# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	20	1.128549e-31	7.425288145500001e-29	2.748838	180	0.01898134	266	0.0007732094831203007	1.47219	70	113	0.008859638	
GO Biological Process	regulation of DNA-templated transcription in response to stress	22	9.566736e-30	5.7222126829090905e-27	2.565091	190	0.02003585	209	0.00019737058176555022	1.497816	75	119	0.009492469	
GO Biological Process	cellular response to epidermal growth factor stimulus	42	5.444417e-24	1.705787697690476e-21	2.928314	121	0.01275968	424	0.008830328328773585	1.68859	27	38	0.003417289	
GO Biological Process	response to epidermal growth factor	46	1.022363e-22	2.924624938478261e-20	2.78079	124	0.01307603	355	0.004151860958309859	1.697525	30	42	0.003796988	
GO Biological Process	liver regeneration	69	1.784053e-19	3.402370061884058e-17	3.162675	86	0.00906886	576	0.031690915651041665	1.629624	24	35	0.00303759	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	82	8.868141e-19	1.4231203343780486e-16	2.564987	116	0.01223242	458	0.011661908040174671	1.462483	48	78	0.00607518	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	102	1.832624e-17	2.3642646290196075e-15	2.384752	123	0.01297058	471	0.012885619679617833	1.369528	68	118	0.008606506	
GO Biological Process	regulation of hematopoietic stem cell differentiation	134	1.962214e-15	1.9269234347761196e-13	2.365557	109	0.01149425	650	0.049619349861538466	1.338243	58	103	0.007340843	
GO Biological Process	cotranslational protein targeting to membrane	144	4.463112e-15	4.0784785283333336e-13	2.402081	103	0.01086154	314	0.0018349135901273884	1.479272	61	98	0.007720542	
GO Biological Process	protein targeting to ER	167	4.376208e-14	3.44829467497006e-12	2.302062	104	0.01096699	300	0.0013185734701666666	1.482393	63	101	0.007973674	
GO Biological Process	viral gene expression	192	4.096978e-13	2.8079236198958334e-11	2.089553	119	0.01254877	437	0.00973165865286041	1.36604	73	127	0.009239337	
GO Biological Process	protein localization to vacuole	193	4.223025e-13	2.879315335492228e-11	2.490235	82	0.008647053	331	0.0025668430414501507	1.713316	31	43	0.003923554	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	201	6.657764e-13	4.3586824117412934e-11	2.315795	93	0.009807023	348	0.0035096210084482756	1.472418	57	92	0.007214277	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	220	3.877131e-12	2.3190530376818181e-10	2.749905	63	0.006643467	627	0.04189865475757576	1.756569	17	23	0.002151626	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	231	8.626853e-12	4.914318555281385e-10	2.075984	107	0.01128335	302	0.001394518053344371	1.471188	65	105	0.008226807	
GO Biological Process	mitochondrial translation	241	1.97306e-11	1.0773235078838173e-9	2.112874	99	0.01043973	496	0.01753827805766129	1.377057	62	107	0.007847108	
GO Biological Process	viral transcription	250	3.234996e-11	1.7027724945599998e-9	2.027601	107	0.01128335	494	0.017347712146153847	1.367033	65	113	0.008226807	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	271	6.928145e-11	3.364112917158672e-9	2.12775	92	0.009701571	447	0.01042666170738255	1.728389	24	33	0.00303759	
GO Biological Process	mitochondrial translational termination	280	8.615588e-11	4.049018660428572e-9	2.254995	80	0.008436149	575	0.030763773871304346	1.393141	51	87	0.006454879	
GO Biological Process	translational elongation	292	1.189753e-10	5.36163004349315e-9	2.009678	103	0.01086154	532	0.022401312695864664	1.35802	64	112	0.00810024	
GO Cellular Component	proteasome complex	41	1.172425e-14	4.94134243902439e-13	2.567317	88	0.009279764	115	0.027708359791304347	1.432911	41	68	0.005189217	
GO Cellular Component	endopeptidase complex	42	1.209094e-14	4.974558171428571e-13	2.565868	88	0.009279764	122	0.03841611698360656	1.412144	41	69	0.005189217	
