# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 6 3.129429e-97 6.863359368499999e-94 4.742849 282 0.02568306 415 0.006777094275662651 1.416162 65 114 0.008597884 GO Biological Process regulation of gene expression, epigenetic 16 2.251674e-73 1.8518611353750002e-70 2.669811 449 0.04089253 216 0.0000708892387962963 1.372061 137 248 0.01812169 GO Biological Process nucleosome organization 29 6.875603e-52 3.1198641336896558e-49 2.694821 311 0.02832423 252 0.0002402933659047619 1.423424 98 171 0.01296296 GO Biological Process chromatin silencing 33 1.552798e-49 6.191899661212121e-47 4.158388 163 0.01484517 448 0.010857088493080357 1.433906 56 97 0.007407407 GO Biological Process chromatin assembly or disassembly 35 3.892329e-49 1.4634044946e-46 2.58126 317 0.02887067 258 0.0003083226125503876 1.409308 101 178 0.01335979 GO Biological Process DNA replication-dependent nucleosome assembly 37 2.372422e-48 8.437486783243242e-46 14.13415 62 0.00564663 543 0.025251709023941065 1.707564 22 32 0.002910053 GO Biological Process nucleosome assembly 41 6.489758e-46 2.0828957444390244e-43 2.74444 266 0.02422587 266 0.0004255202579135339 1.451758 83 142 0.01097884 GO Biological Process chromatin assembly 45 3.335695e-45 9.754313445555557e-43 2.616822 284 0.02586521 309 0.0013068722446278318 1.399063 89 158 0.01177249 GO Biological Process protein-DNA complex subunit organization 55 8.939199e-43 2.138743993472727e-40 2.114209 412 0.03752277 320 0.0015192057275625 1.31141 132 250 0.01746032 GO Biological Process gene silencing 66 1.131109e-38 2.2551914137878788e-36 2.462876 270 0.02459016 301 0.0009804871450498338 1.37985 100 180 0.01322751 GO Biological Process DNA packaging 76 3.438176e-36 5.953020787368421e-34 2.226579 309 0.02814208 494 0.016997624143319838 1.285549 103 199 0.01362434 GO Biological Process Arp2/3 complex-mediated actin nucleation 79 1.195102e-35 1.9906768630379746e-33 4.964925 96 0.008743169 503 0.018096994541153082 1.96084 15 19 0.001984127 GO Biological Process macromolecular complex disassembly 91 1.373296e-33 1.9858463806593405e-31 2.219182 288 0.02622951 229 0.00010472282723580787 1.417417 109 191 0.01441799 GO Biological Process protein-DNA complex assembly 97 1.782196e-32 2.417723418969072e-30 2.019572 346 0.03151184 388 0.00514817386443299 1.304242 115 219 0.01521164 GO Biological Process retrograde transport, endosome to Golgi 99 2.574931e-32 3.422577477676768e-30 2.897358 169 0.01539162 606 0.04339649283663367 1.419274 44 77 0.005820106 GO Biological Process mRNA catabolic process 107 8.971366e-31 1.103310328915888e-28 2.143175 284 0.02586521 93 9.32959516516129e-10 1.574195 135 213 0.01785714 GO Biological Process nuclear-transcribed mRNA catabolic process 109 1.916537e-30 2.3137348975229356e-28 2.203155 264 0.02404372 98 1.1051278659081632e-9 1.5931 127 198 0.01679894 GO Biological Process RNA catabolic process 110 2.907607e-30 3.4782909557272727e-28 2.036204 315 0.02868852 77 3.6993264384415585e-11 1.576808 153 241 0.0202381 GO Biological Process regulation of megakaryocyte differentiation 118 2.903023e-29 3.23736268279661e-27 2.798051 161 0.01466302 287 0.0007717304168292684 1.601352 49 76 0.006481481 GO Biological Process platelet aggregation 133 1.977961e-26 1.9569916390225563e-24 3.33532 111 0.01010929 518 0.020656030327606177 1.635627 27 41 0.003571429 GO Cellular Component nucleosome 20 3.532664e-77 3.052221696e-75 5.250411 202 0.01839709 68 