# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 36 2.343472e-12 8.566041124444445e-10 4.309541 35 0.008254717 365 0.0007494951801369864 3.169649 12 16 0.002700878 GO Biological Process response to epidermal growth factor 67 1.96948e-10 3.8681175104477617e-8 2.708446 54 0.01273585 748 0.03032213592513369 1.911852 19 42 0.00427639 GO Biological Process regulation of heart morphogenesis 72 2.915723e-10 5.328888744027778e-8 2.254631 75 0.01768868 406 0.0017017776274876844 2.361699 19 34 0.00427639 GO Biological Process cellular response to epidermal growth factor stimulus 75 3.282563e-10 5.759366202266667e-8 2.760466 51 0.0120283 682 0.02276522435777126 2.001884 18 38 0.004051317 GO Biological Process positive regulation of mRNA catabolic process 81 4.3357e-10 7.043639049382715e-8 3.460841 36 0.008490566 768 0.033848186347656246 2.197623 13 25 0.002925951 GO Biological Process noradrenergic neuron differentiation 110 5.200876e-9 6.221666116727273e-7 3.417757 32 0.00754717 641 0.020059306566146646 3.622456 6 7 0.001350439 GO Biological Process regulation of mRNA catabolic process 146 2.980024e-8 0.0000026858997134246575 2.782643 39 0.009198113 792 0.03818324766035353 2.044935 15 31 0.003376097 GO Biological Process positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 183 9.085035e-8 0.000006532785549999999 4.352468 20 0.004716981 609 0.017233227350246304 3.073599 8 11 0.001800585 GO Biological Process positive regulation of cardiac muscle hypertrophy 197 1.353373e-7 0.000009040119445177665 2.514894 42 0.00990566 509 0.007268367186836934 2.465282 14 24 0.003151024 GO Biological Process regulation of cardiac muscle hypertrophy 239 7.838033e-7 0.000043155094664016734 2.0038 60 0.01415094 261 0.00006544868133716473 2.457092 25 43 0.005626829 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 257 0.000001004938 0.000051455171758754864 2.411752 39 0.009198113 634 0.020078548070189276 2.185965 15 29 0.003376097 GO Biological Process gene silencing by miRNA 277 0.000001543839 0.00007334071263898917 2.544803 34 0.008018868 697 0.02308460525824964 1.920999 20 44 0.004501463 GO Biological Process cardiac right ventricle morphogenesis 335 0.000004979403 0.00019559392261791044 2.152128 43 0.01014151 710 0.02606034307323944 2.446747 11 19 0.002475805 GO Biological Process regulation of cell adhesion mediated by integrin 339 0.000006017553 0.0002335840115840708 2.286914 37 0.008726415 562 0.01311108438149466 2.058917 19 39 0.00427639 GO Biological Process negative regulation of mesenchymal cell proliferation 368 0.00001091621 0.0003903434983423913 2.671403 26 0.006132075 841 0.04883024821403091 3.169649 6 8 0.001350439 GO Biological Process regulation of glucose import in response to insulin stimulus 445 0.00003383428 0.0010005062708314607 2.445145 27 0.006367925 558 0.012828454409677418 2.535719 12 20 0.002700878 GO Biological Process catecholamine biosynthetic process 484 0.00005951435 0.0016180771315082644 2.244833 30 0.007075472 600 0.016505066133666667 2.582677 11 18 0.002475805 GO Biological Process positive regulation of glucose import in response to insulin stimulus 505 0.00008568568 0.00223274824380198 2.570402 22 0.005188679 655 0.020792525854961833 2.641374 10 16 0.002250731 GO Biological