# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	negative regulation of gene expression, epigenetic	1	1.313871e-32	1.7289228489e-28	5.39966	80	0.02923977	63	5.469855836984127e-8	2.640169	44	114	0.01602914	
GO Biological Process	chromatin assembly or disassembly	3	3.742947e-29	1.6417813190999999e-25	3.594607	110	0.04020468	66	6.997708970303032e-8	2.267336	59	178	0.02149362	
GO Biological Process	DNA conformation change	5	1.20431e-28	3.169503058e-25	2.855906	149	0.05445906	82	2.0646631475609755e-7	1.947455	80	281	0.0291439	
GO Biological Process	chromatin silencing	6	1.977655e-28	4.3373270241666665e-25	6.245303	61	0.02229532	98	0.000001326874068897959	2.609239	37	97	0.01347905	
GO Biological Process	nucleosome organization	7	2.066899e-28	3.885474848714286e-25	3.651279	105	0.03837719	91	6.785329896703296e-7	2.200141	55	171	0.02003643	
GO Biological Process	regulation of gene expression, epigenetic	8	2.655944e-28	4.368695887e-25	3.102157	130	0.04751462	46	8.390850653260868e-9	2.123845	77	248	0.028051	
GO Biological Process	chromosome organization	9	3.295322e-28	4.818126910888889e-25	2.173106	241	0.0880848	68	7.894484675441175e-8	1.656853	140	578	0.05100182	
GO Biological Process	chromatin assembly	10	1.581839e-27	2.0815419400999998e-24	3.697789	100	0.03654971	72	9.995157870694444e-8	2.337871	54	158	0.01967213	
GO Biological Process	nucleosome assembly	13	3.897553e-25	3.9452230713076925e-22	3.726498	90	0.03289474	87	3.554183886321839e-7	2.360433	49	142	0.01785064	
GO Biological Process	DNA packaging	14	1.872225e-24	1.759757769642857e-21	3.152045	109	0.03983918	94	7.839447652021276e-7	2.096817	61	199	0.02222222	
GO Biological Process	DNA replication-dependent nucleosome assembly	16	4.357109e-24	3.5834498331875e-21	21.95713	24	0.00877193	345	0.046112950202898545	2.565164	12	32	0.004371585	
GO Biological Process	protein-DNA complex subunit organization	23	1.430379e-20	8.183633591739129e-18	2.574228	125	0.04568713	104	0.0000036080295166346157	1.915322	70	250	0.02550091	
GO Biological Process	RNA catabolic process	28	1.385984e-19	6.513629805714286e-17	2.749811	106	0.03874269	37	2.1563194513243245e-9	2.185534	77	241	0.028051	
GO Biological Process	ncRNA metabolic process	29	8.036363e-19	3.6465689902413795e-16	2.083799	174	0.06359649	96	0.0000011390638750833332	1.61459	131	555	0.04772313	
GO Biological Process	gene silencing	32	1.537728e-18	6.32342586e-16	3.074994	84	0.03070175	135	0.000022820610727407406	2.014129	53	180	0.01930783	
GO Biological Process	mRNA catabolic process	33	1.878281e-18	7.489787781515151e-16	2.846777	94	0.03435673	53	2.6569138273584908e-8	2.183802	68	213	0.02477231	
GO Biological Process	protein-DNA complex assembly	35	7.290999e-18	2.7412073097428573e-15	2.553265	109	0.03983918	112	0.000005471858798660714	1.967797	63	219	0.02295082	
GO Biological Process	viral gene expression	38	1.949077e-17	6.749448485e-15	3.712495	61	0.02229532	110	0.000004951980524727272	2.316054	43	127	0.01566485	
GO Biological Process	translational initiation	39	2.136202e-17	7.207764645641026e-15	3.367056	69	0.0252193	88	4.594155314431818e-7	2.343926	49	143	0.01785064	
GO Biological Process	nuclear-transcribed mRNA catabolic process	43	8.021556e-17	2.4547826838139535e-14	2.84673	85	0.03106725	73	1.0791479587671231e-7	2.176503	63	198	0.02295082	
GO Cellular Component	nucleosome	14	2.485748e-31	3.068123245714285e-29	6.675874	64	0.02339181	30	4.021461504e-8	2.671028	41	105	0.01493625	
