# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process cellular response to epidermal growth factor stimulus 24 1.989388e-39 1.0907648621666666e-36 3.218607 178 0.01402458 759 0.013314643750461135 1.566895 28 38 0.003171008 GO Biological Process response to epidermal growth factor 31 2.379557e-37 1.0100835665483872e-34 3.049534 182 0.01433974 817 0.018896259574051406 1.518929 30 42 0.003397508 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 45 3.047475e-33 8.911494116666666e-31 2.521649 221 0.01741254 708 0.009393345843644067 1.33612 71 113 0.00804077 GO Biological Process regulation of intrinsic apoptotic signaling pathway 53 1.719318e-31 4.268774634339623e-29 2.164839 285 0.02245509 473 0.000938498210782241 1.344497 98 155 0.01109853 GO Biological Process regulation of DNA-templated transcription in response to stress 63 3.219934e-29 6.725573254920634e-27 2.309938 229 0.01804286 652 0.006271775170398773 1.340231 75 119 0.008493771 GO Biological Process endoplasmic reticulum unfolded protein response 70 4.359844e-28 8.195883885142857e-26 2.41411 201 0.01583675 605 0.003966218301818182 1.361707 73 114 0.008267271 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 75 1.030757e-26 1.808497515066667e-24 2.373939 197 0.01552159 660 0.00706879947090909 1.379963 61 94 0.006908267 GO Biological Process cellular response to topologically incorrect protein 78 1.853151e-26 3.1263607703846153e-24 2.203416 228 0.01796407 408 0.0002718504586495098 1.392169 91 139 0.01030578 GO Biological Process cellular response to unfolded protein 85 1.783135e-25 2.760502760588235e-23 2.246292 210 0.01654586 481 0.001023606875197505 1.388376 79 121 0.008946772 GO Biological Process liver regeneration 89 6.423307e-25 9.497112001460674e-23 3.132396 114 0.008982036 430 0.0004096855734883721 1.761958 29 35 0.003284258 GO Biological Process platelet-derived growth factor receptor signaling pathway 106 9.121891e-24 1.1324053176320755e-21 2.574748 149 0.01173968 399 0.00025206255783709276 1.804304 28 33 0.003171008 GO Biological Process activation of signaling protein activity involved in unfolded protein response 123 5.108584e-22 5.465354215934959e-20 5.639315 51 0.004018279 926 0.033927980437365016 2.126501 8 8 0.0009060023 GO Biological Process regulation of endoplasmic reticulum unfolded protein response 161 8.84415e-19 7.228581978260871e-17 2.967797 91 0.007169871 545 0.002005006890256881 1.849131 20 23 0.002265006 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to hypoxia 183 1.947577e-17 1.400446215464481e-15 2.263411 137 0.0107942 877 0.026179402870011404 1.363141 50 78 0.005662514 GO Biological Process regulation of mitochondrial membrane permeability 196 1.015743e-16 6.819470478061225e-15 2.134366 149 0.01173968 521 0.0016316450272744723 1.485637 51 73 0.005775764 GO Biological Process actin filament bundle organization 287 3.760564e-13 1.7242251455052267e-11 2.026069 129 0.01016388 519 0.0015136795164547205 1.584451 38 51 0.004303511 GO Biological Process negative regulation of cyclin-dependent protein kinase activity 289 4.000591e-13 1.8215839781660897e-11 2.681114 72 0.005672865 425 0.00038493511821176474 1.881135 23 26 0.002604757 GO Biological Process actin filament bundle assembly 303 9.612071e-13 4.174430438580858e-11 2.049108 121 0.009533564 531 0.0018300751625047078 1.594875 36 48 0.00407701 GO Biological Process apoptotic mitochondrial changes 320 1.67837e-12 6.901772134375001e-11 2.011345 124 0.009769934 498 0.001285172413815261 1.549822 43 59 0.004869762 GO Biological Process protein-lipid complex assembly 355 7.248304e-12 2.6867727418591547e-10 2.761473 61 0.004806177 857 0.02312693482263711 1.613207 22 