# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	43	3.094199e-34	9.46896852116279e-32	2.1009	333	0.02719699	318	0.0007005164683647799	1.28829	148	252	0.01728972	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	44	1.056446e-33	3.159493844090909e-31	2.566603	217	0.01772297	407	0.0024682565855036857	1.397676	72	113	0.008411215	
GO Biological Process	nuclear-transcribed mRNA catabolic process	45	1.350596e-33	3.949442836444444e-31	2.200227	294	0.02401176	167	0.000003547606514730539	1.418069	128	198	0.01495327	
GO Biological Process	mRNA catabolic process	46	3.423989e-33	9.794841576304348e-31	2.124946	314	0.02564521	175	0.000004023646980514285	1.400592	136	213	0.01588785	
GO Biological Process	rRNA metabolic process	48	4.2999e-33	1.17879966875e-30	2.059563	337	0.02752369	368	0.0014558960264130433	1.27041	150	259	0.01752336	
GO Biological Process	multi-organism metabolic process	52	1.004855e-32	2.5428628740384615e-30	2.424979	234	0.0191114	148	0.0000010097638670945947	1.50715	101	147	0.01179907	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	58	1.20765e-31	2.73990799137931e-29	2.732952	182	0.01486442	188	0.000008559656520744682	1.524349	82	118	0.009579439	
GO Biological Process	regulation of DNA-templated transcription in response to stress	60	2.601194e-31	5.704851974333333e-29	2.394457	229	0.01870304	324	0.0007988837022839507	1.419372	77	119	0.008995327	
GO Biological Process	cotranslational protein targeting to membrane	68	4.489712e-30	8.688252971764707e-28	2.871905	159	0.01298595	218	0.000033348606214220186	1.544456	69	98	0.008060748	
GO Biological Process	protein targeting to ER	80	3.529246e-28	5.80516851425e-26	2.743002	160	0.01306762	237	0.00006549450840506328	1.520299	70	101	0.00817757	
GO Biological Process	viral gene expression	82	5.54248e-28	8.894328575609756e-26	2.515942	185	0.01510944	190	0.00000987498455368421	1.502685	87	127	0.01016355	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	85	2.18415e-27	3.38132115882353e-25	2.835025	147	0.01200588	230	0.00005492286256086956	1.549808	65	92	0.007593458	
GO Biological Process	viral transcription	92	2.784466e-26	3.982694358043479e-24	2.524351	172	0.0140477	210	0.00002397403119333333	1.514149	78	113	0.00911215	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	112	1.063981e-23	1.2500826766964286e-21	2.449346	163	0.01331264	244	0.00008476515461885245	1.504166	72	105	0.008411215	
GO Biological Process	liver regeneration	128	3.895094e-22	4.00433921453125e-20	3.019148	106	0.008657302	444	0.004221392381306306	1.692186	27	35	0.003154206	
GO Biological Process	triglyceride homeostasis	150	4.457652e-20	3.9105495112000004e-18	3.478944	78	0.006370467	538	0.017058483760780667	1.645181	24	32	0.002803738	
GO Biological Process	protein localization to endoplasmic reticulum	151	5.236915e-20	4.563745992384106e-18	2.173578	174	0.01421104	448	0.0044919274546875	1.362139	77	124	0.008995327	
GO Biological Process	protein targeting to membrane	154	1.320233e-19	1.1281133796753246e-17	2.068814	191	0.01559948	336	0.0008998727320833332	1.391447	85	134	0.009929907	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	169	1.143178e-18	8.901230356213017e-17	2.346228	137	0.01118915	556	0.017629455475359712	1.406138	50	78	0.005841121	
GO Biological Process	regulation of cellular amino acid metabolic process	187	5.131004e-18	3.610635381604278e-16	2.882599	91	0.007432212	562	0.018525834930604983	1.462383	40	60	0.004672897	
GO Cellular Component	ribosomal subunit	38	2.343814e-26	1.0658185768421052e-24	2.17758	233	0.01902973	60	0.000432396	1.339859	113	185	0.01320093	
