# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process posttranscriptional gene silencing 169 3.352593e-36 2.6104598394674557e-34 2.458305 255 0.00923545 396 0.000015017977911363636 1.423095 50 52 0.003941042 GO Biological Process gene silencing by miRNA 172 1.423791e-35 1.0892828935465115e-33 2.597571 226 0.008185144 491 0.00020368333692668023 1.412745 42 44 0.003310475 GO Biological Process posttranscriptional gene silencing by RNA 174 1.805935e-35 1.3657642910919539e-33 2.451135 251 0.00909058 404 0.000021007027599999997 1.421979 49 51 0.003862221 GO Biological Process adherens junction assembly 259 1.774292e-26 9.01463645868726e-25 2.223383 225 0.008148926 757 0.0041012883018494055 1.392959 32 34 0.002522267 GO Biological Process cellular response to dsRNA 319 1.115813e-22 4.602816071159875e-21 2.180133 199 0.007207272 1026 0.02564615994444444 1.276879 44 51 0.003468117 GO Biological Process production of miRNAs involved in gene silencing by miRNA 321 1.278449e-22 5.240844358566979e-21 2.552624 144 0.005215313 558 0.0005908414582437276 1.480019 27 27 0.002128163 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 337 1.000766e-21 3.907738811275964e-20 2.571495 136 0.004925573 1014 0.02441043813806706 1.480019 16 16 0.001261133 GO Biological Process positive regulation of intrinsic apoptotic signaling pathway 344 2.025285e-21 7.747303870639536e-20 2.091496 206 0.007460795 1080 0.033800012451851845 1.260757 46 54 0.003625759 GO Biological Process positive regulation of mRNA catabolic process 403 1.697285e-19 5.5420777456575684e-18 2.27344 154 0.005577487 1203 0.04952645063674148 1.361617 23 25 0.001812879 GO Biological Process production of small RNA involved in gene silencing by RNA 415 5.208112e-19 1.651410742361446e-17 2.251037 153 0.00554127 493 0.00020583638776876267 1.480019 30 30 0.002364625 GO Biological Process negative regulation of homotypic cell-cell adhesion 461 7.424962e-18 2.1194159426898048e-16 2.518596 114 0.004128789 1167 0.0464942650874036 1.480019 14 14 0.001103492 GO Biological Process nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 468 1.576802e-17 4.4335763927350427e-16 2.082955 167 0.006048314 905 0.013018339741215468 1.381351 28 30 0.002206984 GO Biological Process paraxial mesoderm development 497 1.357858e-16 3.5951817750503016e-15 2.112214 152 0.005505052 960 0.017413948942708334 1.480019 17 17 0.001339954 GO Biological Process nucleus localization 861 6.249443e-11 9.55126834343786e-10 2.09744 96 0.003476875 1033 0.02632123561084221 1.412745 21 22 0.001655238 GO Biological Process regulation of nucleobase-containing compound transport 967 4.68561e-10 6.376209099276112e-9 2.417756 64 0.002317917 1167 0.0464942650874036 1.480019 14 14 0.001103492 GO Molecular Function NF-kappaB binding 80 1.95855e-19 1.0336247624999999e-17 2.53097 124 0.004490964 146 0.04985751124657534 1.374303 26 28 0.002049342 Human Phenotype Coxa vara 43 3.382961e-19 5.2498834309302336e-17 2.360866 140 0.005070443 348 0.023849321175287357 1.377949 27 29 0.002128163 Human Phenotype Ectopic kidney 65 1.375163e-17 1.4117634921538461e-15 2.023635 180 0.006519141 314 0.01520875944936306 1.420818 24 25 0.0018917 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 64 2.125366e-35 3.0409338221875e-33 2.518083 238 0.008619753 834 0.024786681446043166 1.320017 33 37 0.002601088 Mouse Phenotype Single KO thoracic vertebral transformation 89 3.593305e-30 3.6970667286516853e-28 2.425257 216 0.007822969 961 0.04050858604786681 1.264183 41 48 0.003231654 Mouse Phenotype Single KO cervical vertebral transformation 99 1.692029e-28 1.565041368989899e-26 2.50555 191 0.006917533 796 0.019449421984924626 1.324227 34 38 0.002679909 Mouse Phenotype Single KO abnormal Mullerian duct morphology 134 2.215212e-23 1.5137833047761193e-21 