# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	29	3.086072e-47	1.4003317740689655e-44	2.216959	416	0.01454342	351	0.000012996563204558403	1.306397	100	114	0.007931472	
GO Biological Process	cellular response to topologically incorrect protein	37	1.112931e-44	3.958124061891892e-42	2.041136	476	0.01664103	270	7.948421022592593e-7	1.307149	122	139	0.009676396	
GO Biological Process	cellular response to unfolded protein	44	8.178492e-41	2.4459267324545454e-38	2.045632	431	0.01506782	298	0.0000021979963434899327	1.316978	107	121	0.008486675	
GO Biological Process	regulation of mitochondrial membrane permeability	55	1.379977e-39	3.3016576987272727e-37	2.211898	348	0.01216613	661	0.0032200929031770045	1.28528	63	73	0.004996827	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	74	2.34193e-34	4.1645211986486486e-32	2.010455	376	0.01314501	825	0.016521260077575758	1.219952	77	94	0.006107234	
GO Biological Process	cytoplasmic sequestering of protein	77	1.245418e-33	2.1283708392207795e-31	3.283145	147	0.005139141	835	0.016755110431137726	1.336545	35	39	0.002776015	
GO Biological Process	regulation of membrane permeability	79	2.404042e-33	4.004403630126582e-31	2.017874	361	0.01262061	588	0.0014171916262925171	1.287043	70	81	0.00555203	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	98	1.749809e-30	2.349564962346939e-28	2.044016	318	0.01111733	904	0.0266394493329646	1.186386	94	118	0.007455584	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	113	2.754162e-29	3.2072582086725665e-27	2.150576	270	0.009439239	651	0.0029293369159754225	1.295037	60	69	0.004758883	
GO Biological Process	cellular response to arsenic-containing substance	143	2.959985e-26	2.7238071758741256e-24	3.392506	108	0.003775696	953	0.03501393114795383	1.489293	15	15	0.001189721	
GO Biological Process	IRE1-mediated unfolded protein response	155	4.200941e-25	3.566463394774194e-23	2.332417	192	0.006712348	591	0.0014405166206260575	1.335228	52	58	0.004124365	
GO Biological Process	negative regulation of Notch signaling pathway	159	1.228968e-24	1.0171062837735849e-22	2.333454	188	0.006572507	703	0.005211145567994311	1.399032	31	33	0.002458756	
GO Biological Process	regulation of viral transcription	176	2.288644e-23	1.7111514997727275e-21	2.045418	239	0.008355475	850	0.01867875154588235	1.260171	55	65	0.00436231	
GO Biological Process	positive regulation of mitochondrial membrane permeability	201	1.043428e-21	6.831079130348259e-20	2.647346	129	0.004509859	719	0.006320359209040334	1.489293	20	20	0.001586294	
GO Biological Process	maintenance of protein localization in organelle	210	1.840113e-21	1.1530498555714288e-19	2.78263	117	0.004090337	755	0.009570816080397351	1.393209	29	31	0.002300127	
GO Biological Process	mitochondrial outer membrane permeabilization involved in programmed cell death	244	7.599526e-20	4.098449288278688e-18	2.634443	118	0.004125297	787	0.012819621531385007	1.489293	18	18	0.001427665	
GO Biological Process	positive regulation of membrane permeability	245	7.796038e-20	4.187267920081632e-18	2.497568	130	0.004544819	905	0.026645942636464085	1.421597	21	22	0.001665609	
GO Biological Process	platelet morphogenesis	254	2.186112e-19	1.1325609373228348e-17	2.584777	119	0.004160257	1029	0.047698420938775514	1.414828	19	20	0.00150698	
GO Biological Process	positive regulation of nuclease activity	279	1.323855e-17	6.243945499999999e-16	3.01216	83	0.002901692	953	0.03501393114795383	1.489293	15	15	0.001189721	
GO Biological Process	regulation of mitophagy	303	2.000438e-16	8.687710772937294e-15	2.022987	167	0.005838344	613	0.0019431865246818923	1.362544	43	47	0.003410533	
GO Cellular Component	PcG protein complex	31	8.945085e-36	4.9861635096774195e-34	2.34313	277	0.00968396	106	0.00004783333856603774	1.424541	44	46	0.003489848	
GO Cellular Component	cytoplasmic stress granule	50	3.961371e-24	1.3690498176000001e-22	2.226846	203	0.00709691	214	0.0348762966728972	1.281484	37	43	0.002934645	
GO Cellular Component	nuclear transcriptional repressor complex	54	2.543608e-21	8.139545599999999e-20	2.311352	164	0.005733464	221	0.04048184036199095	1.335228	26	29	0.002062183	
