# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 1 2.722674e-83 3.5827667166e-79 7.595 159 0.04112778 82 0.0000018255159748780488 2.152516 50 114 0.01306848 GO Biological Process DNA replication-dependent nucleosome assembly 2 5.319647e-77 3.50006174365e-73 40.79051 63 0.01629591 182 0.0006174400908021979 2.760602 18 32 0.004704652 GO Biological Process negative regulation of megakaryocyte differentiation 3 1.272512e-66 5.581661802666667e-63 63.21026 47 0.01215727 404 0.03438130753712871 2.72652 10 18 0.002613696 GO Biological Process chromatin silencing 4 1.485939e-65 4.88836782525e-62 8.404964 116 0.03000517 94 0.000003479728162872341 2.22619 44 97 0.01150026 GO Biological Process nucleosome assembly 5 1.690141e-58 4.4481130837999994e-55 4.805698 164 0.04242111 80 0.0000011354554031374998 2.03913 59 142 0.01542081 GO Biological Process chromatin assembly 6 4.252748e-58 9.326985155333333e-55 4.527334 173 0.04474909 65 4.7866793752307696e-8 2.081129 67 158 0.01751176 GO Biological Process chromatin silencing at rDNA 7 7.883996e-58 1.4820786194857142e-54 18.46378 65 0.01681324 241 0.0038612109709543567 2.453868 18 36 0.004704652 GO Biological Process chromatin assembly or disassembly 8 3.189356e-57 5.2460919505e-54 4.232179 183 0.04733575 55 2.043220419927273e-8 2.040295 74 178 0.01934135 GO Biological Process nucleosome organization 9 8.707735e-56 1.273167609611111e-52 4.306734 175 0.04526643 83 0.0000018891821402409638 1.922914 67 171 0.01751176 GO Biological Process regulation of gene expression, epigenetic 11 2.163042e-48 2.5875881525454545e-45 3.39446 201 0.05199172 147 0.00015438899694557824 1.622719 82 248 0.02143231 GO Biological Process DNA packaging 12 4.405586e-48 4.831092181166667e-45 3.683772 180 0.04655975 110 0.000008185584660545455 1.800325 73 199 0.01907998 GO Biological Process protein-DNA complex subunit organization 13 5.96822e-47 6.041215921538462e-44 3.148075 216 0.0558717 127 0.00006367309570787401 1.648999 84 250 0.02195504 GO Biological Process regulation of hematopoietic progenitor cell differentiation 14 6.190354e-47 5.818490591857142e-44 5.459143 116 0.03000517 187 0.00078259880342246 1.867546 43 113 0.01123889 GO Biological Process regulation of hematopoietic stem cell differentiation 15 1.411773e-46 1.2385013938e-43 5.802529 109 0.02819452 171 0.0003717594492397661 1.953565 41 103 0.01071615 GO Biological Process telomere capping 16 2.108211e-46 1.7338717843124999e-43 14.25298 59 0.01526125 283 0.008281618974911661 2.453868 16 32 0.004181913 GO Biological Process DNA conformation change 17 8.677099e-45 6.716585043588235e-42 2.99781 221 0.05716503 112 0.000009833785320089286 1.659199 95 281 0.02483011 GO Biological Process protein-DNA complex assembly 18 1.675798e-43 1.225101437888889e-40 3.216069 194 0.05018107 153 0.00018972895618954246 1.658322 74 219 0.01934135 GO Biological Process gene silencing 23 7.475455e-40 4.276935319347826e-37 3.756534 145 0.03750647 129 0.0000683234865488372 1.772238 65 180 0.01698902 GO Biological Process protein heterotetramerization 25 2.635675e-37 1.387313893e-34 8.026721 67 0.01733057 220 0.0026115435139090907 2.342329 21 44 0.005488761 GO Biological Process