# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	17	8.923289e-37	6.907150585352942e-34	2.899965	193	0.0200249	317	0.001486897676561514	1.478444	66	113	0.008897277	
GO Biological Process	mRNA catabolic process	18	1.557453e-36	1.1385846681666668e-33	2.364218	275	0.02853289	119	1.634665164117647e-8	1.54491	130	213	0.01752494	
GO Biological Process	nuclear-transcribed mRNA catabolic process	26	1.127014e-33	5.703991240769232e-31	2.376821	250	0.02593899	158	2.7253713170253167e-7	1.521322	119	198	0.01604206	
GO Biological Process	RNA catabolic process	27	1.252092e-33	6.102325417777778e-31	2.18717	297	0.03081552	133	3.128245536466165e-8	1.50196	143	241	0.01927743	
GO Biological Process	regulation of DNA-templated transcription in response to stress	28	1.455125e-33	6.8385678124999995e-31	2.669955	201	0.02085495	272	0.0003196175480183823	1.510257	71	119	0.009571313	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	29	3.701552e-32	1.6796111299310345e-29	3.014075	158	0.01639344	179	9.496916462569833e-7	1.651764	77	118	0.01038016	
GO Biological Process	mitochondrial transport	34	6.010005e-28	2.3260486998529414e-25	2.01135	298	0.03091928	181	0.0000011908335197237569	1.450982	137	239	0.01846859	
GO Biological Process	rRNA metabolic process	39	1.111757e-26	3.751182144358974e-24	2.065205	266	0.02759909	157	2.349428813821656e-7	1.456216	149	259	0.02008628	
GO Biological Process	multi-organism metabolic process	41	1.816443e-26	5.829895960243902e-24	2.435568	185	0.01919485	109	8.202535888990827e-9	1.670297	97	147	0.0130763	
GO Biological Process	rRNA processing	42	2.546544e-26	7.97856488e-24	2.075856	259	0.0268728	165	3.5697559746666664e-7	1.456488	145	252	0.01954705	
GO Biological Process	cotranslational protein targeting to membrane	52	6.414228e-25	1.6231697356153845e-22	2.914157	127	0.01317701	171	5.063869465964913e-7	1.730566	67	98	0.009032084	
GO Biological Process	protein targeting to ER	53	7.39594e-25	1.836286310566038e-22	2.85308	131	0.01359203	113	1.0339878723716815e-8	1.804473	72	101	0.00970612	
GO Biological Process	viral gene expression	60	8.359919e-24	1.8334695686833335e-21	2.574255	149	0.01545964	148	9.435243062837837e-8	1.674229	84	127	0.01132381	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	62	1.569651e-23	3.3314576627419358e-21	2.14061	214	0.02220378	297	0.0008638989835353535	1.42078	87	155	0.01172823	
GO Biological Process	response to topologically incorrect protein	63	1.809491e-23	3.779538423650794e-21	2.108476	221	0.02293007	343	0.002342202636122449	1.364076	97	180	0.0130763	
GO Biological Process	macromolecular complex disassembly	65	2.337113e-23	4.731395379538462e-21	2.054148	234	0.0242789	190	0.000004313896270368421	1.484308	112	191	0.01509841	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	71	5.368121e-23	9.949169611126761e-21	2.763056	127	0.01317701	420	0.012090263617142855	1.492803	46	78	0.006201132	
GO Biological Process	liver regeneration	74	1.11425e-22	1.981407533783784e-20	3.365099	93	0.009649305	551	0.03636376210344827	1.663409	23	35	0.003100566	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	75	1.332109e-22	2.337229644133333e-20	2.615288	137	0.01421457	116	1.328080015775862e-8	1.783946	74	105	0.009975735	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	81	4.538984e-22	7.373887710617284e-20	2.842065	116	0.01203569	166	3.8373665412650607e-7	1.760887	64	92	0.008627662	
GO Cellular Component	ribosomal subunit	33	3.96697e-29	2.0772497454545452e-27	2.433932	205	0.02126997	37	2.447930568648648e-7	1.532448	112	185	0.01509841	
GO Cellular Component	ribosome	37	1.732608e-23	8.091747632432431e-22	2.027678	243	0.0252127	34	1.266015134117647e-7	1.480152	138	236	0.0186034	
GO Cellular Component	large ribosomal subunit	41	3.495708e-21	1.4733130302439025e-19	2.578659	131	0.01359203	58	0.00008375088662068966	1.540776	70	115	0.009436506	
GO Cellular Component	mitochondrial ribosome	47	1.673195e-17	6.151661617021276e-16	2.883795	88	0.009130525	115	0.03405063067826087	1.399646	47	85	0.00633594	
GO Cellular Component	mitochondrial large ribosomal subunit	52	1.990176e-15	6.613507938461539e-14	3.363201	61	0.006329114	108	0.027103136	1.538618	31	51	0.004179024	
GO Cellular Component	PcG protein complex	55	7.444089e-14	2.3387974167272724e-12	2.384954	95	0.009856817	88	0.007237107490909092	1.650832	30	46	0.004044217	