GO Cellular Component	DNA packaging complex	17	5.632166e-28	5.724931087058823e-26	5.589585	66	0.02412281	32	1.0069817400000002e-7	2.565164	42	112	0.01530055	
GO Cellular Component	protein-DNA complex	21	4.925468e-21	4.0529565257142857e-19	2.996412	100	0.03654971	29	1.1247772468965518e-8	2.201131	65	202	0.02367942	
GO Cellular Component	nuclear nucleosome	30	1.887175e-15	1.0870128000000002e-13	9.010261	24	0.00877193	72	0.025738008	2.394153	14	40	0.005100182	
GO Cellular Component	ribosomal subunit	31	3.330702e-14	1.85659776e-12	2.885855	69	0.0252193	46	0.0002901073460869565	1.848767	50	185	0.01821494	
GO Cellular Component	chromosome, telomeric region	39	1.455287e-10	6.448040861538461e-9	2.589685	59	0.02156433	60	0.00660108672	1.720349	42	167	0.01530055	
GO Cellular Component	nuclear chromosome, telomeric region	40	2.029818e-10	8.76881376e-9	2.829122	50	0.01827485	64	0.0147076776	1.761931	34	132	0.01238616	
GO Cellular Component	membrane coat	41	2.706781e-10	1.1408091629268292e-8	2.677943	54	0.01973684	71	0.025817901971830984	1.852618	26	96	0.009471767	
GO Cellular Component	ribosome	42	2.952739e-10	1.2148411885714286e-8	2.233969	76	0.02777778	54	0.00214256	1.652139	57	236	0.02076503	
GO Cellular Component	small ribosomal subunit	44	9.340668e-10	3.668335069090909e-8	3.502019	34	0.0124269	51	0.0017578364611764705	2.280146	24	72	0.008743169	
GO Cellular Component	cytosolic ribosome	46	2.641491e-9	9.922818365217391e-8	2.643853	49	0.01790936	45	0.00022468258560000002	2.137637	35	112	0.01275046	
GO Cellular Component	clathrin coat	62	3.019583e-7	0.000008415870038709678	2.789413	33	0.0120614	74	0.02676041513513513	2.233612	16	49	0.00582878	
GO Cellular Component	preribosome	67	4.410482e-7	0.000011375093874626866	2.848186	31	0.01133041	57	0.004130771873684211	2.160138	24	76	0.008743169	
GO Cellular Component	catalytic step 2 spliceosome	69	5.90933e-7	0.000014799017739130436	2.497134	38	0.01388889	59	0.005391005613559322	1.995128	28	96	0.01020036	
GO Cellular Component	cytosolic large ribosomal subunit	73	0.000003612507	0.00008551249446575343	2.846717	26	0.009502924	83	0.044516798457831325	2.01849	18	61	0.006557377	
GO Cellular Component	mitotic spindle	78	0.000004441427	0.00009839469046153846	2.258176	39	0.01425439	70	0.02478976457142857	1.942346	23	81	0.008378871	
GO Cellular Component	cytoplasmic stress granule	80	0.00000487644	0.000105331104	2.867113	25	0.009137427	42	0.00002444006262857143	3.181599	20	43	0.007285974	
GO Cellular Component	cytosolic small ribosomal subunit	83	0.000005878446	0.00012238499624096387	3.182987	21	0.007675439	68	0.02499246296470588	2.331967	15	44	0.005464481	
GO Cellular Component	Barr body	115	0.0001605598	0.0024125855165217395	6.278686	7	0.00255848	82	0.042423811902439025	5.47235	4	5	0.001457195	
GO Cellular Component	PcG protein complex	124	0.000286958	0.003998898580645162	2.210891	25	0.009137427	63	0.014337298285714286	2.379282	16	46	0.00582878	
GO Molecular Function	structural constituent of ribosome	10	4.451516e-12	1.8794300552e-9	2.780241	61	0.02229532	41	0.011491748526829267	1.773447	42	162	0.01530055	
GO Molecular Function	rRNA binding	12	3.077911e-11	1.0829116868333332e-8	4.979279	27	0.009868421	32	0.0007150600855	2.622168	23	60	0.008378871	
GO Molecular Function	nucleosome binding	13	7.413537e-11	2.4076887087692307e-8	3.342316	41	0.01498538	40	0.011088038055	2.280146	22	66	0.008014572	
