# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	39	1.137045e-38	3.8365064499999997e-36	2.368499	293	0.01635501	552	0.004265611427717392	1.305745	81	113	0.007857974	
GO Biological Process	regulation of DNA-templated transcription in response to stress	43	2.12155e-36	6.49243638372093e-34	2.229629	312	0.01741557	441	0.0009411140749886621	1.331754	87	119	0.008440047	
GO Biological Process	liver regeneration	70	4.52103e-30	8.498890538571428e-28	2.958889	152	0.00848451	664	0.009747200275000001	1.509321	29	35	0.002813349	
GO Biological Process	IRE1-mediated unfolded protein response	82	4.906011e-28	7.872951066951219e-26	2.870626	148	0.008261234	720	0.01426937469638889	1.3819	44	58	0.004268529	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	84	1.927965e-27	3.0202489803571433e-25	3.351274	115	0.006419202	749	0.016843674605073432	1.707745	15	16	0.00145518	
GO Biological Process	endoplasmic reticulum unfolded protein response	88	1.097647e-26	1.6413564628409091e-24	2.127229	250	0.01395479	597	0.00632023022881072	1.294291	81	114	0.007857974	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	98	6.031476e-26	8.098795171836736e-24	2.329213	199	0.01110801	603	0.0066323629545605315	1.354519	58	78	0.005626698	
GO Biological Process	cellular response to epidermal growth factor stimulus	105	1.990166e-25	2.494151847047619e-23	2.382726	186	0.01038236	518	0.003418001983397683	1.533975	32	38	0.003104385	
GO Biological Process	RNA phosphodiester bond hydrolysis	112	2.03201e-24	2.387430320535714e-22	2.009756	261	0.0145688	753	0.016945237497211156	1.246354	91	133	0.008828095	
GO Biological Process	mitochondrial transmembrane transport	113	2.181929e-24	2.5408852841592923e-22	2.30093	191	0.01066146	536	0.0037372959371268655	1.360709	62	83	0.006014746	
GO Biological Process	response to epidermal growth factor	122	1.080242e-23	1.1651561047540982e-21	2.267299	191	0.01066146	633	0.007868805515481832	1.474624	34	42	0.003298409	
GO Biological Process	regulation of cellular amino acid metabolic process	139	9.399728e-23	8.898634586474821e-21	2.749496	127	0.007089032	759	0.0180645503715415	1.366196	45	60	0.004365541	
GO Biological Process	cotranslational protein targeting to membrane	147	6.814489e-22	6.10012658170068e-20	2.234385	181	0.01010327	677	0.011035438676957164	1.301139	70	98	0.006790842	
GO Biological Process	response to cadmium ion	163	9.384798e-21	7.576353182944784e-19	2.419058	145	0.008093776	872	0.03000757534977064	1.350493	43	58	0.004171517	
GO Biological Process	regulation of mitochondrial membrane permeability	187	3.209225e-19	2.2582990254010696e-17	2.019524	199	0.01110801	383	0.0003506952522715405	1.447295	58	73	0.005626698	
GO Biological Process	RNA phosphodiester bond hydrolysis, endonucleolytic	197	1.365212e-18	9.119200359390862e-17	2.258402	148	0.008261234	971	0.04553656365190525	1.301139	50	70	0.004850601	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	198	1.373452e-18	9.127906498989899e-17	2.144558	166	0.009265978	994	0.048368274179074446	1.305023	48	67	0.004656577	
GO Biological Process	protein-lipid complex subunit organization	202	1.607353e-18	1.0470870359900991e-16	2.355507	135	0.007535585	849	0.026811625243816254	1.395264	36	47	0.003492433	
GO Biological Process	establishment of protein localization to mitochondrion	213	1.067503e-17	6.594963369483567e-16	2.045773	176	0.00982417	556	0.004403967024460432	1.392984	52	68	0.005044626	
GO Biological Process	protein targeting to ER	215	1.069687e-17	6.54698196883721e-16	2.050457	175	0.009768351	579	0.005513364183592401	1.316598	73	101	0.007081878	
