# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process intrinsic apoptotic signaling pathway in response to DNA damage 13 1.940025e-21 1.963752998076923e-18 3.041395 101 0.01334919 153 0.000030051268504575162 1.824515 46 69 0.006704562 GO Biological Process DNA replication-dependent nucleosome assembly 20 5.002151e-19 3.2911652504499997e-16 9.594273 29 0.003832937 441 0.02324517357868481 1.796007 21 32 0.003060778 GO Biological Process tumor necrosis factor-mediated signaling pathway 22 1.168445e-18 6.988894434090909e-16 2.403345 130 0.01718213 323 0.0036865818482662537 1.453911 68 128 0.009911092 GO Biological Process regulation of intrinsic apoptotic signaling pathway 24 3.490711e-18 1.9139277520416666e-15 2.115205 166 0.02194026 94 8.19636452861702e-7 1.624407 92 155 0.01340912 GO Biological Process translational elongation 27 1.260289e-17 6.142275167037037e-15 2.592236 106 0.01401004 156 0.00003700773052051282 1.637177 67 112 0.00976534 GO Biological Process mitochondrial membrane organization 43 1.167512e-15 3.572858234418604e-13 2.089095 145 0.01916468 363 0.007710119104958678 1.434599 65 124 0.009473838 GO Biological Process regulation of gene silencing 44 1.40966e-15 4.215844531818182e-13 2.177656 131 0.0173143 207 0.000360841775236715 1.525072 73 131 0.01063985 GO Biological Process chromatin silencing 54 8.085255e-15 1.9702568619444444e-12 2.81376 76 0.01004494 501 0.04591952557884232 1.410708 50 97 0.007287567 GO Biological Process regulation of posttranscriptional gene silencing 56 1.007268e-14 2.366899930714286e-12 2.264151 113 0.01493524 178 0.00014509800920786516 1.606913 64 109 0.009328086 GO Biological Process regulation of gene silencing by RNA 56 1.007268e-14 2.366899930714286e-12 2.264151 113 0.01493524 178 0.00014509800920786516 1.606913 64 109 0.009328086 GO Biological Process mitochondrial translational termination 58 1.044964e-14 2.3708071165517245e-12 2.755685 78 0.01030928 222 0.0005100222716531532 1.635772 52 87 0.00757907 GO Biological Process mitochondrial translational elongation 60 1.289982e-14 2.8291455230000002e-12 2.765457 77 0.01017711 196 0.00022013677672448977 1.674261 52 85 0.00757907 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 61 1.320652e-14 2.8489278144262294e-12 2.264045 112 0.01480307 123 0.000007202057639186992 1.746876 60 94 0.008745081 GO Biological Process multi-organism metabolic process 71 8.174582e-14 1.5150609089859157e-11 2.096327 125 0.01652128 335 0.004619708525671642 1.41493 76 147 0.0110771 GO Biological Process mitochondrial translation 90 1.129213e-12 1.651034874111111e-10 2.353967 88 0.01163098 308 0.0027824086001623375 1.509062 59 107 0.00859933 GO Biological Process positive regulation of gene expression, epigenetic 91 1.837655e-12 2.657329906043956e-10 2.56976 73 0.009648427 209 0.00037476233863636363 1.676274 49 80 0.007141816 GO Biological Process regulation of mitochondrial membrane permeability 93 1.857136e-12 2.6277475939784945e-10 2.258781 94 0.012424 464 0.031103451853448275 1.499602 40 73 0.005830054 GO Biological Process regulation of gene silencing by miRNA 102 3.228228e-12 4.1647306129411765e-10 2.136446 104 0.0137457 221 0.000494845743117647 1.574935 61 106 0.008890832 GO Biological Process translational termination 104 4.338379e-12 