# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of intrinsic apoptotic signaling pathway 123 2.558062e-55 2.7367103949593495e-53 2.096636 555 0.02174765 361 0.0011248754263434902 1.234708 123 155 0.01019224 GO Biological Process endoplasmic reticulum unfolded protein response 175 4.534894e-44 3.4099811512e-42 2.24594 376 0.01473354 793 0.0336017803001261 1.201071 88 114 0.007292012 GO Biological Process mitochondrial membrane organization 189 1.867323e-42 1.3001112887301586e-40 2.007584 470 0.01841693 452 0.003371233905088496 1.242237 99 124 0.008203513 GO Biological Process regulation of membrane permeability 208 8.318679e-40 5.262764276971155e-38 2.20534 352 0.0137931 418 0.0023142988294976075 1.306215 68 81 0.005634736 GO Biological Process cellular response to unfolded protein 218 2.297522e-38 1.3868390824770643e-36 2.074727 390 0.01528213 673 0.019473974770876673 1.208741 94 121 0.007789195 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 229 8.691569e-37 4.994426046768559e-35 2.121563 354 0.01387147 465 0.0038409960744086014 1.274541 77 94 0.00638051 GO Biological Process regulation of mitochondrial membrane permeability 233 4.668323e-36 2.636500530343348e-34 2.222729 312 0.01222571 512 0.0058178200703125 1.300163 61 73 0.00505469 GO Biological Process mitochondrial transmembrane transport 295 5.372537e-30 2.39651574179661e-28 2.207225 261 0.01022727 787 0.03169217238500635 1.237248 66 83 0.005469009 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to hypoxia 303 1.434446e-29 6.2296616877887785e-28 2.177399 265 0.01038401 850 0.0406569907517647 1.236767 62 78 0.005137554 GO Biological Process organelle transport along microtubule 358 5.704198e-26 2.096691102849162e-24 2.017126 277 0.01085423 489 0.0047769349711656445 1.320186 56 66 0.004640371 GO Biological Process translational elongation 367 1.057121e-25 3.79036927493188e-24 2.008325 277 0.01085423 403 0.002055714979776675 1.264196 91 112 0.007540603 GO Biological Process positive regulation of mRNA catabolic process 455 1.42457e-22 4.119981676923077e-21 2.459716 154 0.006034483 517 0.005970930611025145 1.493696 24 25 0.001988731 GO Biological Process cotranslational protein targeting to membrane 459 1.78596e-22 5.1201410980392156e-21 2.027829 234 0.009169279 750 0.027377931132 1.222519 77 98 0.00638051 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 476 4.960805e-22 1.3714124578781513e-20 2.659448 130 0.005094044 649 0.01712299161248074 1.555933 16 16 0.00132582 GO Biological Process mitochondrial translational elongation 494 2.351739e-21 6.264480465789474e-20 2.118922 199 0.007797806 414 0.0022757711766908215 1.299662 71 85 0.005883328 GO Biological Process mitochondrial translational termination 500 2.974912e-21 7.829373401599999e-20 2.105313 201 0.007876176 534 0.007586550384456928 1.269784 71 87 0.005883328 GO Biological Process regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 510 4.459275e-21 1.150580386764706e-19 2.124416 195 0.007641066 783 0.030549131079182633 1.319161 39 46 0.003231687 GO Biological Process Golgi to plasma membrane protein transport 520 9.078201e-21 2.297308595365385e-19 2.565687 130 0.005094044 763 0.02927242832634338 1.431458 23 25 0.001905867 GO Biological Process regulation of release of cytochrome c from mitochondria 533 1.583676e-20 3.9098672577861163e-19 2.188465 177 0.006935737 629 0.015282201511923688 1.348475 39 45 0.003231687 