# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	12	1.557646e-29	1.7080886428333332e-26	2.702765	172	0.01866319	361	0.005840397973130194	1.470515	60	113	0.008849558	
GO Biological Process	regulation of DNA-templated transcription in response to stress	17	7.7132e-26	5.970470517647059e-23	2.458814	177	0.01920573	293	0.002673508191535836	1.489462	64	119	0.009439528	
GO Biological Process	cellular response to epidermal growth factor stimulus	24	1.294124e-22	7.095574048333334e-20	2.888641	116	0.01258681	574	0.04267814453832752	1.676258	23	38	0.00339233	
GO Biological Process	response to topologically incorrect protein	33	3.819699e-20	1.5231339133636363e-17	2.035406	204	0.02213542	528	0.03404382834090909	1.307805	85	180	0.01253687	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	35	4.131676e-20	1.553392128114286e-17	2.662051	117	0.01269531	374	0.006982668538235295	1.562265	44	78	0.006489676	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	36	4.780225e-20	1.7473050215277777e-17	2.526945	128	0.01388889	408	0.0105296640872549	1.446006	59	113	0.008702065	
GO Biological Process	response to unfolded protein	38	1.478566e-19	5.120118419473684e-17	2.063735	191	0.02072483	464	0.019022222165301726	1.350116	78	160	0.01150442	
GO Biological Process	regulation of hematopoietic stem cell differentiation	43	4.327962e-19	1.3244570222790698e-16	2.590408	116	0.01258681	388	0.008264984759278352	1.478843	55	103	0.008112094	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	45	8.663314e-19	2.5333455316888885e-16	2.01895	193	0.02094184	454	0.018269648363436124	1.357933	76	155	0.01120944	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	47	2.315617e-18	6.483234915531915e-16	2.306777	139	0.01508247	443	0.015303034782618512	1.473122	50	94	0.007374631	
GO Biological Process	regulation of cellular amino acid metabolic process	48	3.55972e-18	9.758824058333333e-16	3.240518	77	0.008355035	419	0.011531379306921241	1.615524	35	60	0.005162242	
GO Biological Process	translational elongation	57	5.243211e-17	1.210445851736842e-14	2.389128	119	0.01291233	217	0.00026813572791244237	1.582554	64	112	0.009439528	
GO Biological Process	mitochondrial translational termination	79	2.321737e-15	3.867308504177215e-13	2.610366	90	0.009765625	324	0.003782707259382716	1.559816	49	87	0.007227139	
GO Biological Process	mitochondrial translational elongation	102	4.462136e-14	5.756592904313726e-12	2.535703	86	0.009331597	441	0.015360664814512471	1.498771	46	85	0.006784661	
GO Biological Process	mitochondrial translation	106	6.985185e-14	8.671514095754716e-12	2.283889	104	0.01128472	260	0.000974937151	1.552973	60	107	0.008849558	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	109	1.553935e-13	1.8759844646788992e-11	2.196019	110	0.01193576	556	0.04145037665467626	1.397922	53	105	0.007817109	
GO Biological Process	translational termination	113	2.374463e-13	2.765093682920354e-11	2.323581	96	0.01041667	304	0.003003707968947369	1.545072	53	95	0.007817109	
GO Biological Process	positive regulation of establishment of protein localization to telomere	152	7.913801e-12	6.851164957828947e-10	10.63686	16	0.001736111	558	0.041549212345878134	2.46175	8	9	0.001179941	
GO Biological Process	establishment of protein localization to mitochondrion	157	9.900337e-12	8.297995833312101e-10	2.169154	96	0.01041667	283	0.0019248864304593641	1.669827	41	68	0.006047198	
