# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of immune system process 1 1.068084e-53 1.4054917356e-49 2.109026 457 0.2393924 3 3.693634362033333e-13 1.643824 257 1423 0.1245759 GO Biological Process immune response 2 3.239937e-49 2.13171654915e-45 2.153784 406 0.2126768 51 2.699986841764706e-7 1.448707 237 1489 0.1148812 GO Biological Process DNA replication-dependent nucleosome assembly 3 1.092922e-48 4.7939201993333337e-45 48.51502 37 0.01938188 20 1.6751117501999997e-10 5.973052 21 32 0.01017935 GO Biological Process regulation of immune response 4 5.343243e-46 1.757793365925e-42 2.402647 312 0.1634364 50 2.6158289217e-7 1.593312 160 914 0.07755696 GO Biological Process chromatin silencing 5 8.72867e-44 2.2972113705999996e-40 9.977982 68 0.03562074 2 6.35565817255e-14 4.128649 44 97 0.02132816 GO Biological Process chromatin silencing at rDNA 6 6.224097e-40 1.36504820705e-36 23.01035 40 0.02095338 13 4.371248733e-11 5.815035 23 36 0.01114881 GO Biological Process protein heterotetramerization 8 1.159174e-38 1.90669633325e-35 12.61603 52 0.02723939 34 6.0491845594117654e-9 4.757756 23 44 0.01114881 GO Biological Process negative regulation of gene expression, epigenetic 9 3.385375e-37 4.949794402777778e-34 7.061703 73 0.03823992 1 2.8902782893e-14 3.912174 49 114 0.02375182 GO Biological Process innate immune response 10 3.742138e-37 4.9242793942000005e-34 2.811705 196 0.1026716 118 0.0001626633057457627 1.562788 108 629 0.05235095 GO Biological Process T-helper cell lineage commitment 11 1.685308e-35 2.0160879974545453e-32 31.81345 31 0.01623887 425 0.042463257016470586 5.056552 5 9 0.002423655 GO Biological Process immune effector process 13 1.865536e-34 1.8883529403076925e-31 2.263747 264 0.1382923 171 0.0007155737227192982 1.419638 141 904 0.06834707 GO Biological Process alpha-beta T cell lineage commitment 15 2.248103e-33 1.9721858251333336e-30 23.28367 33 0.01728654 335 0.019410004223283584 4.964615 6 11 0.002908386 GO Biological Process adaptive immune response 16 1.184878e-32 9.74488100125e-30 3.41246 131 0.06862232 184 0.0009764078122826087 1.806723 53 267 0.02569074 GO Biological Process cytokine-mediated signaling pathway 18 2.03424e-32 1.4871424533333332e-29 2.640342 189 0.09900471 121 0.00018133961141322314 1.606199 96 544 0.04653417 GO Biological Process positive regulation of immune system process 21 1.817694e-31 1.1390016831428572e-28 2.057754 294 0.1540073 74 0.000004420677137837839 1.542333 152 897 0.07367911 GO Biological Process regulation of lymphocyte activation 23 3.140668e-30 1.796871748347826e-27 2.487738 195 0.1021477 68 0.0000029863886064705885 1.865868 82 400 0.03974794 GO Biological Process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 25 1.002991e-29 5.2793434276e-27 4.369638 89 0.04662127 401 0.036301972852867834 1.878148 26 126 0.01260301 GO Biological Process gene silencing 26 1.048219e-29 5.305197623461538e-27 4.512047 86 0.04504976 29 1.1587692885172416e-9 2.730538 54 180 0.02617547 GO Biological Process regulation of gene expression, epigenetic 29 3.203959e-29 1.4538240165862068e-26 3.659437 107 0.05605029 21 2.917782040523809e-10 2.495653 68 248 0.03296171 GO Biological Process positive regulation of gene expression, epigenetic 30 3.360747e-29 1.4741356591000003e-26 7.533969 54 0.02828706 55 5.722442367272727e-7 3.2994 29 80 0.0140572 GO Cellular Component nuclear nucleosome 1 3.767176e-66 6.509680128000001e-63 31.74595 59 0.03090623 