GO Biological Process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 557 7.852073e-20 1.8550346249012564e-18 2.174174 173 0.006778997 833 0.0382952491332533 1.345672 32 37 0.002651641 GO Cellular Component ficolin-1-rich granule lumen 68 9.66636e-35 2.4563926588235293e-33 2.031955 370 0.01449843 53 0.0000340096156981132 1.304976 104 124 0.008617832 GO Cellular Component small ribosomal subunit 109 1.021189e-22 1.6189124697247709e-21 2.186453 198 0.007758621 160 0.049287258 1.23178 57 72 0.004723235 GO Cellular Component mitochondrial ribosome 115 1.29278e-21 1.9425424695652174e-20 2.227719 180 0.007053292 96 0.009082548000000001 1.263052 69 85 0.0057176 GO Cellular Component mitochondrial small ribosomal subunit 125 1.264699e-19 1.7483198976e-18 3.089709 90 0.003526646 144 0.034977636000000006 1.389226 25 28 0.002071594 GO Cellular Component clathrin vesicle coat 169 3.686942e-13 3.76984365443787e-12 2.055163 125 0.004898119 126 0.023277353142857143 1.431458 23 25 0.001905867 GO Molecular Function mitogen-activated protein kinase binding 73 6.247312e-18 3.613171406027397e-16 2.396498 126 0.004937304 65 0.006754706350769231 1.498306 26 27 0.002154458 Mouse Phenotype Single KO abnormal erythropoiesis 46 9.593542e-70 1.9097405237826087e-67 2.144286 667 0.02613636 98 0.00005490540003163265 1.329616 94 110 0.007789195 Mouse Phenotype Single KO decreased erythroid progenitor cell number 68 6.719233e-59 9.048237732500001e-57 2.461815 421 0.01649687 122 0.00033033532236065576 1.433899 47 51 0.003894597 Mouse Phenotype Single KO decreased circulating alanine transaminase level 126 3.331036e-37 2.420817194603175e-35 2.018786 404 0.01583072 118 0.0002477284338898305 1.369221 66 75 0.005469009 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 142 9.645091e-35 6.219725231478873e-33 2.066442 355 0.01391066 362 0.03922203644475138 1.21511 82 105 0.006794829 Mouse Phenotype Single KO increased circulating interferon-gamma level 146 7.118448e-34 4.464632077808219e-32 2.842384 184 0.007210031 111 0.00013641141652252252 1.483564 41 43 0.003397415 Mouse Phenotype Single KO abnormal circulating interferon level 147 7.220792e-34 4.4980130846258504e-32 2.230237 290 0.01136364 258 0.012990304759689923 1.262035 73 90 0.006049055 Mouse Phenotype Single KO abnormal platelet volume 151 6.689986e-33 4.056967006754967e-31 2.281104 268 0.01050157 178 0.003257768399101124 1.364854 50 57 0.004143189 Mouse Phenotype Single KO increased respiratory quotient 153 2.315971e-32 1.3861010749673202e-30 2.455623 227 0.008894984 296 0.02327316824560811 1.333657 42 49 0.003480278 Mouse Phenotype Single KO increased mean platelet volume 157 1.254852e-31 7.318904308280254e-30 2.388055 234 0.009169279 188 0.0037864706428191487 1.411195 39 43 0.003231687 Mouse Phenotype Single KO decreased cytotoxic T cell cytolysis 161 3.551509e-31 2.0199483175776396e-29 2.732014 180 0.007053292 370 0.04118150386486486 1.372882 30 34 0.002485913 Mouse Phenotype Single KO abnormal inguinal fat pad morphology 223 3.412397e-25 1.4012250820179372e-23 2.075081 250 0.009796238 376 0.04326046867819149 1.306984 42 50 0.003480278 Mouse Phenotype Single KO abnormal circulating interferon-gamma level 234 1.432595e-24 5.606099322649572e-23 2.13699 227 0.008894984 261 0.013629131445977011 1.292958 59 71 0.004888963 Mouse Phenotype Single KO pancytopenia 274 2.744084e-22 9.170648608759124e-21 3.019747 107 0.00419279 