# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 22 1.709503e-20 1.0225159080454546e-17 3.792726 71 0.02053804 269 0.008016135047955389 1.729244 40 114 0.01049869 GO Biological Process regulation of gene expression, epigenetic 25 5.417552e-20 2.85158267072e-17 2.474049 131 0.03789413 226 0.0039301822268141585 1.5103 76 248 0.01994751 GO Biological Process chromatin assembly 90 3.386352e-13 4.951222885333333e-11 2.458319 84 0.02429852 287 0.011670529114285714 1.590795 51 158 0.01338583 GO Biological Process nucleosome assembly 91 3.578651e-13 5.17488664934066e-11 2.556052 78 0.02256292 282 0.010659545942553191 1.631213 47 142 0.01233596 GO Biological Process chromatin assembly or disassembly 97 9.237763e-13 1.253193023886598e-10 2.327651 90 0.02603413 319 0.021067868380877743 1.522804 55 178 0.0144357 GO Biological Process nucleosome organization 124 7.285858e-12 7.731823017903225e-10 2.311808 84 0.02429852 368 0.038219707611413044 1.498678 52 171 0.01364829 GO Biological Process DNA packaging 150 9.359991e-11 8.2112081046e-9 2.105574 92 0.02661267 361 0.03767326926038781 1.461168 59 199 0.01548556 GO Biological Process regulation of megakaryocyte differentiation 153 1.657078e-10 1.4251953857516342e-8 2.815159 51 0.01475268 395 0.04806506310886076 1.75086 27 76 0.007086614 GO Biological Process negative regulation of transcription from RNA polymerase II promoter in response to stress 162 3.336947e-10 2.7105484921604943e-8 5.792212 21 0.006074631 388 0.04649268015206185 3.032829 8 13 0.002099738 GO Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 172 5.680956e-10 4.346261628139535e-8 3.171394 40 0.01157073 308 0.01749765901688312 2.319222 16 34 0.004199475 GO Biological Process platelet-derived growth factor receptor signaling pathway 250 7.832093e-8 0.0000041225004714800005 2.601135 41 0.01185999 358 0.03572498315167598 2.240157 15 33 0.003937008 GO Biological Process positive regulation of neuron death 253 8.158354e-8 0.000004243311473754941 2.0372 68 0.01967023 224 0.0037373827577678567 1.958702 31 78 0.008136483 GO Biological Process regulation of extrinsic apoptotic signaling pathway in absence of ligand 270 1.679348e-7 0.000008184644567407407 2.431998 44 0.0127278 354 0.034362695174293786 2.035621 19 46 0.004986877 GO Biological Process positive regulation of kidney development 347 0.000001558684 0.00005910871111239193 2.165824 47 0.0135956 373 0.04090155876675603 2.094547 17 40 0.004461942 GO Biological Process positive regulation of tumor necrosis factor-mediated signaling pathway 392 0.000004264882 0.00014316730162755104 4.279136 15 0.004339022 384 0.04561913459114583 3.69626 6 8 0.001574803 GO Biological Process cellular response to ionizing radiation 400 0.000004732635 0.0001556918599125 2.178139 42 0.01214926 267 0.007809097659550562 2.002141 26 64 0.006824147 GO Biological Process negative regulation of PERK-mediated unfolded protein response 408 0.000005411343 0.00017452907484558826 5.754653 11 0.00318195 299 0.01510555057625418 4.928346 5 5 0.001312336 GO Biological Process negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation 466 0.00001573531 0.0004443367903218884 5.689243 10 0.002892682 299 0.01510555057625418 4.928346 5 5 0.001312336 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell activation 645 0.0001195747 0.0024395092671317827 2.123664 31 0.008967313 363 0.037611612060606064 2.299895 14 30 0.003674541 GO Biological Process positive regulation of T cell mediated immunity 902 0.0008974502 0.013092624370066518 2.249932 20 0.005785363 309 0.018113802133333332 2.384684 15 31 0.003937008 GO Cellular Component nucleosome 23 1.605333e-19 1.2060936626086956e-17 4.54054 55 0.01590975 25 0.007803537407999999 1.783592 38 105 0.009973753 GO Cellular Component DNA packaging complex 28 2.656767e-16 1.6396047771428572e-14 3.753534 56 0.01619902 30 0.013563907200000001 1.716121 39 112 0.01023622 GO Cellular Component ficolin-1-rich granule lumen 34 1.750049e-14 8.894366682352942e-13 2.878406 71 0.02053804 20 0.00506032704 1.748768 44 124 0.01154856 GO Cellular Component ESC/E(Z) complex 65 2.123822e-8 5.646099101538461e-7 3.76142 26 0.007520972 43 0.04098064520930233 2.73797 10 18 0.002624672 GO Molecular Function cAMP response element binding 29 1.275746e-7 0.00001857310211034483 4.465182 19 0.005496095 42 0.018652253171428573 3.411932 9 13 0.002362205 GO Molecular Function 1-acylglycerol-3-phosphate O-acyltransferase activity 89 0.00006266151 0.0029725493844943818 2.779811 20 0.005785363 32 0.007558729720625 3.11264 12 19 0.003149606 GO Molecular Function lysophosphatidic acid acyltransferase activity 91 0.00007034046 0.003263488155164835 2.755738 20 0.005785363 37 0.013320581162162162 2.957008 12 20 0.003149606 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 26 6.965914e-18 2.453341326846154e-15 4.722467 48 0.01388487 183 0.008305208854644808 2.549145 15 29 