19 8.336341288421053e-12 5.461076 24 40 0.01163354 GO Cellular Component nucleosome 2 1.807682e-61 1.561837248e-58 12.55792 84 0.0440021 1 1.791094464e-26 5.114341 59 105 0.02859913 GO Cellular Component DNA packaging complex 3 1.663049e-54 9.57916224e-52 10.19589 84 0.0440021 2 9.65462976e-25 4.794695 59 112 0.02859913 GO Cellular Component nuclear chromatin 4 2.227388e-35 9.62231616e-33 3.096563 162 0.08486118 13 2.518941489230769e-13 2.448267 85 316 0.04120213 GO Cellular Component protein-DNA complex 5 2.546198e-35 8.799660288e-33 4.466271 104 0.05447878 6 3.24878112e-16 3.109028 69 202 0.03344644 GO Cellular Component chromosomal part 8 1.136109e-32 2.45399544e-30 2.141945 280 0.1466737 12 9.6038208e-14 1.837451 172 852 0.08337373 GO Cellular Component nuclear chromosome part 9 2.206324e-32 4.23614208e-30 2.551006 200 0.1047669 22 1.1160869236363638e-10 1.965562 111 514 0.05380514 GO Cellular Component chromatin 10 1.472435e-31 2.54436768e-29 2.550326 195 0.1021477 3 3.9795068160000003e-17 2.322268 124 486 0.06010664 GO Cellular Component chromosome 15 1.714883e-30 1.9755452159999999e-28 2.005408 302 0.158198 10 6.234064128e-14 1.783018 191 975 0.09258362 GO Cellular Component nuclear chromosome 17 3.279469e-29 3.333483783529412e-27 2.386978 203 0.1063384 25 7.918407936e-10 1.886554 114 550 0.05525933 GO Cellular Component MHC protein complex 24 9.513774e-26 6.849917279999999e-24 23.4911 25 0.01309586 65 0.003299690436923077 4.095807 9 20 0.004362579 GO Cellular Component side of membrane 32 1.222542e-21 6.601726799999999e-20 2.22282 172 0.09009953 33 1.7227447854545455e-7 1.870807 89 433 0.04314106 GO Cellular Component MHC class II protein complex 33 1.898354e-21 9.940471854545454e-20 32.65353 18 0.00942902 72 0.013275919199999998 4.247504 7 15 0.003393117 GO Cellular Component chromosome, telomeric region 37 5.408673e-20 2.525996471351351e-18 4.026105 64 0.03352541 39 0.00006278036676923077 2.18007 40 167 0.01938924 GO Cellular Component nuclear chromosome, telomeric region 40 1.284035e-18 5.5470311999999994e-17 4.379108 54 0.02828706 35 0.000008026071222857143 2.482307 36 132 0.01745032 GO Cellular Component lysosomal membrane 43 3.682269e-14 1.479758333023256e-12 2.313545 101 0.05290728 58 0.002095852766896552 1.630957 62 346 0.03005332 GO Cellular Component chromosomal region 45 9.723338e-13 3.7337617919999995e-11 2.177064 102 0.05343112 49 0.0013283337012244898 1.650184 64 353 0.03102278 GO Cellular Component vacuolar membrane 47 1.504219e-12 5.530405174468085e-11 2.10598 108 0.05657412 70 0.009045680091428572 1.516966 66 396 0.03199224 GO Cellular Component cytoplasmic side of membrane 48 1.94958e-11 7.018488e-10 2.383321 75 0.03928759 37 0.00002460623896216216 2.144402 45 191 0.02181289 GO Cellular Component phagocytic vesicle 52 2.863504e-10 9.515644061538464e-9 3.079709 43 0.02252488 66 0.0051024776727272726 2.162802 24 101 0.01163354 GO Molecular Function nucleosomal DNA binding 1 4.674581e-27 1.9736080982e-23 8.697892 45 0.02357255 6 0.000013968001469999999 3.957302 20 46 0.009694619 GO Molecular Function nucleosome binding 3 1.214362e-21 1.7090121213333333e-18 5.724926 49 0.02566789 12 0.00008577622781666667 3.171837 23 66 0.01114881 GO Molecular Function chromatin DNA binding 12 4.249979e-17 1.495284278166667e-14 3.788836 58 0.0303824 10 0.000055802933959999994 2.713035 31 104 0.01502666 GO Molecular Function structure-specific DNA binding 13 4.459216e-17 