# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process mammary gland epithelial cell differentiation 59 0.000001049105 0.00023398597788135592 6.115133 12 0.01785714 178 0.011712382338202246 6.694118 6 17 0.006060606 GO Biological Process lymph vessel development 72 0.000007002236 0.0012797558822777778 5.569511 11 0.01636905 168 0.007364089709523809 6.034848 7 22 0.007070707 GO Biological Process placenta blood vessel development 79 0.00001207239 0.0020108934178481013 5.248898 11 0.01636905 103 0.000325697259184466 6.11828 10 31 0.01010101 GO Biological Process ureter development 83 0.00002315671 0.0036713150227710837 4.885007 11 0.01636905 132 0.0014812328660606061 9.483333 6 12 0.006060606 GO Biological Process lacrimal gland development 96 0.00008429886 0.011555090611875 5.889731 8 0.01190476 198 0.015715919973232323 10.8381 4 7 0.004040404 GO Biological Process anterior/posterior pattern specification 101 0.0001254695 0.016347060896039604 2.017004 34 0.05059524 113 0.0005417563793539823 2.612755 27 196 0.02727273 GO Biological Process mammary gland epithelium development 121 0.0002203216 0.023960429209917356 2.756074 17 0.02529762 217 0.027675566123963134 3.512346 10 54 0.01010101 GO Biological Process regulation of cellular response to drug 126 0.0003341148 0.03489378296190476 12.52049 4 0.005952381 176 0.010926710230681818 18.96667 3 3 0.003030303 GO Biological Process morphogenesis of embryonic epithelium 129 0.0003913488 0.03992061131162791 2.0446 28 0.04166667 133 0.001553400162030075 2.824823 21 141 0.02121212 GO Biological Process otic vesicle development 130 0.000392425 0.039722465961538465 4.177415 9 0.01339286 223 0.03194670029058296 6.77381 5 14 0.005050505 GO Molecular Function HMG box domain binding 16 0.00006457744 0.01704037198 4.778382 10 0.01488095 21 0.0042474063876190475 7.375926 7 18 0.007070707 Mouse Phenotype Single KO abnormal KLRG1-positive NK cell number 2 2.126222e-7 0.0009734907427 8.038484 11 0.01636905 179 0.01622456187877095 5.989474 6 19 0.006060606 Mouse Phenotype Single KO abnormal presacral vertebrae morphology 11 0.00001571695 0.013083646468181815 2.063027 41 0.0610119 120 0.004675861039416667 2.100115 32 289 0.03232323 Mouse Phenotype Single KO abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number 12 0.00001848444 0.014105168090000002 3.746784 15 0.02232143 250 0.039502858464 3.414 9 50 0.009090909 Mouse Phenotype Single KO abnormal rib development 14 0.00003031704 0.019829509662857146 5.902073 9 0.01339286 279 0.04811429136200717 5.578431 5 17 0.005050505 Mouse Phenotype Single KO decreased percent body fat/body weight 16 0.00003561158 0.02038095237875 3.215884 17 0.02529762 65 0.0009964788276923076 3.793333 15 75 0.01515152 Mouse Phenotype Single KO decreased molar number 17 0.00004609738 0.02483021815647059 7.673542 7 0.01041667 35 0.0001414942779542857 14.225 6 8 0.006060606 Mouse Phenotype Single KO increased embryonic neuroepithelium apoptosis 27 0.00008222412 0.02788615803111111 6.987893 7 0.01041667 279 0.04811429136200717 5.578431 5 17 0.005050505 Mouse Phenotype Single KO abnormal circulating LDL cholesterol level 31 0.00009985272 0.029495205065806454 2.664696 20 0.0297619 202 0.021155865883663364 2.571751 16 118 0.01616162 Mouse Phenotype Single KO cervical vertebral fusion 33 0.0001054245 0.029253701409090907 3.569191 13 0.01934524 58 0.0007364499883275862 5.215833 11 40 0.01111111 Mouse Phenotype Single KO abnormal otic vesicle morphology 35 0.0001434957 0.03754257499714286 3.457363 13 0.01934524 126 0.0050935158428571424 5.419048 8 28 0.008080808 Mouse Phenotype Single KO abnormal vibrissa number 36 0.0001582139 0.04024346339722222 6.276679 7 0.01041667 197 0.02106490689492386 9.483333 4 8 0.004040404 Mouse Phenotype Single KO abnormal circulating non-HDL cholesterol level 38 0.0001630978 0.03930227775263157 2.566133 20 0.0297619 282 0.047628024843971634 2.316539 16 131 0.01616162 Mouse Phenotype Single KO decreased submandibular gland size 39 0.0001633281 0.0383486003 6.243743 7 0.01041667 165 0.013123551564242424 