# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	liver regeneration	14	3.306824e-19	3.1081783582857146e-16	4.396543	56	0.01260693	212	0.0029465893497169814	2.508897	18	35	0.004676539	
GO Biological Process	protein targeting to ER	16	8.686117e-19	7.143788350187499e-16	3.44964	73	0.01643404	86	0.000006261134826279069	2.173549	45	101	0.01169135	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	21	2.304711e-17	1.4441758118571428e-14	3.1479	76	0.01710941	78	0.0000029059323369230774	2.183669	47	105	0.01221096	
GO Biological Process	translational elongation	22	5.517311e-17	3.3001043385909095e-14	3.124048	75	0.01688429	261	0.00671116058467433	1.742289	40	112	0.01039231	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	23	2.176133e-16	1.2450319194347826e-13	3.402235	64	0.01440792	89	0.000007227483166404494	2.2271	42	92	0.01091193	
GO Biological Process	cotranslational protein targeting to membrane	25	3.823249e-16	2.01240534364e-13	3.285955	66	0.01485817	88	0.000006524653886136365	2.190307	44	98	0.01143154	
GO Biological Process	protein localization to endoplasmic reticulum	28	5.330914e-16	2.5053391902142857e-13	2.82348	82	0.01846015	98	0.000017169581221428572	2.006443	51	124	0.01325019	
GO Biological Process	multi-organism metabolic process	31	1.72392e-15	7.317762348387096e-13	2.599431	91	0.02048627	106	0.00003304537736603773	1.891628	57	147	0.01480904	
GO Biological Process	mitochondrial translational termination	32	1.839941e-15	7.566182380937499e-13	3.490204	58	0.01305718	454	0.04809469577092511	1.68221	30	87	0.007794232	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	38	2.100496e-14	7.273796543157894e-12	2.897366	70	0.01575867	145	0.00027920775275172414	1.901753	46	118	0.01195116	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	39	2.104206e-14	7.0998068600000005e-12	2.300584	106	0.02386312	157	0.0003839327672547771	1.762522	56	155	0.01454923	
GO Biological Process	negative regulation of endoplasmic reticulum unfolded protein response	43	3.452468e-14	1.0565354979534884e-11	7.871722	24	0.005402972	327	0.014792659668807337	3.794319	7	9	0.001818654	
GO Biological Process	rRNA metabolic process	44	4.93541e-14	1.4760240952272728e-11	2.105717	125	0.02814048	130	0.00010499363653846154	1.619858	86	259	0.02234347	
GO Biological Process	rRNA processing	45	6.015962e-14	1.7592009768444444e-11	2.121611	122	0.02746511	139	0.0002163500537410072	1.606778	83	252	0.02156404	
GO Biological Process	endoplasmic reticulum unfolded protein response	51	2.933742e-13	7.569629603529412e-11	2.608111	76	0.01710941	400	0.02994956489425	1.626137	38	114	0.009872694	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	52	4.937209e-13	1.249398715980769e-10	2.542953	78	0.01755966	440	0.04548157132727272	1.597355	37	113	0.009612886	
GO Biological Process	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	56	9.254317e-13	2.1745992393392856e-10	3.798134	42	0.0094552	253	0.006152285003162055	2.517889	16	31	0.004156924	
GO Biological Process	macromolecular complex disassembly	61	2.130404e-12	4.5957354485245907e-10	2.095159	110	0.02476362	255	0.006580129567843137	1.558026	61	191	0.01584827	
GO Biological Process	protein complex disassembly	65	4.720445e-12	9.556359346923076e-10	2.203437	95	0.02138676	331	0.015456732347734137	1.564773	51	159	0.01325019	
GO Biological Process	regulation of DNA-templated transcription in response to stress	66	4.791463e-12	9.553160851060607e-10	2.363361	82	0.01846015	362	0.02040842032790055	1.639802	40	119	0.01039231	
GO Cellular Component	ribosomal subunit	26	8.658006e-19	5.754243987692308e-17	2.704907	105	0.023638	31	0.000028147548077419353	1.766776	67	185	0.01740712	
GO Cellular Component	ribosome	28	4.432946e-18	2.73576096e-16	2.353664	130	0.0292661	33	0.00005073986618181818	1.653698	80	236	0.02078462	
GO Cellular Component	large ribosomal subunit	35	1.083578e-12	5.349779382857142e-11	2.776159	65	0.01463305	55	0.007960415301818182	1.696838	40	115	0.01039231	
GO Cellular Component	spliceosomal complex	37	3.61154e-12	1.6866867891891892e-10	2.076441	110	0.02476362	53	0.001777502635471698	1.599909	61	186	0.01584827	
GO Cellular Component	PRC1 complex	38	2.602293e-11	1.1833585010526315e-9	8.926897	17	0.003827105	66	0.018059016436363637	3.252273	8	12	0.002078462	
GO Cellular Component	catalytic step 2 spliceosome	42	1.870391e-10	7.695322971428572e-9	2.509502	62	0.01395768	78	0.049170417230769224	1.626137	32	96	0.008313848	