GO Cellular Component	catalytic step 2 spliceosome	56	4.278587e-13	1.320249702857143e-11	2.126632	114	0.01182818	95	0.011725047511578946	1.423842	54	96	0.00727959	
GO Cellular Component	methyltransferase complex	61	2.249864e-12	6.373385232786887e-11	2.061984	115	0.01193194	112	0.030901685142857144	1.390811	50	91	0.006740361	
GO Cellular Component	endopeptidase complex	71	1.636137e-11	3.9820348394366197e-10	2.323782	81	0.008404233	84	0.005444317028571429	1.540776	42	69	0.005661903	
GO Cellular Component	small ribosomal subunit	73	3.784586e-11	8.95858165479452e-10	2.309914	79	0.008196721	80	0.00361821816	1.54689	44	72	0.005931518	
GO Cellular Component	peptidase complex	74	4.201453e-11	9.81096051891892e-10	2.083006	99	0.01027184	65	0.00028015452553846156	1.582047	55	88	0.007414397	
GO Cellular Component	proteasome complex	77	8.741909e-11	1.9618206171428574e-9	2.267685	79	0.008196721	90	0.00796001664	1.52621	41	68	0.005527096	
GO Cellular Component	cytosolic small ribosomal subunit	85	3.589973e-10	7.298203934117648e-9	2.538615	59	0.006121602	77	0.0024710444883116883	1.72587	30	44	0.004044217	
GO Cellular Component	nuclear ubiquitin ligase complex	97	3.892042e-9	6.933452140206186e-8	2.652191	48	0.004980286	99	0.016952599854545454	1.645329	26	40	0.003504988	
GO Cellular Component	cytosolic large ribosomal subunit	120	5.175925e-8	7.453332e-7	2.082452	67	0.00695165	96	0.0119624364	1.535364	37	61	0.004987867	
GO Cellular Component	ESCRT III complex	302	0.00105369	0.006029060662251655	2.573901	15	0.001556339	116	0.03738359668965517	2.109396	10	12	0.001348072	
GO Molecular Function	structural constituent of ribosome	8	1.226974e-25	6.475355285e-23	2.393611	185	0.01919485	23	0.00002132401868695652	1.51564	97	162	0.0130763	
GO Molecular Function	protein transporter activity	16	8.33608e-15	2.19968311e-12	2.119344	132	0.01369579	80	0.016311200914999997	1.45021	55	96	0.007414397	
GO Molecular Function	ribonuclease activity	17	9.480736e-15	2.354568670117647e-12	2.206159	120	0.01245072	92	0.039742199982608695	1.406264	55	99	0.007414397	
GO Molecular Function	insulin-like growth factor II binding	240	0.0001290099	0.0022694991575	2.633933	20	0.002075119	88	0.028400659947727277	2.531275	8	8	0.001078458	
Human Phenotype	Increased serum lactate	9	1.795933e-14	1.3315845454444446e-11	2.227653	115	0.01193194	35	0.005013295253142857	1.518765	60	100	0.008088434	
Human Phenotype	Abnormality of mitochondrial metabolism	21	5.939733e-11	1.8874208718571432e-8	2.176408	88	0.009130525	67	0.026358778267164183	1.540776	42	69	0.005661903	
Human Phenotype	Abnormality of the mitochondrion	22	8.30162e-11	2.5180322845454546e-8	2.150732	89	0.009234281	66	0.026617990363636365	1.533026	43	71	0.005796711	
Human Phenotype	Glycosuria	86	3.754295e-7	0.000029130709924418606	2.338293	45	0.004669018	74	0.03012014553918919	1.832992	21	29	0.002830952	
Human Phenotype	Weight loss	126	0.000005796461	0.00030698241470634925	2.467782	32	0.003320191	69	0.026972430407246378	2.320336	11	12	0.001482879	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	220	4.584083e-8	0.0000019080203650454546	2.01767	73	0.007574186	109	0.013391154795412842	1.603141	38	60	0.005122675	
Mouse Phenotype Single KO	decreased total retina thickness	259	1.591178e-7	0.000005625643608494209	2.141885	58	0.006017846	171	0.0499444467631579	1.665313	25	38	0.003370181	
Mouse Phenotype Single KO	abnormal synaptic bouton morphology	501	0.0000799953	0.0014621097047904192	3.157038	16	0.001660095	156	0.03819374134230769	2.301159	10	11	0.001348072	
Mouse Phenotype Single KO	abnormal DNA replication	630	0.0004058956	0.005899660332063492	2.029712	29	0.003008923	114	0.014273770950877195	1.980998	18	23	0.00242653	
Mouse Phenotype	extramedullary hematopoiesis	4	5.561883e-29	1.329429084075e-25	2.034278	301	0.03123055	265	0.03153170175396226	1.301799	90	175	0.01213265	
Mouse Phenotype	abnormal cellular replicative senescence	89	1.814422e-13	1.9491785103370785e-11	2.132043	117	0.01213945	103	0.0009468768838834951	1.597114	53	84	0.007144783	
Mouse Phenotype	early cellular replicative senescence	97	6.015698e-13	5.929493667835052e-11	2.183128	106	0.01099813	111	0.0012639538637837838	1.629725	47	73	0.00633594