# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to epidermal growth factor stimulus	18	1.00699e-56	7.361656338888889e-54	3.50714	231	0.01528182	568	0.010926962543133802	1.60544	28	38	0.003249014	
GO Biological Process	response to epidermal growth factor	25	1.888766e-54	9.941708717599999e-52	3.334292	237	0.01567875	431	0.0018946456431554526	1.660047	32	42	0.003713159	
GO Biological Process	endoplasmic reticulum unfolded protein response	26	4.903806e-54	2.4818916597692307e-51	2.904334	288	0.01905266	585	0.013607521703247862	1.337867	70	114	0.008122534	
GO Biological Process	nuclear-transcribed mRNA catabolic process	30	3.671215e-50	1.6103172728333334e-47	2.352005	388	0.02566817	224	0.000004277695997410714	1.408525	128	198	0.01485263	
GO Biological Process	mRNA catabolic process	32	2.231945e-49	9.178176329687501e-47	2.263887	413	0.02732204	213	0.0000025235885388732393	1.401395	137	213	0.01589696	
GO Biological Process	cellular response to unfolded protein	34	2.749908e-47	1.0642952756470588e-44	2.640508	294	0.01944959	570	0.011738070402631579	1.332496	74	121	0.008586679	
GO Biological Process	cellular response to topologically incorrect protein	38	3.780029e-46	1.3089842529210525e-43	2.52357	311	0.02057423	599	0.015537393687979965	1.301017	83	139	0.009631005	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	39	6.997708e-46	2.3610984505641024e-43	2.672943	279	0.01845726	246	0.000010465411541056911	1.52324	79	113	0.00916686	
GO Biological Process	mitochondrial transport	41	8.472066e-46	2.719119914487805e-43	2.052768	477	0.03155597	280	0.00003612614054392857	1.340106	147	239	0.01705732	
GO Biological Process	RNA catabolic process	48	2.814533e-44	7.715924947291668e-42	2.084775	444	0.02937285	198	7.767983662626263e-7	1.39227	154	241	0.01786958	
GO Biological Process	regulation of DNA-templated transcription in response to stress	54	1.147552e-42	2.796414216296296e-40	2.490034	294	0.01944959	200	9.0257909975e-7	1.556294	85	119	0.009863077	
GO Biological Process	response to topologically incorrect protein	60	1.196751e-40	2.6246744015e-38	2.196006	361	0.02388198	466	0.0026370491985193132	1.307287	108	180	0.01253191	
GO Biological Process	response to unfolded protein	64	5.47927e-40	1.12658928015625e-37	2.239779	340	0.02249272	432	0.0019360358467824077	1.334522	98	160	0.01137155	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	77	6.962966e-38	1.189943760961039e-35	2.712389	223	0.01475258	268	0.00002307584335335821	1.495625	81	118	0.009398932	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	81	5.361876e-37	8.71073164e-35	2.162089	339	0.02242657	696	0.02842597348563218	1.265117	90	155	0.01044326	
GO Biological Process	mitochondrial membrane organization	87	1.921798e-36	2.9067746990804596e-34	2.235534	310	0.02050807	258	0.00001384563457984496	1.49354	85	124	0.009863077	
GO Biological Process	liver regeneration	89	3.058845e-36	4.522622624157303e-34	3.437567	149	0.009857105	587	0.013688357203236799	1.618546	26	35	0.003016941	
GO Biological Process	regulation of receptor catabolic process	98	4.754834e-35	6.384577612857143e-33	5.771202	82	0.005424716	625	0.01898381134832	2.178812	9	9	0.001044326	
GO Biological Process	regulation of mRNA stability	121	2.09059e-32	2.2735598190082647e-30	2.026953	344	0.02275734	303	0.00007941608501650165	1.414063	98	151	0.01137155	
GO Biological Process	RNA phosphodiester bond hydrolysis	122	2.098159e-32	2.263088055819672e-30	2.318016	254	0.01680339	502	0.0046640476498007975	1.343328	82	133	0.009514969	
GO Cellular Component	PcG protein complex	47	7.987795e-27	2.936789310638298e-25	2.625127	164	0.01084943	72	0.00070656936	1.657792	35	46	0.004061267	
GO Cellular Component	nuclear ubiquitin ligase complex	49	1.203977e-25	4.245861746938775e-24	3.523008	100	0.006615507	87	0.003448792055172414	1.634109	30	40	0.003481086	
GO Cellular Component	catalytic step 2 spliceosome	54	4.980957e-22	1.59390624e-20	2.212333	186	0.01230484	96	0.0065935422	1.384453	61	96	0.007078208	
GO Cellular Component	endopeptidase complex	62	5.408862e-19	1.5075021832258064e-17	2.41454	132	0.008732469	68	0.0005234612611764706	1.547272	49	69	0.005685774	
GO Cellular Component	proteasome complex	63	1.263082e-18	3.464453485714286e-17	2.397602	131	0.008666314	73	0.0007631657556164383	1.537985	48	68	0.005569738	
