# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process steroid metabolic process 24 6.807288e-114 3.732379283e-111 2.321806 918 0.0403481 207 2.3956982977777777e-7 1.31584 175 229 0.01604768 GO Biological Process xenobiotic metabolic process 50 2.488586e-77 6.5494606348e-75 3.003237 396 0.01740506 355 0.00016884146095774648 1.361098 83 105 0.007611188 GO Biological Process cellular response to xenobiotic stimulus 51 2.481488e-76 6.4027256062745094e-74 2.962782 399 0.01753692 381 0.0003279449369658793 1.342743 85 109 0.00779459 GO Biological Process lipid homeostasis 54 1.453259e-71 3.5413768853703703e-69 2.557139 478 0.02100914 749 0.018424901507343126 1.25829 76 104 0.00696928 GO Biological Process response to xenobiotic stimulus 59 4.243578e-69 9.464617441016948e-67 2.660188 430 0.01889944 363 0.0002049770904876033 1.339233 91 117 0.008344796 GO Biological Process sterol metabolic process 82 2.221383e-59 3.564777914268293e-57 2.267672 500 0.02197609 477 0.0016498616264989518 1.28478 97 130 0.008895002 GO Biological Process triglyceride homeostasis 90 6.354946e-58 9.291637157111112e-56 4.368456 182 0.007999297 606 0.007188475068316831 1.506637 28 32 0.00256763 GO Biological Process secondary alcohol metabolic process 93 8.324608e-57 1.1778872760430108e-54 2.326649 453 0.01991034 392 0.0004782813108163265 1.324516 90 117 0.008253095 GO Biological Process regulation of cellular ketone metabolic process 96 2.09298e-56 2.86890873125e-54 2.002787 632 0.02777778 315 0.00004404292235238095 1.309889 124 163 0.01137093 GO Biological Process cholesterol metabolic process 107 4.66181e-53 5.73315493364486e-51 2.301344 432 0.01898734 476 0.0016385669734873948 1.306777 85 112 0.00779459 GO Biological Process steroid biosynthetic process 139 9.219728e-46 8.728230269928058e-44 2.157002 427 0.01876758 362 0.0001964983669364641 1.344267 89 114 0.008161394 GO Biological Process regulation of steroid metabolic process 147 3.27277e-44 2.9296857435374153e-42 2.036871 472 0.02074543 305 0.000025405990697049182 1.387063 87 108 0.007977992 GO Biological Process cellular hormone metabolic process 161 3.70095e-42 3.0248944751552793e-40 2.073956 430 0.01889944 417 0.0007627120493045563 1.326946 84 109 0.007702889 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 186 4.44184e-39 3.142482395698925e-37 2.202312 346 0.01520745 933 0.04919268602143623 1.219024 80 113 0.007336084 GO Biological Process regulation of DNA-templated transcription in response to stress 190 8.911616e-39 6.17199762863158e-37 2.115744 376 0.01652602 733 0.016366099631514325 1.244377 86 119 0.007886291 GO Biological Process monosaccharide biosynthetic process 217 5.353335e-36 3.2462919476958526e-34 2.640826 222 0.009757384 404 0.0005690257774752475 1.466779 46 54 0.004218249 GO Biological Process hexose biosynthetic process 225 2.954981e-35 1.7282042212888888e-33 2.69244 210 0.009229958 457 0.001281847848140044 1.470765 41 48 0.003759743 GO Biological Process endoplasmic reticulum unfolded protein response 230 6.69409e-35 3.829892622173913e-33 2.157383 322 0.0141526 805 0.02442331650559006 1.238539 82 114 0.007519486 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 231 7.473779e-35 4.257465708268399e-33 2.286919 283 0.01243847 304 0.000024151955013486844 1.37166 94 118 0.008619899 GO Biological Process gluconeogenesis 240 3.392597e-34 1.8601326634583334e-32 2.751455 196 0.008614627 538 0.00350946861133829 1.454024 38 45 0.00348464 GO Cellular Component high-density lipoprotein particle 47 5.39121e-33 1.982129974468085e-31 4.262502 104 0.004571027 102 0.009309123952941176 1.530552 24 27 0.002200825 GO Cellular Component protein-lipid complex 52 3.890385e-29 1.2928048615384615e-27 2.628935 179 0.00786744 100 0.0077341564800000005 