# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to epidermal growth factor stimulus	26	1.948741e-40	9.86287800730769e-38	3.145398	189	0.01370558	438	0.004963728021232877	1.645403	29	38	0.003329889	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	27	3.13222e-39	1.5265512214814813e-36	2.604412	248	0.01798405	291	0.0006218798696219931	1.431004	75	113	0.008611781	
GO Biological Process	response to epidermal growth factor	31	1.228422e-37	5.214453257419355e-35	2.960937	192	0.01392313	479	0.007739230965970772	1.591367	31	42	0.003559536	
GO Biological Process	regulation of DNA-templated transcription in response to stress	51	1.569726e-33	4.050200869411765e-31	2.358111	254	0.01841914	304	0.0008048304117105263	1.413206	78	119	0.008956252	
GO Biological Process	protein-lipid complex assembly	65	1.902999e-30	3.8525482832307696e-28	4.124886	99	0.007179115	484	0.00810638444586777	1.709967	23	29	0.002640946	
GO Biological Process	protein-lipid complex subunit organization	98	7.743629e-26	1.0397797348061225e-23	2.946773	130	0.009427121	587	0.018127856333901193	1.513819	33	47	0.003789184	
GO Biological Process	plasma lipoprotein particle assembly	102	1.086519e-25	1.4017160314705884e-23	4.152376	82	0.005946338	498	0.00924772770562249	1.741421	21	26	0.002411299	
GO Biological Process	triglyceride homeostasis	108	2.794848e-25	3.405315262222222e-23	3.682942	93	0.006744017	285	0.0004671089476140351	1.819163	27	32	0.003100241	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	117	1.201983e-24	1.3518713074358975e-22	2.386562	179	0.01298042	611	0.02047334077217676	1.315553	72	118	0.00826731	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	136	1.322483e-22	1.2795995438970588e-20	2.417719	159	0.01153009	546	0.013139336212271063	1.409722	51	78	0.005856011	
GO Biological Process	regulation of necrotic cell death	138	1.940207e-22	1.8500857907971015e-20	4.493944	65	0.004713561	597	0.01950356005159129	1.676924	21	27	0.002411299	
GO Biological Process	cotranslational protein targeting to membrane	139	2.121051e-22	2.0079791445323744e-20	2.453711	153	0.011095	473	0.007303806969978859	1.386029	63	98	0.007233896	
GO Biological Process	mitochondrial transmembrane transport	154	8.033089e-22	6.864118061753247e-20	2.410145	154	0.01116751	614	0.02123202506840391	1.376752	53	83	0.006085659	
GO Biological Process	translational elongation	160	1.479942e-21	1.217159798625e-19	2.28097	170	0.01232777	521	0.010659446687140115	1.347528	70	112	0.008037662	
GO Biological Process	plasma lipoprotein particle organization	163	2.020355e-21	1.631033830981595e-19	2.8347	113	0.008194344	620	0.022464577867741933	1.519032	31	44	0.003559536	
GO Biological Process	lipid homeostasis	166	2.419986e-21	1.9183491430120481e-19	2.003584	227	0.0164612	387	0.0023853071081136952	1.409722	68	104	0.007808015	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	167	3.268025e-21	2.5750862859281437e-19	2.256109	171	0.01240029	752	0.037796987670212764	1.297443	68	113	0.007808015	
GO Biological Process	cholesterol efflux	184	3.246224e-20	2.321579435652174e-18	3.684679	73	0.005293691	624	0.022694361463141025	1.706869	19	24	0.002181651	
GO Biological Process	mitochondrial translational termination	200	8.759461e-20	5.76328736495e-18	2.5005	129	0.009354605	467	0.00685080645738758	1.412582	57	87	0.006544953	
GO Biological Process	protein targeting to ER	203	1.288055e-19	8.349515145320197e-18	2.298488	151	0.01094996	454	0.0058386540969163	1.387554	65	101	0.007463543	
GO Cellular Component	high-density lipoprotein particle	39	1.178462e-26	5.221493169230769e-25	4.868768	72	0.005221175	84	0.0040558752	1.756778	22	27	0.002526122	
GO Cellular Component	mitochondrial ribosome	43	1.691013e-22	6.795512706976744e-21	2.794243	122	0.008846991	69	0.0023395847791304347	1.445819	57	85	0.006544953	
GO Cellular Component	chylomicron	46	4.098175e-21	1.539488347826087e-19	5.257157	52	0.003770848	128	0.039830049	1.848039	12	14	0.001377885	
