# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of adherens junction organization 62 1.935718e-37 4.1084053487096775e-35 2.360315 285 0.017444 293 0.000037914725794539246 1.643176 46 57 0.004988072 GO Biological Process regulation of focal adhesion assembly 85 6.879821e-34 1.0650772298705881e-31 2.303138 270 0.01652589 332 0.00015009809386445783 1.621346 43 54 0.004662763 GO Biological Process positive regulation of actin filament bundle assembly 108 1.18972e-31 1.4495856925925927e-29 2.468048 219 0.01340433 753 0.014833614689508631 1.443787 39 55 0.004229018 GO Biological Process positive regulation of adherens junction organization 138 1.554661e-28 1.482448123115942e-26 2.891591 149 0.009119843 575 0.004351447870782608 1.722862 22 26 0.0023856 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 164 1.668676e-26 1.3389089929268292e-24 2.615909 163 0.009976741 950 0.04214837396105263 1.544635 22 29 0.0023856 GO Biological Process positive regulation of focal adhesion assembly 172 9.470203e-26 7.245255888197675e-24 2.80833 140 0.00856898 697 0.01077933361420373 1.696758 20 24 0.002168727 GO Biological Process gene silencing by miRNA 177 2.240375e-25 1.6655985663841808e-23 2.75823 142 0.008691394 661 0.008197224857488652 1.527082 33 44 0.003578399 GO Biological Process positive regulation of stress fiber assembly 180 2.743843e-25 2.0059016687222223e-23 2.362413 188 0.01150692 644 0.007122944223447205 1.516252 35 47 0.003795272 GO Biological Process positive regulation of cell-matrix adhesion 257 1.785616e-21 9.14277079533074e-20 2.0997 204 0.01248623 686 0.01027286875612245 1.50495 34 46 0.003686836 GO Biological Process posttranscriptional gene silencing by RNA 265 3.904518e-21 1.938851032528302e-19 2.426018 147 0.008997429 991 0.04989374938244198 1.39733 35 51 0.003795272 GO Biological Process positive regulation of phosphatase activity 329 1.126321e-18 4.5049416531914895e-17 2.116168 172 0.0105276 819 0.02200777678021978 1.5998 22 28 0.0023856 GO Biological Process production of miRNAs involved in gene silencing by miRNA 359 6.502171e-18 2.383344517799443e-16 2.816018 94 0.005753458 689 0.010474942154136429 1.659052 22 27 0.0023856 GO Biological Process positive regulation of receptor activity 391 3.187378e-17 1.0727035064450127e-15 2.011776 178 0.01089485 783 0.01721719862707535 1.47293 34 47 0.003686836 GO Biological Process regulation of fibroblast migration 419 1.478884e-16 4.64454285346062e-15 2.276192 128 0.007834496 950 0.04214837396105263 1.544635 22 29 0.0023856 GO Biological Process positive regulation of phosphoprotein phosphatase activity 428 2.586433e-16 7.952072861448597e-15 2.410554 112 0.006855184 581 0.004539220831325301 1.908852 15 16 0.001626545 GO Biological Process regulation of lipid catabolic process 442 5.895146e-16 1.7550729912669683e-14 2.072 152 0.009303464 830 0.023406832844578312 1.418005 39 56 0.004229018 GO Biological Process production of small RNA involved in gene silencing by RNA 535 5.636163e-14 1.386285400317757e-12 2.386963 96 0.005875872 866 0.02916936991916859 1.561017 23 30 0.002494036 GO Biological Process deoxyribonucleotide metabolic process 606 5.007055e-13 1.0872580320957096e-11 2.306921 95 0.005814665 668 0.009036799446556887 1.604207 26 33 0.002819345 GO Biological Process regulation of cardiac muscle hypertrophy in response to stress 642 2.235299e-12 4.581666595171339e-11 2.666799 68 0.004162076 845 0.025840040203550293 2.036109 9 9 0.0009759271 GO Biological Process 2'-deoxyribonucleotide metabolic process 664 4.028748e-12 7.984080562048191e-11 2.395706 81 0.004957767 578 0.004341110843771627 1.685056 24 29 0.002602472 GO Cellular Component stress fiber 37 2.639582e-27 1.232756134054054e-25 2.345654 207 0.01266985 80 0.0026737819200000003 1.527082 39 52 0.004229018 GO Cellular Component actin filament bundle 43 8.309228e-25 3.339150228837209e-23 2.168992 221 0.01352675 88 0.005092270690909091 1.474424 42 58 0.004554327 GO Cellular Component actomyosin 46 2.830986e-22 1.0634660452173912e-20 2.031356 230 0.01407761 51 0.00005964354635294118 1.59071 50 64 0.005421817 GO Cellular Component cleavage furrow 54 1.224437e-18 3.9181984e-17 2.226357 153 