5.489300890480769e-10 2.388074 81 0.01070579 248 0.0009486216979032257 1.584448 55 95 0.008016324 GO Biological Process regulation of type I interferon production 106 4.831352e-12 5.997713298867925e-10 2.020228 117 0.01546392 467 0.03132924024839401 1.379512 62 123 0.009036584 GO Cellular Component mitochondrial ribosome 28 5.5663e-17 3.435202285714286e-15 3.130859 75 0.009912768 58 0.00026766931531034484 1.642064 51 85 0.007433319 GO Cellular Component ribosomal subunit 29 1.256056e-16 7.484361268965518e-15 2.162775 143 0.01890034 63 0.0006957380571428571 1.40537 95 185 0.01384638 GO Cellular Component nucleosome 35 3.184234e-15 1.5721018148571429e-13 2.866761 76 0.01004494 67 0.0008005800788059701 1.537806 59 105 0.00859933 GO Cellular Component mitochondrial large ribosomal subunit 43 5.459523e-12 2.1939664520930232e-10 3.300969 47 0.006212001 80 0.00271862568 1.717191 32 51 0.004664043 GO Cellular Component DNA packaging complex 45 1.048721e-11 4.0270886399999996e-10 2.388801 78 0.01030928 76 0.001818546290526316 1.490564 61 112 0.008890832 GO Cellular Component large ribosomal subunit 47 2.931221e-11 1.077691465531915e-9 2.206611 88 0.01163098 100 0.0143347968 1.404084 59 115 0.00859933 GO Cellular Component proteasome regulatory particle, lid subcomplex 93 0.000007341454 0.00013640895174193548 5.571457 11 0.001453873 101 0.014849331897029703 2.736773 7 7 0.001020259 GO Cellular Component Bcl-2 family protein complex 117 0.00006218417 0.0009184123569230769 3.567655 14 0.001850383 101 0.014849331897029703 2.736773 7 7 0.001020259 GO Cellular Component DNA-directed RNA polymerase I complex 154 0.0004492359 0.0050407768519480515 2.930472 14 0.001850383 91 0.004283746180219781 2.345805 12 14 0.001749016 GO Molecular Function unfolded protein binding 3 2.415551e-16 3.399485440666667e-13 2.615188 96 0.01268834 88 0.04155460320454545 1.420024 55 106 0.008016324 GO Molecular Function structural constituent of ribosome 4 1.180774e-15 1.246306957e-12 2.175586 132 0.01744647 57 0.003433177074736842 1.419068 84 162 0.01224311 GO Molecular Function BH domain binding 8 1.603603e-13 8.4630148325e-11 6.311832 27 0.003568596 62 0.008385920261290323 2.508709 11 12 0.001603265 GO Molecular Function kinesin binding 25 6.03368e-8 0.000010189678783999998 2.36803 50 0.006608512 67 0.01487389174925373 1.778902 26 40 0.003789535 GO Molecular Function tumor necrosis factor-activated receptor activity 58 0.000007191948 0.0005235242147586206 2.401753 33 0.004361618 35 0.00041283886097142854 2.280644 20 24 0.002915027 GO Molecular Function RNA polymerase III regulatory region DNA binding 91 0.00006127859 0.00284305721956044 4.400667 11 0.001453873 89 0.04117302464494382 2.736773 7 7 0.001020259 GO Molecular Function death domain binding 92 0.00006334881 0.002907159519782609 2.562736 23 0.003039915 86 0.03814324661860465 2.463096 9 10 0.001311762 Human Phenotype Leukodystrophy 14 4.189804e-8 0.000019970401494285714 2.328676 53 0.007005022 41 0.03573552628536585 1.696799 31 50 0.004518292 Mouse Phenotype Single KO abnormal B cell activation 14 1.583205e-36 1.0355291560714284e-33 2.473031 251 0.03317473 43 1.4638224743953487e-9 1.746493 97 152 0.01413788 Mouse Phenotype Single KO abnormal B cell proliferation 26 7.898451e-32 2.7817736848846154e-29 2.401952 230 