0.00036308202352941174 1.513893 64 105 0.008465608 GO Cellular Component DNA packaging complex 23 3.318531e-67 2.493226768695652e-65 4.41058 209 0.01903461 64 0.00010619769600000001 1.530155 69 112 0.009126984 GO Cellular Component protein-DNA complex 36 1.527014e-34 7.3296672e-33 2.217542 297 0.02704918 82 0.003434912078048781 1.315639 107 202 0.01415344 GO Cellular Component ribosomal subunit 44 1.136739e-26 4.464284072727273e-25 2.261512 217 0.01976321 51 0.0000014139783529411764 1.490238 111 185 0.01468254 GO Cellular Component melanosome 65 5.085862e-19 1.3520568516923077e-17 2.018999 196 0.01785064 59 0.000026039278861016953 1.584856 67 105 0.008862434 GO Cellular Component ficolin-1-rich granule lumen 69 3.518267e-18 8.810964313043478e-17 2.118844 166 0.0151184 93 0.006856824774193548 1.382076 69 124 0.009126984 GO Cellular Component large ribosomal subunit 78 1.088399e-15 2.4112224e-14 2.211654 128 0.01165756 75 0.0016195198464 1.447043 67 115 0.008862434 GO Cellular Component cytosolic ribosome 82 3.331461e-15 7.02044464390244e-14 2.030168 151 0.01375228 57 0.00001857431747368421 1.574508 71 112 0.009391534 GO Cellular Component small ribosomal subunit 99 1.793826e-12 3.1310417454545454e-11 2.309914 90 0.008196721 78 0.002475741046153846 1.552331 45 72 0.005952381 GO Cellular Component cytosolic large ribosomal subunit 105 1.396048e-11 2.2974961371428572e-10 2.291733 84 0.007650273 81 0.0033480042666666665 1.587959 39 61 0.00515873 GO Cellular Component cytosolic small ribosomal subunit 135 6.391256e-9 8.180807679999999e-8 2.303876 61 0.005555556 84 0.003399080914285714 1.693452 30 44 0.003968254 GO Cellular Component Golgi trans cisterna 137 1.028921e-8 1.297792327007299e-7 4.754145 21 0.001912568 121 0.02445155702479339 2.48373 7 7 0.0009259259 GO Cellular Component platelet dense tubular network membrane 143 1.967804e-8 2.3778778405594403e-7 3.470599 29 0.002641166 88 0.0054435887999999995 2.48373 9 9 0.001190476 GO Cellular Component cytoplasmic stress granule 145 2.717195e-8 3.238146868965517e-7 2.057553 72 0.006557377 130 0.031102723938461533 1.559551 27 43 0.003571429 GO Cellular Component platelet dense tubular network 150 4.523767e-8 5.211379584e-7 3.25425 30 0.00273224 107 0.012567190071028037 2.257937 10 11 0.001322751 GO Cellular Component kinetochore microtubule 249 0.00004829823 0.00033517807807228913 2.549843 24 0.002185792 121 0.02445155702479339 2.48373 7 7 0.0009259259 GO Cellular Component Arp2/3 protein complex 307 0.0003947204 0.002221748700977199 2.094685 27 0.002459016 116 0.02082441103448276 2.101618 11 13 0.001455026 GO Molecular Function structural constituent of ribosome 11 6.437172e-25 2.4707036530909093e-22 2.271415 200 0.01821494 38 0.000006849872794736841 1.517835 99 162 0.01309524 GO Molecular Function ribonucleoprotein complex binding 15 6.087917e-21 1.7135457049333335e-18 2.297446 162 0.0147541 69 0.0043010346162318846 1.447043 67 115 0.008862434 GO Molecular Function rRNA binding 20 1.662792e-16 3.510153912e-14 3.216729 70 0.006375228 94 0.029111543382978722 1.531634 37 60 0.00489418 GO Molecular Function O-methyltransferase activity 78 1.301025e-8 7.042214807692308e-7 2.878616 39 0.003551913 77 0.00928950758961039 2.010639 17 21 0.002248677 GO Molecular Function ubiquitin-protein transferase regulator activity 96 1.249456e-7 0.000005495003366666666 2.358072 48 0.004371585 67 0.003911868263880597 2.191527 15 17 0.001984127 GO Molecular