# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	response to water	29	4.113063e-32	1.866337793689655e-29	4.859116	88	0.004040219	1208	0.04958164141639073	1.624654	13	14	0.001211331	
GO Biological Process	endoplasmic reticulum unfolded protein response	32	4.553273e-31	1.87239123146875e-28	2.106588	301	0.01381938	723	0.003289657177178423	1.289199	84	114	0.007827059	
GO Biological Process	cytoplasmic sequestering of protein	65	4.49475e-26	9.0994485e-24	3.285033	112	0.005142096	926	0.013157033255291578	1.435592	32	39	0.002981737	
GO Biological Process	negative regulation of Notch signaling pathway	68	6.961811e-26	1.3472128080735295e-23	2.608017	160	0.007345852	706	0.002754154469546742	1.537551	29	33	0.002702199	
GO Biological Process	regulation of pri-miRNA transcription from RNA polymerase II promoter	70	1.943394e-25	3.6533030922857145e-23	2.335381	194	0.008906845	910	0.012009191162747254	1.508299	25	29	0.002329482	
GO Biological Process	cellular response to arsenic-containing substance	85	1.38631e-23	2.1461709752941175e-21	3.630183	88	0.004040219	745	0.0039908155959731545	1.749627	15	15	0.001397689	
GO Biological Process	intrinsic apoptotic signaling pathway in response to DNA damage	99	7.23026e-22	9.610403165656566e-20	2.123421	203	0.00932005	984	0.01700664345731707	1.31856	52	69	0.004845322	
GO Biological Process	adherens junction assembly	116	9.576072e-21	1.0863063055862068e-18	2.204697	176	0.008080437	673	0.0018582926675037147	1.543789	30	34	0.002795378	
GO Biological Process	metanephric tubule morphogenesis	124	3.898536e-20	4.137164130967742e-18	2.955557	99	0.004545246	1160	0.042123932850000004	1.749627	10	10	0.0009317928	
GO Biological Process	negative regulation of stem cell differentiation	134	3.145501e-19	3.08892892977612e-17	2.492939	126	0.005784858	860	0.009350991965697674	1.652426	17	18	0.001584048	
GO Biological Process	cell-substrate junction assembly	146	1.348804e-18	1.2156788928767126e-16	2.12941	169	0.007759056	680	0.002113476665735294	1.493584	35	41	0.003261275	
GO Biological Process	regulation of ceramide biosynthetic process	172	3.734879e-17	2.8573995791279067e-15	4.290484	51	0.00234149	815	0.0063862935879754595	1.749627	14	14	0.00130451	
GO Biological Process	response to arsenic-containing substance	184	1.653005e-16	1.1821680866847826e-14	2.439249	111	0.005096185	714	0.002943819425770308	1.568631	26	29	0.002422661	
GO Biological Process	cellular protein complex localization	194	2.275973e-16	1.5437901395360823e-14	2.384357	115	0.005279831	868	0.009429393748847928	1.547747	23	26	0.002143123	
GO Biological Process	positive regulation of mitochondrial membrane permeability	233	9.214964e-15	5.204279453905579e-13	2.506415	93	0.004269776	1026	0.02169099548245614	1.574665	18	20	0.001677227	
GO Biological Process	mitochondrial outer membrane permeabilization involved in programmed cell death	252	2.537678e-14	1.325131142936508e-12	2.550792	87	0.003994307	1190	0.04690604061680672	1.555224	16	18	0.001490868	
GO Biological Process	epithelial cell apoptotic process	262	5.387356e-14	2.7058098322137404e-12	2.122634	124	0.005693035	631	0.0012442247413153725	1.620025	25	27	0.002329482	
GO Biological Process	positive regulation of membrane permeability	263	6.147514e-14	3.075860712015209e-12	2.396882	95	0.0043616	1155	0.040820824423376624	1.511042	19	22	0.001770406	
GO Biological Process	corpus callosum development	298	3.162558e-13	1.3965134470469798e-11	2.476499	84	0.003856572	1107	0.0329252325627823	1.632985	14	15	0.00130451	
GO Biological Process	regulation of mitophagy	319	7.312986e-13	3.016664036802508e-11	2.020362	127	0.00583077	850	0.008387235428352941	1.414592	38	47	0.003540813	
GO Cellular Component	cleavage furrow	25	2.092358e-29	1.4462378496000001e-27	2.379474	218	0.01000872	113	0.0012994315327433629	1.446807	43	52	0.004006709	