GO Biological Process	protein targeting to mitochondrion	162	1.648743e-11	1.3392474775925926e-9	2.35179	79	0.008572049	274	0.0014322313230656933	1.762389	35	55	0.005162242	
GO Cellular Component	peptidase complex	37	1.249892e-18	5.837333448648649e-17	2.552452	116	0.01258681	61	0.0002616134211147541	1.636504	52	88	0.007669617	
GO Cellular Component	endopeptidase complex	38	1.885344e-18	8.573353768421053e-17	2.85022	95	0.01030816	63	0.0006639450514285715	1.685764	42	69	0.00619469	
GO Cellular Component	proteasome complex	42	4.240852e-17	1.74480768e-15	2.761773	92	0.009982639	66	0.0010838482036363637	1.669827	41	68	0.006047198	
GO Cellular Component	PcG protein complex	43	1.278072e-16	5.1360660837209304e-15	2.599178	99	0.01074219	68	0.0014174905976470588	1.806175	30	46	0.004424779	
GO Cellular Component	mitochondrial ribosome	46	1.794403e-14	6.740713878260869e-13	2.707405	79	0.008572049	86	0.004664721934883721	1.531353	47	85	0.006932153	
GO Cellular Component	large ribosomal subunit	55	1.389174e-11	4.364532130909091e-10	2.099748	102	0.01106771	100	0.010182284927999998	1.420858	59	115	0.008702065	
GO Cellular Component	mitochondrial large ribosomal subunit	61	1.244563e-10	3.5255817442622955e-9	2.882953	50	0.005425347	104	0.012990180184615384	1.629099	30	51	0.004424779	
GO Cellular Component	proteasome accessory complex	88	1.252803e-8	2.4600495272727273e-7	3.221922	33	0.003580729	124	0.03157223225806452	1.846313	16	24	0.002359882	
GO Cellular Component	prespliceosome	106	5.331654e-8	8.69160199245283e-7	3.307975	29	0.003146701	110	0.016687547345454544	1.978192	15	21	0.002212389	
GO Cellular Component	U2-type prespliceosome	119	3.078507e-7	0.000004470302601680672	3.471874	24	0.002604167	90	0.00559160448	2.250194	13	16	0.001917404	
GO Cellular Component	telomerase holoenzyme complex	141	0.000003146491	0.000038561251404255316	2.875265	26	0.002821181	123	0.031260924878048775	1.888274	15	22	0.002212389	
GO Cellular Component	mitochondrial nucleoid	147	0.000005090693	0.00005984161567346939	2.153174	43	0.004665799	80	0.0040579056	1.780373	27	42	0.003982301	
GO Cellular Component	U1 snRNP	148	0.000006098582	0.00007120506551351351	2.705632	27	0.002929688	108	0.0153636272	2.040661	14	19	0.002064897	
GO Cellular Component	LUBAC complex	208	0.0001319553	0.0010962440307692308	3.155932	15	0.001627604	121	0.031605676958677685	2.769469	6	6	0.0008849558	
GO Cellular Component	nuclear telomere cap complex	230	0.0002731478	0.0020521712973913045	2.483256	20	0.002170139	132	0.04288926109090909	2.130361	10	13	0.001474926	
GO Molecular Function	rRNA binding	9	2.337494e-20	1.0965444075555556e-17	3.832431	70	0.007595486	39	0.0005377924058974359	1.800155	39	60	0.005752212	
GO Molecular Function	structural constituent of ribosome	14	1.674169e-14	5.048815369999999e-12	2.002571	148	0.01605903	63	0.006976667355555556	1.40183	82	162	0.0120944	
GO Molecular Function	ribonucleoprotein complex binding	18	1.047677e-12	2.4573846077777775e-10	2.044446	121	0.01312934	50	0.0027233327036	1.517187	63	115	0.009292035	
GO Molecular Function	dopamine receptor binding	70	9.925387e-8	0.0000059864262734285715	3.832849	23	0.00249566	71	0.01177115601971831	2.373831	12	14	0.001769912	
GO Molecular Function	thyroid hormone receptor binding	85	4.465029e-7	0.000022178061691764707	2.465571	40	0.004340278	66	0.009770750706060606	1.978192	20	28	0.002949853	