0.03039915 48 4.105630612291667e-9 1.76502 89 138 0.01297187 Mouse Phenotype Single KO decreased B cell proliferation 42 9.948259e-27 2.1689573253095237e-24 2.73914 151 0.01995771 152 0.0005867899579736841 1.655579 49 81 0.007141816 Mouse Phenotype Single KO abnormal T cell apoptosis 61 1.753257e-19 2.631897434262295e-17 2.370697 140 0.01850383 111 0.00005412649077927928 1.718439 54 86 0.007870573 Mouse Phenotype Single KO decreased IgM level 65 1.322145e-18 1.8625971946153848e-16 2.25218 148 0.01956119 140 0.00024449059185714287 1.609867 60 102 0.008745081 Mouse Phenotype Single KO decreased IgG1 level 69 7.459339e-18 9.89929959753623e-16 2.142327 158 0.0208829 188 0.0019057748100531912 1.492785 66 121 0.009619589 Mouse Phenotype Single KO decreased susceptibility to autoimmune disorder 73 2.719192e-17 3.4109097457534246e-15 2.004415 179 0.02365847 361 0.03953482750415513 1.317706 78 162 0.01136861 Mouse Phenotype Single KO abnormal circulating interferon level 81 9.763545e-17 1.1037627353703703e-14 2.593985 100 0.01321702 365 0.041920319509589035 1.429204 47 90 0.006850313 Mouse Phenotype Single KO altered susceptibility to parasitic infection 82 1.072566e-16 1.1977423002439024e-14 2.173913 142 0.01876817 243 0.008096321703292182 1.45168 61 115 0.008890832 Mouse Phenotype Single KO abnormal spleen marginal zone morphology 83 2.060349e-16 2.273086240120482e-14 2.197752 136 0.01797515 189 0.0020435182712698415 1.520429 60 108 0.008745081 Mouse Phenotype Single KO increased T cell proliferation 84 4.455813e-16 4.857366623928572e-14 2.147619 140 0.01850383 285 0.014951986565614035 1.428935 59 113 0.00859933 Mouse Phenotype Single KO abnormal marginal zone B cell morphology 95 8.338561e-15 8.037495060736841e-13 2.25215 115 0.01519958 256 0.0098484679625 1.506763 49 89 0.007141816 Mouse Phenotype Single KO abnormal spleen germinal center morphology 96 1.013935e-14 9.671461244791666e-13 2.125304 130 0.01718213 107 0.00004715667581028037 1.669432 61 100 0.008890832 Mouse Phenotype Single KO abnormal spleen secondary B follicle morphology 98 3.922476e-14 3.665113544081632e-12 2.077757 131 0.0173143 105 0.00004645902496761905 1.663529 62 102 0.009036584 Mouse Phenotype Single KO abnormal transitional stage B cell morphology 101 6.290438e-14 5.703122848118812e-12 2.517734 86 0.01136664 159 0.0006961162918238993 1.807303 35 53 0.005101297 Mouse Phenotype Single KO abnormal circulating interferon-gamma level 106 1.12961e-13 9.75833846226415e-12 2.57203 81 0.01070579 291 0.016411052677319588 1.541844 40 71 0.005830054 Mouse Phenotype Single KO increased B cell apoptosis 109 3.757853e-13 3.1569412771559635e-11 2.879268 64 0.008458895 149 0.0004831805973422819 2.260813 19 23 0.002769276 Mouse Phenotype Single KO increased B cell proliferation 110 4.451567e-13 3.7057271835454545e-11 2.295922 96 0.01268834 76 0.000002227617365657895 1.954838 45 63 0.006558811 Mouse Phenotype Single KO spleen hyperplasia 111 6.406301e-13 5.284909752882883e-11 2.143687 110 0.01453873 345 0.0352233162 1.473647 42 78 0.006121557 Mouse Phenotype Single KO glomerulonephritis 112 7.096168e-13 5.801750926428572e-11 2.123408 112 0.01480307 179 0.0012641177112290502 1.615685 49 83 0.007141816 Mouse Phenotype abnormal B cell activation 34 6.792002e-33 1.9099509153529413e-30 