GO Cellular Component	large ribosomal subunit	68	8.104573e-18	2.0595150211764706e-16	2.09599	167	0.0110479	69	0.0005561840973913043	1.420964	75	115	0.008702715	
GO Cellular Component	proteasome core complex	69	8.259226e-18	2.0683974678260868e-16	4.539014	50	0.003307753	141	0.044879468936170216	1.634109	18	24	0.002088652	
GO Cellular Component	mitochondrial ribosome	70	8.543938e-18	2.1091321234285713e-16	2.465549	118	0.007806298	76	0.001480830972631579	1.461086	57	85	0.006614064	
GO Cellular Component	peptidase complex	77	1.069454e-16	2.400021444155844e-15	2.09281	156	0.01032019	102	0.010067614305882353	1.386517	56	88	0.006498027	
GO Cellular Component	high-density lipoprotein particle	99	3.314874e-14	5.785961890909091e-13	3.392944	55	0.003638529	136	0.035662959529411765	1.613935	20	27	0.002320724	
GO Cellular Component	mitochondrial large ribosomal subunit	105	2.978921e-13	4.9024528457142856e-12	2.63654	75	0.00496163	130	0.0294409728	1.452541	34	51	0.003945231	
GO Cellular Component	very-low-density lipoprotein particle	157	3.257381e-9	3.5851938649681526e-8	2.736405	46	0.003043133	125	0.027246799872000002	1.743049	16	20	0.001856579	
GO Cellular Component	prespliceosome	252	0.00000296662	0.00002034253714285714	2.434097	35	0.002315427	113	0.01687402704424779	1.7638	17	21	0.001972615	
GO Molecular Function	cadherin binding	6	1.356429e-77	9.54473873e-75	2.034607	829	0.05484255	10	4.854962239999999e-11	1.45493	203	304	0.02355535	
GO Molecular Function	unfolded protein binding	14	1.927033e-34	5.811380947142856e-32	2.727037	200	0.01323101	109	0.019209178132110094	1.356619	66	106	0.007658389	
GO Molecular Function	endoribonuclease activity	31	1.282326e-21	1.7464452812903225e-19	2.67307	126	0.008335539	116	0.02694513520862069	1.478479	38	56	0.004409376	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	125	1.947422e-10	6.5776125472e-9	2.313653	73	0.00482932	121	0.03516734090909091	1.652892	22	29	0.002552796	
GO Molecular Function	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	145	5.328605e-10	1.55154278e-8	2.191304	78	0.005160095	129	0.04893802021705426	1.548103	27	38	0.003132977	
Human Phenotype	Increased serum lactate	33	3.331251e-17	6.73619331e-15	2.062605	167	0.0110479	67	0.019585334677611938	1.39444	64	100	0.007426317	
Human Phenotype	External ophthalmoplegia	52	1.768128e-14	2.2689842584615386e-12	2.535036	89	0.005887801	68	0.01985953492647059	1.702197	25	32	0.002900905	
Human Phenotype	Abnormality of monocarboxylic acid metabolism	383	0.000002279502	0.00003971570978067885	2.30413	40	0.002646203	95	0.04581655810421052	2.011211	12	13	0.001392434	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	28	7.892121e-39	2.581005428464286e-36	2.529007	259	0.01713416	99	0.00026760481546464645	1.685496	41	53	0.004757484	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	41	1.505984e-34	3.363486704390244e-32	4.412819	105	0.006946282	227	0.024686194943171806	1.782664	18	22	0.002088652	
Mouse Phenotype	extramedullary hematopoiesis	8	1.251392e-70	1.495569864e-67	2.357117	547	0.03618682	353	0.028925816898016998	1.257486	101	175	0.01171966	
Mouse Phenotype	absent segment of posterior cerebral artery	73	1.505984e-34	1.9724264416438356e-32	4.412819	105	0.006946282	315	0.018574603915238096	1.782664	18	22	0.002088652	
Mouse Phenotype	abnormal embryonic hematopoiesis	81	8.479485e-34	1.000893285e-31	2.29915	270	0.01786187	154	0.0005553947028506494	1.60732	45	61	0.005221629	
Mouse Phenotype	pale liver	112	4.092558e-29	3.4936559855357146e-27	2.066968	293	0.01938343	354	0.028846212211864408	1.327094	67	110	0.007774426	
Mouse Phenotype	abnormal inguinal fat pad morphology	178	2.578594e-23	1.3850526535955058e-21	2.075581	229	0.01514951	361	0.030139688534626036	1.429845	42	64	0.004873521	
Mouse Phenotype	decreased fibroblast cell migration	231	7.9478e-19	3.289563454545454e-17	2.037659	190	0.01256946	293	0.014614102709897612	1.570771	31	43	0.003597122	
Mouse Phenotype	impaired fibroblast cell migration	710	3.85008e-8	5.184593645070423e-7	2.204748	60	0.003969304	250	0.007255143034800001	2.178812	11	11	0.001276398	
Mouse Phenotype	increased cardiac stroke volume	942	0.000002442003	0.000024785552742038217	2.154652	46	0.003043133	375	0.03363903996	1.997244	11	12	0.001276398	
Mouse Phenotype	abnormal heart iron level	1123	0.00002091028	0.0001780259902760463	2.923181	21	0.001389256	340	0.025355077421470588	2.178812	9	9	0.001044326