# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis 59 1.282231e-9 2.859809784576271e-7 3.907938 29 0.02566372 193 0.01170724866580311 2.735253 16 71 0.0103426 GO Biological Process Fc-gamma receptor signaling pathway 62 1.603638e-9 3.4035923293548386e-7 3.868408 29 0.02566372 234 0.018845408792307693 2.589373 16 75 0.0103426 GO Biological Process Fc receptor mediated stimulatory signaling pathway 66 2.774363e-9 5.531491320757575e-7 3.772686 29 0.02566372 214 0.014861473295794392 2.660315 16 73 0.0103426 GO Biological Process mammary gland epithelium development 69 4.066168e-9 7.754594885797101e-7 3.27802 34 0.0300885 103 0.0025937666572815534 3.371579 15 54 0.009696186 GO Biological Process amelogenesis 79 1.567462e-8 0.000002610915501012658 5.405108 18 0.0159292 166 0.008450242100602409 4.855074 8 20 0.005171299 GO Biological Process dendritic spine organization 81 1.665878e-8 0.0000027063319261728394 4.818629 20 0.01769912 61 0.000597168579 5.135175 11 26 0.007110537 GO Biological Process response to light stimulus 82 2.098966e-8 0.0000033683284870731706 2.180925 62 0.05486726 154 0.007362200737922079 1.824897 43 286 0.02779573 GO Biological Process regulation of ATP metabolic process 83 2.455398e-8 0.00000389284123879518 3.500303 28 0.02477876 321 0.04549824684735202 2.26748 17 91 0.01098901 GO Biological Process vascular endothelial growth factor receptor signaling pathway 85 2.883227e-8 0.000004463574599176471 3.147993 32 0.02831858 101 0.0024742072948514848 2.992854 18 73 0.01163542 GO Biological Process positive regulation of T cell activation 91 4.130521e-8 0.000005972914927362637 2.303781 53 0.04690265 165 0.008239615514545455 1.992754 33 201 0.02133161 GO Biological Process regulation of cellular response to insulin stimulus 99 9.710521e-8 0.000012907146044343433 3.456786 26 0.02300885 311 0.04064054755209003 2.536233 14 67 0.009049774 GO Biological Process positive regulation of leukocyte cell-cell adhesion 108 2.066664e-7 0.000025180769977777778 2.167489 54 0.04778761 168 0.008486709064285714 1.965149 34 210 0.02197802 GO Biological Process regulation of phosphatidylinositol 3-kinase activity 118 4.098948e-7 0.000045710217569491524 3.772157 21 0.01858407 177 0.009581053031073447 3.387261 12 43 0.007756949 GO Biological Process regulation of lipid kinase activity 123 4.591647e-7 0.00004912315680731707 3.482894 23 0.02035398 134 0.005477093972835821 3.267838 14 52 0.009049774 GO Biological Process lens fiber cell differentiation 125 5.052321e-7 0.000053186793631200006 4.255453 18 0.0159292 305 0.03647623026885245 3.734673 8 26 0.005171299 GO Biological Process regulation of lymphocyte differentiation 137 7.347228e-7 0.0000705709293810219 2.282178 44 0.03893805 291 0.03293583293573883 1.983282 25 153 0.01616031 GO Biological Process platelet-derived growth factor receptor signaling pathway 166 0.000001981705 0.000157091904186747 3.687683 19 0.01681416 205 0.014258495430731708 3.678087 10 33 0.006464124 GO Biological Process intracellular receptor signaling pathway 179 0.000003106086 0.00022834070208938546 2.075034 48 0.04247788 171 0.008979678514035087 2.057235 30 177 0.01939237 GO Biological Process establishment of endothelial barrier 187 0.000004029179 0.0002835292324117647 3.837625 17 0.01504425 323 0.04544588980804953 3.596351 8 27 0.005171299 GO Biological Process dendritic spine morphogenesis 198 0.000004546647 0.0003021683225909091 4.873652 13 0.01150442 186 0.010569570565053765 5.310238 7 16 0.004524887 GO Molecular Function phosphatase binding 9 1.97001e-11 9.241535799999999e-9 2.85788 54 0.04778761 24 0.006028278909166666 