GO Cellular Component	large ribosomal subunit	68	3.110398e-11	7.904070211764706e-10	2.060635	103	0.01086154	79	0.007236914308860759	1.38459	67	115	0.008479939	
GO Cellular Component	PcG protein complex	80	6.980023e-10	1.507684968e-8	2.117755	83	0.008752504	127	0.04500578721259843	1.49825	29	46	0.003670421	
GO Cellular Component	axon cytoplasm	133	5.969629e-7	0.000007756029257142858	2.083103	56	0.005905304	124	0.040067163870967745	1.544748	26	40	0.003290723	
GO Cellular Component	Bcl-2 family protein complex	151	0.000004309145	0.000049312599735099336	3.659721	18	0.001898134	117	0.034441344	2.376535	7	7	0.0008859638	
GO Cellular Component	platelet dense tubular network	271	0.0006114169	0.003898628794095941	2.386382	19	0.002003585	104	0.01958134707692308	2.160486	10	11	0.001265663	
GO Molecular Function	SUMO transferase activity	22	1.101792e-12	2.114439010909091e-10	3.712321	43	0.00453443	108	0.047004972425925926	1.876212	15	19	0.001898494	
GO Molecular Function	calcium channel inhibitor activity	111	0.00000469262	0.00017848866342342343	3.237221	21	0.002214489	105	0.04738720527619048	2.160486	10	11	0.001265663	
GO Molecular Function	fatty acid synthase activity	321	0.001082318	0.014235347651090344	2.167664	21	0.002214489	105	0.04738720527619048	2.160486	10	11	0.001265663	
Mouse Phenotype Single KO	glomerulonephritis	49	1.391186e-15	2.599814326938775e-13	2.117698	140	0.01476326	244	0.0046112888151639345	1.488913	52	83	0.006581445	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	188	2.519781e-9	1.2273209902659575e-7	2.134922	76	0.008014341	232	0.004066161903017241	1.584356	40	60	0.00506265	
Mouse Phenotype Single KO	increased circulating iron level	275	1.344962e-7	0.0000044784789214545455	2.039233	66	0.006959823	221	0.0032131486225791856	1.751131	28	38	0.003543855	
Mouse Phenotype Single KO	increased lactate dehydrogenase level	283	1.908704e-7	0.000006175972624734982	2.551967	40	0.004218074	172	0.0012676647341279068	2.052462	19	22	0.002404759	
Mouse Phenotype Single KO	early cellular replicative senescence	312	4.29495e-7	0.000012605402932692307	2.006923	63	0.006643467	318	0.016750381779245285	1.553888	34	52	0.004303253	
Mouse Phenotype Single KO	abnormal DNA replication	444	0.00001136366	0.0002343626905855856	2.347424	33	0.003479911	420	0.04352598990238095	1.756569	17	23	0.002151626	
Mouse Phenotype Single KO	decreased transitional stage T1 B cell number	468	0.00001789253	0.00035008952395299144	3.284791	18	0.001898134	369	0.029245497558265585	2.160486	10	11	0.001265663	
Mouse Phenotype Single KO	absent brain internal capsule	983	0.002903802	0.027049964307222788	3.12744	9	0.0009490668	434	0.049202333322580644	2.376535	7	7	0.0008859638	
Mouse Phenotype	extramedullary hematopoiesis	9	9.59072e-33	1.0188541546666667e-29	2.122479	309	0.03258463	516	0.022300773093023255	1.276539	94	175	0.01189723	
Mouse Phenotype	increased susceptibility to endotoxin shock	116	1.437466e-13	1.1847941746551724e-11	2.256427	104	0.01096699	624	0.04184963083653846	1.399877	43	73	0.005442349	
Mouse Phenotype	decreased transitional stage T1 B cell number	222	4.742032e-10	2.0422778356756757e-8	3.384516	37	0.003901719	469	0.01695000785565032	1.957146	14	17	0.001771928	
Mouse Phenotype	lymph node hyperplasia	287	1.112836e-8	3.7072560961672473e-7	2.016375	80	0.008436149	517	0.022296695837524177	1.566352	29	44	0.003670421	
Mouse Phenotype	increased lactate dehydrogenase level	360	1.771997e-7	0.000004706128699166666	2.262013	51	0.005378045	331	0.0035987604	1.82201	23	30	0.002911024	
Mouse Phenotype	abnormal locus ceruleus morphology	605	0.00001746494	0.0002760037873388429	2.062313	42	0.004428978	588	0.03503012188265306	2.010914	11	13	0.001392229