# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 56 1.314192e-66 3.0881165228571425e-64 2.091621 672 0.03203661 553 0.02446296173056058 1.165145 169 248 0.01538882 GO Biological Process endoplasmic reticulum unfolded protein response 118 1.967815e-42 2.194447252966102e-40 2.361847 325 0.0154939 552 0.02445154365036232 1.244853 83 114 0.007557822 GO Biological Process regulation of membrane permeability 172 1.34824e-32 1.0314819860465116e-30 2.195247 288 0.01372998 330 0.0030697538504242425 1.350951 64 81 0.005827718 GO Biological Process regulation of mitochondrial membrane permeability 206 4.083521e-29 2.6084977106310676e-27 2.201525 254 0.01210908 430 0.010305005694651162 1.335048 57 73 0.005190311 GO Biological Process translational elongation 309 4.089167e-23 1.7414028657928806e-21 2.055267 233 0.01110793 527 0.02064236599127135 1.251816 82 112 0.007466764 GO Biological Process mitochondrial translational termination 393 2.184389e-19 7.314090292875318e-18 2.166345 170 0.0081045 564 0.027062486757092198 1.277435 65 87 0.005918776 GO Biological Process mitochondrial translational elongation 394 2.312006e-19 7.72174795786802e-18 2.176352 168 0.008009153 537 0.021827198419366853 1.287377 64 85 0.005827718 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 584 1.230606e-14 2.7728671839041094e-13 2.004659 150 0.00715103 657 0.04654394380974125 1.329843 42 54 0.00382444 GO Biological Process platelet morphogenesis 587 1.463845e-14 3.281556448892674e-13 2.576911 87 0.004147597 663 0.048085645586727 1.538818 18 20 0.001639046 GO Biological Process iron ion import 590 1.777937e-14 3.965402200508475e-13 3.35829 57 0.002717391 610 0.034472416578688526 1.709798 12 12 0.001092697 GO Biological Process gene silencing by miRNA 609 3.224664e-14 6.967709946798029e-13 2.057583 136 0.0064836 405 0.008327447335061728 1.437785 37 44 0.00336915 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 643 1.312891e-13 2.6868324524105755e-12 2.364448 95 0.004528986 654 0.046452356522935785 1.602935 15 16 0.001365871 GO Biological Process heme biosynthetic process 740 4.248596e-12 7.55503713027027e-11 3.187131 50 0.002383677 427 0.010214290074238876 1.624308 19 20 0.001730104 GO Biological Process negative regulation of actin filament depolymerization 820 2.957767e-11 4.746494628414635e-10 2.091097 100 0.004767353 351 0.0041554210008547 1.514392 31 35 0.002822801 GO Biological Process GPI anchor biosynthetic process 862 7.735763e-11 1.1809153749071925e-9 2.415711 70 0.003337147 618 0.035243357911003234 1.442642 27 32 0.002458569 GO Biological Process GPI anchor metabolic process 864 7.975784e-11 1.2147377506481481e-9 2.396648 71 0.003384821 561 0.026482100470588237 1.450738 28 33 0.002549627 GO Biological Process actin filament capping 1029 1.604731e-9 2.052153083479106e-8 2.070751 84 0.004004577 325 0.002879943109476923 1.549504 29 32 0.002640685 GO Biological Process positive regulation of vascular endothelial growth factor receptor signaling pathway 1176 1.475931e-8 1.6515115670918366e-7 2.014847 79 0.003766209 421 0.009978019605938243 1.709798 15 15 0.001365871 GO Biological Process miRNA mediated inhibition of translation 1260 4.490917e-8 4.690156889126984e-7 2.419235 49 0.002336003 610 0.034472416578688526 1.709798 12 12 0.001092697 GO Biological Process