GO Cellular Component	very-low-density lipoprotein particle	48	1.588101e-20	5.7171636e-19	4.173258	64	0.004641044	120	0.03253106879999999	1.724836	16	20	0.00183718	
GO Cellular Component	large ribosomal subunit	52	5.373611e-19	1.7856922707692308e-17	2.201229	160	0.01160261	80	0.0034590888	1.36862	73	115	0.008382133	
GO Cellular Component	mitochondrial large ribosomal subunit	57	4.262539e-18	1.292222349473684e-16	3.121266	81	0.005873822	109	0.017349405357798164	1.479639	35	51	0.004018831	
GO Cellular Component	protein-lipid complex	62	2.61669e-17	7.292968258064516e-16	2.56855	106	0.00768673	106	0.014440522686792452	1.540032	30	42	0.003444712	
GO Cellular Component	plasma lipoprotein particle	65	2.00455e-16	5.3290190769230766e-15	2.554787	101	0.007324148	117	0.031737260307692305	1.509232	28	40	0.003215065	
GO Cellular Component	proteasome complex	76	5.454443e-14	1.240168092631579e-12	2.226903	111	0.008049311	76	0.002817731368421053	1.490208	47	68	0.005396716	
GO Cellular Component	endopeptidase complex	77	5.649316e-14	1.2677945516883118e-12	2.225646	111	0.008049311	85	0.004358676705882352	1.468611	47	69	0.005396716	
GO Cellular Component	U1 snRNP	107	8.57311e-11	1.384517203738318e-9	3.08064	46	0.003335751	74	0.002669274291891892	1.929093	17	19	0.001952004	
GO Cellular Component	spliceosomal snRNP complex	127	1.824209e-9	2.482073348031496e-8	2.095064	81	0.005873822	129	0.04056942139534884	1.390997	40	62	0.00459295	
GO Cellular Component	platelet dense tubular network	182	5.829001e-7	0.000005534348202197802	2.763871	32	0.002320522	127	0.039786655748031495	1.960041	10	11	0.001148237	
GO Molecular Function	RNA polymerase II core binding	107	3.070857e-9	1.2116970330841123e-7	2.176863	72	0.005221175	75	0.006206779088	1.771037	23	28	0.002640946	
GO Molecular Function	RNA polymerase core enzyme binding	114	5.144227e-9	1.9051689819298244e-7	2.076844	78	0.005656273	85	0.010122627463529413	1.663235	27	35	0.003100241	
Human Phenotype	Abnormal CSF metabolite level	23	2.413722e-15	7.002942133043479e-13	2.466211	100	0.007251632	55	0.01681325440181818	1.50581	44	63	0.005052245	
Human Phenotype	Glycosuria	27	7.951971e-15	1.965314906777778e-12	2.796403	77	0.005583756	70	0.02842318592285714	1.709967	23	29	0.002640946	
Human Phenotype	Increased serum lactate	31	1.773684e-14	3.817997849032258e-12	2.003706	148	0.01073241	53	0.01645882859433962	1.40143	65	100	0.007463543	
Human Phenotype	Increased CSF lactate	39	1.96972e-13	3.3702414256410256e-11	2.423697	89	0.006453952	75	0.037364716124	1.486928	40	58	0.00459295	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	143	4.763665e-14	3.0504112171328674e-12	2.99442	65	0.004713561	175	0.006434069247428571	1.862039	19	22	0.002181651	
Mouse Phenotype Single KO	abnormal cerebral artery morphology	266	3.250505e-10	1.1189802362781954e-8	2.419917	65	0.004713561	283	0.03482141773498233	1.706869	19	24	0.002181651	
Mouse Phenotype	decreased circulating free fatty acid level	40	2.206447e-27	5.27395994175e-25	2.031986	286	0.02073967	201	0.001962827635522388	1.395088	77	119	0.008841428	
Mouse Phenotype	absent segment of posterior cerebral artery	206	4.763665e-14	2.210941799271845e-12	2.99442	65	0.004713561	247	0.004759670955060729	1.862039	19	22	0.002181651	
Mouse Phenotype	increased follicular B cell number	222	2.490644e-13	1.0726597875675675e-11	2.247528	103	0.007469181	292	0.008135350121917809	1.684411	25	32	0.002870594	
Mouse Phenotype	abnormal cerebral artery morphology	369	3.250505e-10	8.42224344308943e-9	2.419917	65	0.004713561	410	0.025095689480487807	1.706869	19	24	0.002181651	
Mouse Phenotype	decreased liver cholesterol level	430	3.032803e-9	6.743402205348836e-8	2.08117	80	0.005801305	397	0.02284528941460957	1.617034	24	32	0.00275577	
Mouse Phenotype	abnormal Sertoli cell phagocytosis	618	2.806433e-7	0.0000043417970733009715	2.756827	34	0.002465555	477	0.042852141427672956	2.156045	8	8	0.00091859	
Mouse Phenotype	decreased abdominal adipose tissue amount	742	0.000002596114	0.00003345208349595687	2.170208	45	0.003263234	497	0.04871454543259557	1.638595	19	25	0.002181651