0.009364671 123 0.036787813463414636 1.409614 36 52 0.003903709 GO Cellular Component SMAD protein complex 78 3.610978e-13 7.999705107692307e-12 3.076623 58 0.003550006 113 0.025374196672566372 2.036109 9 9 0.0009759271 GO Molecular Function transforming growth factor beta receptor, cytoplasmic mediator activity 36 1.084253e-21 1.2715878238888888e-19 3.795425 76 0.004651732 108 0.031842316181481485 2.036109 10 10 0.001084363 Human Phenotype Mitral valve prolapse 17 1.480446e-17 5.811185975294118e-15 2.066924 170 0.01040519 57 0.01623128812982456 1.589158 32 41 0.003469963 Mouse Phenotype Single KO abnormal pharyngeal arch artery morphology 10 1.675208e-44 1.5339879656e-41 2.453848 316 0.01934141 228 0.000299606396995614 1.665908 36 44 0.003903709 Mouse Phenotype Single KO increased papilloma incidence 144 4.032839e-16 2.564493522430556e-14 2.278434 124 0.007589668 508 0.013428491746850393 1.59071 25 32 0.002710909 Mouse Phenotype Single KO abnormal inguinal fat pad morphology 145 4.118833e-16 2.6011140538620687e-14 2.04849 158 0.009670706 642 0.03170890809501558 1.425277 35 50 0.003795272 Mouse Phenotype Single KO dilated dorsal aorta 159 1.462193e-15 8.42094421446541e-14 2.28945 118 0.007222426 688 0.04000530922965116 1.696758 15 18 0.001626545 Mouse Phenotype Single KO abnormal fourth pharyngeal arch artery morphology 205 4.618419e-14 2.0629689162439025e-12 2.197984 115 0.007038805 409 0.004487086721271394 1.908852 15 16 0.001626545 Mouse Phenotype Single KO increased myocardial infarction size 207 5.637713e-14 2.4939390309661836e-12 2.527565 86 0.005263802 530 0.016917058184339622 1.682003 19 23 0.002060291 Mouse Phenotype Single KO abnormal fourth pharyngeal arch morphology 222 2.392886e-13 9.870115811711712e-12 2.053954 127 0.007773289 337 0.0021916548570326414 1.842194 19 21 0.002060291 Mouse Phenotype Single KO osteosclerosis 524 4.893193e-8 8.550948149045802e-7 2.205828 59 0.003611213 406 0.004426205106403941 2.036109 12 12 0.001301236 Mouse Phenotype Single KO dilated bile duct 890 0.00001607546 0.00016539661485393258 2.050928 43 0.002631901 406 0.004426205106403941 2.036109 12 12 0.001301236 Mouse Phenotype Single KO small vulva 1766 0.004374258 0.022681246039637597 2.592635 11 0.000673277 719 0.04304714615020862 2.036109 8 8 0.0008674908 Mouse Phenotype pale kidney 76 3.821891e-29 4.808039454078947e-27 2.492466 197 0.01205778 1168 0.046928236654109584 1.402653 31 45 0.003361527 Mouse Phenotype abnormal inguinal fat pad morphology 127 1.122578e-22 8.451156108661417e-21 2.012581 240 0.01468968 482 0.00125367799219917 1.495268 47 64 0.005096508 Mouse Phenotype conotruncal ridge hypoplasia 184 1.305303e-18 6.782609773369565e-17 2.673575 107 0.006549149 1124 0.04220492495551601 1.851008 10 11 0.001084363 Mouse Phenotype increased myocardial infarction size 216 1.077957e-16 4.7714568875e-15 2.640294 97 0.005937079 559 0.003252147639177102 1.722862 22 26 0.0023856 Mouse Phenotype enhanced wound healing 223 5.460683e-16 2.341237227040359e-14 2.501448 102 0.006243114 1116 0.04094332902956989 1.527082 21 28 0.002277163 Mouse Phenotype thick interventricular septum 278 4.375826e-14 1.5049378556115109e-12 2.035763 138 0.008446566 1044 0.031079962847701145 1.461822 28 39 0.003036218 Mouse Phenotype increased white fat cell number 647 2.130454e-8 3.1482644040185474e-7 2.179064 64 0.003917248 864 0.018361856236111113 2.036109 9 9 0.0009759271 Mouse Phenotype osteosclerosis 749 1.455677e-7 0.000001858174605740988 2.118049 60 0.00367242 499 0.0018455174856913828 2.036109 13 13 0.001409673 Mouse Phenotype dilated fourth ventricle 847 7.814503e-7 0.000008821070033412042 2.588747 35 0.002142245 1037 0.031163383400192864 2.036109 8 8 0.0008674908 Mouse Phenotype decreased renal tubule number 940 0.000002765936 0.00002813310010212766 2.608083 31 0.001897417 1037 0.031163383400192864 2.036109 8 8 0.0008674908 Mouse Phenotype abnormal pancreatic islet cell apoptosis 1004 0.000006027406 0.00005739843502589641 2.290722 37 0.002264659 995 0.028882387688442212 1.696758 15 18 0.001626545 Mouse Phenotype small vulva 2036 0.004374258 0.02054139525442043 2.592635 11 0.000673277 1037 0.031163383400192864 2.036109 8 8 0.0008674908