# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	14	2.449508e-20	2.3023625551428573e-17	2.870415	104	0.01982085	354	0.008379937426836159	1.583182	48	113	0.00952759	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	16	1.044667e-19	8.591733158124999e-17	2.443719	133	0.02534782	213	0.00009331263127699531	1.659149	69	155	0.01369591	
GO Biological Process	regulation of cellular amino acid metabolic process	21	1.084571e-18	6.796128470952381e-16	4.213374	57	0.01086335	372	0.010473814078494624	1.801419	29	60	0.005756252	
GO Biological Process	regulation of DNA-templated transcription in response to stress	22	1.810194e-18	1.0827428566363638e-15	2.635163	108	0.02058319	306	0.002223763921862745	1.628637	52	119	0.01032156	
GO Biological Process	nuclear-transcribed mRNA catabolic process	24	2.385027e-18	1.3076904288749998e-15	2.340115	134	0.0255384	229	0.00016202452594759825	1.562359	83	198	0.01647479	
GO Biological Process	mRNA catabolic process	25	3.315151e-18	1.74496288036e-15	2.258222	143	0.02725367	198	0.00004835186158737374	1.57482	90	213	0.01786423	
GO Biological Process	RNA catabolic process	27	7.384565e-18	3.599018179074074e-15	2.137269	158	0.03011245	164	0.000009965615603658536	1.577434	102	241	0.02024613	
GO Biological Process	multi-organism metabolic process	29	2.327917e-17	1.056312407e-14	2.563364	106	0.02020202	74	2.23597728e-9	1.977631	78	147	0.01548233	
GO Biological Process	viral gene expression	30	3.229043e-17	1.4163658945666666e-14	2.824432	89	0.01696207	103	6.085942959611651e-8	1.966252	67	127	0.01329893	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	34	2.174633e-16	8.416469307941177e-14	2.873338	82	0.01562798	231	0.00017588689674891773	1.737196	55	118	0.01091703	
GO Biological Process	response to topologically incorrect protein	38	6.995232e-16	2.422375207578947e-13	2.225645	127	0.02420431	433	0.025040765578983833	1.408006	68	180	0.01349742	
GO Biological Process	rRNA metabolic process	41	1.016434e-15	3.262257318536585e-13	2.082142	146	0.02782542	206	0.00006441451869417475	1.510976	105	259	0.0208416	
GO Biological Process	rRNA processing	44	1.839267e-15	5.500662375681819e-13	2.090555	142	0.02706308	215	0.00009535519398604652	1.508578	102	252	0.02024613	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	46	3.165988e-15	9.056790454782609e-13	2.774005	80	0.01524681	440	0.02754048904409091	1.517216	46	113	0.009130607	
GO Biological Process	response to unfolded protein	47	4.841434e-15	1.3554985107659576e-12	2.239412	118	0.02248904	413	0.020525405013801453	1.444241	62	160	0.01230647	
GO Biological Process	macromolecular complex disassembly	50	2.311389e-14	6.083113570199999e-12	2.096212	130	0.02477606	264	0.0008596236377272727	1.522051	78	191	0.01548233	
GO Biological Process	regulation of ubiquitin protein ligase activity	51	2.332564e-14	6.018472485490196e-12	2.818314	73	0.01391271	191	0.00004286826720680628	1.904049	47	92	0.009329099	
GO Biological Process	translational initiation	52	3.041373e-14	7.69642832826923e-12	2.417296	95	0.01810558	175	0.000016116594281714286	1.746252	67	143	0.01329893	
GO Biological Process	positive regulation of nuclease activity	54	3.495601e-14	8.518261770185186e-12	5.935222	30	0.005717553	480	0.03951228256875001	2.484716	10	15	0.001984915	
GO Biological Process	regulation of hematopoietic stem cell differentiation	62	2.575743e-13	5.4668067962903224e-11	2.745615	70	0.01334096	377	0.012127002807161802	1.592148	44	103	0.008733624	
GO Cellular Component	proteasome complex	28	3.275507e-16	2.0214557485714284e-14	3.374516	64	0.01219745	45	0.00016590915839999999	1.973157	36	68	0.007145693	
GO Cellular Component	endopeptidase complex	29	3.360967e-16	2.0026727503448275e-14	3.372611	64	0.01219745	47	0.0002467063761702128	1.94456	36	69	0.007145693	
GO Cellular Component	ribosomal subunit	31	1.66735e-14	9.294131612903227e-13	2.311726	106	0.02020202	35	0.000001946627053714286	1.692293	84	185	0.01667328	
GO Cellular Component	peptidase complex	33	6.353702e-14	3.3270294109090912e-12	2.782682	72	0.01372213	49	0.00028745255314285715	1.821184	43	88	0.008535133	
GO Cellular Component	large ribosomal subunit	34	6.782472e-14	3.4470916517647064e-12	2.711813	75	0.01429388	36	0.000007676136000000001	1.847332	57	115	0.01131401	