GO Cellular Component	large ribosomal subunit	42	5.291522e-23	2.1770833371428573e-21	2.44818	158	0.01290428	103	0.021607599844660198	1.316145	69	115	0.008060748	
GO Cellular Component	spherical high-density lipoprotein particle	88	5.841428e-11	1.1470440436363635e-9	5.752458	23	0.001878471	110	0.029252180945454547	2.193575	8	8	0.0009345794	
GO Cellular Component	endopeptidase complex	102	1.012589e-9	1.715444894117647e-8	2.032434	90	0.007350539	75	0.002972526336	1.494174	47	69	0.005490654	
GO Cellular Component	proteasome complex	108	2.033249e-9	3.2531984e-8	2.010987	89	0.007268866	81	0.0041686656	1.483889	46	68	0.005373832	
GO Cellular Component	zonula adherens	144	1.635815e-7	0.000001962978	3.487722	25	0.002041816	110	0.029252180945454547	2.193575	8	8	0.0009345794	
GO Cellular Component	platelet dense tubular network	299	0.000984746	0.005691107317725753	2.140087	22	0.001796798	79	0.0038523047696202525	2.193575	11	11	0.001285047	
GO Cellular Component	platelet dense tubular network membrane	352	0.003491578	0.017140473818181817	2.039102	19	0.00155178	99	0.014809563927272729	2.193575	9	9	0.001051402	
GO Molecular Function	structural constituent of ribosome	10	2.222994e-24	9.385480668e-22	2.179512	214	0.01747795	60	0.0033746509329999996	1.340518	99	162	0.01156542	
GO Molecular Function	C-acyltransferase activity	41	2.091734e-11	2.15397584097561e-9	2.828667	56	0.004573669	84	0.016769628188095236	1.864539	17	20	0.001985981	
Human Phenotype	Increased serum lactate	15	3.474013e-17	1.5454725832666665e-14	2.195714	144	0.01176086	85	0.02610224026	1.381952	63	100	0.007359813	
Human Phenotype	Jaundice	20	4.922533e-16	1.6424031354499997e-13	2.135667	142	0.01159752	56	0.009747603815714285	1.481375	52	77	0.006074766	
Human Phenotype	Glycosuria	81	9.000039e-10	7.414476573703704e-8	2.454151	60	0.004900359	127	0.0473164827992126	1.664091	22	29	0.002570093	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	197	3.423025e-11	1.591098473350254e-9	2.110389	97	0.007922248	273	0.010354024506959707	1.498943	41	60	0.00478972	
Mouse Phenotype Single KO	increased liver adenoma incidence	291	6.174063e-9	1.9428142574226805e-7	2.677318	46	0.003756942	397	0.04163125102015113	1.75486	16	20	0.001869159	
Mouse Phenotype Single KO	increased circulating glucagon level	396	2.939273e-7	0.000006796697692171717	2.133056	56	0.004573669	276	0.011258203042391304	1.935507	15	17	0.001752336	
Mouse Phenotype	abnormal cellular replicative senescence	116	1.897523e-15	1.5639842588793103e-13	2.079896	145	0.01184254	263	0.0011072346895437263	1.488497	57	84	0.006658879	
Mouse Phenotype	early cellular replicative senescence	117	2.022341e-15	1.6526155812820512e-13	2.156198	133	0.01086246	344	0.004563103983139535	1.4724	49	73	0.005724299	
Mouse Phenotype	increased adrenal gland tumor incidence	206	2.339501e-12	1.0858237408252427e-10	3.500944	45	0.00367527	597	0.0347025543517588	1.806473	14	17	0.001635514	
Mouse Phenotype	pancytopenia	224	4.77863e-12	2.0396643495535715e-10	2.46534	76	0.006207122	362	0.005735992533149172	1.739732	23	29	0.002686916	
Mouse Phenotype	increased urine uric acid level	445	1.403661e-7	0.000003015820858651685	2.745987	36	0.002940216	617	0.03860246776823339	1.994159	10	11	0.001168224	
Mouse Phenotype	absent segment of posterior cerebral artery	628	0.000004937662	0.00007517354519426752	2.179163	42	0.003430252	623	0.03892705134510433	1.695035	17	22	0.001985981	
Mouse Phenotype	fusion of vertebral bodies	1047	0.0003742425	0.0034175095916905446	2.421534	20	0.001633453	617	0.03860246776823339	1.994159	10	11	0.001168224	
Mouse Phenotype	empty decidua capsularis	1166	0.000852284	0.006988582610634649	2.164936	22	0.001796798	609	0.03861391179310345	1.880207	12	14	0.001401869