2.117256 220 0.007967839 933 0.03917514763022508 1.310874 31 35 0.002443446 Mouse Phenotype Single KO subcutaneous edema 168 4.585118e-21 2.499162233690476e-19 2.375733 153 0.00554127 966 0.04151549661387163 1.332017 27 30 0.002128163 Mouse Phenotype Single KO thick ventricular wall 207 8.256244e-19 3.6522911259903384e-17 2.057445 186 0.006736446 549 0.0032946919358834243 1.369017 37 40 0.002916371 Mouse Phenotype Single KO increased incidence of tumors by ionizing radiation induction 222 5.338552e-18 2.202032462342342e-16 3.34745 73 0.002643874 871 0.029279228900114813 1.480019 15 15 0.001182313 Mouse Phenotype Single KO abnormal pharynx morphology 265 4.775067e-16 1.650010887509434e-14 2.202802 133 0.004816921 828 0.02285107231642512 1.412745 21 22 0.001655238 Mouse Phenotype Single KO abnormal stapedial artery morphology 275 8.799077e-16 2.929932657781818e-14 2.581192 95 0.003440658 762 0.015266653746719159 1.480019 17 17 0.001339954 Mouse Phenotype Single KO absent stapedial artery 282 1.239615e-15 4.025232111702127e-14 2.596502 93 0.003368223 810 0.021264679328395063 1.480019 16 16 0.001261133 Mouse Phenotype Single KO absent segment of posterior cerebral artery 358 6.500157e-14 1.6626239566759775e-12 2.323822 101 0.003657962 828 0.02285107231642512 1.412745 21 22 0.001655238 Mouse Phenotype enlarged liver sinusoidal spaces 76 4.8215e-47 6.065573881578947e-45 2.629607 296 0.01072037 939 0.007122717938977637 1.335627 37 41 0.002916371 Mouse Phenotype abnormal liver sinusoid morphology 89 7.656124e-43 8.224741748764047e-41 2.098503 426 0.01542863 1047 0.01216413064183381 1.233349 65 78 0.005123355 Mouse Phenotype thoracic vertebral transformation 131 2.279904e-31 1.6639818430534352e-29 2.325017 245 0.008873275 1292 0.027350631729102168 1.246332 48 57 0.0037834 Mouse Phenotype cervical vertebral transformation 180 1.211837e-25 6.4368741983333335e-24 2.198041 223 0.008076491 1066 0.013845386347091933 1.307924 38 43 0.002995192 Mouse Phenotype subcutaneous edema 249 4.585118e-21 1.7605748272289158e-19 2.375733 153 0.00554127 1339 0.0312720888103062 1.332017 27 30 0.002128163 Mouse Phenotype increased skin papilloma incidence 260 1.044678e-20 3.8416024453846153e-19 2.080891 201 0.007279707 1135 0.017156443723348017 1.303826 37 42 0.002916371 Mouse Phenotype increased body temperature 271 6.670584e-20 2.3534115728413286e-18 2.096799 189 0.006845098 990 0.009242326075454546 1.35316 32 35 0.002522267 Mouse Phenotype lymphoid hyperplasia 291 4.816878e-19 1.5826175449484536e-17 2.154513 169 0.006120749 1179 0.01948202557760814 1.341267 29 32 0.002285804 Mouse Phenotype abnormal stapedial artery morphology 320 5.608048e-18 1.6755795915e-16 2.461022 120 0.004346094 865 0.004325442823352602 1.480019 20 20 0.001576417 Mouse Phenotype absent stapedial artery 325 8.089486e-18 2.379802327569231e-16 2.470017 118 0.004273659 914 0.006061484662910285 1.480019 19 19 0.001497596 Mouse Phenotype increased susceptibility to kidney reperfusion injury 364 8.223692e-17 2.160074703626374e-15 3.410266 66 0.002390352 1448 0.040308238388121545 1.480019 13 13 0.001024671 Mouse Phenotype abnormal transitional stage T2 B cell morphology 368 9.577289e-17 2.488273373070652e-15 2.092547 157 0.00568614 1428 0.03941709720588235 1.326914 26 29 0.002049342 Mouse Phenotype increased incidence of tumors by ionizing radiation induction 418 1.928659e-15 4.411461411244019e-14 2.790431 81 0.002933613 1421 0.0395077946453202 1.402123 18 19 0.001418775 Mouse Phenotype small hair follicles 470 1.552769e-14 3.1587285976595743e-13 2.211315 118 0.004273659 1313 0.030025202744097486 1.480019 14 14 0.001103492 Mouse Phenotype absent segment of posterior cerebral artery 500 6.500157e-14 1.2429600215399998e-12 2.323822 101 0.003657962 1140 0.01732934604736842 1.412745 21 22 0.001655238