Process positive regulation of transcription regulatory region DNA binding 539 0.0001217816 0.0029731429951762524 2.041463 34 0.008018868 747 0.03034680312717537 2.305199 12 22 0.002700878 GO Biological Process limb bud formation 544 0.0001312311 0.003174393464889706 2.009557 35 0.008254717 504 0.007176365086507937 3.380959 8 10 0.001800585 GO Molecular Function Roundabout binding 132 0.001341412 0.04290485957575758 2.863136 12 0.002830189 73 0.042825197673972595 4.226199 5 5 0.001125366 Mouse Phenotype Single KO abnormal palatal shelf elevation 5 1.856704e-14 3.4003677056e-11 2.931212 69 0.01627358 775 0.04004880707483871 1.981031 15 32 0.003376097 Mouse Phenotype Single KO genital tubercle hypoplasia 125 0.000004944236 0.00036219495241600005 3.619516 18 0.004245283 751 0.0381826293701731 4.226199 4 4 0.0009002926 Mouse Phenotype Single KO decreased type I pneumocyte number 167 0.00002109635 0.0011567621374251498 3.949156 14 0.003301887 791 0.04129907715423515 3.521832 5 6 0.001125366 Mouse Phenotype Single KO increased thyroid tumor incidence 215 0.00006264164 0.0026679511510697674 2.973082 18 0.004245283 329 0.0021946078125835867 3.457799 9 11 0.002025658 Mouse Phenotype Single KO pharyngeal arch hypoplasia 219 0.00006867173 0.0028713563087214614 2.488548 24 0.005660377 404 0.005637053733168316 3.169649 9 12 0.002025658 Mouse Phenotype Single KO abnormal genital tubercle morphology 280 0.0002249811 0.007357685473928572 2.59297 19 0.004481132 791 0.04129907715423515 3.521832 5 6 0.001125366 Mouse Phenotype Single KO abnormal nervous system regeneration 322 0.0003915258 0.011134166927329192 2.093831 27 0.006367925 705 0.03194940944397163 2.324409 11 20 0.002475805 Mouse Phenotype Single KO pulmonary artery hypoplasia 337 0.000454334 0.012345211982195846 2.225002 23 0.005424528 508 0.014376412489960631 3.073599 8 11 0.001800585 Mouse Phenotype Single KO abnormal lymphatic vessel endothelial cell morphology 353 0.0005282834 0.013703940775637392 2.245853 22 0.005188679 747 0.038255567876840695 3.169649 6 8 0.001350439 Mouse Phenotype Single KO abnormal forelimb bud morphology 363 0.0005716884 0.014421351732231405 2.232129 22 0.005188679 323 0.0019711012331888544 3.756621 8 9 0.001800585 Mouse Phenotype Single KO increased circulating erythropoietin level 408 0.0008958743 0.02010666903210784 3.192154 11 0.00259434 791 0.04129907715423515 3.521832 5 6 0.001125366 Mouse Phenotype Single KO abnormal conotruncal ridge morphology 418 0.0009377792 0.020543646254545456 2.001445 26 0.006132075 599 0.021563542602671116 2.716842 9 14 0.002025658 Mouse Phenotype Single KO increased type II pneumocyte number 527 0.002035388 0.03536631483111954 2.143442 19 0.004481132 805 0.0444439715689441 2.600738 8 13 0.001800585 Mouse Phenotype Single KO thick lung-associated mesenchyme 551 0.002412344 0.04009044284573503 2.023309 21 0.00495283 787 0.040934151970775094 2.347888 10 18 0.002250731 Mouse Phenotype Single KO abnormal rostral-caudal body axis extension 557 0.002507649 0.04122538939497306 2.209546 17 0.004009434 805 0.0444439715689441 2.600738 8 13 0.001800585 Mouse Phenotype Single KO lung epithelium hyperplasia 590 0.003101405 0.04813485692372881 3.754948 7 0.001650943 751 0.0381826293701731 4.226199 4 4 0.0009002926 