2.143647 302 0.03991541 63 9.276356889047618e-10 1.642064 123 205 0.01792742 Mouse Phenotype abnormal B cell proliferation 43 5.691854e-30 1.2655771184651163e-27 2.120647 281 0.03713984 64 1.22505332025e-9 1.665232 115 189 0.01676141 Mouse Phenotype decreased susceptibility to autoimmune disorder 67 5.594138e-24 7.982918420597014e-22 2.105375 226 0.02987047 294 0.005370257602040816 1.341555 100 204 0.01457513 Mouse Phenotype decreased B cell proliferation 69 8.328796e-23 1.154081428347826e-20 2.199828 194 0.02564103 140 0.00002744376464357143 1.627908 69 116 0.01005684 Mouse Phenotype decreased IgM level 70 8.412532e-23 1.1490316921714286e-20 2.199624 194 0.02564103 108 0.0000036335066675 1.637917 79 132 0.01151436 Mouse Phenotype abnormal spleen marginal zone morphology 79 1.103001e-20 1.3349104507594937e-18 2.060909 203 0.02683056 148 0.00003794674980202703 1.520429 90 162 0.01311762 Mouse Phenotype abnormal spleen germinal center morphology 80 1.482005e-20 1.771181225625e-18 2.148112 183 0.02418715 92 1.1128463595652174e-7 1.697998 85 137 0.01238886 Mouse Phenotype abnormal marginal zone B cell morphology 82 9.480453e-20 1.1053976967439024e-17 2.138829 177 0.02339413 181 0.00022748471453038673 1.516054 77 139 0.01122285 Mouse Phenotype abnormal spleen secondary B follicle morphology 83 1.288959e-19 1.4847875902409637e-17 2.087172 186 0.02458366 86 6.767965081395349e-8 1.700709 87 140 0.01268037 Mouse Phenotype altered susceptibility to parasitic infection 84 1.482077e-19 1.6869212139285712e-17 2.196244 165 0.02180809 312 0.006882458270192307 1.420615 68 131 0.009911092 Mouse Phenotype decreased IgG1 level 90 1.039145e-18 1.1039183716666666e-16 2.012918 193 0.02550886 214 0.000724129588317757 1.457243 82 154 0.01195161 Mouse Phenotype abnormal circulating interferon level 95 2.053506e-16 2.066691670105263e-14 2.391689 114 0.01506741 391 0.017977430927109975 1.418146 57 110 0.008307827 Mouse Phenotype abnormal circulating interferon-gamma level 101 8.670334e-16 8.207630037029703e-14 2.589914 94 0.012424 281 0.004447892884697508 1.541401 49 87 0.007141816 Mouse Phenotype abnormal B-2 B cell morphology 102 1.179212e-15 1.1053378364705881e-13 3.40191 61 0.008062384 269 0.003623114292936803 1.942226 22 31 0.00320653 Mouse Phenotype increased B cell proliferation 103 1.559552e-15 1.4476579293203883e-13 2.330117 113 0.01493524 128 0.00000872710900078125 1.790728 53 81 0.007724821 Mouse Phenotype decreased susceptibility to experimental autoimmune encephalomyelitis 104 2.018556e-15 1.8557128765384618e-13 2.213057 125 0.01652128 506 0.044594714745059286 1.381419 53 105 0.007724821 Mouse Phenotype abnormal follicular B cell morphology 105 2.403579e-15 2.188630363714286e-13 2.087715 142 0.01876817 258 0.0027839234338372094 1.514525 57 103 0.008307827 Mouse Phenotype increased pre-B cell number 116 2.676792e-14 2.2062765786206897e-12 2.684461 79 0.01044145 355 0.01154359319915493 1.775204 24 37 0.003498032 Mouse Phenotype abnormal class switch recombination 126 1.593657e-13 1.2092821092857142e-11 2.103955 121 0.0159926 165 0.00010132794156363636 1.665862 56 92 0.008162075 Mouse Phenotype increased immature B cell number 129 3.166374e-13 2.3467985902325584e-11 2.088946 120 0.01586043 131 0.000012509984622137406 1.865982 45 66 0.006558811