# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	RNA catabolic process	24	6.575307e-50	3.6051860338749998e-47	2.124165	481	0.02992782	91	3.8155691795604395e-15	1.477275	193	241	0.01896061	
GO Biological Process	nuclear-transcribed mRNA catabolic process	25	1.538244e-48	8.096701118400001e-46	2.280518	400	0.024888	71	3.066730897323944e-17	1.555867	167	198	0.01640633	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	27	7.674156e-48	3.7401562520000005e-45	2.90568	254	0.01580388	127	7.084598371653543e-12	1.594554	102	118	0.01002063	
GO Biological Process	rRNA metabolic process	29	5.545363e-47	2.5162562661034484e-44	2.11841	455	0.0283101	104	1.2564009488557692e-13	1.438708	202	259	0.01984478	
GO Biological Process	mRNA catabolic process	31	1.262075e-45	5.357304814516129e-43	2.165315	420	0.0261324	76	2.529488775e-16	1.524243	176	213	0.0172905	
GO Biological Process	rRNA processing	33	1.239677e-44	4.943305952424242e-42	2.105177	438	0.02725236	105	1.8168656364761903e-13	1.442071	197	252	0.01935357	
GO Biological Process	viral gene expression	45	2.060218e-33	6.0245352582222225e-31	2.445087	236	0.01468392	145	2.5468273456551726e-10	1.539654	106	127	0.0104136	
GO Biological Process	protein localization to endoplasmic reticulum	47	3.674583e-33	1.0288050573829787e-30	2.36962	249	0.01549278	133	5.275609318947368e-11	1.562028	105	124	0.01031536	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	51	8.420265e-32	2.1725934732352942e-29	2.718096	185	0.0115107	167	7.567606946107784e-9	1.584019	79	92	0.007761077	
GO Biological Process	viral transcription	53	1.339459e-31	3.325649241698113e-29	2.459786	220	0.0136884	130	1.3669984214615385e-11	1.599811	98	113	0.009627665	
GO Biological Process	cotranslational protein targeting to membrane	55	5.126562e-31	1.2265532610545456e-28	2.628207	191	0.01188402	159	2.4702596194339624e-9	1.581154	84	98	0.008252284	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	61	5.424363e-29	1.1701507002786887e-26	2.404005	210	0.0130662	170	9.985606522352943e-9	1.546018	88	105	0.00864525	
GO Biological Process	protein targeting to ER	63	5.97295e-28	1.24758808015873e-25	2.481494	190	0.0118218	181	5.4316760538121546e-8	1.534189	84	101	0.008252284	
GO Biological Process	multi-organism metabolic process	70	3.174516e-26	5.9676365777142855e-24	2.068458	262	0.01630164	135	5.758243885777777e-11	1.51841	121	147	0.01188722	
GO Biological Process	translational initiation	73	1.194682e-25	2.15353704630137e-23	2.085073	251	0.01561722	177	3.619701888474576e-8	1.457684	113	143	0.01110129	
GO Biological Process	RNA phosphodiester bond hydrolysis	84	4.783515e-22	7.493604033928571e-20	2.008471	234	0.01455948	452	0.0020801409491150442	1.303759	94	133	0.009234699	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	85	4.818022e-22	7.458864882117648e-20	2.03639	226	0.01406172	481	0.002793100340956341	1.322293	81	113	0.00795756	
GO Biological Process	negative regulation of ubiquitin-protein transferase activity	132	1.216629e-16	1.2128500765909092e-14	2.101232	154	0.009581882	680	0.017543797471617648	1.317629	60	84	0.005894489	
GO Biological Process	RNA 3'-end processing	139	2.784418e-16	2.6359824792805757e-14	2.008149	168	0.01045296	398	0.0007386920369849247	1.36196	79	107	0.007761077	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	158	4.441416e-15	3.6990248825316455e-13	2.009202	154	0.009581882	699	0.020510080506437767	1.324386	56	78	0.005501523	
GO Cellular Component	ribosomal subunit	27	1.623475e-36	1.039024e-34	2.228517	313	0.01947486	31	6.810978890322579e-16	1.545543	155	185	0.01522743	
GO Cellular Component	large ribosomal subunit	37	4.344231e-23	2.0288732886486488e-21	2.242814	190	0.0118218	42	2.7474109714285717e-10	1.555948	97	115	0.009529423	
GO Cellular Component	cytosolic ribosome	41	8.221841e-21	3.4652051824390243e-19	2.011553	219	0.01362618	39	5.052432738461538e-11	1.581154	96	112	0.009431182	
GO Cellular Component	cytoplasmic stress granule	45	8.271268e-19	3.1761669119999996e-17	2.459923	126	0.007839721	90	0.000873297024	1.544383	36	43	0.003536693	
GO Cellular Component	small ribosomal subunit	55	1.787776e-16	5.6168671418181814e-15	2.261911	129	0.008026381	65	0.000004745146486153846	1.537234	60	72	0.005894489	