Mouse Phenotype abnormal sympathetic system morphology 8 2.254773e-14 2.6947355816250002e-11 2.210566 115 0.02712264 475 0.0011886241238526316 1.866114 34 77 0.007652487 Mouse Phenotype abnormal sympathetic ganglion morphology 11 6.999627e-14 6.083948522454545e-11 2.366406 96 0.02264151 717 0.00762397340334728 1.792933 28 66 0.006302048 Mouse Phenotype abnormal superior cervical ganglion morphology 16 1.490356e-12 8.9058085725e-10 2.501616 77 0.01816038 1253 0.038985507818834794 1.690479 22 55 0.004951609 Mouse Phenotype abnormal palatal shelf elevation 17 5.337137e-12 3.001668638647059e-9 2.316041 85 0.02004717 635 0.004412243404724409 2.021225 22 46 0.004951609 Mouse Phenotype abnormal paravertebral ganglion morphology 18 8.191663e-12 4.351138330166666e-9 2.365505 80 0.01886792 1128 0.029972260164893613 1.690479 24 60 0.005401756 Mouse Phenotype clavicle hypoplasia 54 1.621423e-8 0.0000028708195005555555 3.327318 31 0.007311321 620 0.004238613361935484 3.380959 8 10 0.001800585 Mouse Phenotype abnormal stellate ganglion morphology 68 4.404491e-8 0.000006192843889852941 3.17906 31 0.007311321 1070 0.027885701955140188 3.169649 6 8 0.001350439 Mouse Phenotype increased papilloma incidence 105 5.06342e-7 0.00004610605582857143 2.075167 57 0.0134434 899 0.016008942654060068 1.760916 25 60 0.005626829 Mouse Phenotype abnormal sympathetic neuron morphology 114 9.004312e-7 0.0000755177430105263 2.45602 38 0.008962264 960 0.01973639384375 2.485999 10 17 0.002250731 Mouse Phenotype increased muscle cell glucose uptake 127 0.000001509041 0.00011360583465354331 2.236038 44 0.01037736 843 0.012831224932384342 2.052725 17 35 0.003826244 Mouse Phenotype absent atrioventricular cushions 169 0.000005592615 0.0003163964024556213 2.212152 40 0.009433962 756 0.008929943647619048 2.388721 13 23 0.002925951 Mouse Phenotype small forelimb buds 192 0.00001147522 0.0005714300959375 3.147375 20 0.004716981 816 0.011448912013602942 3.622456 6 7 0.001350439 Mouse Phenotype conotruncal ridge hypoplasia 194 0.00001200888 0.0005918396993814433 2.599593 27 0.006367925 785 0.009713923627643312 3.073599 8 11 0.001800585 Mouse Phenotype premature suture closure 218 0.00002027026 0.0008890089718348623 2.346272 31 0.007311321 1157 0.03228683591097666 2.600738 8 13 0.001800585 Mouse Phenotype premature neuronal precursor differentiation 222 0.00002382723 0.001026180837972973 2.094453 39 0.009198113 796 0.010194016273492463 2.275645 14 26 0.003151024 Mouse Phenotype increased thyroid tumor incidence 241 0.00003818574 0.0015149122827385893 2.586898 24 0.005660377 700 0.006831630891 2.366671 14 25 0.003151024 Mouse Phenotype decreased tracheal cartilage ring number 257 0.00005431646 0.0020206991208560313 2.654596 22 0.005188679 1070 0.027885701955140188 3.169649 6 8 0.001350439 Mouse Phenotype lung epithelium hyperplasia 270 0.00007211194 0.002553563919777778 4.31773 11 0.00259434 816 0.011448912013602942 3.622456 6 7 0.001350439 Mouse Phenotype genital tubercle hypoplasia 274 0.00007733031 0.0026983762551459852 2.589243 22 0.005188679 816 0.011448912013602942 3.622456 6 7 0.001350439 Mouse Phenotype decreased retinal apoptosis 349 0.0002127325 0.005827895222063037 3.014548 15 0.003537736 1009 0.0235583608543112 2.958339 7 10 0.001575512