813503024700854 2.75023 21 58 0.008495146 Mouse Phenotype Single KO abnormal notochord morphology 21 9.475114e-19 4.1316008999047616e-16 4.06505 59 0.03333333 233 0.006377878010300429 2.40536 19 60 0.007686084 Mouse Phenotype Single KO abnormal endocardium morphology 24 4.75319e-18 1.8135400345833334e-15 5.456932 42 0.02372881 329 0.0211963369218845 3.03835 10 25 0.004045307 Mouse Phenotype Single KO incomplete somite formation 26 1.783428e-17 6.281096229230769e-15 4.408545 50 0.02824859 201 0.00423156723761194 2.848453 15 40 0.006067961 Mouse Phenotype Single KO abnormal placenta development 28 1.005039e-16 3.2868364724999997e-14 2.885024 82 0.04632768 168 0.002015049630654762 2.017654 34 128 0.01375405 Mouse Phenotype Single KO impaired somite development 33 1.403938e-15 3.8957152321212125e-13 3.24093 64 0.03615819 184 0.0026181012601630437 2.219019 26 89 0.0105178 Mouse Phenotype Single KO abnormal placenta physiology 34 3.6439e-15 9.813880088235295e-13 2.680007 83 0.04689266 275 0.011606927046545455 1.796322 35 148 0.01415858 Mouse Phenotype Single KO abnormal vascular smooth muscle morphology 35 4.048551e-15 1.0592166144857142e-12 3.357948 59 0.03333333 284 0.013324595746478873 2.155586 21 74 0.008495146 Mouse Phenotype Single KO distended pericardium 38 1.089057e-13 2.6243407760526318e-11 3.350023 53 0.0299435 161 0.0018138924985093168 2.672622 19 54 0.007686084 Mouse Phenotype Single KO abnormal vasculogenesis 39 1.502219e-13 3.527133175128205e-11 3.418524 51 0.02881356 278 0.0116736762823741 2.480285 16 49 0.006472492 Mouse Phenotype Single KO abnormal smooth muscle morphology 40 1.672671e-13 3.82916208675e-11 2.798343 68 0.03841808 245 0.007477322146122448 2.03058 27 101 0.01092233 Mouse Phenotype Single KO abnormal dorsal aorta morphology 44 3.562599e-12 7.414254327954545e-10 2.784927 61 0.03446328 204 0.0042991778345588235 2.268897 23 77 0.009304207 Mouse Phenotype Single KO abnormal rostral-caudal axis patterning 47 4.460927e-12 8.691214582765959e-10 2.534431 71 0.04011299 164 0.0018965676889024388 2.102429 31 112 0.01254045 Mouse Phenotype Single KO kinked tail 52 4.308437e-11 7.586991847884615e-9 2.544286 64 0.03615819 293 0.015409133953242319 1.955373 26 101 0.0105178 Mouse Phenotype Single KO abnormal artery development 53 4.945121e-11 8.543862829622641e-9 2.316665 76 0.04293785 87 0.0001674045901494253 2.27227 35 117 0.01415858 Mouse Phenotype Single KO abnormal embryo turning 59 1.185745e-10 1.840316434745763e-8 2.179073 83 0.04689266 133 0.0009721456757894735 1.921309 43 170 0.01739482 Mouse Phenotype Single KO abnormal somite development 61 2.547992e-10 3.824911925245902e-8 2.099331 87 0.04915254 142 0.0011614880669014083 1.88824 44 177 0.01779935 Mouse Phenotype failure of somite differentiation 9 4.987639e-24 5.298535164333333e-21 5.368746 58 0.03276836 381 0.006573139820472442 2.327768 19 62 0.007686084 Mouse Phenotype absent somites 10 3.492385e-23 3.3390692985e-20 6.086348 50 0.02824859 719 0.04507184387065369 2.17025 14 49 0.00566343 Mouse Phenotype abnormal chorioallantoic fusion 12 1.491782e-22 1.1885773085e-19 3.919118 75 0.04237288 117 0.00003319000636923077 2.589502 30 88 0.01213592 Mouse Phenotype failure of chorioallantoic fusion 17 1.921849e-20 1.0808704875882353e-17 3.997906 66 0.03728814 190 0.00025705362416842103 2.6043 24 70 0.009708738 Mouse Phenotype abnormal placenta development 18 1.823616e-19 9.686440320000001e-17 2.857229 98 0.05536723 87 0.000012975617737931036 2.219574 45 154 0.01820388 Mouse Phenotype impaired somite development 19 2.435323e-19 1.2254801685789474e-16 2.986192 91 0.05141243 63 0.0000023126040566666666 2.471673 41 126 0.01658576 Mouse Phenotype failure of initiation of embryo turning 20 3.719698e-19 1.7782016289000003e-16 4.282051 57 0.03220339 311 0.00253333543755627 2.450282 20 62 0.008090615 Mouse Phenotype absent limb buds 22 2.198392e-18 9.554011778181818e-16 5.579389 42 0.02372881 756 0.04999201551587302 3.127713 7 17 0.002831715 Mouse Phenotype kinked neural tube 23 9.152002e-18 3.804447440086956e-15 3.864406 59 0.03333333 324 0.0031260840361111114 2.411389 20 63 0.008090615 Mouse Phenotype abnormal notochord morphology 24 2.661078e-17 1.06010694825e-14 3.372465 68 0.03841808 413 0.009184220204600484 2.079823 23 84 0.009304207 Mouse Phenotype abnormal endocardium morphology 25 2.827243e-17 1.08125081292e-14 4.936626 44 0.02485876 322 0.003080132565838509 3.255374 12 28 0.004854369 Mouse Phenotype abnormal placenta physiology 26 3.282342e-17 1.2070181485384614e-14 2.619242 99 0.0559322 174 0.00015355301184482757 1.985285 46 176 0.01860841 Mouse Phenotype incomplete somite formation 28 4.811795e-17 1.6430561426785714e-14 3.671272 60 0.03389831 101 0.000018891106583168316 3.119734 23 56 0.009304207 Mouse Phenotype abnormal extracellular matrix morphology 29 9.438911e-17 3.1119113127931037e-14 4.38608 48 0.02711864 634 0.03349248460883281 2.191117 15 52 0.006067961 Mouse Phenotype abnormal head mesenchyme morphology 31 1.891038e-16 5.83232719935484e-14 4.148577 50 0.02824859 540 0.024647124844444444 2.363161 14 45 0.00566343 Mouse Phenotype abnormal head development 34 1.547406e-15 4.3513966958823533e-13 3.527522 57 0.03220339 415 0.009228763313493977 2.317385 18 59 0.007281553 Mouse Phenotype incomplete embryo turning 35 5.712488e-15 1.560488507657143e-12 3.043443 67 0.03785311 494 0.017144725201821864 2.045043 21 78 0.008495146 Mouse Phenotype abnormal vitelline vascular remodeling 37 3.615936e-14 9.343774080000002e-12 3.225665 58 0.03276836 268 0.0014273277983955224 2.337192 24 78 0.009708738 Mouse Phenotype abnormal embryo turning 40 5.461427e-14 1.305417588675e-11 2.193355 111 0.06271186 105 0.000029637688614285715 1.969301 56 216 0.02265372 Mouse Phenotype abnormal somite development 41 6.541064e-14 1.5253442171707317e-11 2.103025 121 0.06836158 70 0.000004296183447428571 2.00226 63 239 0.02548544