GO Molecular Function	telomeric DNA binding	102	0.000001103943	0.00004569458182352942	2.292179	43	0.004665799	70	0.01097478742857143	1.873464	23	34	0.00339233	
GO Molecular Function	ubiquitin-protein transferase regulator activity	128	0.000008615916	0.0002841906043125	2.224125	38	0.004123264	87	0.04011252803908046	2.117829	13	17	0.001917404	
GO Molecular Function	mismatch repair complex binding	131	0.000009950113	0.0003206822678320611	3.982884	15	0.001627604	76	0.01600980177894737	2.769469	8	8	0.001179941	
Human Phenotype	Increased serum lactate	6	1.633571e-20	1.8168032138333333e-17	2.572751	127	0.01378038	113	0.005099657775929203	1.523208	55	100	0.008112094	
Human Phenotype	Abnormal CNS myelination	16	2.238565e-15	9.336215153125e-13	2.061614	147	0.01595052	50	0.000015629086874	1.639526	74	125	0.01091445	
Human Phenotype	Abnormality of brainstem morphology	21	1.657147e-14	5.265781871904762e-12	2.239109	114	0.01236979	172	0.028351749684302326	1.552581	37	66	0.005457227	
Human Phenotype	Delayed myelination	43	3.524908e-11	5.470165368372093e-9	2.009462	109	0.01182726	198	0.04765266814646465	1.503426	38	70	0.00560472	
Human Phenotype	Nephrocalcinosis	54	2.622555e-10	3.240798058333333e-8	2.818622	50	0.005425347	166	0.0251121230313253	1.749138	24	38	0.003539823	
Human Phenotype	CNS hypomyelination	59	6.158737e-10	6.965635932372882e-8	3.066004	42	0.004557292	86	0.0005369079505465116	2.12326	23	30	0.00339233	
Human Phenotype	Irritability	78	7.919784e-9	6.775476747692308e-7	2.087333	75	0.008138021	150	0.019557820072666664	1.641167	32	54	0.004719764	
Human Phenotype	Glycosuria	256	0.00004122014	0.001074460914921875	2.064973	38	0.004123264	194	0.041654620242268035	1.81448	19	29	0.00280236	
Human Phenotype	Obstructive sleep apnea	463	0.0009454692	0.01362660037062635	2.297722	19	0.002061632	134	0.013810386021641792	2.517699	10	11	0.001474926	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	36	5.405567e-15	1.3749660283055556e-12	3.653399	53	0.005750868	189	0.025174821687830685	2.014159	16	22	0.002359882	
Mouse Phenotype Single KO	heterochrony	76	4.256512e-11	5.128536892631579e-9	3.101752	47	0.005099826	230	0.03290837484304348	2.117829	13	17	0.001917404	
Mouse Phenotype Single KO	abnormal branching of the mammary ductal tree	98	3.644436e-10	3.4053163726530615e-8	2.005379	98	0.01063368	206	0.027768753634951453	1.749138	24	38	0.003539823	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	470	0.0001556304	0.0030321437719148937	2.155422	29	0.003146701	198	0.02633403358181818	1.961707	17	24	0.002507375	
Mouse Phenotype Single KO	abnormal DNA replication	542	0.0004354866	0.007357473793726937	2.049457	28	0.003038194	158	0.014515328665822785	2.046999	17	23	0.002507375	
Mouse Phenotype	absent segment of posterior cerebral artery	35	5.405567e-15	1.4766464596285715e-12	3.653399	53	0.005750868	294	0.016897831724489793	2.014159	16	22	0.002359882	
Mouse Phenotype	heterochrony	93	4.256512e-11	4.375968949677419e-9	3.101752	47	0.005099826	326	0.02424190670153374	2.117829	13	17	0.001917404	
Mouse Phenotype	dry eyes	117	2.791027e-10	2.2807700125641024e-8	2.81328	50	0.005425347	246	0.011318879241463412	2.250194	13	16	0.001917404	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	195	4.533955e-8	0.0000022230330130769232	2.625759	42	0.004557292	310	0.019878796328709678	1.846313	20	30	0.002949853	
Mouse Phenotype	dry skin	258	6.674327e-7	0.000024733814126744185	2.060171	57	0.006184896	380	0.04443130050789473	1.661681	24	40	0.003539823