regulation of megakaryocyte differentiation 27 1.085549e-35 5.290644181851852e-33 4.837226 98 0.0253492 99 0.000004227235706565657 2.389293 37 76 0.009670674 GO Cellular Component nucleosome 1 5.933746e-106 1.0253513088e-102 11.44232 155 0.04009312 15 8.77433472e-12 2.617459 56 105 0.0146367 GO Cellular Component DNA packaging complex 4 3.300869e-95 1.4259754079999999e-92 9.409998 157 0.04061045 17 1.5142535152941177e-11 2.541506 58 112 0.01515944 GO Cellular Component nuclear nucleosome 13 4.332326e-61 5.758661021538462e-59 18.33283 69 0.0178479 41 0.0002808324948292683 2.576562 21 40 0.005488761 GO Cellular Component protein-DNA complex 14 1.212181e-55 1.4961776914285713e-53 4.007907 189 0.04888774 23 1.9436987269565218e-8 1.943658 80 202 0.02090957 GO Cellular Component chromatin 15 1.167462e-48 1.344916224e-46 2.344293 363 0.0938955 13 1.3636445538461538e-13 1.757091 174 486 0.04547831 GO Cellular Component nuclear chromosome, telomeric region 26 2.130864e-34 1.416204996923077e-32 4.284693 107 0.02767719 53 0.010716736483018869 1.635912 44 132 0.01150026 GO Cellular Component nuclear chromatin 27 5.978028e-34 3.82593792e-32 2.359657 250 0.06466632 20 2.026321056e-9 1.786043 115 316 0.0300575 GO Cellular Component chromosome, telomeric region 32 3.611547e-31 1.95023538e-29 3.63442 117 0.03026384 54 0.011112620800000002 1.557545 53 167 0.01385259 GO Cellular Component ficolin-1-rich granule lumen 49 3.016554e-12 1.0637970024489797e-10 2.573888 71 0.01836524 47 0.0023884827778723407 1.741455 44 124 0.01150026 GO Cellular Component melanosome 68 4.460994e-8 0.0000011336172988235294 2.047946 70 0.01810657 52 0.009302528492307692 1.729393 37 105 0.009670674 GO Cellular Component perinuclear endoplasmic reticulum 117 0.0000315131 0.0004654242461538462 3.270081 17 0.00439731 51 0.009095036611764706 3.569263 8 11 0.002090957 GO Cellular Component ciliary base 163 0.0006284395 0.006662229791411044 2.059004 26 0.006725297 64 0.046527129 2.278592 13 28 0.003397804 GO Cellular Component MLL3/4 complex 167 0.0007176676 0.007425925825149701 3.281935 11 0.002845318 55 0.011103154036363637 3.817128 7 9 0.001829587 GO Molecular Function nucleosomal DNA binding 8 5.067272e-23 2.6742527979999998e-20 5.344826 56 0.01448526 49 0.02783932517142857 2.133798 20 46 0.005227392 GO Molecular Function nucleosome binding 10 1.224057e-18 5.167968654e-16 3.75 65 0.01681324 38 0.012404202668421052 2.00771 27 66 0.007056979 GO Molecular Function chromatin DNA binding 12 1.105725e-17 3.890309125e-15 2.87086 89 0.02302121 32 0.002184179134375 1.887591 40 104 0.01045478 GO Molecular Function histone binding 13 1.56391e-16 5.0790984769230774e-14 2.180792 138 0.03569581 30 0.00041601547366666665 1.685485 68 198 0.01777313 GO Molecular Function structure-specific DNA binding 14 2.20067e-14 6.636591957142857e-12 2.307196 105 0.02715986 35 0.008219458358285714 1.694758 48 139 0.01254574 GO Molecular Function protein serine/threonine kinase inhibitor activity 58 0.000007220177 0.0005255790912758621 2.436894 32 0.008277289 46 0.02575813747391304 2.379509 16 33 0.004181913 Human Phenotype Bone marrow hypocellularity 57 0.00003282811 0.0038431925970175435 2.552957 25 