310 0.024945543708064514 1.555933 16 16 0.00132582 Mouse Phenotype Single KO increased skin tumor incidence 348 1.962556e-18 5.1641164632183914e-17 2.184327 158 0.006191223 321 0.028350910678504676 1.34376 38 44 0.003148823 Mouse Phenotype Single KO increased skin papilloma incidence 584 2.985384e-12 4.68102076849315e-11 2.266645 92 0.003605016 303 0.023758223330363037 1.485209 21 22 0.001740139 Mouse Phenotype Single KO abnormal thymus development 767 2.161583e-9 2.5806539153846154e-8 2.067332 83 0.003252351 310 0.024945543708064514 1.555933 16 16 0.00132582 Mouse Phenotype abnormal erythropoiesis 54 1.154734e-75 2.044520698888889e-73 2.058515 797 0.03123041 141 0.00011613326287234041 1.273985 122 149 0.01010938 Mouse Phenotype decreased erythroid progenitor cell number 75 1.746051e-61 2.2258658148000003e-59 2.267384 519 0.02033699 185 0.00046457054043243245 1.351205 66 76 0.005469009 Mouse Phenotype increased circulating interferon-gamma level 104 1.8226e-49 1.6755652499999998e-47 3.152981 233 0.009130094 118 0.00003468042894152542 1.466168 49 52 0.004060325 Mouse Phenotype abnormal platelet activation 112 1.772559e-46 1.5131639820535712e-44 2.173554 427 0.01673197 568 0.035855147117957745 1.213628 78 100 0.006463374 Mouse Phenotype abnormal circulating tumor necrosis factor level 119 4.77331e-45 3.8350938579831936e-43 2.013512 496 0.01943574 515 0.027852436858252425 1.182935 111 146 0.009197879 Mouse Phenotype abnormal embryonic hematopoiesis 145 2.612065e-39 1.722341618275862e-37 2.057879 408 0.01598746 555 0.03413442379459459 1.275355 50 61 0.004143189 Mouse Phenotype abnormal circulating interferon level 152 3.632854e-38 2.2851129667105266e-36 2.170756 349 0.01367555 576 0.037704915630208335 1.202312 85 110 0.007043421 Mouse Phenotype abnormal circulating interferon-gamma level 164 2.538195e-36 1.479736731402439e-34 2.328027 285 0.01116771 437 0.016447849560411898 1.2519 70 87 0.005800464 Mouse Phenotype increased respiratory quotient 176 3.387808e-35 1.840388198181818e-33 2.396821 260 0.01018809 467 0.020173789845610277 1.305872 47 56 0.003894597 Mouse Phenotype increased circulating tumor necrosis factor level 183 2.071631e-34 1.0823422945901639e-32 2.092496 341 0.01336207 521 0.028635488619961614 1.222519 77 98 0.00638051 Mouse Phenotype abnormal platelet volume 235 8.898827e-29 3.620497231787234e-27 2.109474 277 0.01085423 323 0.006994845360371517 1.316559 55 65 0.004557507 Mouse Phenotype increased mean platelet volume 257 5.870131e-27 2.183825777859922e-25 2.190335 237 0.009286834 438 0.016421892833561644 1.333657 42 49 0.003480278 Mouse Phenotype enlarged liver sinusoidal spaces 309 2.518884e-23 7.793867289320388e-22 2.114576 220 0.00862069 425 0.015427224663529414 1.366185 36 41 0.002983096 Mouse Phenotype decreased classified tumor incidence 342 9.97094e-22 2.7874899807017547e-20 2.484148 145 0.005681818 405 0.01316113907259259 1.444795 26 28 0.002154458 Mouse Phenotype lymph node hyperplasia 344 1.056985e-21 2.9377423212209305e-20 2.051117 219 0.008581505 629 0.04894344301430842 1.308398 37 44 0.00306596 Mouse Phenotype abnormal circulating interleukin-10 level 383 7.699554e-20 1.922074041618799e-18 2.353738 146 0.005721003 327 0.007333307466972478 1.422567 32 35 0.002651641 Mouse Phenotype decreased inguinal fat pad weight 407 8.256629e-19 1.9395977854791155e-17 2.070889 183 0.007170846 391 0.01253185945319693 1.414485 30 33 0.002485913