# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process liver regeneration 32 1.788664e-25 7.355321742499999e-23 3.526225 99 0.01011133 695 0.03642136659712231 1.682732 22 35 0.003136584 GO Biological Process cellular response to epidermal growth factor stimulus 56 4.56901e-21 1.0736357605357141e-18 2.742438 117 0.01194975 390 0.0033532388008974353 1.831682 26 38 0.003706872 GO Biological Process response to epidermal growth factor 64 9.710516e-21 1.9965731256875e-18 2.649873 122 0.01246042 394 0.003652126817005076 1.784716 28 42 0.003992016 GO Biological Process mitochondrial membrane organization 65 1.568618e-20 3.1756068095384614e-18 2.115354 190 0.01940558 285 0.0005275189154385965 1.511252 70 124 0.00998004 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 69 2.8714e-20 5.4760511014492755e-18 2.343136 150 0.01532019 635 0.025775724862992126 1.423976 50 94 0.0071286 GO Biological Process regulation of intrinsic apoptotic signaling pathway 71 3.758247e-20 6.965460883521128e-18 2.028387 206 0.02103973 561 0.01504329843101604 1.347173 78 155 0.01112062 GO Biological Process regulation of mitochondrial membrane permeability 116 7.350605e-17 8.338500965086207e-15 2.32111 125 0.01276683 271 0.00036435416115129153 1.686924 46 73 0.006558312 GO Biological Process triglyceride homeostasis 131 3.448835e-16 3.4643679209923667e-14 3.458126 62 0.006332346 471 0.008617024473248408 1.840489 22 32 0.003136584 GO Biological Process protein-lipid complex subunit organization 143 1.684204e-15 1.5498210095104895e-13 2.713685 85 0.008681442 436 0.0061885479208715595 1.708771 30 47 0.00427716 GO Biological Process mitochondrial transmembrane transport 144 1.769532e-15 1.6170327491666666e-13 2.380584 108 0.01103054 638 0.026315401200626958 1.451426 45 83 0.00641574 GO Biological Process reverse cholesterol transport 152 3.44937e-15 2.986201304605263e-13 4.526791 42 0.004289654 425 0.005978009850588235 2.20465 14 17 0.001996008 GO Biological Process regulation of membrane permeability 157 5.441787e-15 4.561049371528662e-13 2.139231 131 0.01337963 304 0.0008402921852631579 1.619465 49 81 0.006986028 GO Biological Process high-density lipoprotein particle remodeling 169 1.4892e-14 1.159549278106509e-12 4.761243 38 0.003881115 425 0.005978009850588235 2.20465 14 17 0.001996008 GO Biological Process protein-lipid complex assembly 198 2.249066e-13 1.4947201764646466e-11 3.227578 55 0.005617404 697 0.03649447583500717 1.753945 19 29 0.002708868 GO Biological Process negative regulation of collagen metabolic process 219 6.618742e-13 3.9769874875799084e-11 5.475211 29 0.002961904 499 0.009971307406613226 2.677074 8 8 0.001140576 GO Biological Process plasma lipoprotein particle organization 237 1.602556e-12 8.897904811814345e-11 2.579222 73 0.007455827 490 0.009615302784081632 1.703593 28 44 0.003992016 GO Biological Process regulation of release of cytochrome c from mitochondria 264 6.318984e-12 3.149678426363636e-10 2.449252 76 0.007762231 552 0.014574226611231885 1.665735 28 45 0.003992016 GO Biological Process plasma lipoprotein particle remodeling 276 1.436005e-11 6.846518041666667e-10 2.856628 56 0.005719538 459 0.007481570951633987 1.912196 20 28 0.00285144 GO Biological Process cholesterol efflux 296 4.144564e-11 1.842510732297297e-9 3.199091 45 0.004596058 586 0.020122565400511945 1.896261 17 24 0.002423724 GO Biological Process negative regulation of collagen biosynthetic process 338 1.838425e-10 7.1573475073964504e-9 4.96089 25 0.002553365 602 0.022140542111295684 2.677074 7 7 0.000998004 GO Cellular Component high-density lipoprotein particle 39 2.460593e-19 1.0902319753846155e-17 4.857289 51 0.005208865 87 0.010055124744827587 1.883867 19 27 0.002708868 GO Cellular Component protein-lipid complex 69 1.174208e-10 2.940625252173913e-9 2.389007 70 0.007149423 96 0.019119438000000002 1.657237 26 42 0.003706872 GO Cellular Component