GO Cellular Component	methyltransferase complex	48	2.041773e-9	7.3503828e-8	2.373153	61	0.01373255	74	0.0408706092972973	1.661876	31	91	0.00805404	
GO Cellular Component	PcG protein complex	53	1.517137e-8	4.946439124528302e-7	2.560134	47	0.01058082	58	0.010462327944827586	2.121048	20	46	0.005196155	
GO Cellular Component	signal recognition particle, endoplasmic reticulum targeting	54	2.341276e-8	7.4920832e-7	10.1019	11	0.002476362	60	0.01229344992	4.181494	6	7	0.001558846	
GO Cellular Component	nuclear ubiquitin ligase complex	59	6.52282e-8	0.000001910412366101695	3.356835	28	0.006303467	72	0.031341504	2.073324	17	40	0.004416732	
GO Cellular Component	small ribosomal subunit	60	7.99377e-8	0.00000230220576	2.601123	41	0.009230077	57	0.007930392252631579	1.897159	28	72	0.007274617	
GO Cellular Component	mitochondrial intermembrane space	76	0.000001844005	0.00004192685052631579	2.32103	40	0.009004953	71	0.028375341971830986	1.751224	28	78	0.007274617	
GO Cellular Component	cytosolic small ribosomal subunit	92	0.00002034819	0.00038219209043478255	2.520675	27	0.006078343	73	0.03816231189041096	1.995713	18	44	0.004676539	
GO Cellular Component	U2-type spliceosomal complex	97	0.00002487644	0.00044315967340206186	2.490796	27	0.006078343	70	0.024886631314285715	2.168182	16	36	0.004156924	
GO Cellular Component	transcription factor AP-1 complex	118	0.0001071205	0.0015686798644067796	5.706169	8	0.001800991	59	0.010577981288135592	4.87841	5	5	0.001299039	
GO Molecular Function	structural constituent of ribosome	4	9.012002e-17	9.512168111e-14	2.666943	95	0.02138676	21	0.0019213342898095236	1.716478	57	162	0.01480904	
GO Molecular Function	RNA polymerase II core promoter sequence-specific DNA binding	20	6.303017e-9	0.0000013305668887	2.118817	73	0.01643404	41	0.024271485087804877	2.018652	24	58	0.006235386	
GO Molecular Function	protein transporter activity	21	8.470338e-9	0.0000017029412874285711	2.229543	64	0.01440792	53	0.03894207903018868	1.72777	34	96	0.008833463	
GO Molecular Function	ubiquitin-protein transferase regulator activity	139	0.0003574296	0.010856602670503597	2.428676	20	0.004502476	55	0.04632175744	2.869653	10	17	0.002598077	
Human Phenotype	Abnormal CNS myelination	6	5.179615e-10	5.760595149166666e-7	2.211402	76	0.01710941	5	0.010239913351599999	1.834282	47	125	0.01221096	
Mouse Phenotype Single KO	kinked neural tube	52	3.710509e-8	0.000006534063637115385	2.273276	56	0.01260693	61	0.031152564344262293	2.104412	22	51	0.00571577	
Mouse Phenotype Single KO	abnormal cervical atlas morphology	93	0.000001799722	0.00017720488552688173	2.098702	50	0.01125619	62	0.036245089706451614	2.168182	20	45	0.005196155	
Mouse Phenotype Single KO	abnormal paraxial mesoderm morphology	159	0.00002580529	0.0014861574876100629	2.160268	36	0.008104457	40	0.0108674039805	2.508897	18	35	0.004676539	
Mouse Phenotype Single KO	abnormal mitochondrial crista morphology	181	0.00004968927	0.002513837819834254	2.268352	30	0.006753715	53	0.02095097411698113	2.439205	17	34	0.004416732	
Mouse Phenotype Single KO	abnormal mitochondrial inner membrane morphology	185	0.00005637706	0.002790512099567568	2.252017	30	0.006753715	59	0.029636739142372883	2.369513	17	35	0.004416732	
Mouse Phenotype	abnormal amino acid metabolism	3	5.381387e-21	1.7150480369e-17	16.08868	24	0.005402972	142	0.02874062859084507	4.181494	6	7	0.001558846	
Mouse Phenotype	abnormal lung endothelial cell proliferation	122	0.00000295826	0.0002318354414754098	4.415102	15	0.003376857	142	0.02874062859084507	4.181494	6	7	0.001558846	
Mouse Phenotype	ruffled hair	123	0.000003092597	0.00024039284485365852	2.638071	30	0.006753715	93	0.004880372355483871	2.508897	18	35	0.004676539	
Mouse Phenotype	early cellular replicative senescence	129	0.000003524653	0.000261234165372093	2.100292	47	0.01058082	95	0.004853688951789474	2.004826	30	73	0.007794232	
Mouse Phenotype	abnormal cellular replicative senescence	134	0.00000424244	0.00030270126	2.016455	51	0.01148131	76	0.0028684673175	1.974595	34	84	0.008833463	
Mouse Phenotype	absent amnion	236	0.0001044296	0.004230726294915254	2.172768	30	0.006753715	150	0.030699937568	2.439205	14	28	0.003637308	
Mouse Phenotype	abnormal lipoprotein lipase activity	442	0.002094972	0.0453168038280543	2.861492	11	0.002476362	198	0.0486447745	3.414887	7	10	0.001818654