GO Cellular Component	catalytic step 2 spliceosome	36	3.273441e-13	1.57125168e-11	2.604216	76	0.01448447	44	0.00011560021527272727	1.824713	47	96	0.009329099	
GO Cellular Component	mitochondrial large ribosomal subunit	40	1.119281e-10	4.83529392e-9	3.645872	36	0.006861063	75	0.004714739712	1.900077	26	51	0.005160778	
GO Cellular Component	mitochondrial ribosome	47	7.544846e-10	2.7739348697872337e-8	2.829146	47	0.0089575	101	0.02370282201980198	1.578526	36	85	0.007145693	
GO Cellular Component	nuclear chromosome, telomeric region	52	1.597511e-8	5.308651938461539e-7	2.094812	71	0.01353154	98	0.01928359836734694	1.468241	52	132	0.01032156	
GO Cellular Component	nuclear ubiquitin ligase complex	53	1.685637e-8	5.495812709433963e-7	3.247801	32	0.006098723	62	0.0011554815483870969	2.143068	23	40	0.004565304	
GO Cellular Component	anaphase-promoting complex	72	0.000001788382	0.000042921168000000004	3.90278	18	0.003430532	94	0.014257860357446807	2.307236	13	21	0.002580389	
GO Cellular Component	mitochondrial nucleoid	78	0.000008358547	0.0001851739643076923	2.550586	29	0.005526968	61	0.0009229655921311476	2.129757	24	42	0.004763795	
GO Cellular Component	transcription factor AP-1 complex	79	0.000009527817	0.00020840592121518987	6.038404	10	0.001905851	102	0.02352189176470588	3.727074	5	5	0.0009924573	
GO Cellular Component	cytosolic large ribosomal subunit	89	0.00003210362	0.0006233152287640449	2.112408	37	0.007051649	85	0.008557139350588236	1.771888	29	61	0.005756252	
GO Cellular Component	transcription elongation factor complex	91	0.000038787	0.0007365267692307693	2.006669	41	0.007813989	116	0.04555635144827587	1.663872	25	56	0.004962287	
GO Cellular Component	Bcl-2 family protein complex	108	0.0001276855	0.002042968	4.042061	11	0.002096436	109	0.03181829812844037	3.194635	6	7	0.001190949	
GO Molecular Function	unfolded protein binding	6	2.956497e-14	2.080388389e-11	2.828261	72	0.01372213	30	0.0019423198413333334	1.722893	49	106	0.009726082	
GO Molecular Function	structural constituent of ribosome	12	1.685749e-10	5.931026898333334e-8	2.115182	89	0.01696207	21	0.00008613350451428572	1.679484	73	162	0.01448988	
GO Molecular Function	SNAP receptor activity	49	0.000005898629	0.0005082451354693877	2.32064	36	0.006861063	42	0.024331999195238097	1.999893	22	41	0.004366812	
GO Molecular Function	ubiquitin-protein transferase inhibitor activity	80	0.00009869713	0.00520874103575	5.776031	8	0.001524681	45	0.03492616662222222	3.727074	6	6	0.001190949	
GO Molecular Function	C-acyltransferase activity	103	0.0002024816	0.0082997797592233	2.475286	21	0.004002287	46	0.03593999527826087	2.422598	13	20	0.002580389	
GO Molecular Function	ADP-ribosylation factor binding	134	0.0004865799	0.01533089804328358	3.228209	12	0.002287021	52	0.04961712262307692	3.26119	7	8	0.00138944	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	69	0.000004975449	0.0006602925578695651	2.054886	48	0.009148085	35	0.004009630532	1.992057	31	58	0.006153235	
Mouse Phenotype	increased hepatocyte apoptosis	55	3.555311e-7	0.00006180423358363635	2.01589	63	0.01200686	70	0.007701053596714287	1.836529	34	69	0.00674871	
Mouse Phenotype	early cellular replicative senescence	62	7.461134e-7	0.00011505790673225805	2.080712	55	0.01048218	46	0.0024879571845652176	1.889065	37	73	0.007344184	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	68	0.000001162976	0.00016351784611764707	2.964837	27	0.005145798	112	0.045244683712500004	2.112009	17	30	0.003374355	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	85	0.000004975449	0.0005596502104588235	2.054886	48	0.009148085	52	0.0028178583703846152	1.992057	31	58	0.006153235	
Mouse Phenotype	abnormal neuroendocrine cell morphology	150	0.0001156096	0.007368955903999999	2.07349	33	0.006289308	68	0.007269613552058823	2.484716	16	24	0.003175863	
Mouse Phenotype	pale lung	193	0.0003814945	0.01889880266580311	3.54821	11	0.002096436	99	0.035951194939393936	3.727074	6	6	0.001190949	
Mouse Phenotype	disorganized mitochondrial cristae	217	0.000725542	0.03196731364976959	2.67284	15	0.002858776	91	0.025046657515384617	2.86698	10	13	0.001984915