0.006466632 2 0.044500135005 2.781051 17 30 0.004443283 Human Phenotype Generalized joint laxity 109 0.0003587246 0.02196118583302752 5.489937 7 0.001810657 12 0.03967308143416667 4.907737 6 6 0.001568217 Mouse Phenotype Single KO abnormal induced cell death 18 9.416733e-16 4.790501337833334e-13 2.150692 135 0.03491981 148 0.007101637104054054 1.535121 66 211 0.01725039 Mouse Phenotype Single KO thrombocytopenia 36 5.848979e-13 1.4877527973055555e-10 2.075348 118 0.0305225 62 0.0003518816513548387 1.796296 56 153 0.0146367 Mouse Phenotype Single KO enlarged lymph nodes 54 4.985429e-11 8.45399506537037e-9 2.085859 97 0.02509053 78 0.0009438423959358974 1.808113 49 133 0.01280711 Mouse Phenotype Single KO increased IgG1 level 57 7.440331e-11 1.1952826485438596e-8 2.524429 64 0.01655458 112 0.0025590528291071428 2.04489 30 72 0.007841087 Mouse Phenotype Single KO decreased erythroid progenitor cell number 64 1.086666e-9 1.5547813378125e-7 2.393227 62 0.01603725 71 0.0005889992624084506 2.405753 25 51 0.006534239 Mouse Phenotype Single KO polyploidy 70 1.614089e-9 2.1114589961428572e-7 3.684689 31 0.008018624 233 0.028336124277682406 2.453868 13 26 0.003397804 Mouse Phenotype Single KO abnormal spleen red pulp morphology 79 4.279347e-9 4.960250693544304e-7 2.056546 80 0.02069322 72 0.0006144067202777778 1.953565 41 103 0.01071615 Mouse Phenotype Single KO glomerulonephritis 102 5.677837e-8 0.000005097250334215686 2.189131 59 0.01526125 218 0.026325875145412844 1.773881 30 83 0.007841087 Mouse Phenotype Single KO embryonic lethality between somite formation and embryo turning, complete penetrance 118 1.484299e-7 0.000011518411816101694 2.175064 56 0.01448526 197 0.018637167728426395 1.856981 28 74 0.007318348 Mouse Phenotype Single KO decreased spleen red pulp amount 138 4.008501e-7 0.000026598437432608695 4.343312 18 0.004655975 90 0.0015158803033333335 3.599007 11 15 0.002875065 Mouse Phenotype Single KO embryonic lethality between somite formation and embryo turning 139 4.86618e-7 0.000032057273568345326 2.033766 60 0.01551992 234 0.02853942232435898 1.725797 32 91 0.008363826 Mouse Phenotype Single KO increased skin tumor incidence 164 0.000001495679 0.00008351178416463414 2.737793 30 0.007759959 207 0.022251014548792268 2.11925 19 44 0.004966022 Mouse Phenotype Single KO abnormal vascular branching morphogenesis 234 0.00001759306 0.0006884600445299145 2.173645 37 0.009570616 230 0.028272169817826088 2.369252 14 29 0.003659174 Mouse Phenotype Single KO increased circulating interleukin-1 beta level 242 0.00002028645 0.0007676157960743802 3.389458 17 0.00439731 269 0.0392916657732342 2.453868 12 24 0.003136435 Mouse Phenotype Single KO increased B cell derived lymphoma incidence 336 0.0001095644 0.0029859559845238095 2.078548 33 0.008535954 220 0.026341242638181817 2.04489 20 48 0.005227392 Mouse Phenotype Single KO abnormal forelimb bud morphology 362 0.000167863 0.0042461919640883975 2.448067 22 0.005690636 100 0.0019943131027 4.362432 8 9 0.002090957 Mouse Phenotype Single KO small forelimb buds 540 0.001294885 0.02195789249074074 2.734984 13 0.003362649 188 0.01707201855531915 4.907737 5 5 0.001306848 Mouse Phenotype abnormal