10.8381 4 7 0.004040404 Mouse Phenotype Single KO small otic vesicle 40 0.0001642105 0.03759188871250001 4.712304 9 0.01339286 108 0.003736886912962963 8.128571 6 14 0.006060606 Mouse Phenotype Single KO abnormal cervical vertebrae morphology 44 0.0001847516 0.038449327299999995 2.412864 22 0.0327381 183 0.016695042400000002 2.558995 17 126 0.01717172 Mouse Phenotype Single KO abnormal artery development 49 0.0002026702 0.037874510640816324 2.167791 27 0.04017857 29 0.00005471850604827586 3.566382 22 117 0.02222222 Mouse Phenotype Single KO abnormal pharyngeal pouch morphology 57 0.0002834106 0.04552966428421052 6.893809 6 0.008928571 106 0.003674349050283019 10.53704 5 9 0.005050505 Mouse Phenotype Single KO abnormal corpus callosum morphology 60 0.0003048461 0.04652459562833333 2.185826 25 0.03720238 81 0.0017132679170370369 3.256902 17 99 0.01717172 Mouse Phenotype cervical vertebral fusion 8 1.999508e-7 0.00023896619985 4.524031 18 0.02678571 38 0.000026406727184210526 5.531944 14 48 0.01414141 Mouse Phenotype abnormal KLRG1-positive NK cell number 10 2.126222e-7 0.00020328808541999997 8.038484 11 0.01636905 258 0.011753207596511626 5.989474 6 19 0.006060606 Mouse Phenotype abnormal presacral vertebrae morphology 23 0.000001433108 0.0005957367646956522 2.081724 50 0.07440476 87 0.00023749403113793103 2.266457 38 318 0.03838384 Mouse Phenotype abnormal hair follicle outer root sheath morphology 29 0.000002848129 0.0009389986678965518 5.542015 12 0.01785714 119 0.0006783305338739496 6.096429 9 28 0.009090909 Mouse Phenotype abnormal cervical vertebrae morphology 35 0.000004301063 0.0011749275240857144 2.614693 29 0.04315476 141 0.0010646241308510638 2.824823 21 141 0.02121212 Mouse Phenotype abnormal rib development 41 0.00000650938 0.0015179556629268294 5.613647 11 0.01636905 407 0.03329729834152334 4.023232 7 33 0.007070707 Mouse Phenotype decreased percent body fat/body weight 43 0.00001102572 0.0024515560213953487 3.131107 20 0.0297619 102 0.0003759660781764706 3.582593 17 90 0.01717172 Mouse Phenotype abnormal pharyngeal pouch morphology 48 0.00001344411 0.002677898660625 5.770899 10 0.01488095 170 0.002637269683235294 6.638333 7 20 0.007070707 Mouse Phenotype cornea ulcer 57 0.00003601301 0.006040708572105264 13.96117 5 0.007440476 301 0.017836318671428573 14.225 3 4 0.003030303 Mouse Phenotype thin dermal layer 64 0.00005956624 0.0088986378225 4.392389 11 0.01636905 328 0.022602268128658537 4.425556 7 30 0.007070707 Mouse Phenotype abnormal ultimobranchial body morphology 65 0.00006744154 0.009920131752923078 9.011121 6 0.008928571 149 0.0012682640832885907 11.85417 5 8 0.005050505 Mouse Phenotype small first pharyngeal arch 66 0.00006975432 0.010104864447272729 4.313897 11 0.01636905 70 0.00011064579250285716 7.759091 9 22 0.009090909 Mouse Phenotype decreased molar number 72 0.00009139312 0.012136244726666669 6.868546 7 0.01041667 81 0.00018292187825925924 12.64444 6 9 0.006060606 Mouse Phenotype abnormal vibrissa number 82 0.0001582139 0.01844735485243902 6.276679 7 0.01041667 290 0.014940938434137933 9.483333 4 8 0.004040404 Mouse Phenotype decreased submandibular gland size 84 0.0001633281 0.01859023766785714 6.243743 7 0.01041667 242 0.009342649674793388 10.8381 4 7 0.004040404 Mouse Phenotype decreased susceptibility to diet-induced obesity 85 0.0001653332 0.018597067355294115 2.563423 20 0.0297619 353 0.026170390867988665 2.408466 16 126 0.01616162 Mouse Phenotype abnormal third pharyngeal arch artery morphology 95 0.000234497 0.023600271757894736 4.487607 9 0.01339286 304 0.018219929085197366 5.419048 6 21 0.006060606 Mouse Phenotype absent hypaxial muscle 99 0.0002858255 0.027603814196969695 8.925498 5 0.007440476 392 0.032892961959183675 11.38 3 5 0.003030303 Mouse Phenotype increased energy expenditure 103 0.0003190822 0.02961888266213592 2.266773 23 0.03422619 435 0.04039740095172414 2.14717 18 159 0.01818182 Mouse Phenotype eyelids open at birth 106 0.0003350498 0.03022085979056604 2.258706 23 0.03422619 102 0.0003759660781764706 3.582593 17 90 0.01717172