0.003937008 Mouse Phenotype Single KO embryonic lethality between somite formation and embryo turning, complete penetrance 30 6.196186e-17 1.891282506733333e-14 3.170803 73 0.02111658 273 0.03048661812380952 1.79818 27 74 0.007086614 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 57 4.761952e-12 7.650034116491227e-10 2.103936 105 0.03037316 185 0.008356430713513515 1.577071 56 175 0.01469816 Mouse Phenotype Single KO abnormal erythropoiesis 62 1.497021e-11 2.2110034349999996e-9 2.183363 92 0.02661267 41 0.000005256008562682927 2.150551 48 110 0.01259843 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 74 1.616755e-10 2.0006250722972972e-8 2.561763 60 0.01735609 169 0.00618951430887574 2.138716 23 53 0.006036745 Mouse Phenotype Single KO abnormal kidney arterial blood vessel morphology 75 1.75322e-10 2.1405647386666666e-8 4.771318 26 0.007520972 306 0.041022791428104576 3.032829 8 13 0.002099738 Mouse Phenotype Single KO abnormal NK cell morphology 77 1.886345e-10 2.243280670779221e-8 2.048411 95 0.02748047 135 0.0030731610994074073 1.69943 50 145 0.01312336 Mouse Phenotype Single KO decreased erythroid progenitor cell number 83 2.830075e-10 3.1222887680722893e-8 2.546869 59 0.01706682 140 0.003601894830785714 2.222588 23 51 0.006036745 Mouse Phenotype Single KO abnormal NK cell number 92 2.526811e-9 2.515000905108696e-7 2.019742 86 0.02487706 128 0.002321008336015625 1.739416 48 136 0.01259843 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 133 6.921349e-8 0.000004765322766390977 2.4544 46 0.01330633 199 0.0114999587959799 1.928483 27 69 0.007086614 Mouse Phenotype Single KO increased number of Howell-Jolly bodies 162 3.363903e-7 0.00001901435788333333 5.69831 14 0.004049754 202 0.011799288615346534 3.584252 8 11 0.002099738 Mouse Phenotype Single KO scoliosis 164 3.578796e-7 0.000019982338397560976 2.48275 40 0.01157073 184 0.008340031371195652 2.393768 17 35 0.004461942 Mouse Phenotype Single KO extramedullary hematopoiesis 168 4.789026e-7 0.000026103042310714283 2.020334 61 0.01764536 110 0.0010731446255454545 1.858938 43 114 0.01128609 Mouse Phenotype Single KO abnormal neural fold formation 438 0.0007133395 0.014913355711187213 2.009345 27 0.00781024 230 0.017179220765652176 2.464173 14 28 0.003674541 Mouse Phenotype Single KO abnormal neuroendocrine cell morphology 540 0.002637038 0.04471732771481481 2.141902 18 0.005206827 242 0.02095214683553719 2.899027 10 17 0.002624672 Mouse Phenotype abnormal embryonic erythropoiesis 28 2.473263e-18 8.445309836785715e-16 4.487653 52 0.01504194 162 0.0013331167883333331 2.702642 17 31 0.004461942 Mouse Phenotype abnormal embryonic erythrocyte morphology 35 2.355511e-16 6.434583048857143e-14 3.941488 53 0.01533121 271 0.00863819062583026 2.274621 18 39 0.004724409 Mouse Phenotype embryonic lethality between somite formation and embryo turning, complete penetrance 40 2.301235e-15 5.500526958749999e-13 2.703549 84 0.02429852 316 0.016421065910126584 1.752301 32 90 0.00839895 Mouse Phenotype abnormal NK cell number 48 7.934309e-14 1.5804151739375e-11 2.155584 116 0.03355511 184 0.0023459716579891303 1.663317 54 160 0.01417323 Mouse Phenotype abnormal erythropoiesis 59 8.272192e-13 1.3405157239322033e-10 2.116411 111 0.03210876 37 0.0000016622788192702703 2.017645 61 149 0.0160105 Mouse Phenotype abnormal NK cell morphology 60 1.080023e-12 1.7210166505e-10 2.060502 117 0.03384437 211 0.0037198216913744077 1.623108 55 167 0.0144357 Mouse Phenotype extramedullary hematopoiesis 66 3.610203e-12 5.229871345909091e-10 2.072641 110 0.0318195 67 0.000010390539473283581 1.858691 66 175 0.01732283 Mouse Phenotype abnormal mean corpuscular hemoglobin 69 6.785386e-12 9.40218486173913e-10 2.042726 111 0.03210876 194 0.0027301090515463922 1.607069 60 184 0.01574803 Mouse Phenotype decreased NK cell number 86 1.245649e-10 1.384843033604651e-8 2.19041 83 0.02400926 234 0.0046129128307692314 1.783592 38 105 0.009973753 Mouse Phenotype abnormal embryonic hematopoiesis 94 6.824092e-10 6.94097272468085e-8 2.382984 64 0.01851316 260 0.0065618503603846155 2.019814 25 61 0.00656168 Mouse Phenotype decreased erythroid progenitor cell number 103 2.347328e-9 2.1789129133980585e-7 2.225297 69 0.0199595 220 0.004181032253454545 1.9454 30 76 0.007874016 Mouse Phenotype decreased mean corpuscular hemoglobin 146 1.397046e-7 0.000009148737538356163 2.253775 52 0.01504194 189 0.0024021506626984127 1.984139 31 77 0.008136483 Mouse Phenotype scoliosis 168 4.902272e-7 0.00002789918011428571 2.261825 47 0.0135956 201 0.003078463147462687 2.346832 20 42 0.005249344 Mouse Phenotype increased number of Howell-Jolly bodies 347 0.0001377713 0.003796055905763688 3.14054 15 0.004339022 348 0.023973718460344826 2.957008 9 15 0.002362205 Mouse Phenotype abnormal neural fold formation 375 0.0001923173 0.0049033218808 2.094004 30 0.008678045 230 0.004413590389565218 2.464173 17 34 0.004461942