Function ATPase activator activity 167 0.000006330445 0.00016004274724550898 2.133932 43 0.003916211 80 0.0124679829225 1.943789 18 23 0.002380952 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 18 4.607649e-39 2.3440134385e-36 2.189121 347 0.03160291 166 0.006356750786144579 1.348311 95 175 0.01256614 Mouse Phenotype Single KO abnormal induced cell death 21 6.415924e-38 2.797648384190476e-35 2.092246 373 0.03397086 131 0.00234340491740458 1.341921 114 211 0.01507937 Mouse Phenotype Single KO abnormal erythropoiesis 39 4.000157e-31 9.392163499743588e-29 2.144456 287 0.02613843 121 0.0016575184080991738 1.490238 66 110 0.008730159 Mouse Phenotype Single KO decreased circulating alanine transaminase level 47 1.069751e-28 2.0841935972340426e-26 2.404128 207 0.01885246 181 0.009100434023756905 1.523354 46 75 0.006084656 Mouse Phenotype Single KO abnormal platelet aggregation 66 2.157414e-24 2.993248484545454e-22 2.371027 179 0.01630237 259 0.022374012275289575 1.464764 46 78 0.006084656 Mouse Phenotype Single KO abnormal platelet activation 67 4.064238e-24 5.554660800895522e-22 2.331187 183 0.01666667 278 0.028868216562949637 1.431797 49 85 0.006481481 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 73 2.075312e-22 2.6032372580821918e-20 2.312135 172 0.01566485 286 0.031528742050349653 1.546473 33 53 0.004365079 Mouse Phenotype Single KO increased skin tumor incidence 124 4.310381e-16 3.183077323951613e-14 2.763359 86 0.007832423 246 0.01911000386504065 1.637004 29 44 0.003835979 Mouse Phenotype Single KO decreased susceptibility to hepatic steatosis 147 4.47161e-15 2.785478419727891e-13 2.098612 138 0.01256831 109 0.0005855614188623853 1.681294 44 65 0.005820106 Mouse Phenotype Single KO pale liver 171 1.941823e-13 1.0398405386549708e-11 2.0327 131 0.01193078 168 0.006413028641666667 1.521285 49 80 0.006481481 Mouse Phenotype Single KO increased integument system tumor incidence 177 3.850982e-13 1.9922848685875707e-11 2.123094 115 0.01047359 204 0.012516092833333332 1.50331 46 76 0.006084656 Mouse Phenotype Single KO abnormal platelet volume 202 2.90598e-12 1.3173296465346537e-10 2.116764 107 0.009744991 225 0.016098612396888888 1.568672 36 57 0.004761905 Mouse Phenotype Single KO increased B cell derived lymphoma incidence 214 1.23683e-11 5.292360892523364e-10 2.151183 97 0.008834244 183 0.009666759681967212 1.65582 32 48 0.004232804 Mouse Phenotype Single KO ruffled hair 278 8.471925e-10 2.790554576438849e-8 2.658223 52 0.004735883 304 0.03946519403618421 1.788286 18 25 0.002380952 Mouse Phenotype Single KO increased susceptibility to weight loss 281 1.07669e-9 3.5086300106761565e-8 2.310593 67 0.006102004 268 0.027782553257835824 1.635627 27 41 0.003571429 Mouse Phenotype Single KO abnormal lymph organ development 283 1.318141e-9 4.265094394699647e-8 2.471178 58 0.005282332 306 0.041112476163398685 1.93179 14 18 0.001851852 Mouse Phenotype Single KO increased mean platelet volume 307 4.059449e-9 1.2108265307166125e-7 2.016164 85 0.007741348 275 0.028458450922181817 1.617313 28 43 0.003703704 Mouse Phenotype Single KO poikilocytosis 377 8.206059e-8 0.0000019931799008753316 2.474206 45 0.004098361 253 0.021438089708695655 1.731085 23 33 0.003042328 Mouse Phenotype Single KO salivary gland inflammation 392 1.856056e-7 0.000004335689997959183 2.349391 47 0.00428051 253 0.021438089708695655 1.731085 23 33 0.003042328 Mouse Phenotype Single KO abnormal erythrocyte osmotic