porphyrin-containing compound biosynthetic process 1416 2.324435e-7 0.000002160115830861582 2.2037 53 0.002526697 450 0.011710296447777777 1.567315 22 24 0.002003278 GO Cellular Component melanosome 56 1.78987e-35 5.523027428571429e-34 2.03283 377 0.01797292 65 0.001183256772923077 1.318987 81 105 0.007375706 GO Cellular Component ficolin-1-rich granule lumen 62 8.471832e-30 2.361181563870968e-28 2.051204 307 0.01463577 53 0.00008781885101886793 1.337503 97 124 0.008832635 GO Molecular Function death receptor binding 301 4.797284e-7 0.000006728947856478406 2.132806 54 0.002574371 70 0.00657846708 1.709798 17 17 0.001547988 Mouse Phenotype Single KO abnormal erythropoiesis 41 1.003379e-61 2.2409613421951215e-59 2.190296 560 0.02669718 81 0.00005205486572962963 1.383382 89 110 0.00810417 Mouse Phenotype Single KO abnormal platelet activation 76 8.807505e-44 1.0611884642763158e-41 2.320518 348 0.01659039 379 0.046756076897097626 1.267262 63 85 0.00573666 Mouse Phenotype Single KO decreased erythroid progenitor cell number 96 1.99673e-37 1.9045892302083334e-35 2.248115 316 0.01506484 295 0.02453860888101695 1.374543 41 51 0.003733382 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 113 1.811382e-33 1.4678606171681415e-31 2.160244 307 0.01463577 330 0.032907150169696975 1.354934 42 53 0.00382444 Mouse Phenotype Single KO increased circulating interferon-gamma level 117 2.694831e-32 2.1091083305128204e-30 3.007066 160 0.007627765 135 0.0013444612633333331 1.510984 38 43 0.003460208 Mouse Phenotype Single KO abnormal circulating interferon level 122 1.168648e-31 8.77156535737705e-30 2.3204 248 0.01182304 325 0.03254248470461539 1.27285 67 90 0.006100892 Mouse Phenotype Single KO decreased circulating alanine transaminase level 124 1.606758e-31 1.1865389520967743e-29 2.030549 334 0.01592296 138 0.0014476069057246376 1.390636 61 75 0.005554544 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 129 6.56244e-31 4.65831496744186e-29 2.110421 298 0.01420671 321 0.031038321872274146 1.253852 77 105 0.007011473 Mouse Phenotype Single KO abnormal platelet volume 162 3.422753e-26 1.934700569197531e-24 2.247129 217 0.01034516 236 0.012466219517372881 1.379837 46 57 0.004188672 Mouse Phenotype Single KO abnormal circulating interferon-gamma level 174 3.251527e-25 1.711162801091954e-23 2.290681 200 0.009534706 278 0.02013729045539568 1.324491 55 71 0.005008195 Mouse Phenotype Single KO increased mean platelet volume 229 3.954325e-22 1.581211966157205e-20 2.247321 181 0.008628909 243 0.014015523320987653 1.431459 36 43 0.003278091 Mouse Phenotype Single KO increased circulating tumor necrosis factor level 293 2.194607e-18 6.85870863447099e-17 2.072299 178 0.008485889 343 0.036794321020408166 1.323714 48 62 0.004370789 Mouse Phenotype Single KO increased susceptibility to weight loss 312 9.166862e-18 2.6904152350641026e-16 2.346776 130 0.006197559 293 0.024185274634129693 1.417881 34 41 0.003095975 Mouse Phenotype Single KO abnormal circulating interleukin-10 level 384 4.47309e-15 1.06666888359375e-13 2.600406 89 0.004242944 352 0.03852623049147727 1.504622 22 25 0.002003278 Mouse Phenotype Single KO intestinal ulcer 857 2.512685e-7 0.0000026847907287047843 2.197933 53 0.002526697 362 0.03930591658839779 1.54696 19 21 0.001730104 Mouse Phenotype abnormal