plasma lipoprotein particle 75 2.978062e-10 6.861454848000001e-9 2.386961 67 0.006843019 113 0.04577338959292035 1.606245 24 40 0.003421728 GO Cellular Component PcG protein complex 92 2.87755e-9 5.404789565217391e-8 2.051136 83 0.008477173 93 0.01873830193548387 1.629524 28 46 0.003992016 GO Cellular Component zonula adherens 125 1.817635e-7 0.0000025126986239999998 3.83814 22 0.002246961 82 0.007968189424390244 2.677074 8 8 0.001140576 GO Cellular Component DNA replication factor C complex 294 0.001306889 0.007681306775510204 2.431373 16 0.001634154 111 0.04223534010810811 2.677074 6 6 0.000855432 GO Molecular Function rRNA binding 32 2.876179e-11 3.794758668125e-9 2.834356 55 0.005617404 93 0.03457636862580646 1.561627 35 60 0.00499002 GO Molecular Function glucocorticoid receptor binding 41 9.113881e-11 9.385074532195123e-9 2.609972 60 0.006128077 89 0.03154880486741573 2.265217 11 13 0.001568292 GO Molecular Function armadillo repeat domain binding 45 1.948186e-10 1.8278313982222222e-8 3.574169 36 0.003676846 96 0.04122188401666666 2.409367 9 10 0.001283148 GO Molecular Function C-acyltransferase activity 190 0.00002139764 0.00047547808463157897 2.210844 35 0.003574711 90 0.03260584455333333 2.007806 15 20 0.00213858 Human Phenotype Lipid accumulation in hepatocytes 38 1.099223e-10 1.9302934418421054e-8 2.062146 97 0.009907058 13 0.0022300442236153845 1.710353 46 72 0.006558312 Human Phenotype Abnormality of monocarboxylic acid metabolism 345 0.0002711784 0.005245140473043478 2.223294 25 0.002553365 33 0.012643775944545453 2.471146 12 13 0.001710864 Mouse Phenotype Single KO expanded mesangial matrix 33 3.712527e-24 1.0301699920909093e-21 2.974506 119 0.01215402 392 0.04493505753826531 1.682732 22 35 0.003136584 Mouse Phenotype Single KO abnormal mesangial matrix morphology 36 4.495231e-23 1.1434119518611111e-20 2.867208 120 0.01225615 387 0.04472676313178295 1.664127 23 37 0.003279156 Mouse Phenotype Single KO abnormal branching of the mammary ductal tree 42 1.660647e-22 3.620605852142857e-20 2.619538 136 0.01389031 153 0.0015134809299346404 1.902132 27 38 0.003849444 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 53 8.794391e-21 1.5194384601320756e-18 2.33664 155 0.01583087 351 0.03678552127065527 1.565836 31 53 0.004419732 Mouse Phenotype Single KO abnormal interscapular fat pad morphology 88 1.345099e-16 1.3996672207954547e-14 2.841071 85 0.008681442 374 0.042301691890374325 1.862313 16 23 0.002281152 Mouse Phenotype Single KO abnormal mammary gland duct morphology 96 5.368371e-16 5.1206430465625e-14 2.076783 151 0.01542233 145 0.0013288183707586207 1.767879 35 53 0.00499002 Mouse Phenotype Single KO abnormal osteoblast differentiation 112 2.633899e-15 2.1534476020535712e-13 2.206884 125 0.01276683 293 0.01910677118156997 1.665735 28 45 0.003992016 Mouse Phenotype Single KO abnormal vitelline vein morphology 214 2.441018e-10 1.044504758224299e-8 2.314943 72 0.007353692 384 0.0435699360078125 1.820411 17 25 0.002423724 Mouse Phenotype Single KO abnormal adrenal gland secretion 404 3.335189e-7 0.000007559486552722773 2.049048 61 0.006230211 306 0.02079943423627451 2.007806 15 20 0.00213858 Mouse Phenotype Single KO abnormal retinol level 440 6.820152e-7 0.000014193666332727272 3.822047 20 0.002042692 320 0.0268215626675 2.409367 9 10 0.001283148 Mouse Phenotype Single KO abnormal kidney inner medulla morphology 454 9.974094e-7 0.000020117352149339207 2.559127 35 0.003574711 326 0.028450995622699392 2.677074 7 7 0.000998004 Mouse Phenotype Single KO decreased spongiotrophoblast size 471 0.000001516437 0.000029481982184713373 2.550309 34 0.003472577 190 0.004134892990578947 2.230895 15 18 0.00213858 Mouse Phenotype Single KO increased neural tube apoptosis 489 0.000002636441 0.00004936991868507157 2.127313 47 0.004800327 239 0.008847784584937238 1.956324 19 26 0.002708868 Mouse Phenotype Single KO decreased vascular