29 0.002491506 GO Cellular Component PcG protein complex 35 1.132694e-21 5.592272091428572e-20 2.573636 135 0.01063662 62 0.00040273910709677415 1.664218 36 46 0.00407701 GO Cellular Component nuclear ubiquitin ligase complex 40 1.319993e-18 5.70236976e-17 3.272767 78 0.006145604 72 0.0019415855999999998 1.648038 31 40 0.003510759 GO Cellular Component cleavage furrow 46 2.85224e-15 1.071450156521739e-13 2.247778 120 0.009454775 76 0.002756862568421053 1.553981 38 52 0.004303511 GO Cellular Component stress fiber 52 2.197462e-14 7.302335261538462e-13 2.042163 140 0.01103057 88 0.0071140405090909095 1.513087 37 52 0.00419026 GO Cellular Component cell division site part 67 1.067756e-12 2.753854280597015e-11 2.000399 128 0.01008509 133 0.03452401082706767 1.394427 40 61 0.004530011 GO Cellular Component cytoplasmic stress granule 85 1.371957e-10 2.789107877647059e-9 2.15085 87 0.006854712 99 0.013157032145454545 1.533059 31 43 0.003510759 GO Cellular Component platelet dense tubular network 160 0.000007082066 0.0000764863128 2.627605 28 0.002206114 143 0.04015486523076923 1.933182 10 11 0.001132503 GO Cellular Component very-low-density lipoprotein particle 185 0.0000295111 0.00027564962594594594 2.267146 32 0.002521273 134 0.03481961265671642 1.7012 16 20 0.001812005 GO Molecular Function GTPase activating protein binding 63 7.428506e-9 4.978278147936507e-7 3.101261 36 0.002836432 104 0.01753702695 1.974608 13 14 0.001472254 Human Phenotype Somatic mutation 19 1.930803e-18 6.781183378421052e-16 2.039732 185 0.01457611 78 0.03061899205897436 1.417667 52 78 0.005889015 Mouse Phenotype Single KO decreased fatty acid level 50 2.383271e-24 4.3647225093999995e-22 2.056016 245 0.0193035 256 0.0018813532234765624 1.382225 78 120 0.008833522 Mouse Phenotype Single KO decreased circulating free fatty acid level 55 7.192007e-24 1.1974037836181819e-21 2.176233 210 0.01654586 280 0.0033007060571428573 1.417667 62 93 0.007021518 Mouse Phenotype Single KO decreased percent body fat/body weight 69 6.895705e-21 9.151300099275364e-19 2.063278 206 0.0162307 230 0.0011186290732608695 1.502727 53 75 0.006002265 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 74 4.840007e-20 5.989181635e-18 2.128179 183 0.01441853 272 0.0025778082792279416 1.564783 39 53 0.004416761 Mouse Phenotype Single KO expanded mesangial matrix 85 2.011931e-18 2.1674414314117645e-16 2.429603 126 0.009927513 552 0.049890388333333334 1.518929 25 35 0.002831257 Mouse Phenotype Single KO decreased circulating total protein level 114 3.904168e-16 3.13600582245614e-14 2.213002 132 0.01040025 375 0.014545296242666666 1.466552 40 58 0.004530011 Mouse Phenotype Single KO abnormal hair texture 133 7.899273e-15 5.438619763984962e-13 2.058858 142 0.01118815 517 0.03826389716441006 1.417667 38 57 0.004303511 Mouse Phenotype Single KO scoliosis 139 1.145089e-14 7.54358271438849e-13 2.147069 127 0.0100063 325 0.007628009220615384 1.640443 27 35 0.003057758 Mouse Phenotype Single KO abnormal fourth pharyngeal arch artery morphology 271 7.863973e-11 2.657210360184502e-9 2.165101 88 0.006933501 423 0.021120880273049647 1.860688 14 16 0.001585504 Mouse Phenotype Single KO decreased creatinine clearance 334 1.133415e-9 3.1073895673652695e-8 3.050908 41 0.003230381 365 0.012940955890684933 1.876324 15 17 0.001698754 Mouse Phenotype Single KO abnormal B-2 B cell morphology 430 2.902407e-8 6.180776953255815e-7 2.454143 49 0.0038607 471 0.030096142757961783 1.721453 17 21 0.001925255 Mouse Phenotype Single KO abnormal Peyer's patch follicle morphology 435 3.069272e-8 6.460993954942529e-7 2.353928 53 0.004175859 224 0.0009619015617410714 1.87132 22 25 0.002491506 Mouse Phenotype