# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	31	3.548973e-18	1.506481797e-15	2.526134	115	0.01373955	328	0.002046476446707317	1.503676	63	118	0.009449528	
GO Biological Process	heterochromatin assembly	42	8.717484e-17	2.731270760857143e-14	5.792487	37	0.00442055	520	0.015396237507307694	2.534768	9	10	0.001349933	
GO Biological Process	heterochromatin organization	43	1.396268e-16	4.272904793488372e-14	4.981044	42	0.005017921	307	0.0014951367244299676	2.599762	12	13	0.00179991	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	69	1.052311e-13	2.006863833188406e-11	2.110847	122	0.01457587	358	0.0034420823332122906	1.495439	60	113	0.00899955	
GO Biological Process	viral gene expression	114	9.276907e-12	1.0708317474824562e-9	2.088892	105	0.0125448	550	0.017757484326363638	1.397116	63	127	0.009449528	
GO Biological Process	cotranslational protein targeting to membrane	116	1.187217e-11	1.346774870948276e-9	2.272318	86	0.01027479	514	0.014566675064591438	1.465682	51	98	0.007649618	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	119	1.500383e-11	1.6591209997478992e-9	2.313403	82	0.009796894	627	0.03209161093939394	1.438818	47	92	0.007049648	
GO Biological Process	regulation of viral transcription	120	1.550427e-11	1.7001724077500002e-9	2.339782	80	0.009557945	464	0.009541369692672412	1.603187	37	65	0.005549723	
GO Biological Process	viral transcription	125	3.03908e-11	3.1993002976e-9	2.103997	98	0.01170848	480	0.010835222033958333	1.445591	58	113	0.008699565	
GO Biological Process	protein targeting to ER	130	6.616382e-11	6.6973054413846154e-9	2.181842	87	0.01039427	617	0.029444488824959484	1.422147	51	101	0.007649618	
GO Biological Process	regulation of cholesterol metabolic process	143	4.060294e-10	3.7363222899300697e-8	2.333428	69	0.008243728	410	0.006148716063658536	1.700473	32	53	0.00479976	
GO Biological Process	translational elongation	151	6.205827e-10	5.408111092251655e-8	2.033749	92	0.01099164	259	0.0006779405024710425	1.559084	62	112	0.009299535	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	156	8.125883e-10	6.85439066647436e-8	2.022313	92	0.01099164	596	0.025104170565436245	1.421616	53	105	0.007949603	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	168	1.555253e-9	1.2181889420833334e-7	2.07934	83	0.009916368	455	0.008770528449670328	1.552636	43	78	0.006449678	
GO Biological Process	negative regulation of cyclin-dependent protein serine/threonine kinase activity	179	4.241106e-9	3.117805243240223e-7	2.782999	44	0.00525687	654	0.037236227532110096	1.877606	16	24	0.00239988	
GO Biological Process	negative regulation of cyclin-dependent protein kinase activity	182	5.4598e-9	3.9475553956043955e-7	2.653904	47	0.005615293	492	0.012812811316260162	1.949822	18	26	0.002699865	
GO Biological Process	mitochondrial translational termination	190	8.699584e-9	6.025148729263158e-7	2.171625	68	0.008124253	335	0.0022476832907164183	1.586253	49	87	0.007349633	
GO Biological Process	mitochondrial translational elongation	195	1.046764e-8	7.063778192820513e-7	2.175163	67	0.008004779	339	0.0024057132413274336	1.590443	48	85	0.00719964	
GO Biological Process	regulation of cholesterol biosynthetic process	223	3.282522e-8	0.000001936982376591928	2.266543	57	0.006810036	381	0.004692696266929134	1.810549	27	42	0.004049798	
GO Biological Process	cellular protein complex localization	236	5.392344e-8	0.0000030066887583050844	2.481897	46	0.005495818	492	0.012812811316260162	1.949822	18	26	0.002699865	