lysis 569 0.0000132898 0.0002138746899824253 2.067317 43 0.003916211 327 0.046528593204892964 1.712917 20 29 0.002645503 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 25 5.669215e-37 2.1681345846e-34 2.064707 375 0.03415301 377 0.018647830193633953 1.297059 94 180 0.01243386 Mouse Phenotype decreased erythroid progenitor cell number 28 1.114123e-36 3.8043321439285714e-34 2.508031 247 0.02249545 362 0.016902432338121547 1.47063 45 76 0.005952381 Mouse Phenotype abnormal erythropoiesis 29 1.163202e-36 3.834956662758621e-34 2.113084 352 0.03205829 132 0.000036744668606818184 1.50024 90 149 0.01190476 Mouse Phenotype abnormal mean corpuscular hemoglobin 38 2.102126e-35 5.289059654210527e-33 2.068485 357 0.03251366 270 0.004649241634444444 1.336355 99 184 0.01309524 Mouse Phenotype decreased circulating alanine transaminase level 61 6.097259e-28 9.556703819508197e-26 2.325987 215 0.01958106 413 0.02887959082808717 1.415149 49 86 0.006481481 Mouse Phenotype abnormal platelet activation 62 9.853509e-28 1.5195064443387095e-25 2.389859 202 0.01839709 399 0.0246761502406015 1.390889 56 100 0.007407407 Mouse Phenotype abnormal platelet aggregation 63 1.537012e-27 2.3325986876190474e-25 2.399044 199 0.01812386 349 0.015097890160744986 1.426824 54 94 0.007142857 Mouse Phenotype abnormal platelet physiology 68 2.459293e-26 3.457838290147059e-24 2.078178 259 0.02358834 120 0.000024192485130000003 1.542923 82 132 0.01084656 Mouse Phenotype abnormal early pro-B cell 89 7.392044e-22 7.941048616179775e-20 9.068436 35 0.003187614 446 0.03670427169282511 2.48373 7 7 0.0009259259 Mouse Phenotype abnormal circulating tumor necrosis factor level 101 6.111904e-21 5.785734073663366e-19 2.028567 215 0.01958106 305 0.008102163811475408 1.360948 80 146 0.01058201 Mouse Phenotype decreased mean corpuscular volume 104 4.753496e-20 4.3700168515384615e-18 2.066534 196 0.01785064 262 0.004020736229770993 1.452748 62 106 0.008201058 Mouse Phenotype increased circulating tumor necrosis factor level 108 2.373164e-19 2.100909352222222e-17 2.239176 157 0.01429872 239 0.002039889755271967 1.495307 59 98 0.007804233 Mouse Phenotype abnormal embryonic hematopoiesis 110 4.465492e-19 3.881324455636364e-17 2.098414 179 0.01630237 482 0.04631187727593361 1.465808 36 61 0.004761905 Mouse Phenotype microcytic anemia 125 6.771534e-18 5.17941092592e-16 3.327469 73 0.006648452 442 0.03594144297285068 1.712917 20 29 0.002645503 Mouse Phenotype increased circulating interleukin-1 beta level 131 1.816411e-17 1.3257027153435114e-15 2.944862 85 0.007741348 208 0.0011198233913942307 1.862798 27 36 0.003571429 Mouse Phenotype abnormal circulating interleukin-1 beta level 138 6.744356e-17 4.67266577652174e-15 2.598152 101 0.009198543 252 0.003147492961547619 1.641036 37 56 0.00489418 Mouse Phenotype decreased susceptibility to hepatic steatosis 153 8.405592e-16 5.2526709223529415e-14 2.077436 149 0.01357013 217 0.0012447924123041474 1.580556 49 77 0.006481481 Mouse Phenotype increased body temperature 157 1.184464e-15 7.213159429299363e-14 2.594525 93 0.008469945 367 0.017072981308446866 1.703129 24 35 0.003174603 Mouse Phenotype abnormal circulating interleukin-1 level 191 7.725425e-14 3.86716169764398e-12 2.313349 101 0.009198543 481 0.04575884661330562 1.458699 37 63 0.00489418 Mouse Phenotype microcytosis 201 1.868195e-13 8.886473828358208e-12 3.427006 51 0.004644809 488 0.04668593197131147 1.759309 17 24 0.002248677