1.4482161501538463e-14 3.203934 72 0.03771608 14 0.0001949329668142857 2.357299 36 139 0.01745032 GO Molecular Function histone binding 30 2.668979e-9 3.7561431126666665e-7 2.208209 69 0.03614458 13 0.0001969157688 2.114558 46 198 0.02229762 GO Molecular Function RNA polymerase II distal enhancer sequence-specific DNA binding 58 0.000001566029 0.000113996111 2.496073 35 0.01833421 29 0.009624293584827585 2.528276 20 72 0.009694619 Mouse Phenotype Single KO abnormal lymphocyte physiology 1 3.248511e-69 2.9746615227e-65 2.677056 383 0.2006286 4 8.03164361725e-19 2.014418 191 863 0.09258362 Mouse Phenotype Single KO abnormal leukocyte physiology 2 4.405117e-67 2.01688281845e-63 2.342799 460 0.2409639 1 8.8345289194e-20 1.865306 249 1215 0.120698 Mouse Phenotype Single KO abnormal immune cell physiology 3 5.369834e-67 1.6390523312666666e-63 2.335205 462 0.2420115 2 3.07025190355e-19 1.838004 250 1238 0.1211827 Mouse Phenotype Single KO abnormal cell-mediated immunity 4 2.780442e-66 6.3651268485e-63 2.322215 462 0.2420115 3 8.233040385999999e-19 1.820359 250 1250 0.1211827 Mouse Phenotype Single KO abnormal adaptive immunity 5 7.55742e-66 1.3840658988e-62 2.302693 466 0.2441069 5 1.02163989696e-18 1.806025 252 1270 0.1221522 Mouse Phenotype Single KO abnormal blood cell physiology 6 6.313538e-60 9.635511244333332e-57 2.197278 466 0.2441069 6 3.1633711153333332e-18 1.774953 258 1323 0.1250606 Mouse Phenotype Single KO abnormal hematopoietic system physiology 7 2.51273e-56 3.2870098014285714e-53 2.105687 478 0.2503929 7 1.0255174155285716e-17 1.742757 265 1384 0.1284537 Mouse Phenotype Single KO abnormal B cell physiology 8 2.216805e-55 2.537410423125e-52 2.979686 266 0.13934 11 6.062863851727272e-13 2.082329 124 542 0.06010664 Mouse Phenotype Single KO abnormal T cell physiology 9 1.599564e-52 1.627467505333333e-49 2.961075 255 0.1335778 10 3.3108232339999997e-13 2.115083 122 525 0.05913718 Mouse Phenotype Single KO abnormal professional antigen presenting cell physiology 10 1.235122e-50 1.1310012154e-47 2.433513 334 0.1749607 8 2.275696495375e-14 1.886826 176 849 0.08531265 Mouse Phenotype Single KO abnormal lymphocyte morphology 11 1.865331e-47 1.5528032697272726e-44 2.089513 417 0.218439 13 1.1854800120769232e-11 1.661253 213 1167 0.1032477 Mouse Phenotype Single KO abnormal immunoglobulin level 12 7.566063e-47 5.7735365742500005e-44 3.048426 219 0.1147197 26 7.243271526153846e-9 1.977773 98 451 0.04750364 Mouse Phenotype Single KO abnormal immune serum protein physiology 14 2.33171e-45 1.5251048907142856e-42 2.284769 337 0.1765322 14 1.3713686717857142e-11 1.743306 181 945 0.08773631 Mouse Phenotype Single KO decreased immunoglobulin level 16 2.57833e-43 1.475610488125e-40 3.677069 159 0.08328968 60 0.0000030691287975 2.047904 63 280 0.03053805 Mouse Phenotype Single KO abnormal humoral immune response 17 3.081692e-43 1.659944332e-40 2.842124 224 0.1173389 29 1.7599933982413794e-8 1.909338 103 491 0.04992729 Mouse Phenotype Single KO abnormal hemopoiesis 22 2.23778e-40 9.314250663636364e-38 2.245819 312 0.1634364 19 2.1734814226315787e-10 1.807975 146 735 0.07077072 Mouse Phenotype Single KO abnormal blood cell morphology/development 23 3.908985e-39 1.556285897608696e-36 2.121242 339 0.1775799 17 6.674618097058824e-11 1.758903 166 859 0.08046534 Mouse Phenotype Single KO abnormal IgG level 24 4.199688e-39 1.602355959e-36 3.136367 176 0.09219487 43 3.4826541260465115e-7 2.002395 77 350 0.03732429 Mouse