GO Cellular Component	ribosomal subunit	28	8.189006e-16	5.05378656e-14	2.064396	151	0.01804062	51	0.0001139906371764706	1.461488	96	185	0.01439928	
GO Cellular Component	SWI/SNF superfamily-type complex	37	8.517832e-12	3.978057755675676e-10	2.12694	101	0.01206691	100	0.01557431712	1.525555	39	72	0.005849708	
GO Cellular Component	nuclear transcriptional repressor complex	38	1.46071e-11	6.64238652631579e-10	2.793519	58	0.00692951	122	0.04502809652459016	1.748116	18	29	0.002699865	
GO Cellular Component	mitochondrial ribosome	41	7.340661e-11	3.093820050731708e-9	2.490503	66	0.007885305	65	0.0016475972233846155	1.590443	48	85	0.00719964	
GO Cellular Component	large ribosomal subunit	42	8.617674e-11	3.545557302857143e-9	2.107983	93	0.01111111	63	0.00108727872	1.518412	62	115	0.009299535	
GO Cellular Component	cleavage furrow	46	3.147577e-10	1.1823941426086955e-8	2.215498	78	0.009318996	75	0.002646358272	1.733175	32	52	0.00479976	
GO Cellular Component	mitochondrial large ribosomal subunit	57	1.0799e-8	3.2738021052631576e-7	2.729939	43	0.005137395	66	0.0017508706036363638	1.767159	32	51	0.00479976	
GO Cellular Component	Sin3 complex	124	0.00003646892	0.0005082120464516129	2.596762	24	0.002867384	116	0.04225357737931034	2.166469	10	13	0.001499925	
GO Cellular Component	Sin3-type complex	151	0.0001303082	0.0014912090701986755	2.292219	26	0.003106332	109	0.023764121834862383	2.112307	12	16	0.00179991	
GO Cellular Component	CCR4-NOT core complex	160	0.0002401993	0.0025941524399999997	3.752423	11	0.001314217	111	0.031146966486486485	2.816409	6	6	0.000899955	
GO Cellular Component	BLOC complex	175	0.0004733297	0.004673792694857143	2.219703	23	0.002747909	101	0.015730452784158414	1.959241	16	23	0.00239988	
GO Cellular Component	cytoplasmic ubiquitin ligase complex	208	0.001451129	0.012055533230769232	2.4058	16	0.001911589	116	0.04225357737931034	2.166469	10	13	0.001499925	
GO Cellular Component	MOZ/MORF histone acetyltransferase complex	281	0.005962732	0.03666761884697509	2.131604	15	0.001792115	96	0.0127796688	2.816409	7	7	0.001049948	
GO Molecular Function	chromatin DNA binding	8	3.546549e-18	1.87169123475e-15	2.219957	149	0.01780167	54	0.000012402351737037035	1.706094	63	104	0.009449528	
GO Molecular Function	unfolded protein binding	22	3.306729e-9	6.345913562727273e-7	2.043858	83	0.009916368	141	0.044829495432624114	1.408205	53	106	0.007949603	
GO Molecular Function	SNAP receptor activity	34	4.523399e-8	0.000005616997228823529	2.26297	56	0.006690562	127	0.025680138806299213	1.717323	25	41	0.003749813	
GO Molecular Function	histone deacetylase activity	42	1.650008e-7	0.00001658650899047619	2.079138	62	0.007407407	136	0.03682524636764706	1.664242	26	44	0.003899805	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	58	0.000001090442	0.00007937665731034483	2.34677	41	0.004898447	105	0.010081400165714285	1.942351	20	29	0.00299985	
Human Phenotype	Laryngomalacia	1	4.889206e-19	3.2625671638e-15	4.96966	49	0.005854241	301	0.028033716388704322	2.212893	11	14	0.001649918	
Human Phenotype	Trigonocephaly	32	3.085908e-7	0.0000643508252625	2.502627	40	0.004778973	315	0.03530294512063492	2.034073	13	18	0.001949903	
Human Phenotype	Mildly elevated creatine phosphokinase	51	0.000002968075	0.00038835224460784316	2.817419	27	0.003225806	325	0.036433368593846154	1.971486	14	20	0.002099895	
Human Phenotype	Lipomatous tumor	175	0.000177807	0.00678003492	2.644762	19	0.002270012	301	0.028033716388704322	2.212893	11	14	0.001649918	
Human Phenotype	Infantile encephalopathy	210	0.0003038242	0.00965437565047619	4.882892	8	0.0009557945	331	0.0403355633836858	2.816409	6	6	0.000899955	
