# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Cellular Component cell cortex part 31 6.308781e-8 0.0000035166366348387096 2.450678 46 0.02988954 16 0.0117842904 2.070625 29 135 0.01488706 GO Molecular Function nucleosome binding 6 6.02693e-11 4.2409497433333336e-8 4.347728 30 0.01949318 10 0.039446137556 2.62885 18 66 0.009240246 GO Molecular Function nucleosomal DNA binding 13 3.606415e-9 0.0000011712526253846155 5.034868 21 0.01364522 16 0.04093450655 2.933644 14 46 0.007186858 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 32 1.67342e-11 4.78859591875e-9 2.700569 60 0.03898635 20 0.00053898971915 2.203227 40 175 0.02053388 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 34 2.180265e-11 5.8719666485294115e-9 2.404318 73 0.0474334 77 0.027880294115584413 1.698848 46 261 0.02361396 Mouse Phenotype Single KO decreased susceptibility to autoimmune disorder 37 5.043418e-11 1.2481778007027028e-8 2.862633 52 0.03378817 104 0.04982948841346154 1.844522 31 162 0.01591376 Mouse Phenotype Single KO abnormal erythropoiesis 43 4.368947e-10 9.303825041627908e-8 2.718749 51 0.0331384 4 0.000024945911465 2.891735 33 110 0.01694045 Mouse Phenotype Single KO increased neutrophil cell number 62 1.084873e-8 0.0000016022874291935484 2.46109 51 0.0331384 39 0.004322071128717949 2.114387 34 155 0.0174538 Mouse Phenotype Single KO increased granulocyte number 65 1.203397e-8 0.000001695308666 2.079872 72 0.04678363 48 0.006863904059999999 1.807334 48 256 0.02464066 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 67 1.697338e-8 0.000002319779711343284 3.475732 29 0.0188434 52 0.009185177145576925 2.65425 19 69 0.009753593 Mouse Phenotype Single KO abnormal neutrophil morphology 68 1.898281e-8 0.0000025562586936764705 2.05564 72 0.04678363 61 0.013801205227868853 1.721271 50 280 0.02566735 Mouse Phenotype Single KO decreased erythroid progenitor cell number 102 4.147509e-7 0.000037234058738235294 2.908953 30 0.01949318 98 0.0475646255744898 2.646032 14 51 0.007186858 Mouse Phenotype Single KO decreased circulating alanine transaminase level 136 0.00000335834 0.00022611999544117648 2.568696 31 0.02014295 36 0.004124203424722222 2.698953 21 75 0.01078029 Mouse Phenotype Single KO abnormal circulating alanine transaminase level 154 0.000008919069 0.0005303371093051948 2.032076 46 0.02988954 97 0.04778090503298969 1.836022 32 168 0.0164271 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 182 0.00003501998 0.0017619667959340658 2.11938 36 0.02339181 86 0.0373626788872093 2.268028 20 85 0.01026694 Mouse Phenotype Single KO decreased macrophage cell number 195 0.00005362892 0.002518359079179487 2.099405 35 0.02274204 50 0.007322929818800001 2.43626 23 91 0.01180698 Mouse Phenotype Single KO abnormal vascular endothelial cell development 218 0.00008734987 0.003669095227477064 2.887482 18 0.01169591 73 0.02156906262328767 3.420332 11 31 0.005646817 Mouse Phenotype abnormal pre-B cell morphology 24 4.566933e-15 1.819351933875e-12 2.992172 69 0.04483431 50 0.0022758966155999997 2.246711 31 133 0.01591376 Mouse Phenotype decreased pre-B cell number 32 6.48764e-14 1.93838518875e-11 3.136317 59 0.03833658 68 0.006572859895147058 2.317095 25 104 0.01283368 Mouse Phenotype decreased inflammatory response 39 5.299202e-12 1.2991197518461539e-9 2.411886 77 0.05003249 102 0.016382754752941178 1.659716 52 302 0.02669405 Mouse Phenotype skin inflammation 40 6.85806e-12 1.6392477915000002e-9 2.918991 55 0.03573749 89 0.011353580073033708 2.019004 31 148 0.01591376 Mouse Phenotype altered susceptibility to autoimmune disorder 43 1.024525e-11 2.2780194244186047e-9 2.225458 88 0.05717999 109 0.021147239088990827 1.60652 56 336 0.02874743 Mouse Phenotype abnormal mean corpuscular hemoglobin 57 1.620974e-10 2.7189705989473686e-8 2.521609 61 0.03963613 29 0.0005766156677586207 2.147847 41 184 0.02104723 Mouse Phenotype abnormal erythropoiesis 67 7.803949e-10 1.1136351699850746e-7 2.484081 58 0.03768681 7 0.000015185941178571427 2.587682 40 149 0.02053388 Mouse Phenotype abnormal circulating alanine transaminase level 77 8.501302e-9 0.0000010555967327532468 2.229251 63 0.04093567 131 0.033052216433587786 1.732376 39 217 0.02002053 Mouse Phenotype increased neutrophil cell number 102 9.398915e-8 0.000008810100619117646 2.054711 65 0.04223522 62 0.0040382626069354844 1.884983 44 225 0.02258727 Mouse Phenotype abnormal mean corpuscular volume 112 1.487655e-7 0.000012699526299107143 2.054231 63 0.04093567 88 0.011186782861363636 1.77045 45 245 0.02310062 Mouse Phenotype decreased mean corpuscular hemoglobin 130 3.821143e-7 0.000028103037094615386 2.920715 30 0.01949318 79 0.010005354131392403 2.503667 20 77 0.01026694 Mouse Phenotype decreased mean corpuscular volume 133 4.683799e-7 0.00003367052799924812 2.632803 35 0.02274204 75 0.0083424480004 2.273377 25 106 0.01283368 Mouse Phenotype extramedullary hematopoiesis 167 0.000002700126 0.0001545862556047904 2.073902 49 0.03183886 108 0.02073262127222222 1.872743 34 175 0.0174538 Mouse Phenotype decreased circulating alanine transaminase level 185 0.00000516555 0.0002669612083783784 2.469918 32 0.02079272 69 0.006634808837826087 2.465821 22 86 0.01129363 Mouse Phenotype abnormal circulating interleukin-10 level 193 0.000008909861 0.00044138435762176165 4.009947 15 0.009746589 94 0.013026638731914892 3.30484 12 35 0.006160164 Mouse Phenotype abnormal iron homeostasis 202 0.00001491941 0.0007061607871782177 2.239497 35 0.02274204 135 0.03496993824222222 1.927823 28 140 0.01437372