# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	20	1.010501e-31	6.648591329500001e-29	2.371005	236	0.02459358	254	0.0005767097532677166	1.458077	84	155	0.01203611	
GO Biological Process	mitochondrial transport	26	3.431261e-29	1.7366139807307695e-26	2.04049	301	0.03136724	160	0.000001518428524125	1.474709	131	239	0.0187706	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	27	7.086657e-29	3.4538266467777775e-26	2.69358	169	0.0176115	445	0.015867586461348313	1.459739	51	94	0.007307637	
GO Biological Process	nuclear-transcribed mRNA catabolic process	28	1.01682e-28	4.7786908500000004e-26	2.253539	236	0.02459358	211	0.000056264073502843605	1.453957	107	198	0.01533171	
GO Biological Process	mRNA catabolic process	31	4.381903e-28	1.8600471476451613e-25	2.167331	251	0.02615673	233	0.00016737118472103004	1.414723	112	213	0.01604814	
GO Biological Process	response to unfolded protein	39	9.104132e-26	3.071827512512821e-23	2.23106	215	0.02240517	583	0.03923530776672384	1.311619	78	160	0.01117639	
GO Biological Process	cellular response to insulin stimulus	40	1.020983e-25	3.35877882425e-23	2.041856	263	0.02740725	274	0.0009687987176277371	1.454324	80	148	0.01146296	
GO Biological Process	RNA catabolic process	41	1.207613e-25	3.875848650487805e-23	2.011832	272	0.02834514	226	0.00012014953046460177	1.395488	125	241	0.01791088	
GO Biological Process	response to topologically incorrect protein	44	2.173565e-25	6.500441326136365e-23	2.165616	226	0.02355148	539	0.03331280194619666	1.300408	87	180	0.01246597	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	49	9.896055e-25	2.657595668265306e-22	2.490096	165	0.01719466	554	0.034325679048736464	1.380965	58	113	0.008310646	
GO Biological Process	cellular response to epidermal growth factor stimulus	51	4.788883e-24	1.2356257136666667e-21	2.917747	122	0.01271363	401	0.010456748486034912	1.770066	25	38	0.003582175	
GO Biological Process	mitochondrial translation	57	3.198041e-23	7.38298623140351e-21	2.741809	130	0.01354731	150	7.493701347866667e-7	1.734995	69	107	0.009886803	
GO Biological Process	response to epidermal growth factor	63	2.649733e-22	5.53457722968254e-20	2.748044	124	0.01292205	495	0.025896553118181818	1.665548	26	42	0.003725462	
GO Biological Process	regulation of DNA-templated transcription in response to stress	66	4.107668e-22	8.189818668484848e-20	2.294738	172	0.01792414	459	0.017600340246840956	1.401773	62	119	0.008883794	
GO Biological Process	translational elongation	70	2.763756e-21	5.195466457714286e-19	2.564462	133	0.01385994	157	0.000001269663297133758	1.705585	71	112	0.01017338	
GO Biological Process	mitochondrial translational termination	90	4.660442e-20	6.814084030888889e-18	2.869117	103	0.01073364	208	0.00004476256540769231	1.700891	55	87	0.007880785	
GO Biological Process	mitochondrial translational elongation	97	1.311047e-19	1.7785636570103092e-17	2.86005	101	0.01052522	209	0.00004462973070287081	1.709259	54	85	0.007737498	
GO Biological Process	translational termination	100	1.725975e-19	2.2712105025e-17	2.649987	114	0.01187995	179	0.000005710866323463688	1.727584	61	95	0.008740507	
GO Biological Process	protein-lipid complex assembly	101	2.414651e-19	3.1459794563366337e-17	3.891922	65	0.006773656	333	0.0048295900990990995	1.948293	21	29	0.003009027	
GO Biological Process	regulation of necrotic cell death	110	1.111432e-18	1.3295757898181818e-16	4.86838	49	0.005106294	435	0.01422753500045977	1.893315	19	27	0.002722453	
GO Cellular Component	catalytic step 2 spliceosome	39	2.493805e-22	1.104947446153846e-20	2.585611	138	0.01438099	49	0.0000015596254432653061	1.737615	62	96	0.008883794	
GO Cellular Component	mitochondrial ribosome	40	1.572638e-19	6.7937961599999994e-18	3.028072	92	0.009587328	64	0.00042015347999999997	1.6143	51	85	0.007307637	
