# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	9	2.77612e-48	4.058995897777778e-45	2.319724	384	0.02406166	328	0.000583780580304878	1.331369	105	155	0.01099016	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	10	4.330452e-48	5.6984417868e-45	2.667866	294	0.01842221	461	0.008570622257917571	1.321832	76	113	0.007954783	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	11	2.564712e-46	3.0680950189090912e-43	2.683402	280	0.01754496	515	0.013465011906213591	1.338114	64	94	0.006698765	
GO Biological Process	liver regeneration	14	4.183169e-44	3.931880062214286e-41	3.671178	168	0.01052698	397	0.002874646527581864	1.628437	29	35	0.003035378	
GO Biological Process	regulation of DNA-templated transcription in response to stress	16	3.51063e-43	2.887273760625e-40	2.454769	306	0.01917413	403	0.003381383006699752	1.337763	81	119	0.008478124	
GO Biological Process	endoplasmic reticulum unfolded protein response	20	1.475121e-40	9.7055586195e-38	2.550331	267	0.01673037	583	0.02009695522281304	1.292997	75	114	0.007850115	
GO Biological Process	negative regulation of endoplasmic reticulum unfolded protein response	30	3.152034e-35	1.3825871802e-32	6.664296	73	0.004574221	724	0.04146784401243094	1.965355	9	9	0.0009420138	
GO Biological Process	cellular response to unfolded protein	32	3.395206e-35	1.3961723673125e-32	2.330891	274	0.017169	505	0.012623011781188118	1.299408	80	121	0.008373456	
GO Biological Process	cellular response to topologically incorrect protein	35	1.326691e-33	4.987979105428571e-31	2.221181	289	0.0181089	709	0.03776970790973202	1.244253	88	139	0.009210802	
GO Biological Process	positive regulation of nuclease activity	40	9.794578e-33	3.22217129755e-30	5.333778	82	0.005138167	535	0.015041255981121495	1.834331	14	15	0.001465355	
GO Biological Process	cellular response to epidermal growth factor stimulus	42	1.887541e-32	5.913845718809524e-30	2.717904	189	0.01184285	619	0.025015918012924073	1.499876	29	38	0.003035378	
GO Biological Process	regulation of receptor catabolic process	45	5.643335e-32	1.6502365614444442e-29	5.333025	80	0.005012845	724	0.04146784401243094	1.965355	9	9	0.0009420138	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	50	2.2315e-31	5.8728617e-29	2.638603	192	0.01203083	589	0.020530642756366724	1.548461	26	33	0.002721373	
GO Biological Process	response to epidermal growth factor	53	3.389916e-30	8.416585781886793e-28	2.571839	193	0.01209349	711	0.038007707887482416	1.450619	31	42	0.003244714	
GO Biological Process	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	87	7.90428e-25	1.195545063448276e-22	3.020475	120	0.007519268	534	0.015057481457865167	1.584964	25	31	0.002616705	
GO Biological Process	regulation of cellular response to insulin stimulus	127	2.193254e-21	2.272521998897638e-19	2.042827	217	0.01359734	491	0.011527562724236252	1.408015	48	67	0.005024074	
GO Biological Process	regulation of mitochondrial membrane permeability	135	8.65157e-21	8.433037750370371e-19	2.141731	188	0.01178019	292	0.00022797931447945206	1.507669	56	73	0.005861419	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	159	1.011368e-19	8.370183340880503e-18	2.775243	107	0.006704681	365	0.0016489856552876713	1.794454	21	23	0.002198032	
GO Biological Process	negative regulation of response to endoplasmic reticulum stress	187	1.341834e-18	9.442349521925134e-17	2.464602	124	0.00776991	414	0.0043754088205314005	1.572284	32	40	0.003349382	
GO Biological Process	apoptotic mitochondrial changes	207	1.519274e-17	9.658032157487923e-16	2.102698	163	0.01021367	425	0.005186417046588235	1.465688	44	59	0.004605401	
GO Cellular Component	PcG protein complex	32	2.609354e-30	1.40905116e-28	2.698719	178	0.01115358	66	0.00020118198109090907	1.623554	38	46	0.003977392	
GO Cellular Component	mitochondrial ribosome	46	1.156342e-19	4.343823860869566e-18	2.513429	127	0.007957892	87	0.0033669504	1.387309	60	85	0.006280092	
GO Cellular Component	mitochondrial large ribosomal subunit	50	1.766264e-16	6.104208384e-15	2.83024	85	0.005326148	125	0.04615183872	1.387309	36	51	0.003768055	
