# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA metabolic process	39	2.017592e-46	6.807562340512821e-44	2.046147	489	0.02734441	126	6.881742387063492e-14	1.375302	217	259	0.01897019	
GO Biological Process	rRNA processing	40	4.590407e-46	1.5101291428249999e-43	2.060451	477	0.02667338	123	6.03646765398374e-14	1.380936	212	252	0.01853309	
GO Biological Process	DNA replication-dependent nucleosome assembly	42	3.9371e-45	1.2335309261904762e-42	9.937986	71	0.003970251	686	0.01879468511166181	1.436303	28	32	0.002447766	
GO Biological Process	telomere organization	45	5.723464e-43	1.673668061688889e-40	2.579501	278	0.01554549	355	0.00018800400450140844	1.318804	94	117	0.008217502	
GO Biological Process	regulation of hematopoietic stem cell differentiation	60	2.716527e-38	5.9577964654999996e-36	2.669933	232	0.01297321	391	0.00048745513043478263	1.322754	83	103	0.007255879	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	78	5.010562e-35	8.453075045897436e-33	2.47226	243	0.01358832	433	0.0011877787488683601	1.292855	89	113	0.0077804	
GO Biological Process	telomere maintenance	88	1.111744e-31	1.6624362836363637e-29	2.329011	246	0.01375608	470	0.002038112396468085	1.294251	82	104	0.007168459	
GO Biological Process	multi-organism metabolic process	95	1.89763e-29	2.6285171757894735e-27	2.078943	293	0.01638428	233	2.8412997514592277e-7	1.362325	122	147	0.01066527	
GO Biological Process	positive regulation of gene expression, epigenetic	104	3.81016e-28	4.8209514846153847e-26	2.606355	175	0.00978583	304	0.000025967520423684213	1.415785	69	80	0.006031996	
GO Biological Process	telomere capping	113	3.691656e-27	4.298982416283186e-25	4.334641	83	0.004641279	536	0.00483337926119403	1.4876	29	32	0.002535187	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	131	3.906679e-25	3.9242739664885496e-23	2.210457	215	0.01202259	321	0.000056332859124610586	1.335449	96	118	0.008392342	
GO Biological Process	tumor necrosis factor-mediated signaling pathway	139	2.166524e-24	2.0510280083453236e-22	2.017987	258	0.01442711	324	0.0000636642979691358	1.320886	103	128	0.009004284	
GO Biological Process	viral gene expression	140	2.244711e-24	2.1098680035e-22	2.122984	228	0.01274954	242	4.4590174142148757e-7	1.382987	107	127	0.009353965	
GO Biological Process	cotranslational protein targeting to membrane	142	3.796148e-24	3.5178529247887325e-22	2.312584	187	0.01045686	180	1.8304337142777778e-9	1.490741	89	98	0.0077804	
GO Biological Process	protein targeting to ER	145	6.952141e-24	6.309187821999999e-22	2.265408	193	0.01079237	175	5.573153067942857e-10	1.495218	92	101	0.008042661	
GO Biological Process	negative regulation of G2/M transition of mitotic cell cycle	147	9.722944e-24	8.703688441904763e-22	2.201705	204	0.01140748	322	0.00005742951311490684	1.383278	75	89	0.006556517	
GO Biological Process	negative regulation of cell cycle G2/M phase transition	158	1.184294e-22	9.863370092405063e-21	2.148393	205	0.0114634	331	0.0000977950641510574	1.370914	76	91	0.006643937	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	163	6.154895e-22	4.968850509509203e-20	2.284382	173	0.009673992	202	1.810328579059406e-8	1.480909	83	92	0.007255879	
GO Biological Process	protein heterotetramerization	168	1.696556e-21	1.328867881190476e-19	2.874801	111	0.006207012	804	0.04078276887935324	1.343037	36	44	0.003147128	
GO Biological Process	viral transcription	171	5.534877e-21	4.259265873859649e-19	2.070005	206	0.01151932	269	0.000003446215891003718	1.380013	95	113	0.008304922	
GO Cellular Component	ribosomal subunit	34	1.72724e-35	8.778443294117646e-34	2.137212	334	0.01867696	44	1.2119261236363636e-9	1.366429	154	185	0.01346272	
GO Cellular Component	chromosome, telomeric region	36	1.781375e-34	8.5506e-33	2.148922	320	0.01789409	106	0.00038774706113207545	1.248318	127	167	0.01110237	
GO Cellular Component	nuclear chromosome, telomeric region	38	4.130533e-34	1.8783055326315787e-32	2.320023	268	0.0149863	82	0.000028215247609756097	1.318166	106	132	0.009266544	
GO Cellular Component	large ribosomal subunit	45	7.043645e-28	2.70475968e-26	2.312734	218	0.01219035	53	2.0715257479245282e-8	1.427382	100	115	0.008742023	
GO Cellular Component	ficolin-1-rich granule lumen	48	6.955131e-24	2.5038471599999997e-22	2.006285	256	0.01431527	149	0.01473055055033557	1.217879	92	124	0.008042661	