GO Cellular Component	ribosomal subunit	42	1.736887e-18	7.146049371428572e-17	2.086841	175	0.01823677	51	0.000007206593505882352	1.497954	103	185	0.01475856	
GO Cellular Component	mitochondrial large ribosomal subunit	45	3.754723e-17	1.441813632e-15	3.544049	64	0.006669446	60	0.000143706096	1.846422	35	51	0.005015045	
GO Cellular Component	large ribosomal subunit	49	3.694898e-16	1.3030170906122449e-14	2.332928	118	0.01229679	57	0.00004096897010526316	1.590904	68	115	0.009743516	
GO Cellular Component	spliceosomal snRNP complex	55	4.240223e-13	1.3322009716363637e-11	2.676201	72	0.007503126	55	0.00003090125533090909	1.822597	42	62	0.006018054	
GO Cellular Component	ESCRT III complex	59	5.738518e-12	1.680704932881356e-10	4.997989	29	0.003022093	77	0.0033053789922077924	2.466292	11	12	0.001576157	
GO Cellular Component	ESCRT complex	66	8.259044e-11	2.1623678836363636e-9	3.284326	42	0.004376824	86	0.004847678958139535	1.921786	20	28	0.00286574	
GO Cellular Component	small nuclear ribonucleoprotein complex	77	1.15772e-9	2.598104103896104e-8	2.228964	72	0.007503126	68	0.0013557179011764707	1.637696	42	69	0.006018054	
GO Cellular Component	zona pellucida receptor complex	78	1.180462e-9	2.615177353846154e-8	9.070046	14	0.001458941	129	0.02933726065116279	2.391556	8	9	0.001146296	
GO Cellular Component	spliceosomal tri-snRNP complex	98	1.214024e-8	2.1406464e-7	2.98498	37	0.003855773	123	0.025361813853658537	1.762741	19	29	0.002722453	
GO Cellular Component	mitochondrial intermembrane space	99	1.555531e-8	2.7151086545454545e-7	2.041375	76	0.007919967	143	0.04728951138461539	1.414237	41	78	0.005874767	
GO Cellular Component	DNA-directed RNA polymerase I complex	101	2.922023e-8	4.999263112871287e-7	3.960927	24	0.002501042	127	0.02659956661417323	2.113964	11	14	0.001576157	
GO Cellular Component	Fanconi anaemia nuclear complex	157	0.000005134785	0.000056515340636942674	2.571605	30	0.003126303	146	0.04962533128767123	2.069615	10	13	0.00143287	
GO Cellular Component	mitochondrial nucleoid	175	0.00001315977	0.0001299433289142857	2.067908	43	0.004481034	91	0.006182373837362636	1.729607	27	42	0.003868749	
GO Cellular Component	pore complex	182	0.00001569223	0.00014898996395604398	2.421673	30	0.003126303	133	0.03501206039097744	1.943139	13	18	0.001862731	
GO Cellular Component	retromer complex	200	0.00006167796	0.0005328975744000001	2.177371	32	0.003334723	119	0.02178290662184874	1.921786	15	21	0.002149305	
GO Cellular Component	mRNA cleavage factor complex	220	0.0001222171	0.0009599597672727272	2.346772	25	0.002605252	135	0.0375508224	1.88335	14	20	0.002006018	
GO Cellular Component	U2 snRNP	229	0.0001499735	0.0011316777641921397	2.603372	20	0.002084202	117	0.019753063384615386	1.982474	14	19	0.002006018	
GO Cellular Component	prespliceosome	243	0.000210103	0.0014940657777777779	2.410123	22	0.002292622	119	0.02178290662184874	1.921786	15	21	0.002149305	
GO Molecular Function	ribonucleoprotein complex binding	12	4.744075e-19	1.669123720833333e-16	2.320484	143	0.01490204	42	0.00033482390057142856	1.567509	67	115	0.009600229	
GO Molecular Function	structural constituent of ribosome	13	1.408269e-16	4.5736243984615386e-14	2.066216	159	0.0165694	19	0.000026775435136842106	1.544546	93	162	0.01332569	
GO Molecular Function	snRNA binding	24	1.265231e-11	2.2257522008333336e-9	3.321174	45	0.004689454	100	0.04264177780000001	1.699263	24	38	0.003438888	
GO Molecular Function	endoribonuclease activity	51	8.111077e-9	6.714699430196078e-7	2.205618	66	0.006877866	40	0.0003189514122	1.825696	38	56	0.005444906	
GO Molecular Function	snRNP binding	111	0.000001180569	0.000044904165027027026	6.770892	11	0.001146311	97	0.042569054938144335	2.6905	7	7	0.001003009	