2.227803 29 158 0.01874596 GO Molecular Function nuclear hormone receptor binding 28 0.000001420956 0.00021425986542857145 2.359539 39 0.03451327 34 0.04051566552352942 2.12631 24 137 0.0155139 GO Molecular Function histone deacetylase binding 39 0.00000666894 0.0007219555046153847 2.474484 31 0.02743363 30 0.024278216946666667 2.360106 21 108 0.01357466 GO Molecular Function repressing transcription factor binding 41 0.000009112269 0.0009383414565365853 2.820924 24 0.02123894 32 0.0386766073375 2.832127 14 60 0.009049774 GO Molecular Function syntaxin-1 binding 104 0.001190876 0.04834498530769231 3.072454 11 0.009734513 28 0.010393389379285715 5.110605 8 19 0.005171299 Mouse Phenotype Single KO abnormal supraoccipital bone morphology 8 8.221358e-13 9.41037190075e-10 5.184246 30 0.02654867 46 0.0005510604964565218 5.135175 11 26 0.007110537 Mouse Phenotype Single KO abnormal squamosal bone morphology 13 4.151814e-10 2.9244739075384615e-7 5.404538 22 0.01946903 173 0.039939938694219655 4.24819 7 20 0.004524887 Mouse Phenotype Single KO increased insulin sensitivity 14 4.361069e-10 2.852450630928571e-7 2.677248 52 0.0460177 33 0.0002193342911818182 2.57718 31 146 0.02003878 Mouse Phenotype Single KO abnormal occipital bone morphology 21 5.674414e-9 0.000002474314714190476 2.992841 38 0.03362832 91 0.004971230648571428 2.801004 18 78 0.01163542 Mouse Phenotype Single KO abnormal frontal bone morphology 26 2.250237e-8 0.000007925161618846154 2.885404 37 0.03274336 56 0.0014504647120535715 3.275249 17 63 0.01098901 Mouse Phenotype Single KO absent ulna 39 0.000001563225 0.00036703721346153845 5.89679 12 0.01061947 93 0.006771835840430107 8.669776 5 7 0.003232062 Mouse Phenotype Single KO abnormal temporal bone morphology 59 0.000009564546 0.0014844499613898305 2.566757 28 0.02477876 130 0.018270328153846153 3.166353 12 46 0.007756949 Mouse Phenotype Single KO abnormal basicranium morphology 63 0.00001270471 0.0018466195153968253 2.353762 32 0.02831858 60 0.0015508875143333334 3.121119 18 70 0.01163542 Mouse Phenotype Single KO abnormal enteric neuron morphology 65 0.00001343897 0.0018932407429230768 3.864721 15 0.01327434 156 0.030980073927564102 4.471779 7 19 0.004524887 Mouse Phenotype Single KO pale yolk sac 81 0.00002967464 0.0033546997343209873 2.362813 29 0.02566372 110 0.011449979396363635 2.600933 18 84 0.01163542 Mouse Phenotype Single KO abnormal sphenoid bone morphology 84 0.00003338246 0.003639085550238095 2.146476 35 0.03097345 108 0.01016603357037037 2.715009 17 76 0.01098901 Mouse Phenotype Single KO abnormal parietal bone morphology 86 0.000035363 0.003765337104651163 2.475994 26 0.02300885 139 0.0227132731352518 2.922035 13 54 0.008403361 Mouse Phenotype Single KO abnormal basisphenoid bone morphology 93 0.00004511229 0.004441862790645161 2.547404 24 0.02123894 158 0.03232471421455696 3.104989 11 43 0.007110537 Mouse Phenotype Single KO chondrodystrophy 99 0.00005719624 0.00529036333010101 4.860171 10 0.008849558 175 0.04227780620914286 4.855074 6 15 0.003878474 Mouse Phenotype Single KO malocclusion 124 0.0001117894 0.008255286579032257 2.826164 18 0.0159292 115 0.013623227217391303 3.513541 11 38 0.007110537 Mouse Phenotype Single KO absent supraoccipital bone 126 0.0001153673 0.008384272746825397 4.952763 9 0.007964602 166 0.03685332287891566 6.068843 5 10 0.003232062 Mouse Phenotype Single KO abnormal enteric nervous system morphology 134 0.0001398162 0.009554454801492538 2.992429 16 0.01415929 178 0.04349307492134831 3.734673 8 26 0.005171299 Mouse Phenotype Single KO oligodactyly 144 0.0001546529 0.00983442087013889 2.585654 