GO Cellular Component	mitochondrial ribosome	66	3.981122e-14	1.0423301236363636e-12	2.220635	113	0.007030861	69	0.000049493701565217394	1.454042	67	85	0.006582179	
GO Cellular Component	cytosolic large ribosomal subunit	69	2.245674e-13	5.6239488e-12	2.143458	115	0.007155301	58	2.680720286896552e-7	1.632996	54	61	0.00530504	
GO Cellular Component	cytosolic small ribosomal subunit	73	1.412984e-12	3.344707331506849e-11	2.322225	90	0.005599801	86	0.0005844511925581395	1.551208	37	44	0.003634935	
GO Cellular Component	mitochondrial large ribosomal subunit	79	7.784109e-11	1.7026506774683544e-9	2.380524	72	0.004479841	112	0.004442393314285714	1.446808	40	51	0.003929659	
GO Cellular Component	mitochondrial nucleoid	81	8.984597e-11	1.916714026666667e-9	2.268351	79	0.004915381	132	0.012185108509090908	1.449392	33	42	0.003241969	
GO Cellular Component	spliceosomal snRNP complex	85	2.623296e-10	5.333006456470588e-9	2.063904	93	0.005786461	98	0.002276493648979592	1.42814	48	62	0.004715591	
GO Cellular Component	nuclear ubiquitin ligase complex	113	1.190251e-7	0.000001820136042477876	2.087474	63	0.003919861	124	0.008705418735483871	1.475744	32	40	0.003143727	
GO Cellular Component	endoplasmic reticulum subcompartment	126	5.252854e-7	0.000007203914057142857	2.160984	52	0.003235441	142	0.01901312315492958	1.593133	19	22	0.001866588	
GO Cellular Component	U2 snRNP	184	0.00003128995	0.00029385344347826085	2.331566	30	0.0018666	138	0.015358964869565218	1.650503	17	19	0.001670105	
GO Cellular Component	U12-type spliceosomal complex	207	0.00007746542	0.0006466678539130434	2.002309	38	0.00236436	104	0.0036600552	1.631833	23	26	0.002259554	
GO Cellular Component	cytosolic proteasome complex	229	0.0001547046	0.0011673779423580785	2.46567	22	0.00136884	126	0.008807038628571429	1.84468	12	12	0.001178898	
GO Molecular Function	structural constituent of ribosome	7	4.12385e-27	2.4872706714285715e-24	2.079379	268	0.01667496	11	3.0433047267272728e-15	1.582781	139	162	0.01365557	
GO Molecular Function	rRNA binding	13	1.180486e-19	3.833855301538462e-17	2.982445	95	0.005910901	101	0.011198742134653465	1.414255	46	60	0.004519108	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	15	3.080659e-18	8.671028198666666e-16	2.831821	95	0.005910901	125	0.04277183228800001	1.526632	24	29	0.002357795	
GO Molecular Function	mRNA 5'-UTR binding	17	1.3517e-17	3.3569867058823527e-15	3.318176	72	0.004479841	134	0.049227921358208956	1.593133	19	22	0.001866588	
GO Molecular Function	snRNA binding	21	1.245754e-14	2.504558756190476e-12	2.996459	68	0.004230961	91	0.004534113901758241	1.553415	32	38	0.003143727	
GO Molecular Function	polyubiquitin binding	45	3.935126e-9	3.6920226604444447e-7	2.000426	87	0.005413141	116	0.03330069743103448	1.434751	35	45	0.003438452	
GO Molecular Function	peptide disulfide oxidoreductase activity	58	4.703117e-8	0.0000034235448231034485	3.106415	32	0.00199104	105	0.013990393148571426	1.84468	13	13	0.001277139	
GO Molecular Function	3'-5'-exoribonuclease activity	64	8.088085e-8	0.000005335608573437501	2.083833	65	0.004044301	113	0.030443119573451326	1.537234	25	30	0.002456037	
Mouse Phenotype Single KO	cervical vertebral transformation	16	2.069974e-13	1.184671994875e-10	2.276163	101	0.006284221	162	0.0011312608672222222	1.601959	33	38	0.003241969	
Mouse Phenotype Single KO	abnormal DNA replication	72	3.23776e-8	0.000004117801155555556	2.308426	55	0.003422101	343	0.025759650138775507	1.60407	20	23	0.00196483	
Mouse Phenotype	abnormal cellular replicative senescence	1	4.719207e-33	4.5120338126999996e-29	2.480578	227	0.01412394	515	0.016830837233592234	1.317629	60	84	0.005894489	
Mouse Phenotype	early cellular replicative senescence	2	4.285394e-29	2.0486326017e-25	2.470134	200	0.012444	368	0.004071702539673912	1.389828	55	73	0.005403281	
Mouse Phenotype	thoracic vertebral transformation	17	1.286179e-16	7.23362201117647e-14	2.217233	136	0.008461921	408	0.0064897513713235285	1.423964	44	57	0.004322625	
Mouse Phenotype	enlarged liver sinusoidal spaces	28	1.667951e-14	5.695456968214286e-12	2.075632	136	0.008461921	559	0.02337265982468694	1.43975	32	41	0.003143727	
Mouse Phenotype	abnormal DNA replication	185	4.226029e-7	0.000021840574740000002	2.009254	63	0.003919861	486	0.01416063775	1.571394	23	27	0.002259554