# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to epidermal growth factor stimulus	22	3.308172e-74	1.9787379703636365e-71	3.026164	376	0.01318604	625	0.00502906872208	1.384011	35	38	0.002800896	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	23	1.506301e-72	8.618006460434782e-70	4.64589	215	0.007539891	757	0.012858340317173051	1.440031	23	24	0.001840589	
GO Biological Process	response to epidermal growth factor	24	1.685596e-71	9.241982401666666e-69	2.89368	388	0.01360687	653	0.006572845939050537	1.359532	38	42	0.003040973	
GO Biological Process	liver regeneration	28	2.356125e-69	1.1072946026785715e-66	3.497796	286	0.01002981	739	0.011397339320162382	1.373843	32	35	0.002560819	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	35	1.161349e-65	4.366340426e-63	2.437756	480	0.01683325	351	0.00009847277094301994	1.289878	97	113	0.007762484	
GO Biological Process	endoplasmic reticulum unfolded protein response	43	2.826786e-61	8.650622552093023e-59	2.421675	453	0.01588638	313	0.00002633178541884984	1.304925	99	114	0.007922535	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	56	2.719043e-58	6.3892655066071425e-56	2.062373	610	0.02139225	250	0.0000020582249816400002	1.289363	133	155	0.01064341	
GO Biological Process	IRE1-mediated unfolded protein response	58	6.761998e-58	1.5341574427931034e-55	3.229269	265	0.009293354	592	0.00394135611722973	1.321288	51	58	0.004081306	
GO Biological Process	regulation of DNA-templated transcription in response to stress	62	1.235714e-57	2.622703310645161e-55	2.240382	499	0.01749956	305	0.00002304706089836066	1.300605	103	119	0.008242638	
GO Biological Process	cellular response to topologically incorrect protein	66	5.525733e-57	1.1017139476818182e-54	2.20236	512	0.01795546	263	0.000004273831555247149	1.297244	120	139	0.009603073	
GO Biological Process	cellular response to unfolded protein	75	1.59519e-53	2.798814028e-51	2.228176	468	0.01641241	265	0.0000044805098962641515	1.316363	106	121	0.008482714	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	98	3.518318e-47	4.724239445102041e-45	2.220549	414	0.01451867	361	0.00014222983520775624	1.310814	82	94	0.0065621	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	151	8.458976e-39	7.37163345589404e-37	2.932249	202	0.007083991	810	0.017371764498765433	1.437309	22	23	0.001760563	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	179	2.809273e-36	2.0652080115642455e-34	2.160008	335	0.0117482	561	0.002620064799108734	1.235222	97	118	0.007762484	
GO Biological Process	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	198	2.982199e-35	1.981957406111111e-33	2.789276	198	0.006943714	926	0.032767657901727865	1.357224	28	31	0.002240717	
GO Biological Process	regulation of mitochondrial membrane permeability	227	9.12788e-33	5.29135563524229e-31	2.084909	327	0.01146765	393	0.00028403339878625954	1.337968	65	73	0.005201665	
GO Biological Process	cotranslational protein targeting to membrane	239	5.961469e-31	3.2823000238912133e-29	2.171605	280	0.009819393	741	0.01202547912280702	1.226646	80	98	0.006402049	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	267	8.223479e-29	4.052912365580524e-27	2.141308	268	0.009398562	646	0.00639211054380805	1.284867	59	69	0.004721511	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	277	1.831027e-28	8.698369780866425e-27	2.081067	283	0.009924601	750	0.012662498648266667	1.252201	65	78	0.005201665	
GO Biological Process	protein targeting to ER	286	6.886666e-28	3.1685887375524477e-26	2.068533	281	0.009854463	774	0.013815989427002583	1.219966	82	101	0.0065621	
GO Cellular Component	cleavage furrow	57	2.06377e-28	6.256481684210525e-27	2.159378	259	0.009082939	175	0.02847833856	1.271465	44	52	0.003521127	
GO Cellular Component	mitochondrial ribosome	89	3.714737e-20	7.2124331865168535e-19	2.104499	190	0.00666316	110	0.0020687238981818186	1.272825	72	85	0.005761844	
GO Cellular Component	DNA-directed RNA polymerase III complex	119	1.583421e-15	2.299286964705882e-14	3.612914	56	0.001963879	184	0.04308381078260869	1.423554	18	19	0.001440461	
GO Cellular Component	mitochondrial large ribosomal subunit	141	1.109543e-12	1.3597803574468085e-11	2.10579	113	0.003962827	126	0.004970345142857143	1.32586	45	51	0.003601152	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	33	1.353884e-20	1.732150984242424e-18	2.419364	144	0.005049974	90	0.005384349437777778	1.450826	28	29	0.002240717	
GO Molecular Function	RNA polymerase III activity	73	2.191868e-14	1.2676803693150685e-12	3.580451	52	0.001823602	127	0.04904960028346456	1.502641	16	16	0.00128041	
Human Phenotype	Increased mean platelet volume	329	5.079574e-10	1.030273474224924e-8	2.27742	72	0.002524987	227	0.02885192663480176	1.502641	17	17	0.001360435	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	51	4.665446e-46	8.376762553333333e-44	2.179194	421	0.01476416	321	0.02065022170155763	1.304179	46	53	0.003681178	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	62	1.977277e-42	2.920310562741936e-40	2.052593	445	0.01560582	151	0.0003120350235629139	1.308752	81	93	0.006482074	
Mouse Phenotype Single KO	absent hypoglossal nerve	88	1.75359e-37	1.8247299579545453e-35	4.469088	113	0.003962827	417	0.04870437017985611	1.502641	15	15	0.001200384	
Mouse Phenotype Single KO	renal glomerulus hypertrophy	115	1.45715e-32	1.1602715260869566e-30	2.703198	192	0.006733298	276	0.009583619985144927	1.502641	20	20	0.001600512	
Mouse Phenotype Single KO	cardia bifida	518	2.65913e-13	4.700705291505791e-12	2.289453	99	0.003471857	367	0.036813585193460494	1.502641	16	16	0.00128041	
Mouse Phenotype	thick epidermis	56	4.453227e-57	7.603089883392858e-55	2.009014	637	0.02233912	674	0.04010338753264095	1.181564	92	117	0.007362356	
Mouse Phenotype	decreased circulating free fatty acid level	72	2.804846e-52	3.724601750833333e-50	2.006589	584	0.02048045	193	0.00008355709625906737	1.287978	102	119	0.008162612	
Mouse Phenotype	absent hypoglossal nerve	147	1.75359e-37	1.1405492510204082e-35	4.469088	113	0.003962827	630	0.033659955785714284	1.502641	15	15	0.001200384	
Mouse Phenotype	renal glomerulus hypertrophy	231	1.165645e-29	4.8245592402597405e-28	2.170324	268	0.009398562	738	0.04846119811788618	1.32586	30	34	0.002400768	
Mouse Phenotype	increased renal glomerulus basement membrane thickness	319	7.819569e-24	2.34366455200627e-22	2.032566	248	0.008697177	690	0.04369805166521739	1.309995	34	39	0.002720871	
Mouse Phenotype	ruffled hair	403	8.112462e-20	1.9246463816873446e-18	2.232842	163	0.00571629	479	0.012775939144885177	1.373843	32	35	0.002560819	
Mouse Phenotype	mammary gland hyperplasia	785	9.907487e-12	1.2066940535923567e-10	2.0086	116	0.004068034	699	0.04373061883261803	1.427509	19	20	0.001520487