# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process chromatin silencing 2 4.837082e-34 3.1825581019e-30 6.544363 71 0.02336295 55 0.000024546702898181817 2.26605 40 97 0.01170618 GO Biological Process negative regulation of gene expression, epigenetic 3 5.059683e-31 2.2193456199e-27 4.982825 82 0.02698256 52 0.000020254416309038464 2.169147 45 114 0.01316945 GO Biological Process DNA replication-dependent nucleosome assembly 4 8.588582e-30 2.82542876345e-26 23.88624 29 0.009542613 201 0.01237728338557214 2.575862 15 32 0.004389816 GO Biological Process regulation of gene expression, epigenetic 5 1.045558e-24 2.7516995443999995e-21 2.814343 131 0.04310628 49 0.000015879384239591836 1.772636 80 248 0.02341235 GO Biological Process gene silencing 8 2.464305e-23 4.0534736868750004e-20 3.262764 99 0.03257651 56 0.00003127553575892857 1.892781 62 180 0.01814457 GO Biological Process chromatin silencing at rDNA 9 3.180493e-23 4.650234154111112e-20 11.56348 32 0.01052978 213 0.015504798710798122 2.442298 16 36 0.00468247 GO Biological Process nucleosome organization 11 8.533323e-22 1.020818157790909e-18 3.099391 99 0.03257651 62 0.00005262182223870968 1.895995 59 171 0.01726661 GO Biological Process chromatin assembly or disassembly 13 1.960345e-21 1.9843215273076923e-18 3.00085 102 0.03356367 53 0.000020840533973207546 1.914048 62 178 0.01814457 GO Biological Process nucleosome assembly 14 4.787932e-21 4.500314084857143e-18 3.280397 88 0.02895689 67 0.00007671848230298507 1.973618 51 142 0.01492537 GO Biological Process chromatin assembly 15 4.884485e-21 4.2849958743333334e-18 3.129359 94 0.03093123 58 0.00004073264085517241 1.947656 56 158 0.01638865 GO Biological Process regulation of hematopoietic progenitor cell differentiation 17 1.868723e-19 1.446501526882353e-16 3.891446 65 0.02138861 153 0.005233223351568628 1.847934 38 113 0.01112087 GO Biological Process positive regulation of gene expression, epigenetic 18 2.694196e-19 1.9696069535555553e-16 4.644951 53 0.01743995 217 0.015473189039631336 1.92331 28 80 0.008194323 GO Biological Process DNA conformation change 19 6.856265e-19 4.748504796578948e-16 2.346831 136 0.04475156 114 0.001660776612631579 1.564462 80 281 0.02341235 GO Biological Process DNA packaging 20 9.406863e-19 6.18924551085e-16 2.707601 104 0.03422178 96 0.0008546142706041666 1.712063 62 199 0.01814457 GO Biological Process hemostasis 22 5.660913e-18 3.3859979166818185e-15 2.090956 165 0.05429418 110 0.0015630523379999998 1.537234 87 311 0.02546093 GO Biological Process blood coagulation 24 1.292274e-17 7.0854306525e-15 2.082497 163 0.05363606 125 0.00228700156568 1.526436 85 306 0.02487562 GO Biological Process coagulation 25 1.414122e-17 7.4433725592e-15 2.080361 163 0.05363606 129 0.0028750864482170544 1.516525 85 308 0.02487562 GO Biological Process protein-DNA complex subunit organization 28 1.085856e-16 5.103135394285714e-14 2.299027 124 0.0408029 54 0.00002119108302037037 1.758455 80 250 0.02341235 GO Biological Process protein-DNA complex assembly 31 1.358943e-15 5.768493850645162e-13 2.340873 111 0.03652517 64 0.0000531987117375 1.78154 71 219 0.02077846 GO Biological Process regulation of gene silencing 35 6.295404e-15 2.3668920353142857e-12 2.938407 71 0.02336295 204 0.012542991087254901 1.719863 41 131 0.01199883 GO Cellular Component nucleosome 11 3.087827e-31 4.8506955054545453e-29 6.291995 67 0.02204673 9 5.87111616e-8 2.459743 47 105 0.01375476 GO Cellular Component DNA packaging complex 12 2.128804e-28 3.06547776e-26 5.337269 70 0.02303389 11 1.9054923054545458e-7 2.355073 48 112 0.01404741 GO Cellular Component