GO Cellular Component	cleavage furrow	58	1.898761e-13	5.656998289655172e-12	2.011085	135	0.008459177	117	0.03467229046153846	1.398426	37	52	0.003872723	
GO Cellular Component	signal recognition particle	161	2.969541e-7	0.0000031871843776397514	3.726871	22	0.001378532	106	0.018915715018867924	1.965355	10	10	0.001046682	
GO Molecular Function	unfolded protein binding	17	1.480742e-23	3.677466308235294e-21	2.324689	180	0.0112789	111	0.010324813517117117	1.334958	72	106	0.007536111	
GO Molecular Function	drug transporter activity	25	2.806584e-18	4.7397590592e-16	3.289314	76	0.004762203	129	0.033410780635658915	1.637796	20	24	0.002093364	
GO Molecular Function	GTPase activating protein binding	73	4.187582e-11	2.421913863561644e-9	3.151506	46	0.002882386	132	0.03606649896969697	1.824972	13	14	0.001360687	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase inhibitor activity	78	1.050171e-10	5.684387130769231e-9	3.660543	36	0.00225578	113	0.011211756385840708	1.965355	12	12	0.001256018	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	121	4.104141e-9	1.4320399423140495e-7	2.161419	72	0.004511561	93	0.0033769648840860215	1.694271	25	29	0.002616705	
Human Phenotype	Aplasia/hypoplasia of the femur	46	7.661595e-20	1.1114309442391303e-17	2.786396	107	0.006704681	151	0.040610574334437086	1.548461	26	33	0.002721373	
Human Phenotype	Abnormality of transition element cation homeostasis	54	5.838572e-19	7.214961288148148e-17	3.778044	66	0.004135597	82	0.006053388350365854	1.694271	25	29	0.002616705	
Human Phenotype	Abnormality of iron homeostasis	68	1.514637e-15	1.486348926617647e-13	3.565404	57	0.003571652	158	0.043114379702531645	1.637796	20	24	0.002093364	
Human Phenotype	Renal cell carcinoma	87	6.488946e-14	4.977096167586207e-12	2.289759	104	0.006516699	157	0.043299779401273886	1.6014	22	27	0.0023027	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	297	8.205834e-8	0.0000018436878882828282	2.968303	33	0.002067799	148	0.037738853920270266	1.746982	16	18	0.001674691	
Human Phenotype	Enlarged thorax	300	8.663885e-8	0.0000019271368201666667	2.079692	65	0.004072937	73	0.004181047677534247	1.794454	21	23	0.002198032	
Human Phenotype	Tethered cord	435	0.000001325667	0.000020336036531034484	2.610589	33	0.002067799	126	0.031251523203174605	1.965355	11	11	0.00115135	
Human Phenotype	Blepharospasm	891	0.0005762041	0.004315387159708193	2.187786	23	0.001441193	166	0.04664422980120482	1.965355	10	10	0.001046682	
Mouse Phenotype Single KO	extramedullary hematopoiesis	1	1.593528e-60	1.4591935896e-56	2.668886	372	0.02330973	294	0.014147811055442178	1.310237	76	114	0.007954783	
Mouse Phenotype Single KO	pale liver	62	7.148607e-28	1.0558031338548386e-25	2.316639	217	0.01359734	393	0.04419937108396947	1.326615	54	80	0.005652083	
Mouse Phenotype Single KO	empty decidua capsularis	313	1.551852e-11	4.540034748881789e-10	4.240634	33	0.002067799	404	0.04691686413118812	1.814174	12	13	0.001256018	
Mouse Phenotype	extramedullary hematopoiesis	7	1.367589e-64	1.867931204142857e-61	2.248934	551	0.03452597	210	0.0002845405957857143	1.325211	118	175	0.01235085	
Mouse Phenotype	abnormal inguinal fat pad morphology	122	2.617479e-23	2.051288255655738e-21	2.043207	238	0.01491322	511	0.023017237467710373	1.38189	45	64	0.004710069	
Mouse Phenotype	absent spleen germinal center	149	1.625055e-20	1.0427618023489932e-18	3.35243	84	0.005263488	566	0.03404091007420495	1.502918	26	34	0.002721373	
Mouse Phenotype	abnormal Peyer's patch follicle morphology	489	5.929617e-10	1.1593674465644172e-8	2.186054	78	0.004887524	591	0.03631877697969543	1.521565	24	31	0.002512037	
Mouse Phenotype	abnormal lipoprotein lipase activity	604	2.157305e-8	3.414899520695364e-7	2.823822	39	0.002443762	501	0.022143714928143713	1.965355	10	10	0.001046682	
Mouse Phenotype	abnormal kidney inner medulla morphology	756	6.865868e-7	0.000008683143379365079	2.031013	59	0.003696973	593	0.036785423499156825	1.965355	9	9	0.0009420138	
Mouse Phenotype	decreased macrophage nitric oxide production	1165	0.0002079787	0.0017068535199141629	2.117901	29	0.001817156	501	0.022143714928143713	1.965355	10	10	0.001046682