GO Cellular Component	mitochondrial ribosome	55	1.038903e-19	3.2640443345454546e-18	2.419629	137	0.007660907	122	0.0018596707672131148	1.313192	68	85	0.005944576	
GO Cellular Component	mitochondrial large ribosomal subunit	62	1.08032e-17	3.0109563870967737e-16	2.79317	94	0.005256389	103	0.00026973778019417476	1.448373	45	51	0.00393391	
GO Cellular Component	endopeptidase complex	70	6.642421e-15	1.6397290697142856e-13	2.10279	136	0.007604988	74	0.000009404464864864865	1.451172	61	69	0.005332634	
GO Cellular Component	proteasome complex	72	1.355456e-14	3.2530944e-13	2.088507	135	0.007549069	77	0.000013187299324675325	1.448373	60	68	0.005245214	
GO Cellular Component	cytosolic large ribosomal subunit	73	4.881444e-14	1.1554979769863013e-12	2.110655	126	0.007045798	94	0.00014402629991489363	1.426212	53	61	0.004633272	
GO Cellular Component	spliceosomal snRNP complex	79	4.011926e-13	8.775453326582278e-12	2.174016	109	0.006095174	79	0.000025907466531645568	1.45616	55	62	0.004808113	
GO Cellular Component	small nuclear ribonucleoprotein complex	82	3.34624e-12	7.05158868292683e-11	2.010045	121	0.006766203	74	0.000009404464864864865	1.451172	61	69	0.005332634	
GO Cellular Component	proteasome accessory complex	102	1.95759e-10	3.316387764705882e-9	2.717046	54	0.003019628	146	0.010441735890410959	1.504699	22	24	0.001923245	
GO Cellular Component	spliceosomal tri-snRNP complex	112	7.66191e-10	1.1821232571428573e-8	2.510831	58	0.003243304	180	0.0282854208	1.415077	25	29	0.002185506	
GO Cellular Component	proteasome regulatory particle	121	2.971199e-9	4.243166836363636e-8	2.58711	51	0.00285187	135	0.005562944	1.563323	20	21	0.001748405	
GO Cellular Component	transcription factor TFIID complex	124	3.794589e-9	5.287943380645161e-8	2.050104	82	0.00458536	113	0.0008828393288495576	1.500791	32	35	0.002797447	
GO Cellular Component	precatalytic spliceosome	158	2.500845e-7	0.0000027351013670886075	2.325224	47	0.002628194	147	0.011410797453061224	1.465616	25	28	0.002185506	
GO Cellular Component	ESCRT complex	170	8.834719e-7	0.00000898023201882353	2.140016	51	0.00285187	192	0.037941777	1.406991	24	28	0.002098085	
GO Cellular Component	ESCRT III complex	200	0.000009224277	0.00007969775327999999	2.589436	28	0.001565733	174	0.025891488	1.64149	12	12	0.001049043	
GO Cellular Component	preribosome, large subunit precursor	203	0.00001208458	0.00010286775487684729	2.020406	46	0.002572275	139	0.007217488023021582	1.51017	23	25	0.002010665	
GO Molecular Function	unfolded protein binding	12	1.301925e-20	4.5806061250000004e-18	2.143732	186	0.01040094	90	0.001987264438666667	1.300803	84	106	0.007343299	
GO Molecular Function	nucleosome binding	17	3.262049e-18	8.101394634117646e-16	2.107784	169	0.009450316	154	0.042648204012987016	1.293295	52	66	0.004545852	
GO Molecular Function	snRNA binding	42	1.895464e-10	1.905392620952381e-8	2.494994	63	0.003522899	127	0.015150128392125983	1.425504	33	38	0.002884868	
GO Molecular Function	polyubiquitin binding	46	4.855046e-10	4.456087872173913e-8	2.004493	97	0.005424146	134	0.01769763466567164	1.386147	38	45	0.003321969	
GO Molecular Function	5'-3' RNA polymerase activity	53	3.654458e-9	2.9111550332075467e-7	2.142225	74	0.004138008	134	0.01769763466567164	1.386147	38	45	0.003321969	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	55	4.809632e-9	3.692048418909091e-7	2.153033	72	0.00402617	120	0.010689284228333335	1.412445	37	43	0.003234548	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	90	3.102492e-13	3.156613249333333e-11	2.719536	71	0.003970251	216	0.037400833842592594	1.504699	22	24	0.001923245	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	119	5.957142e-14	4.786238206890756e-12	2.609713	81	0.004529441	213	0.003089704929859155	1.532057	28	30	0.002447766	
Mouse Phenotype	absent spleen germinal center	123	1.621934e-13	1.2607569897560977e-11	2.671204	75	0.004193927	304	0.01450743052598684	1.448373	30	34	0.002622607	
Mouse Phenotype	absent B-1 B cells	189	2.28783e-10	1.157351461904762e-8	2.336528	71	0.003970251	384	0.039529207546875	1.64149	13	13	0.001136463	
Mouse Phenotype	absent lymph node germinal center	370	0.000001445817	0.000037360692802702707	2.379255	39	0.002180842	384	0.039529207546875	1.64149	13	13	0.001136463