1.434892 35 42 0.003209537 GO Cellular Component plasma lipoprotein particle 53 1.237369e-28 4.034289871698114e-27 2.652309 173 0.007603727 112 0.014443845942857142 1.420543 33 40 0.003026135 GO Cellular Component cytosolic large ribosomal subunit 78 2.725782e-18 6.038655507692308e-17 2.146125 163 0.007164205 121 0.021533379173553715 1.326687 47 61 0.00430995 GO Cellular Component endoribonuclease complex 134 1.069101e-11 1.3786615880597015e-10 2.333993 82 0.003604079 114 0.017367248842105262 1.484371 25 29 0.002292526 GO Cellular Component endoplasmic reticulum quality control compartment 176 2.009495e-9 1.9729587272727274e-8 2.050524 85 0.003735935 96 0.0039439746 1.584121 23 25 0.002109124 GO Cellular Component microtubule plus-end 201 3.165802e-8 2.721644704477612e-7 2.028526 74 0.003252461 144 0.040724196000000004 1.540621 17 19 0.001558918 GO Cellular Component RNAi effector complex 203 3.324506e-8 2.8299243192118226e-7 2.307152 55 0.00241737 136 0.03214254070588235 1.721871 11 11 0.001008712 GO Cellular Component chromocenter 218 2.438135e-7 0.0000019326134311926607 2.006229 66 0.002900844 101 0.00846631718019802 1.721871 14 14 0.001283815 GO Cellular Component RISC complex 282 0.00001665342 0.00010204648851063829 2.088832 41 0.001802039 151 0.04986660111258278 1.721871 10 10 0.0009170105 GO Molecular Function oxidoreductase activity, acting on CH-OH group of donors 10 4.470224e-58 1.8873285728000002e-55 2.245744 499 0.02193214 27 2.670155425185185e-7 1.41576 111 135 0.01017882 GO Molecular Function oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 11 1.31206e-50 5.035924836363636e-48 2.253835 430 0.01889944 54 0.000006717415445555555 1.3981 95 117 0.0087116 GO Molecular Function steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 47 6.016684e-21 5.40477443574468e-19 2.826398 111 0.004878692 98 0.0036866331673469387 1.594325 25 27 0.002292526 GO Molecular Function steroid dehydrogenase activity 55 2.308648e-19 1.7722021556363634e-17 2.671761 112 0.004922644 105 0.009177586573333334 1.543746 26 29 0.002384227 GO Molecular Function NAD binding 72 3.66411e-18 2.1485933916666667e-16 2.016496 188 0.00826301 143 0.03046211381818182 1.352898 44 56 0.004034846 GO Molecular Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 74 8.71816e-18 4.974063718918919e-16 2.414531 123 0.005406118 104 0.008813360046153846 1.513159 29 33 0.002659331 GO Molecular Function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 121 2.473701e-13 8.631376547107438e-12 2.14132 115 0.005054501 148 0.03714778048648649 1.515246 22 25 0.002017423 GO Molecular Function mRNA 5'-UTR binding 270 2.194372e-8 3.431347623703704e-7 2.148628 66 0.002900844 99 0.004594098933333334 1.643604 21 22 0.001925722 Human Phenotype Hypoglycemia 6 6.152327e-51 6.842413011833333e-48 2.291443 418 0.01837201 187 0.03454196018823529 1.249499 82 113 0.007519486 Human Phenotype Abnormality of blood glucose concentration 8 3.4365e-49 2.8664705625000002e-46 2.106261 486 0.02136076 143 0.016021775004895107 1.257239 92 126 0.008436497 Human Phenotype Hepatic steatosis 15 5.341432e-32 2.376225049066667e-29 2.396975 235 0.01032876 51 0.00013770154198039213 1.496052 53 61 0.004860156 Human Phenotype Lipid accumulation in hepatocytes 17 5.469508e-31 2.1469427578823526e-28 2.287153 250 0.01098805 70 0.0013559755255714285 1.410977 59 72 0.005410362 Human Phenotype Hepatic failure 35 9.227658e-23 1.759318909542857e-20 2.056307 229 0.01006505 147 0.019021005185714285 1.360833 49 62 0.004493352 Human Phenotype Abnormality of cholesterol metabolism 46 2.016809e-20 2.9256883602173917e-18 2.034641 209 0.009186006 97 0.0046457955712371135 1.434892 45 54 0.004126547 Human Phenotype Hyperbilirubinemia 47 3.669569e-20 5.210007220638297e-18 2.29841 156 