GO Molecular Function	aminoacyl-tRNA editing activity	114	0.000001249687	0.000046282267666666665	3.532198	21	0.002188412	85	0.031425379148235295	2.276577	11	13	0.001576157	
GO Molecular Function	endoribonuclease activity, producing 3'-phosphomonoesters	317	0.0006570765	0.008751346949526813	3.319896	11	0.001146311	78	0.019763138697435897	2.445909	10	11	0.00143287	
Human Phenotype	Exercise intolerance	6	4.028393e-15	4.480244414833334e-12	2.688558	84	0.008753647	116	0.012534971633620691	1.575864	41	70	0.005874767	
Human Phenotype	Increased serum lactate	13	6.896689e-14	3.5401235151538465e-11	2.198491	113	0.01177574	29	0.000010373254434137932	1.72192	64	100	0.009170368	
Human Phenotype	Increased CSF lactate	16	3.106743e-13	1.2957060024375e-10	2.739431	70	0.007294706	75	0.0009639584469333332	1.762741	38	58	0.005444906	
Human Phenotype	Abnormal CSF metabolite level	18	5.234071e-13	1.940386432388889e-10	2.622623	74	0.007711546	66	0.0006371015407121212	1.75096	41	63	0.005874767	
Human Phenotype	Abnormality of mitochondrial metabolism	63	5.054195e-10	5.353435434126985e-8	2.111414	85	0.008857857	11	0.0000015798928070000002	1.949638	50	69	0.00716435	
Human Phenotype	Abnormality of the mitochondrion	66	6.819276e-10	6.894701325454545e-8	2.087331	86	0.008962068	12	0.0000016603864255833334	1.932613	51	71	0.007307637	
Human Phenotype	Progressive macrocephaly	67	1.408562e-9	1.402885705373134e-7	3.311684	36	0.003751563	106	0.011530068955660376	2.017875	18	24	0.002579166	
Human Phenotype	Leukodystrophy	83	1.117764e-8	8.986553219277109e-7	2.21712	64	0.006669446	71	0.0008760408385915493	1.82954	34	50	0.004871758	
Human Phenotype	Acute encephalopathy	106	6.793786e-8	0.0000042768805639622646	2.697897	39	0.004064193	80	0.0027266570323749998	2.129979	19	24	0.002722453	
Human Phenotype	Abnormal mitochondria in muscle tissue	126	2.461158e-7	0.0000130343709	2.936576	31	0.003230513	128	0.019512988495312498	1.98863	17	23	0.002435879	
Human Phenotype	Telangiectasia	146	0.000001331279	0.00006084674497945205	2.0902	52	0.005418925	123	0.017551281198373986	1.748825	26	40	0.003725462	
Human Phenotype	Acute necrotizing encephalopathy	149	0.000001792323	0.0000802696065704698	2.832232	28	0.002917882	144	0.030276744868055556	2.017875	15	20	0.002149305	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	292	0.0002209527	0.005049374544863014	2.460055	21	0.002188412	150	0.03990586570266666	2.1524	12	15	0.001719444	
Mouse Phenotype Single KO	decreased fibroblast proliferation	25	7.717123e-17	2.8266278124400004e-14	2.034562	168	0.01750729	30	0.000013844370625333334	1.707433	66	104	0.009456942	
Mouse Phenotype Single KO	abnormal osteoblast differentiation	26	1.19943e-16	4.224300196153847e-14	2.287758	127	0.01323468	132	0.03862297038106061	1.674089	28	45	0.004012036	
Mouse Phenotype Single KO	decreased bone ossification	127	2.196846e-8	0.00000158397786	2.118848	68	0.007086286	124	0.03473182160967742	1.893315	19	27	0.002722453	
Mouse Phenotype	decreased fibroblast proliferation	25	4.533705e-20	1.7338701402e-17	2.06176	197	0.02052939	32	0.0000041099063990624994	1.655692	80	130	0.01146296	
Mouse Phenotype	decreased sensitivity to induced cell death	33	3.370341e-16	9.764797060909091e-14	2.034335	161	0.01677782	115	0.002735232496173913	1.562226	54	93	0.007737498	
Mouse Phenotype	absent somites	48	4.404966e-14	8.77414165125e-12	2.312635	103	0.01073364	130	0.004325620715769231	1.757061	32	49	0.004585184	
Mouse Phenotype	abnormal cellular replicative senescence	57	2.898256e-12	4.861443090526316e-10	2.068165	113	0.01177574	178	0.01859398571797753	1.505399	47	84	0.006734489	
Mouse Phenotype	increased cellular sensitivity to oxidative stress	112	3.220528e-10	2.749238232857143e-8	2.382165	67	0.006982076	217	0.03921390396912442	1.62551	29	48	0.004155323