GO Molecular Function	ribonucleoprotein complex binding	15	1.38726e-9	3.9046744800000004e-7	2.731856	48	0.01754386	30	0.0005830006400666667	2.141354	36	115	0.01311475	
GO Molecular Function	nucleosomal DNA binding	17	5.656726e-9	0.0000014048645395294118	3.776151	28	0.01023392	54	0.04086849088888889	2.379282	16	46	0.00582878	
GO Molecular Function	aminoacyl-tRNA ligase activity	48	0.00002212367	0.0019459611404166668	2.906064	21	0.007675439	49	0.033931068028571425	2.432155	16	45	0.00582878	
Mouse Phenotype Single KO	abnormal induced cell death	7	1.344793e-13	1.7591813572857142e-10	2.273587	101	0.0369152	7	0.0000049677078198571435	2.074825	64	211	0.02331512	
Mouse Phenotype Single KO	abnormal cell nucleus morphology	10	1.538485e-11	1.4087907145e-8	2.372108	77	0.02814327	26	0.005429407181153847	1.934193	41	145	0.01493625	
Mouse Phenotype Single KO	increased sensitivity to induced cell death	16	9.599042e-10	5.493651724625001e-7	2.340199	65	0.02375731	13	0.00011644463830769229	2.155206	46	146	0.01675774	
Mouse Phenotype Single KO	increased integument system tumor incidence	56	0.00001207619	0.00197467271125	2.370869	32	0.01169591	48	0.025994071285416667	2.160138	24	76	0.008743169	
Mouse Phenotype Single KO	increased circulating interferon-gamma level	57	0.00001236523	0.0019864633528070175	3.02586	21	0.007675439	56	0.03525301104285714	2.545279	16	43	0.00582878	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	66	0.00001920885	0.002665082415909091	3.755364	15	0.005482456	60	0.038370149773333334	3.1352	11	24	0.004007286	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	71	0.00002431506	0.003135957808732395	3.677839	15	0.005482456	58	0.03781615232586207	3.621408	9	17	0.003278689	
Mouse Phenotype Single KO	increased neural tube apoptosis	91	0.00007905614	0.007955132681098901	2.915526	18	0.006578947	46	0.0240948141	3.157125	12	26	0.004371585	
Mouse Phenotype	decreased pre-B cell number	9	2.622165e-13	2.7856132850000003e-10	2.48181	83	0.03033626	74	0.042980661522972974	1.90743	29	104	0.01056466	
Mouse Phenotype	abnormal pre-B cell morphology	12	3.861859e-11	3.07693615825e-8	2.170951	89	0.03252924	70	0.04020003035571429	1.800115	35	133	0.01275046	
Mouse Phenotype	increased sensitivity to induced cell death	29	9.979046e-8	0.000032899882346896554	2.01127	69	0.0252193	32	0.00165827866321875	1.868972	50	183	0.01821494	
Mouse Phenotype	decreased level of surface class I molecules	51	0.000002936209	0.0005504528284117647	9.507744	8	0.002923977	45	0.012502137822666667	4.560291	8	12	0.00291439	
Mouse Phenotype	increased circulating interferon-gamma level	52	0.000003032184	0.0005575136773846153	3.029293	24	0.00877193	68	0.036006965025	2.367844	18	52	0.006557377	
Mouse Phenotype	increased B cell derived lymphoma incidence	55	0.000004791515	0.0008329395439090909	2.224133	40	0.01461988	37	0.006637618303783783	2.280146	26	78	0.009471767	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	63	0.00001113303	0.0016895698385714286	3.401675	18	0.006578947	80	0.046599214485	3.009792	11	25	0.004007286	
Mouse Phenotype	increased neural tube apoptosis	76	0.00002246527	0.002826190085131579	2.743292	23	0.008406433	64	0.0322073041125	2.545279	16	43	0.00582878	
Mouse Phenotype	abnormal level of surface class I molecules	84	0.00004279221	0.004870670473928571	6.52094	8	0.002923977	69	0.03756769088695653	3.908821	8	14	0.00291439