Single KO abnormal jejunum morphology 478 9.89658e-8 0.0000018958783066945609 2.517787 43 0.003387961 496 0.03381807485685484 1.842967 13 15 0.001472254 Mouse Phenotype Single KO abnormal Peyer's patch germinal center morphology 592 0.000001827455 0.00002826690107263513 2.385578 38 0.002994012 283 0.003500992897879859 1.993594 15 16 0.001698754 Mouse Phenotype extramedullary hematopoiesis 14 2.138882e-46 1.4607036287142856e-43 2.170906 423 0.03332808 458 0.0023749440497816596 1.300203 107 175 0.01211778 Mouse Phenotype abnormal sebaceous lipid secretion 24 4.226239e-37 1.6836279616249998e-34 8.351958 65 0.005121336 869 0.03656065887341772 1.933182 10 11 0.001132503 Mouse Phenotype dry eyes 55 2.135217e-27 3.7117835885454545e-25 3.881316 95 0.00748503 451 0.002293777178048781 1.993594 15 16 0.001698754 Mouse Phenotype abnormal osteoblast differentiation 66 5.752666e-26 8.333521155454545e-24 2.066988 259 0.02040656 450 0.0022482670253333335 1.491724 47 67 0.005322763 Mouse Phenotype decreased circulating free fatty acid level 73 2.813634e-25 3.685089681369863e-23 2.030228 263 0.02072171 340 0.0004263120545294118 1.41171 79 119 0.008946772 Mouse Phenotype decreased epididymal fat pad weight 127 5.211591e-19 3.9234662638582675e-17 2.213982 158 0.01244879 915 0.042983131695081965 1.371936 40 62 0.004530011 Mouse Phenotype expanded mesangial matrix 143 4.211778e-18 2.8160006613986015e-16 2.199086 152 0.01197605 864 0.03589542445138889 1.432133 33 49 0.003737259 Mouse Phenotype abnormal mesangial matrix morphology 147 6.853795e-18 4.457764217346939e-16 2.167454 155 0.01221242 883 0.03942379275084938 1.417667 34 51 0.00385051 Mouse Phenotype decreased circulating total protein level 173 1.647928e-16 9.107421738728324e-15 2.22358 134 0.01055783 567 0.006698824435978835 1.477738 41 59 0.004643262 Mouse Phenotype abnormal Mullerian duct morphology 220 4.196634e-14 1.8238189851818183e-12 2.001596 144 0.01134573 719 0.018689228449235047 1.498216 31 44 0.003510759 Mouse Phenotype increased cellular sensitivity to oxidative stress 274 9.382635e-13 3.27399172390511e-11 2.365592 88 0.006933501 775 0.023709935291612905 1.461969 33 48 0.003737259 Mouse Phenotype mesangial cell hyperplasia 321 1.265965e-11 3.7706826682242985e-10 2.170685 95 0.00748503 778 0.023659751371465296 1.535806 26 36 0.002944507 Mouse Phenotype abnormal ileum morphology 339 2.664328e-11 7.514348084955753e-10 2.067971 103 0.008115348 835 0.03173018802754491 1.48855 28 40 0.003171008 Mouse Phenotype increased hepatocyte proliferation 420 6.193548e-10 1.4099169625714286e-8 2.072959 88 0.006933501 281 0.00007760306438434164 1.822715 30 35 0.003397508 Mouse Phenotype decreased creatinine clearance 438 1.133415e-9 2.4741052089041096e-8 3.050908 41 0.003230381 599 0.008233462332721202 1.876324 15 17 0.001698754 Mouse Phenotype increased cellular sensitivity to ultraviolet irradiation 456 2.449981e-9 5.136900951973685e-8 2.496782 55 0.004333438 854 0.035188958220140516 1.559434 22 30 0.002491506 Mouse Phenotype abnormal jejunum morphology 500 7.522625e-9 1.4384763525e-7 2.311998 60 0.004727387 582 0.0072746626278350525 1.717558 21 26 0.002378256 Mouse Phenotype lethality during fetal growth through weaning, incomplete penetrance 538 1.795543e-8 3.1909268815985125e-7 2.718871 42 0.003309171 852 0.03502945040492957 1.751236 14 17 0.001585504 Mouse Phenotype abnormal Peyer's patch follicle morphology 560 3.149354e-8 5.376959570357143e-7 2.18491 62 0.004884967 371 0.0006472178498652291 1.783517 26 31 0.002944507 Mouse Phenotype abnormal B-2 B cell morphology 605 1.053914e-7 0.0000016655325213223141 2.094449 63 0.004963757 606 0.008616540438613861 1.646323 24 31 0.002718007