Phenotype Single KO decreased IgG level 25 8.927358e-39 3.26991268824e-36 3.841976 135 0.07071765 65 0.000006464427821846153 2.153549 53 224 0.02569074 Mouse Phenotype Single KO abnormal effector T cell morphology 27 6.843448e-37 2.3209427161481484e-34 2.410893 251 0.1314825 49 5.095683622448979e-7 1.734406 113 593 0.0547746 Mouse Phenotype abnormal cell-mediated immunity 1 1.004032e-64 9.599549952e-61 2.1351 525 0.2750131 3 1.4366967317e-19 1.745058 292 1523 0.1415414 Mouse Phenotype abnormal adaptive immunity 2 3.073894e-64 1.4694750267000001e-60 2.118951 529 0.2771084 4 2.241688552725e-19 1.733114 294 1544 0.1425109 Mouse Phenotype abnormal lymphocyte physiology 3 5.988705e-63 1.9086002834999998e-59 2.3613 429 0.224725 6 1.2680274656500002e-18 1.877088 225 1091 0.1090645 Mouse Phenotype abnormal leukocyte physiology 4 1.502663e-62 3.5917402357500003e-59 2.1236 515 0.2697748 1 4.9534154655e-20 1.774911 289 1482 0.1400873 Mouse Phenotype abnormal immune cell physiology 5 1.65533e-62 3.165322026e-59 2.11634 518 0.2713463 2 1.2657836583e-19 1.752893 291 1511 0.1410567 Mouse Phenotype abnormal B cell physiology 6 1.496197e-57 2.3841899195e-54 2.767431 307 0.1608172 9 1.4304987603333333e-15 2.05263 152 674 0.07367911 Mouse Phenotype abnormal lymphocyte morphology 7 4.271537e-57 5.834309322428571e-54 2.057165 506 0.2650602 10 4.1656760706e-15 1.665729 265 1448 0.1284537 Mouse Phenotype abnormal blood cell physiology 8 1.521683e-56 1.8186013953750001e-53 2.014592 523 0.2739654 5 1.2000433696199998e-18 1.70127 300 1605 0.1454193 Mouse Phenotype abnormal immunoglobulin level 10 1.186273e-53 1.1341956153000002e-50 2.931694 264 0.1382923 23 9.774488816086957e-13 2.052041 124 550 0.06010664 Mouse Phenotype abnormal professional antigen presenting cell physiology 11 1.965596e-52 1.7084603050909091e-49 2.292137 383 0.2006286 8 3.191228750625e-16 1.845198 208 1026 0.100824 Mouse Phenotype abnormal humoral immune response 12 8.755328e-52 6.975807584e-49 2.785283 275 0.1440545 29 1.5081485134137932e-12 1.990542 131 599 0.06349976 Mouse Phenotype abnormal hemopoiesis 15 8.93891e-50 5.697661234000001e-47 2.202687 393 0.2058669 35 8.127713221714284e-12 1.713385 189 1004 0.09161415 Mouse Phenotype abnormal B cell morphology 18 5.511778e-49 2.9276727476666666e-46 2.419615 327 0.1712939 16 2.63069241825e-13 1.926106 153 723 0.07416384 Mouse Phenotype abnormal immune serum protein physiology 19 9.612612e-49 4.837167543789473e-46 2.172025 396 0.2074384 15 7.898418587999999e-14 1.721324 219 1158 0.1061561 Mouse Phenotype abnormal blood cell morphology/development 20 1.182652e-48 5.653667886e-46 2.097987 423 0.221582 28 1.2996178519285714e-12 1.686696 212 1144 0.102763 Mouse Phenotype abnormal IgG level 23 8.201497e-48 3.409326644217391e-45 3.092773 219 0.1147197 32 7.5645048459375e-12 2.15903 102 430 0.04944256 Mouse Phenotype abnormal lymphopoiesis 24 2.014603e-47 8.025674701249999e-45 2.490318 302 0.158198 44 6.255679727727273e-11 1.873487 134 651 0.06495395 Mouse Phenotype decreased IgG level 25 2.725803e-47 1.04245609932e-44 3.820413 166 0.08695652 54 8.292382779999999e-10 2.351017 70 271 0.03393117 Mouse Phenotype decreased immunoglobulin level 26 1.314721e-46 4.834633646538461e-44 3.377863 190 0.09952855 56 5.6853547473214286e-9 2.118521 81 348 0.03926321 Mouse Phenotype abnormal B cell number 27 1.430677e-45 5.066186221111111e-43 2.445133 300 0.1571503 17 2.8430966415882356e-13 1.979257 142 653 0.0688318