# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 1 4.407803e-35 5.8002279677e-31 6.768949 71 0.03665462 131 0.016662669132824427 2.03436 28 114 0.01235112 GO Biological Process regulation of gene expression, epigenetic 7 9.110899e-25 1.7127188563e-21 3.370597 100 0.05162623 104 0.0056501570125961536 1.736706 52 248 0.0229378 GO Biological Process nucleosome organization 11 8.714389e-23 1.0424785895545455e-19 3.831218 78 0.04026846 35 0.000004406528012 2.324983 48 171 0.02117336 GO Biological Process nucleosome assembly 12 1.708152e-21 1.873131014e-18 4.035468 69 0.0356221 38 0.0000062873667371052626 2.449828 42 142 0.01852669 GO Biological Process chromatin assembly 17 4.099168e-20 3.172997159529412e-17 3.708403 71 0.03665462 45 0.000017732647312 2.306589 44 158 0.01940891 GO Biological Process chromatin assembly or disassembly 18 4.382215e-20 3.203642621388889e-17 3.507993 76 0.03923593 53 0.00003190255545849057 2.187019 47 178 0.02073225 GO Biological Process protein-DNA complex subunit organization 19 7.849084e-20 5.436110334526316e-17 2.879776 99 0.05110996 40 0.0000060199332635 2.054123 62 250 0.02734892 GO Biological Process protein-DNA complex assembly 22 1.547381e-18 9.255448445e-16 2.944733 89 0.04594734 48 0.000019935783566041666 2.080143 55 219 0.02426114 GO Biological Process DNA packaging 25 3.227081e-17 1.69860635516e-14 3.104317 76 0.03923593 69 0.000321147874231884 1.99785 48 199 0.02117336 GO Biological Process DNA conformation change 28 1.756416e-16 8.254527908571429e-14 2.599054 96 0.04956118 78 0.0005442368389102565 1.798035 61 281 0.02690781 GO Biological Process DNA replication-independent nucleosome assembly 48 2.055808e-13 5.6359119733333335e-11 5.507597 30 0.01548787 84 0.0010507666717738096 2.969289 19 53 0.00838112 GO Biological Process DNA replication-independent nucleosome organization 49 3.133966e-13 8.416297672244898e-11 5.414699 30 0.01548787 87 0.0013891473803333333 2.914302 19 54 0.00838112 GO Biological Process chromatin remodeling at centromere 54 2.326909e-12 5.670332505740741e-10 5.586239 27 0.01393908 91 0.001844920720879121 3.061017 17 46 0.007498897 GO Biological Process histone exchange 60 2.427769e-11 5.324502045166667e-9 4.676429 29 0.01497161 83 0.0008941546841686748 2.906229 20 57 0.008822232 GO Biological Process regulation of gene silencing 65 5.863459e-11 1.1870347227846151e-8 3.051775 47 0.02426433 97 0.0035639713506185567 2.086495 33 131 0.01455668 GO Biological Process viral transcription 67 7.86001e-11 1.5437294267164176e-8 3.52532 38 0.01961797 109 0.006626982259541284 2.125662 29 113 0.01279224 GO Biological Process centromere complex assembly 71 9.477145e-11 1.7564753669718312e-8 4.720728 27 0.01393908 105 0.005600786216000001 2.816136 17 50 0.007498897 GO Biological Process viral gene expression 75 1.838419e-10 3.2255674161333336e-8 3.352642 39 0.02013423 132 0.0207505965719697 1.956556 30 127 0.01323335 GO Biological Process protein peptidyl-prolyl isomerization 76 1.981567e-10 3.4309789675e-8 4.406623 28 0.01445534 136 0.025457024046323527 2.760918 14 42 0.006175562 GO Biological Process regulation of posttranscriptional gene silencing 77 2.278485e-10 3.8938420928571425e-8 3.208836 41 0.02116675 115 0.008228181955913043 2.12768 28 109 0.01235112 GO Cellular Component nucleosome 15 1.321169e-27 1.5219866879999999e-25 7.514235 51 0.02632938 28 0.0007596775542857143 2.287617 29 105 0.01279224 GO Cellular Component DNA packaging complex 16 2.91672e-25 3.1500576e-23 6.340127 53 0.0273619 27 0.00038170368 2.292548 31 112 0.01367446 GO Cellular Component chromatin 19 1.260112e-18 1.1460387031578947e-16 2.113885 164 0.08466701 13 3.488960935384616e-10 1.925825 113 486 0.04984561 GO Cellular Component nuclear chromatin 22 6.987323e-16 5.488224610909091e-14 2.260593 120 0.06195147 16 1.51493652e-8 2.070688 79 316 0.03484782 GO Cellular Component protein-DNA complex 26 4.945738e-14 3.287013563076923e-12 2.878041 68 0.03510583 42 0.02259386742857143 1.681153 41 202 0.01808558 GO Cellular Component ribosomal subunit 36 4.422744e-11 2.12291712e-9 2.953806 50 0.02581311 39 0.014950868676923076 1.746094 39 185 0.01720335 GO Cellular Component cytosolic part 38 7.765452e-11 3.53123712e-9 2.392662 70 0.03613836 31 0.0020281279587096774 1.760085 51 240 0.02249669 GO Cellular Component cytosolic ribosome 46 4.884687e-9 1.8349432904347827e-7 2.972298 39 0.02013423 35 0.00591397632 2.070688 28 112 0.01235112 GO Cellular Component ribosome 47 6.29661e-9 2.3150089531914896e-7 2.3666 57 0.02942695 46 0.04551608347826087 1.579338 45 236 0.01985002 GO Molecular Function chromatin DNA binding 19 3.559724e-7 0.00007910081435789473 2.510838 39 0.02013423 17 0.0512052604 2.070688 26 104 0.0114689 Mouse Phenotype Single KO decreased erythroid progenitor cell number 143 0.0000816246 0.005226828406993007 2.234202 29 0.01497161 46 0.04340738495 2.598511 16 51 0.007057786 Mouse Phenotype Single KO scoliosis 166 0.0001747588 0.009640158624096387 2.437055 22 0.01135777 37 0.031020178954054057 3.076451 13 35 0.005734451 Mouse Phenotype abnormal platelet physiology 21 4.646129e-9 0.000002115316160428571 2.456119 54 0.02787816 93 0.04348570002258064 1.882444 30 132 0.01323335 Mouse Phenotype abnormal erythropoiesis 25 7.225446e-9 0.00000276329956824 2.211873 65 0.03355705 40 0.0073342789537500005 2.001202 36 149 0.01588002 Mouse Phenotype decreased erythroid progenitor cell number 76 8.523731e-7 0.00010723077906710526 2.359894 41 0.02116675 24 0.002257689922 2.615606 24 76 0.01058668 Mouse Phenotype abnormal proerythroblast morphology 180 0.0001213323 0.006444767335 2.037157 34 0.01755292 81 0.032579827525925927 2.229972 21 78 0.009263344