20 0.01769912 51 0.0009833691527058822 3.715618 15 49 0.009696186 Mouse Phenotype Single KO abnormal erythropoiesis 158 0.0002077612 0.012040944989873417 2.105509 29 0.02566372 73 0.003286098581369863 2.53788 23 110 0.01486749 Mouse Phenotype Single KO rib bifurcation 179 0.0003234321 0.016545629830726254 4.299649 9 0.007964602 144 0.023846748426388887 3.766868 9 29 0.005817712 Mouse Phenotype abnormal supraoccipital bone morphology 4 4.396241e-12 1.0508115050249999e-8 4.839544 30 0.02654867 126 0.002207651593809524 4.17233 11 32 0.007110537 Mouse Phenotype increased insulin sensitivity 12 1.506608e-9 0.000001200389924 2.428756 58 0.05132743 42 0.000044435020671428576 2.481184 37 181 0.02391726 Mouse Phenotype abnormal myocardial fiber morphology 20 1.257509e-8 0.0000060115217745000005 2.149523 66 0.05840708 53 0.00006781655183207547 2.249657 43 232 0.02779573 Mouse Phenotype decreased tumor incidence 26 2.909492e-8 0.000010699097312307693 2.247626 57 0.05044248 63 0.0001878442081904762 2.227098 40 218 0.0258565 Mouse Phenotype abnormal occipital bone morphology 31 6.185255e-8 0.000019076523566129035 2.643113 40 0.03539823 192 0.008803420221875 2.479742 19 93 0.01228184 Mouse Phenotype abnormal hair follicle morphology 34 9.226971e-8 0.000025946785215 2.061202 64 0.05663717 83 0.0004545397313855422 2.129419 40 228 0.0258565 Mouse Phenotype small myocardial fiber 36 1.269264e-7 0.000033709536400000005 4.240552 20 0.01769912 98 0.0009130305242755103 5.057369 10 24 0.006464124 Mouse Phenotype abnormal frontal bone morphology 44 2.661849e-7 0.000057840768838636367 2.495176 40 0.03539823 100 0.0009238098259200001 2.924744 20 83 0.01292825 Mouse Phenotype increased B cell acute lymphoblastic leukemia incidence 50 4.737969e-7 0.000090599443218 21.78086 6 0.005309735 407 0.049219652137592135 9.103264 3 4 0.001939237 Mouse Phenotype abnormal squamosal bone morphology 51 4.899791e-7 0.0000918566701 3.359308 24 0.02123894 405 0.049223474681481486 3.034421 9 36 0.005817712 Mouse Phenotype abnormal epidermis stratum basale morphology 55 6.176025e-7 0.00010736177277272727 3.217714 25 0.02212389 147 0.0041116013830612246 3.085852 15 59 0.009696186 Mouse Phenotype abnormal presphenoid bone morphology 57 8.234737e-7 0.00013812687799473684 3.363499 23 0.02035398 378 0.04262556853968254 3.121119 9 35 0.005817712 Mouse Phenotype decreased lung tumor incidence 69 0.000001679491 0.00023271903552173913 6.503105 11 0.009734513 388 0.04497622537113402 5.057369 5 12 0.003232062 Mouse Phenotype increased oxygen consumption 73 0.00000216378 0.00028339589835616434 2.573639 32 0.02831858 382 0.04338243680890052 2.077622 19 111 0.01228184 Mouse Phenotype abnormal blinking 76 0.000002459839 0.0003094542194605264 7.046024 10 0.008849558 189 0.008645364782539683 7.586054 5 8 0.003232062 Mouse Phenotype abnormal neurotransmitter secretion 77 0.000002520484 0.0003129655522597402 2.432833 35 0.03097345 193 0.009336053944041451 2.540446 18 86 0.01163542 Mouse Phenotype increased myocardial infarction size 79 0.000002712162 0.0003282402643291139 5.116163 13 0.01150442 309 0.02615963860194175 3.734673 8 26 0.005171299 Mouse Phenotype decreased pre-B cell number 80 0.000002726421 0.0003258413897625 2.461541 34 0.0300885 129 0.0023884712093023256 2.567587 22 104 0.01422107 Mouse Phenotype abnormal keratinocyte physiology 86 0.000003685233 0.00040970363619767443 2.598821 30 0.02654867 311 0.026642879353697753 2.148263 20 113 0.01292825 Mouse Phenotype abnormal oxygen consumption 88 0.000004152739 0.0004511856543068182 2.13067 44 0.03893805 273 0.01904625796813187 1.886687 30 193 0.01939237