Human Phenotype	Arachnoid cyst	282	0.0008644459	0.02045548755567376	2.626507	15	0.001792115	310	0.03341313170322581	2.503475	8	9	0.00119994	
Human Phenotype	Impaired horizontal smooth pursuit	334	0.001541998	0.030807642676646704	2.681875	13	0.001553166	331	0.0403355633836858	2.816409	6	6	0.000899955	
Mouse Phenotype Single KO	vertebral transformation	4	6.733672e-14	1.5415058626e-10	2.089247	127	0.01517324	118	0.002337547742881356	1.591883	52	92	0.00779961	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	20	8.545281e-10	3.91245690585e-7	2.259681	71	0.008482676	159	0.005368331563836478	1.689846	36	60	0.00539973	
Mouse Phenotype Single KO	thoracic vertebral transformation	29	1.245903e-8	0.000003934046127931034	2.259387	61	0.007287933	269	0.03505258750929369	1.642905	28	48	0.00419979	
Mouse Phenotype Single KO	cervical vertebral transformation	55	3.599179e-7	0.000059923058369090914	2.206971	51	0.00609319	292	0.04507288645205479	1.704669	23	38	0.003449828	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	67	9.959514e-7	0.00013611831298208953	2.64488	33	0.003942652	162	0.005794108707407407	2.319396	14	17	0.002099895	
Mouse Phenotype Single KO	pale placenta	97	0.00000782014	0.0007382373399999999	2.727038	26	0.003106332	123	0.0025968358634146345	2.599762	12	13	0.00179991	
Mouse Phenotype Single KO	abnormal sperm annulus morphology	162	0.00009350597	0.0052853960943827155	3.258847	15	0.001792115	302	0.047065645867549674	2.503475	8	9	0.00119994	
Mouse Phenotype Single KO	fusion of atlas and odontoid process	213	0.0002675345	0.011501471438967136	2.225125	25	0.002986858	240	0.023213307864166664	2.534768	9	10	0.001349933	
Mouse Phenotype	abnormal cellular replicative senescence	12	4.772933e-12	3.80283436775e-9	2.140285	102	0.01218638	153	0.000133360015	1.709963	51	84	0.007649618	
Mouse Phenotype	thoracic vertebral transformation	17	5.587248e-11	3.1423340075294114e-8	2.347892	75	0.008960573	352	0.012414564651988636	1.630553	33	57	0.004949753	
Mouse Phenotype	fusion of vertebral bodies	29	1.764592e-9	5.81767728e-7	4.427907	25	0.002986858	501	0.04356604191017964	2.304335	9	11	0.001349933	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	96	0.00000144286	0.000143699838125	2.478136	36	0.004301075	471	0.035429899299363056	1.783726	19	30	0.002849858	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	109	0.000002606744	0.00022865210444036698	2.34744	38	0.004540024	306	0.006895830631372549	2.027815	18	25	0.002699865	
Mouse Phenotype	increased kidney tumor incidence	118	0.000004013076	0.0003251611833559322	2.905972	25	0.002986858	446	0.03213460674887893	2.112307	12	16	0.00179991	
Mouse Phenotype	abnormal small intestinal crypt cell proliferation	140	0.00000746777	0.0005099953497857142	2.32809	35	0.004181601	479	0.03657918837995825	1.920279	15	22	0.002249888	
Mouse Phenotype	pale placenta	171	0.00001967398	0.0011000170922807018	2.580937	26	0.003106332	365	0.01453009268958904	2.253127	12	15	0.00179991	
Mouse Phenotype	abnormal sperm annulus morphology	225	0.00009350597	0.003973380351866666	3.258847	15	0.001792115	451	0.032906714847006656	2.503475	8	9	0.00119994	
Mouse Phenotype	absent fetal ductus arteriosus	258	0.0001750243	0.0064860749313953485	2.648142	19	0.002270012	489	0.03911915411042945	2.816409	6	6	0.000899955	
Mouse Phenotype	fusion of atlas and odontoid process	299	0.0002808825	0.008981664155518394	2.217649	25	0.002986858	501	0.04356604191017964	2.304335	9	11	0.001349933