0.00685654 185 0.03376809248432432 1.420543 33 40 0.003026135 Human Phenotype Papillary thyroid carcinoma 229 3.647022e-8 0.0000010627326552838428 2.043354 72 0.003164557 205 0.04780335382439024 1.721871 12 12 0.001100413 Mouse Phenotype Single KO abnormal white fat cell size 76 2.68163e-30 3.2310113039473682e-28 2.037213 318 0.01397679 352 0.02981909413068182 1.324516 50 65 0.004585053 Mouse Phenotype Single KO decreased liver triglyceride level 98 3.660024e-28 3.4198816089795925e-26 2.040903 293 0.01287799 251 0.011066829157768925 1.366564 50 63 0.004585053 Mouse Phenotype Single KO abnormal circulating ketone body level 108 9.455815e-27 8.017305366203703e-25 2.169523 240 0.01054852 353 0.03036074686402266 1.384983 37 46 0.003392939 Mouse Phenotype Single KO abnormal bile salt homeostasis 229 7.093591e-18 2.8365071086026204e-16 2.151575 158 0.006944444 247 0.010875616901214575 1.482722 31 36 0.002842733 Mouse Phenotype Single KO decreased circulating VLDL cholesterol level 277 8.410467e-16 2.7803121414801446e-14 2.319054 117 0.005142405 331 0.024269538512688822 1.565337 20 22 0.001834021 Mouse Phenotype Single KO abnormal bile salt level 289 2.497521e-15 7.913425535294118e-14 2.112363 139 0.006109353 207 0.006065751628502415 1.589419 24 26 0.002200825 Mouse Phenotype Single KO abnormal bile duct physiology 372 4.285774e-13 1.0549686160752689e-11 2.092019 119 0.005230309 293 0.017325044 1.572143 21 23 0.001925722 Mouse Phenotype Single KO abnormal bile composition 514 3.280236e-10 5.84379787003891e-9 2.012728 98 0.004307314 402 0.04946126215671642 1.549684 18 20 0.001650619 Mouse Phenotype decreased liver triglyceride level 75 3.034118e-40 3.8678936264e-38 2.113017 392 0.01722925 247 0.001333592279271255 1.35428 70 89 0.006419074 Mouse Phenotype abnormal bile salt homeostasis 129 1.018292e-30 7.547201404651163e-29 2.419317 221 0.009713432 159 0.00016911514839622641 1.538693 42 47 0.003851444 Mouse Phenotype increased hepatocyte apoptosis 145 4.662464e-29 3.0743322968275866e-27 2.095734 284 0.01248242 385 0.008449053216623377 1.347551 54 69 0.004951857 Mouse Phenotype abnormal circulating ketone body level 158 3.317649e-28 2.0075976005696202e-26 2.105993 272 0.01195499 317 0.0034257696378548895 1.414394 46 56 0.004218249 Mouse Phenotype abnormal bile salt level 159 4.178394e-28 2.5125550335849054e-26 2.426122 200 0.008790436 143 0.00007443459138461539 1.626211 34 36 0.003117836 Mouse Phenotype decreased circulating VLDL cholesterol level 198 8.238031e-25 3.9779704237878787e-23 2.502107 165 0.00725211 332 0.004213964672891566 1.549684 27 30 0.002475928 Mouse Phenotype increased bile salt level 199 8.288459e-25 3.9822088692964827e-23 3.054702 118 0.005186357 448 0.018722403553794644 1.565337 20 22 0.001834021 Mouse Phenotype abnormal xenobiotic pharmacokinetics 214 2.097574e-23 9.371450941121496e-22 2.344605 176 0.007735584 547 0.033606198361974406 1.404684 31 38 0.002842733 Mouse Phenotype increased circulating ketone body level 239 8.057495e-22 3.2233351336820085e-20 2.018928 229 0.01006505 455 0.019672024367472528 1.420543 33 40 0.003026135 Mouse Phenotype abnormal bile composition 485 1.610164e-13 3.1741810317525774e-12 2.087915 124 0.00545007 503 0.026288834361829026 1.557883 19 21 0.00174232 Mouse Phenotype decreased lung tumor incidence 525 9.713389e-13 1.7689468995999996e-11 2.437053 83 0.003648031 513 0.027370142374269008 1.721871 12 12 0.001100413 Mouse Phenotype abnormal DNA replication 527 1.135135e-12 2.059397672675522e-11 2.230385 99 0.004351266 590 0.04152283961694915 1.466779 23 27 0.002109124 Mouse Phenotype decreased cerebellar granule cell precursor proliferation 722 8.806353e-10 1.1661709284349032e-8 2.179288 77 0.003384318 585 0.04134498368717948 1.721871 11 11 0.001008712