nuclear nucleosome 14 1.427323e-25 1.7617243885714288e-23 11.82986 35 0.01151695 28 0.005278989394285714 2.472827 18 40 0.005267779 GO Cellular Component nuclear chromatin 21 1.233508e-21 1.0150008685714287e-19 2.185302 182 0.05988812 7 1.9491659794285715e-8 1.825927 105 316 0.03072871 GO Cellular Component protein-DNA complex 32 2.285018e-13 1.23390972e-11 2.400916 89 0.02928595 25 0.00016468102655999999 1.741044 64 202 0.01872988 GO Cellular Component granular component 50 4.965494e-9 1.7160747264e-7 13.987 10 0.003290556 46 0.03807674295652174 4.579309 5 6 0.001463272 GO Cellular Component sex chromosome 56 7.968977e-8 0.0000024589986171428572 4.194113 21 0.006910168 45 0.037852581120000006 2.536233 12 26 0.003511853 Mouse Phenotype Single KO abnormal platelet physiology 3 2.460103e-35 7.509054390333333e-32 3.954414 120 0.03948667 219 0.035137010429680364 1.698507 34 110 0.009950249 Mouse Phenotype Single KO abnormal blood coagulation 5 1.825533e-29 3.3432811362000003e-26 2.675549 171 0.05626851 101 0.0032728913134653466 1.613261 64 218 0.01872988 Mouse Phenotype Single KO abnormal hemostasis 6 2.773907e-29 4.233444399833333e-26 2.665377 171 0.05626851 106 0.00422731954745283 1.598595 64 220 0.01872988 Mouse Phenotype Single KO decreased myeloid cell number 12 5.144351e-21 3.925568508916667e-18 2.084969 196 0.0644949 120 0.007839658718333333 1.47739 82 305 0.02399766 Mouse Phenotype Single KO thrombocytopenia 38 2.613988e-15 6.299023188421052e-13 2.371625 106 0.03487989 152 0.014083574438157895 1.652143 46 153 0.0134621 Mouse Phenotype Single KO abnormal pre-B cell morphology 40 2.644234e-14 6.0533126845e-12 2.712846 77 0.02533728 187 0.024884103428877005 1.853793 28 83 0.008194323 Mouse Phenotype Single KO abnormal platelet cell number 41 3.998443e-14 8.930181110000001e-12 2.09063 127 0.04179006 113 0.005877810230265486 1.592059 62 214 0.01814457 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 57 1.705344e-12 2.7396201768421053e-10 4.140932 37 0.01217506 78 0.0009952722168461538 3.031819 16 29 0.00468247 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 61 4.260496e-12 6.395633093770492e-10 3.834069 39 0.01283317 79 0.0010047848597468355 2.826088 18 35 0.005267779 Mouse Phenotype Single KO increased bleeding time 80 2.08908e-9 2.391213195e-7 2.407876 59 0.01941428 116 0.0063037553714655175 1.986206 30 83 0.008779631 Mouse Phenotype Single KO decreased circulating total protein level 97 1.636606e-8 0.0000015449898084536083 2.800704 40 0.01316222 224 0.03584102125714285 1.989631 21 58 0.006145742 Mouse Phenotype Single KO increased mean platelet volume 103 2.473255e-8 0.0000021987957315533983 2.999484 35 0.01151695 221 0.0353705077239819 2.17251 17 43 0.004975124 Mouse Phenotype Single KO abnormal thyroid gland morphology 110 4.513961e-8 0.000003757667352454545 2.520318 45 0.0148075 110 0.005326609418454545 2.198068 24 60 0.007023705 Mouse Phenotype Single KO hypervolemia 118 1.238527e-7 0.000009611179439830507 8.537091 11 0.003619612 237 0.04231125148101266 5.495171 4 4 0.001170618 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 123 1.577829e-7 0.000011746487929268292 2.331297 48 0.01579467 112 0.005394562846517857 2.281014 22 53 0.006438396 Mouse Phenotype Single KO abnormal somite size 147 9.30988e-7 0.000057993585823129256 2.484884 37 0.01217506 85 0.0016142422836470589 2.830846 17 33 0.004975124 Mouse Phenotype Single KO abnormal granulocyte differentiation 148 0.000001005264 0.00006219731383783784 2.984864 27 0.008884501 71 0.000654222509859155 2.909208 18 34 0.005267779 Mouse Phenotype Single KO microcytic anemia 214 0.00002754484 