GO Cellular Component	outer mitochondrial membrane protein complex	49	7.662712e-19	2.7022788440816328e-17	4.639451	52	0.002902596	144	0.019750848	1.700155	14	15	0.001358168	
GO Cellular Component	proteasome complex	62	3.330827e-16	9.283337187096774e-15	2.161991	140	0.00781468	104	0.0030917641846153845	1.392984	52	68	0.005044626	
GO Cellular Component	endopeptidase complex	63	3.477585e-16	9.538518857142856e-15	2.16077	140	0.00781468	114	0.005348566231578948	1.372796	52	69	0.005044626	
GO Cellular Component	high-density lipoprotein particle	67	6.733897e-16	1.7367423904477615e-14	3.331302	64	0.003572425	168	0.038092381714285715	1.484262	22	27	0.002134265	
GO Cellular Component	PcG protein complex	70	2.596222e-15	6.40895945142857e-14	2.039405	151	0.008428691	109	0.0042306624	1.465196	37	46	0.003589445	
GO Cellular Component	fibrinogen complex	127	7.396158e-10	1.0063433877165355e-8	2.765601	49	0.002735138	172	0.04542183627906977	1.821595	9	9	0.0008731083	
GO Cellular Component	platelet dense tubular network	172	1.847562e-7	0.000001856155311627907	2.592865	39	0.002176947	140	0.016803516342857143	1.821595	11	11	0.001067132	
GO Cellular Component	Fanconi anaemia nuclear complex	216	0.000001845528	0.000014764224	2.158014	47	0.0026235	178	0.04652644853932584	1.681472	12	13	0.001164144	
GO Cellular Component	CCR4-NOT complex	218	0.000002075508	0.00001645173313761468	2.235836	43	0.002400223	131	0.012646437911450382	1.707745	15	16	0.00145518	
GO Cellular Component	proteasome accessory complex	219	0.000002133543	0.000016834531068493152	2.209935	44	0.002456042	125	0.010250074368	1.593896	21	24	0.002037253	
GO Cellular Component	platelet dense tubular network membrane	257	0.00001541923	0.00010367482272373541	2.347156	32	0.001786213	172	0.04542183627906977	1.821595	9	9	0.0008731083	
GO Cellular Component	proteasome regulatory particle	263	0.00001901464	0.0001249326917110266	2.076118	41	0.002288585	160	0.0327452004	1.561367	18	21	0.001746217	
GO Cellular Component	nuclear origin of replication recognition complex	330	0.0003843926	0.0020128194327272727	2.737778	16	0.0008931063	172	0.04542183627906977	1.821595	9	9	0.0008731083	
GO Molecular Function	ribonuclease activity	14	7.610607e-22	2.295141625285714e-19	2.086931	211	0.01177784	128	0.029761283707812503	1.287996	70	99	0.006790842	
GO Molecular Function	mRNA 5'-UTR binding	82	6.186489e-10	3.185287385121951e-8	2.480683	60	0.003349149	87	0.0017099007795402298	1.738795	21	22	0.002037253	
Human Phenotype	Increased serum lactate	13	9.057275e-20	4.649168928846154e-17	2.052986	197	0.01099637	91	0.010618436915384616	1.329764	73	100	0.007081878	
Human Phenotype	Aplasia/hypoplasia of the femur	78	1.365378e-10	1.1680983838461538e-8	2.111006	91	0.005079542	158	0.04806697049367089	1.490396	27	33	0.002619325	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	25	6.380249e-26	2.3369576037200002e-23	2.01898	275	0.01535027	340	0.028808729970588236	1.292745	66	93	0.006402794	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	115	1.560752e-17	1.2975956410434782e-15	2.304043	133	0.007423946	463	0.011933387656587472	1.561367	24	28	0.002328289	
Mouse Phenotype	increased liver adenoma incidence	303	1.153028e-10	3.638317065346535e-9	2.327394	74	0.004130617	617	0.037854261408427875	1.49631	23	28	0.002231277	
Mouse Phenotype	early eyelid opening	350	8.063831e-10	2.2028082340285713e-8	2.034456	91	0.005079542	622	0.038136384950160765	1.821595	10	10	0.0009701203