endothelial cell number 515 0.000004761493 0.00008466211922524273 2.581915 30 0.003064038 326 0.028450995622699392 2.677074 7 7 0.000998004 Mouse Phenotype Single KO abnormal DNA replication 548 0.000008839464 0.0001477061530072993 2.342476 34 0.003472577 271 0.013551677448708487 1.978707 17 23 0.002423724 Mouse Phenotype Single KO abnormal nucleotide metabolism 641 0.00003046878 0.0004352614952574103 2.84602 21 0.002144827 218 0.006520086433027523 2.453985 11 12 0.001568292 Mouse Phenotype Single KO abnormal infrahyoid muscle morphology 962 0.0007093728 0.006752314687733888 2.496822 17 0.001736288 320 0.0268215626675 2.409367 9 10 0.001283148 Mouse Phenotype abnormal epidermis stratum granulosum morphology 52 1.264287e-22 2.324586155192308e-20 2.335786 170 0.01736288 403 0.01617082771935484 1.491029 44 79 0.006273168 Mouse Phenotype impaired lipolysis 67 3.340867e-21 4.7674670726865665e-19 4.078322 68 0.006945154 577 0.04128115024263432 2.007806 12 16 0.001710864 Mouse Phenotype expanded mesangial matrix 69 4.081211e-21 5.655138894347826e-19 2.531835 135 0.01378817 394 0.014198482970558377 1.639025 30 49 0.00427716 Mouse Phenotype abnormal mesangial matrix morphology 73 2.649398e-20 3.4699855175342465e-18 2.465245 136 0.01389031 391 0.013912624350383632 1.627241 31 51 0.004419732 Mouse Phenotype pale liver 76 3.228191e-20 4.061149230394737e-18 2.091111 192 0.01960985 306 0.005477346923529411 1.460222 60 110 0.00855432 Mouse Phenotype abnormal embryonic hematopoiesis 95 2.509904e-17 2.5260202256842106e-15 2.103456 160 0.01634154 466 0.023588895096566524 1.536026 35 61 0.00499002 Mouse Phenotype abnormal branching of the mammary ductal tree 130 2.068814e-15 1.5215331272307692e-13 2.020335 155 0.01583087 263 0.0024082014136882126 1.667686 38 61 0.005417736 Mouse Phenotype pale lung 155 3.38362e-14 2.0871477948387096e-12 5.531598 32 0.003268308 594 0.04366888564646464 2.677074 6 6 0.000855432 Mouse Phenotype abnormal interscapular fat pad morphology 165 1.346959e-13 7.80501515090909e-12 2.347694 96 0.009804923 536 0.034480658401119406 1.753945 19 29 0.002708868 Mouse Phenotype abnormal vitelline vein morphology 246 2.441018e-10 9.487224836585366e-9 2.314943 72 0.007353692 522 0.033465533086206894 1.820411 17 25 0.002423724 Mouse Phenotype advanced circadian phase 337 8.50033e-9 2.4116218139465874e-7 2.716748 44 0.004493923 565 0.03847987748495575 2.379622 8 9 0.001140576 Mouse Phenotype increased neural tube apoptosis 410 9.547086e-8 0.0000022263338840487805 2.09978 63 0.006434481 514 0.03232479234046693 1.618696 26 43 0.003706872 Mouse Phenotype abnormal urine ammonia level 439 1.933266e-7 0.0000042104683886104785 4.150577 20 0.002042692 565 0.03847987748495575 2.379622 8 9 0.001140576 Mouse Phenotype abnormal retinol level 484 6.820152e-7 0.000013472618444628099 3.822047 20 0.002042692 434 0.02064878155023041 2.409367 9 10 0.001283148 Mouse Phenotype decreased urine ammonia level 489 7.371176e-7 0.00001441223184785276 4.386481 17 0.001736288 594 0.04366888564646464 2.677074 6 6 0.000855432 Mouse Phenotype decreased spongiotrophoblast size 536 0.000002275695 0.00004059313413246269 2.501853 34 0.003472577 335 0.0075898928238805966 2.11348 15 19 0.00213858 Mouse Phenotype abnormal lipoprotein lipase activity 605 0.000009357539 0.00014788005021322315 2.832452 24 0.002451231 249 0.0020228000353012046 2.677074 10 10 0.00142572 Mouse Phenotype abnormal triglyceride lipase activity 613 0.0000109317 0.00017050242039151714 2.80504 24 0.002451231 359 0.010196891723398329 2.433704 10 11 0.00142572 Mouse Phenotype decreased vascular endothelial cell number 640 0.00001569507 0.000234469631671875 2.276143 34 0.003472577 434 0.02064878155023041 2.409367 9 10 0.001283148 Mouse Phenotype abnormal kidney inner medulla morphology 658 0.00002124566 0.00030870783474164134 2.132175 38 0.003881115 296 0.004559007806756757 2.677074 9 9 0.001283148