induced cell death 40 3.240295e-15 7.74511512375e-13 2.001865 154 0.03983445 231 0.007468262658441559 1.464712 77 258 0.02012546 Mouse Phenotype thrombocytopenia 46 7.31639e-15 1.5206957563043479e-12 2.018596 147 0.0380238 78 0.000050574453969230765 1.730748 73 207 0.01907998 Mouse Phenotype decreased sensitivity to induced cell death 52 6.853216e-14 1.2600691956923078e-11 2.57181 82 0.02121055 243 0.008651508891358024 1.794226 34 93 0.008886566 Mouse Phenotype pancytopenia 69 4.877621e-12 6.758686142173913e-10 3.903987 38 0.009829281 230 0.00724891325347826 2.538484 15 29 0.003920544 Mouse Phenotype abnormal platelet physiology 82 5.544124e-11 6.4643133614634145e-9 2.119368 93 0.02405587 266 0.0118145277 1.635912 44 132 0.01150026 Mouse Phenotype polyploidy 99 1.359828e-9 1.3132641927272728e-7 3.533204 33 0.008535954 359 0.0288583205097493 2.290277 14 30 0.003659174 Mouse Phenotype increased incidence of tumors by UV-induction 102 1.797502e-9 1.6848937864705883e-7 7.936603 15 0.003879979 375 0.03597982772 3.020146 8 13 0.002090957 Mouse Phenotype abnormal embryonic erythropoiesis 108 3.821799e-9 3.383353725833333e-7 3.009664 39 0.01008795 389 0.039537315732647814 2.216397 14 31 0.003659174 Mouse Phenotype increased sensitivity to skin irradiation 110 3.96568e-9 3.4468969527272735e-7 9.17222 13 0.003362649 422 0.049775993353080576 3.123105 7 11 0.001829587 Mouse Phenotype absent erythroid progenitor cell 141 4.192651e-8 0.000002842974199361702 6.23128 15 0.003879979 373 0.03493112631635389 3.680802 6 8 0.001568217 Mouse Phenotype decreased erythroid progenitor cell number 151 7.570202e-8 0.000004793291478278145 2.018713 70 0.01810657 169 0.0021644135226035503 2.00184 31 76 0.008102457 Mouse Phenotype abnormal conotruncus septation 155 1.136981e-7 0.00000701333892967742 5.360359 16 0.004138645 280 0.01407834371892857 4.206631 6 7 0.001568217 Mouse Phenotype increased skin tumor incidence 213 0.000002479946 0.00011131813946478874 2.056113 51 0.01319193 355 0.02825434401126761 1.709436 31 89 0.008102457 Mouse Phenotype increased Leydig cell tumor incidence 218 0.000002936333 0.00012878110005963304 11.8665 7 0.001810657 400 0.041740672822500005 4.08978 5 6 0.001306848 Mouse Phenotype ovary degeneration 231 0.000005495902 0.00022747324251948053 8.72081 8 0.002069322 400 0.041740672822500005 4.08978 5 6 0.001306848 Mouse Phenotype increased circulating interleukin-1 beta level 242 0.000008215099 0.0003245643038801653 2.656747 27 0.006983963 254 0.010231049183858268 2.317542 17 36 0.004443283 Mouse Phenotype abnormal cellular hemoglobin content 339 0.00008687323 0.002450132601858407 4.225825 11 0.002845318 422 0.049775993353080576 3.123105 7 11 0.001829587 Mouse Phenotype decreased spleen red pulp amount 344 0.0001071372 0.0029777289802325585 2.669477 20 0.005173306 364 0.030318062332417583 2.453868 12 24 0.003136435 Mouse Phenotype abnormal forelimb bud morphology 418 0.0003614367 0.00826721600167464 2.177139 25 0.006466632 143 0.0012673921193706295 3.775182 10 13 0.002613696 Mouse Phenotype abnormal sublingual duct morphology 446 0.0005242497 0.011238456012780269 3.412155 11 0.002845318 400 0.041740672822500005 4.08978 5 6 0.001306848