0.0011786359807476636 3.305008 17 0.005593945 129 0.009635634260465117 2.997366 12 22 0.003511853 Mouse Phenotype Single KO decreased somite size 223 0.00003922116 0.0016105298749775785 2.297135 30 0.009871668 202 0.0288011630460396 2.637682 12 25 0.003511853 Mouse Phenotype Single KO abnormal cellular hemoglobin content 327 0.0002780367 0.0077858778651376135 4.398377 9 0.0029615 123 0.0086647479699187 3.996488 8 11 0.002341235 Mouse Phenotype abnormal platelet physiology 5 5.823758e-35 1.1136190047599999e-31 3.710775 128 0.04211912 249 0.01858768601084337 1.665203 40 132 0.01170618 Mouse Phenotype abnormal blood coagulation 11 2.907699e-25 2.527319103545454e-22 2.290288 194 0.06383679 115 0.00043410764399999996 1.589196 83 287 0.02429031 Mouse Phenotype abnormal hemostasis 12 4.024522e-25 3.2065379034999997e-22 2.283711 194 0.06383679 119 0.0005615070048655462 1.578198 83 289 0.02429031 Mouse Phenotype decreased myeloid cell number 15 3.553494e-24 2.2649970755999996e-21 2.052774 235 0.07732807 152 0.0028071441957236844 1.44021 103 393 0.0301434 Mouse Phenotype decreased pre-B cell number 31 6.333834e-18 1.953476995935484e-15 2.692005 100 0.03290556 156 0.002898474761153846 1.902175 36 104 0.01053556 Mouse Phenotype abnormal pre-B cell morphology 33 3.676807e-17 1.0652712644545456e-14 2.459594 112 0.03685423 111 0.00039991983364864864 1.900586 46 133 0.0134621 Mouse Phenotype thrombocytopenia 35 4.946136e-17 1.3511430370285715e-14 2.270945 130 0.04277723 208 0.008015248308173076 1.566257 59 207 0.01726661 Mouse Phenotype decreased erythrocyte cell number 46 4.336818e-15 9.013981934347826e-13 2.044329 144 0.04738401 193 0.006297533466839378 1.54626 65 231 0.01902253 Mouse Phenotype increased pre-B cell number 63 4.96514e-13 7.535191038095238e-11 3.72236 44 0.01447845 354 0.03390495351694915 2.227772 15 37 0.004389816 Mouse Phenotype abnormal pro-B cell morphology 70 5.280174e-12 7.211963373428572e-10 2.16225 98 0.03224745 186 0.005913360272580645 1.815369 37 112 0.01082821 Mouse Phenotype abnormal embryonic erythropoiesis 90 6.57135e-11 6.98096415e-9 3.632339 37 0.01217506 134 0.0018505458201492537 2.836217 16 31 0.00468247 Mouse Phenotype abnormal embryonic erythrocyte morphology 95 3.078481e-10 3.098248088526316e-8 3.299268 39 0.01283317 164 0.0033017625096951222 2.536233 18 39 0.005267779 Mouse Phenotype increased bleeding time 109 3.77114e-9 3.3078779394495414e-7 2.310368 62 0.02040145 176 0.004826343908522727 1.908849 33 95 0.009657594 Mouse Phenotype decreased circulating total protein level 123 2.143662e-8 0.000001666305071707317 2.77209 40 0.01316222 343 0.031521418390670554 1.955908 21 59 0.006145742 Mouse Phenotype abnormal axillary lymph node morphology 124 2.260075e-8 0.000001742627183467742 3.133111 33 0.01085884 281 0.02357109736654804 2.747586 11 22 0.003219198 Mouse Phenotype microcytic anemia 145 1.181088e-7 0.000007787849908965517 3.787831 23 0.007568279 154 0.0027913091162337666 2.84233 15 29 0.004389816 Mouse Phenotype decreased megakaryocyte cell number 148 1.393437e-7 0.000009001791322297296 3.010225 31 0.01020072 305 0.02690899876918033 2.463353 13 29 0.003804507 Mouse Phenotype abnormal embryonic hematopoiesis 187 0.00000294371 0.00015050701235294118 2.075419 49 0.01612372 219 0.011235371216438356 2.07195 23 61 0.006731051 Mouse Phenotype abnormal translation 205 0.000008306383 0.00038740159933170736 8.231006 8 0.002632445 285 0.02424419672105263 4.121378 6 8 0.001755926 Mouse Phenotype abnormal seminal vesicle size 207 0.000008785339 0.00040578080279710143 2.040788 46 0.01513656 374 0.03769615981283422 1.785931 26 80 0.007609014