GO Cellular Component	mitochondrial small ribosomal subunit	177	4.20024e-9	4.100573288135593e-8	2.17464	71	0.00248217	157	0.0023020338955414012	1.436103	27	28	0.002141497	
GO Cellular Component	ESCRT complex	191	2.024015e-8	1.8311507434554975e-7	2.019999	77	0.002691931	157	0.0023020338955414012	1.436103	27	28	0.002141497	
GO Molecular Function	protein deacetylase activity	30	6.153986e-20	8.660709630666667e-18	2.018338	208	0.00727171	83	0.00021327524561445783	1.423102	43	45	0.003410533	
GO Molecular Function	histone deacetylase activity	31	1.599253e-19	2.1780794083870968e-17	2.011612	205	0.00716683	85	0.0002973021137882353	1.421597	42	44	0.003331218	
GO Molecular Function	DNA polymerase binding	136	5.509486e-10	1.7103713155882352e-8	2.944394	45	0.001573207	155	0.04636042006451613	1.489293	16	16	0.001269036	
GO Molecular Function	NAD-dependent protein deacetylase activity	171	8.553262e-9	2.1118053897076022e-7	2.022013	81	0.002831772	147	0.032809564095238095	1.489293	17	17	0.00134835	
GO Molecular Function	NAD-dependent histone deacetylase activity	187	2.247284e-8	5.073814464171123e-7	2.004504	78	0.002726891	155	0.04636042006451613	1.489293	16	16	0.001269036	
Mouse Phenotype Single KO	abnormal embryonic erythropoiesis	2	1.890843e-56	8.6572246755e-53	3.162874	266	0.009299399	294	0.03348185413605442	1.386583	27	29	0.002141497	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	3	9.444575e-56	2.8827991091666667e-52	2.987207	286	0.009998602	204	0.006293076430392157	1.40419	33	35	0.002617386	
Mouse Phenotype Single KO	decreased circulating total protein level	15	2.016283e-49	1.2308735620666665e-46	2.514362	338	0.01181653	189	0.0031345433289417983	1.335228	52	58	0.004124365	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	40	3.231906e-37	7.3986408105e-35	2.03825	395	0.01380926	147	0.0008235058289795919	1.376893	49	53	0.003886421	
Mouse Phenotype Single KO	abnormal transitional stage T2 B cell morphology	67	3.296552e-28	4.505451740895522e-26	3.28305	122	0.004265138	328	0.04751603592987805	1.489293	16	16	0.001269036	
Mouse Phenotype Single KO	decreased transitional stage B cell number	178	6.438769e-17	3.312348749044943e-15	2.09154	159	0.005558663	280	0.026531691291785713	1.361639	32	35	0.002538071	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	17	2.444559e-52	1.374848741117647e-49	2.750289	306	0.0106978	271	0.0012326263466789667	1.412919	37	39	0.002934645	
Mouse Phenotype	abnormal embryonic erythropoiesis	20	1.545608e-49	7.388779044e-47	2.847418	273	0.00954412	424	0.01238256159268868	1.393209	29	31	0.002300127	
Mouse Phenotype	decreased circulating total protein level	21	6.537238e-49	2.976311072285714e-46	2.496037	339	0.01185149	280	0.0016414973582142857	1.337839	53	59	0.00420368	
Mouse Phenotype	decreased transitional stage T1 B cell number	31	1.333118e-43	4.1115939348387095e-41	4.245627	140	0.00489442	510	0.021415721394117647	1.489293	17	17	0.00134835	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	65	1.389282e-31	2.043526954153846e-29	2.58599	201	0.007026989	335	0.00413887984119403	1.437938	28	29	0.002220812	
Mouse Phenotype	absent spleen germinal center	76	1.943691e-29	2.4452144277631582e-27	3.095096	139	0.00485946	507	0.02097162919526627	1.357884	31	34	0.002458756	
Mouse Phenotype	abnormal transitional stage T1 B cell morphology	91	5.382608e-27	5.655287372307693e-25	2.522824	178	0.006222906	579	0.0344550698238342	1.378975	25	27	0.001982868	
Mouse Phenotype	decreased transitional stage T2 B cell number	97	7.185275e-26	7.08231075e-24	2.507649	172	0.006013145	409	0.01013495688190709	1.432012	25	26	0.001982868	
Mouse Phenotype	pancytopenia	156	5.353549e-20	3.2811078198076927e-18	2.249442	162	0.005663544	335	0.00413887984119403	1.437938	28	29	0.002220812	
Mouse Phenotype	abnormal B-2 B cell morphology	182	4.818368e-18	2.531231672967033e-16	2.212706	150	0.005244022	611	0.044158957247135845	1.345167	28	31	0.002220812	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	334	1.120159e-12	3.206538981736527e-11	2.155287	107	0.003740736	463	0.01588163874427646	1.390006	28	30	0.002220812	
Mouse Phenotype	lethality during fetal growth through weaning, incomplete penetrance	535	2.331332e-9	4.16632995364486e-8	2.154289	75	0.002622011	510	0.021415721394117647	1.489293	17	17	0.00134835