erythropoiesis 51 4.306558e-68 8.073529615294118e-66 2.111655 672 0.03203661 110 0.000002042361715636364 1.365543 119 149 0.01083591 Mouse Phenotype abnormal platelet physiology 76 5.872384e-50 7.387613608421053e-48 2.095865 499 0.02378909 299 0.0016612365406354517 1.282348 99 132 0.009014751 Mouse Phenotype increased circulating interferon-gamma level 80 5.431359e-48 6.4911529248749996e-46 3.375027 205 0.009773074 187 0.00012085809571122996 1.512513 46 52 0.004188672 Mouse Phenotype decreased erythroid progenitor cell number 100 5.493519e-43 5.2523535159e-41 2.147321 404 0.01926011 419 0.008036326269451074 1.327343 59 76 0.005372428 Mouse Phenotype abnormal circulating tumor necrosis factor level 116 2.094995e-38 1.7267454478448277e-36 2.029889 411 0.01959382 545 0.016388118888440367 1.217938 104 146 0.009470042 Mouse Phenotype abnormal circulating interferon-gamma level 125 4.470516e-37 3.41940827808e-35 2.504389 252 0.01201373 463 0.010715704478617711 1.297088 66 87 0.006009834 Mouse Phenotype increased respiratory quotient 136 5.799122e-35 4.0768680472058824e-33 2.557143 228 0.01086957 723 0.04257091452282158 1.31288 43 56 0.003915498 Mouse Phenotype abnormal embryonic erythrocyte morphology 141 1.550284e-33 1.0512244910638297e-31 2.598345 212 0.01010679 617 0.024521129241491083 1.402911 32 39 0.002913859 Mouse Phenotype increased number of Howell-Jolly bodies 146 5.497591e-33 3.600169010342466e-31 3.93364 114 0.005434783 748 0.047580009729946526 1.595811 14 15 0.001274813 Mouse Phenotype increased circulating tumor necrosis factor level 148 6.938912e-33 4.48263092108108e-31 2.187438 293 0.01396834 499 0.013134656547895793 1.273625 73 98 0.006647241 Mouse Phenotype abnormal susceptibility to induced colitis 157 1.695573e-31 1.0325715575159235e-29 2.001677 346 0.01649504 616 0.024553098112012985 1.234028 83 115 0.007557822 Mouse Phenotype abnormal embryonic hematopoiesis 169 2.431404e-30 1.3755416357396449e-28 2.012758 328 0.01563692 393 0.00619528715038168 1.373444 49 61 0.004461847 Mouse Phenotype reticulocytosis 173 3.475979e-30 1.921030937514451e-28 2.013319 326 0.01554157 631 0.027628471702060224 1.251502 71 97 0.006465125 Mouse Phenotype poikilocytosis 211 1.197232e-26 5.424992963033176e-25 2.969412 133 0.00634058 444 0.009554079041891893 1.446752 33 39 0.003004917 Mouse Phenotype abnormal platelet volume 263 4.185433e-23 1.5215560803422053e-21 2.084659 225 0.01072654 597 0.02276184227135678 1.315229 50 65 0.004552905 Mouse Phenotype increased susceptibility to weight loss 277 3.499328e-22 1.2078366428880867e-20 2.279728 176 0.008390542 390 0.006149073797692308 1.408069 42 51 0.00382444 Mouse Phenotype abnormal circulating interleukin-10 level 306 5.60495e-21 1.7512721225490195e-19 2.569417 131 0.006245233 250 0.00070663477044 1.563244 32 35 0.002913859 Mouse Phenotype decreased spongiotrophoblast size 359 3.535751e-18 9.41652237075209e-17 2.988179 87 0.004147597 755 0.04762033973245034 1.529819 17 19 0.001547988 Mouse Phenotype increased circulating iron level 366 5.713972e-18 1.4926580954098363e-16 2.11131 166 0.007913806 577 0.020918656060658576 1.391696 35 43 0.003187033 Mouse Phenotype enlarged liver sinusoidal spaces 394 5.610757e-17 1.3615342049999999e-15 2.023041 173 0.008247521 516 0.014339005987209302 1.417881 34 41 0.003095975