GO Cellular Component	cell division site part	32	1.760658e-24	9.507553199999999e-23	2.112744	232	0.01065149	103	0.0006016998337864078	1.434121	50	61	0.004658964	
GO Cellular Component	cytoplasmic stress granule	43	3.036058e-18	1.2200716799999999e-16	2.204116	153	0.007024471	159	0.02395808966037736	1.383426	34	43	0.003168095	
GO Molecular Function	BH domain binding	73	9.454402e-11	5.468011677260274e-9	3.329385	41	0.001882375	143	0.03578413672727273	1.749627	12	12	0.001118151	
GO Molecular Function	ubiquitin protein ligase activity involved in ERAD pathway	349	0.0001549011	0.0018739038515759312	2.157027	29	0.001331436	135	0.021654053174814815	1.749627	13	13	0.001211331	
Human Phenotype	Aplasia/Hypoplasia involving the femoral head and neck	275	7.013312e-8	0.0000017018120354909088	2.054317	68	0.003121987	43	0.0015175347083023257	1.682334	25	26	0.002329482	
Mouse Phenotype Single KO	absent stapedial artery	50	1.753252e-17	3.2109057128e-15	2.972962	84	0.003856572	595	0.025842239023529414	1.640276	15	16	0.001397689	
Mouse Phenotype Single KO	abnormal stapedial artery morphology	52	2.717303e-17	4.7850660713461535e-15	2.927656	85	0.003902484	539	0.01723588641929499	1.646708	16	17	0.001490868	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	265	3.350145e-9	1.1576331232075474e-7	2.186744	71	0.003259722	539	0.01723588641929499	1.646708	16	17	0.001490868	
Mouse Phenotype	abnormal renal glomerulus basement membrane thickness	22	4.339152e-27	1.8857560123636362e-24	2.242483	226	0.01037602	1052	0.028100006210076047	1.374707	33	42	0.003074916	
Mouse Phenotype	increased renal glomerulus basement membrane thickness	29	6.799879e-26	2.2418497627241378e-23	2.263971	211	0.009687342	803	0.011023863957160648	1.435592	32	39	0.002981737	
Mouse Phenotype	abnormal renal glomerulus basement membrane morphology	38	1.555875e-24	3.9146633881578945e-22	2.018171	260	0.01193701	1068	0.0288334872752809	1.328421	41	54	0.00382035	
Mouse Phenotype	absent stapedial artery	47	8.691883e-22	1.7681509226170214e-19	2.918871	110	0.005050273	688	0.0051018941267441855	1.657542	18	19	0.001677227	
Mouse Phenotype	podocyte foot process effacement	48	1.077281e-21	2.145809091875e-19	2.010238	230	0.01055966	991	0.022053502937436936	1.369274	36	46	0.003354454	
Mouse Phenotype	abnormal stapedial artery morphology	49	1.318426e-21	2.5725450991836736e-19	2.885769	111	0.005096185	638	0.0032969579938871476	1.662146	19	20	0.001770406	
Mouse Phenotype	ruffled hair	68	4.583796e-19	6.444951993529412e-17	2.403094	134	0.006152151	1117	0.03413744350581916	1.399702	28	35	0.00260902	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	94	1.060456e-16	1.078619129361702e-14	2.247147	133	0.006106239	1073	0.029840950263746505	1.447967	24	29	0.002236303	
Mouse Phenotype	dry eyes	117	3.471842e-15	2.8371180651282053e-13	2.428331	102	0.004682981	585	0.0021092922517948714	1.749627	16	16	0.001490868	
Mouse Phenotype	abnormal transitional stage T1 B cell morphology	120	4.707323e-15	3.7505596002500004e-13	2.233558	120	0.005509389	944	0.019408819871822035	1.490423	23	27	0.002143123	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	135	2.445725e-14	1.7321167944444446e-12	2.373879	100	0.004591157	815	0.011386601975705523	1.539672	22	25	0.002049944	
Mouse Phenotype	increased incidence of corneal inflammation	141	4.827462e-14	3.2734300838297873e-12	2.4753	90	0.004132042	1187	0.04411121598652064	1.499681	18	21	0.001677227	
Mouse Phenotype	decreased transitional stage T1 B cell number	225	8.584781e-12	3.6479596062666667e-10	2.628492	66	0.003030164	823	0.011786168821385175	1.646708	16	17	0.001490868	
Mouse Phenotype	abnormal neck morphology	832	0.00001875323	0.0002155043654206731	2.226634	35	0.001606905	1101	0.03224630914986376	1.749627	10	10	0.0009317928