# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	steroid metabolic process	8	7.088297e-49	1.1659362527875e-45	2.934506	251	0.05099553	205	0.00009745504047804878	1.555797	91	229	0.01897415	
GO Biological Process	ncRNA metabolic process	32	4.300491e-30	1.76844253340625e-27	2.037054	306	0.06216985	106	8.26778852726415e-8	1.453186	206	555	0.04295246	
GO Biological Process	alcohol metabolic process	37	2.52572e-25	8.982689048648648e-23	2.171589	221	0.04490045	159	0.000011682841587421384	1.560276	108	271	0.02251877	
GO Biological Process	ncRNA processing	42	4.519426e-24	1.415979207952381e-21	2.116396	222	0.04510362	145	0.000005176370350275862	1.47312	149	396	0.03106756	
GO Biological Process	secondary alcohol metabolic process	44	6.281546e-24	1.8786105412272725e-21	2.896479	122	0.02478667	228	0.0003880266473640351	1.740061	52	117	0.01084237	
GO Biological Process	rRNA processing	45	9.024993e-24	2.6391085086e-21	2.479704	158	0.03210077	119	3.267548887142857e-7	1.66238	107	252	0.02231026	
GO Biological Process	cholesterol metabolic process	47	2.659928e-23	7.44723245787234e-21	2.905747	118	0.02397399	234	0.0004843381956111111	1.747829	50	112	0.01042535	
GO Biological Process	rRNA metabolic process	51	7.528774e-23	1.9425713150196077e-20	2.417263	159	0.03230394	126	8.661019862222222e-7	1.632567	108	259	0.02251877	
GO Biological Process	ribosome biogenesis	52	1.617727e-22	4.093782614038462e-20	2.17294	195	0.03961804	108	1.1204819049722222e-7	1.599994	132	323	0.02752294	
GO Biological Process	modification of morphology or physiology of other organism involved in symbiotic interaction	55	3.071928e-22	7.34972737309091e-20	2.893405	113	0.02295815	505	0.0340395187980198	1.55055	40	101	0.008340284	
GO Biological Process	sterol metabolic process	63	5.792411e-21	1.2098783547460317e-18	2.620584	125	0.02539618	281	0.00219957133772242	1.626288	54	130	0.01125938	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	64	8.025328e-21	1.6500826742500001e-18	2.97168	101	0.02052011	152	0.00000843006229013158	1.905598	55	113	0.01146789	
GO Biological Process	mRNA catabolic process	76	3.780225e-20	6.545260628289473e-18	2.390498	142	0.02885006	111	1.2581474014414415e-7	1.746188	95	213	0.01980817	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	82	1.93294e-19	3.101897251219512e-17	3.175128	85	0.0172694	138	0.000002687845897391304	1.92439	58	118	0.01209341	
GO Biological Process	endoplasmic reticulum unfolded protein response	83	2.117761e-19	3.357544216746988e-17	2.942206	95	0.0193011	201	0.00006742894190049752	1.820196	53	114	0.01105088	
GO Biological Process	nuclear-transcribed mRNA catabolic process	84	2.215056e-19	3.469990702857142e-17	2.438783	131	0.0266152	123	5.685037836829269e-7	1.740061	88	198	0.01834862	
GO Biological Process	regulation of DNA-templated transcription in response to stress	90	4.74326e-19	6.935173148888888e-17	2.731131	105	0.02133279	141	0.000003861618674964539	1.908218	58	119	0.01209341	
GO Biological Process	cellular response to starvation	96	1.234455e-18	1.6921034734375e-16	2.276861	144	0.0292564	257	0.0008493576394552529	1.653058	57	135	0.0118849	
GO Biological Process	RNA catabolic process	101	3.590923e-18	4.6785104709901e-16	2.191871	152	0.03088176	120	4.1643322306666665e-7	1.673275	103	241	0.02147623	
GO Biological Process	response to topologically incorrect protein	105	6.255994e-18	7.840250004380952e-16	2.372605	127	0.02580252	147	0.000005486878689387755	1.71831	79	180	0.01647206	
GO Cellular Component	blood microparticle	13	4.389475e-56	5.834625230769231e-54	4.85748	156	0.03169443	97	0.038099211216494844	1.485052	44	116	0.009174312	
GO Cellular Component	ribosomal subunit	32	1.326694e-19	7.1641476e-18	2.65036	114	0.02316132	43	8.129729637209302e-7	1.735358	82	185	0.01709758	
GO Cellular Component	ribosome	42	1.649501e-16	6.786518400000001e-15	2.205829	135	0.02742787	44	9.354390545454546e-7	1.642367	99	236	0.0206422	
GO Cellular Component	large ribosomal subunit	47	2.914002e-15	1.0713607353191489e-13	2.890874	75	0.01523771	50	0.000007062719616	1.872457	55	115	0.01146789	
GO Cellular Component	transcription factor AP-1 complex	54	9.730386e-14	3.11372352e-12	11.58682	18	0.00365705	83	0.022597264192771083	3.915138	5	5	0.001042535	
GO Cellular Component	mitochondrial membrane part	57	2.786689e-13	8.448067705263158e-12	2.06694	123	0.02498984	66	0.008140215272727272	1.422008	77	212	0.01605505	
GO Cellular Component	cytosolic large ribosomal subunit	58	5.764246e-13	1.7173477737931034e-11	3.22568	53	0.01076798	48	0.0000046113623999999996	2.24639	35	61	0.007297748	
GO Cellular Component	cytosolic ribosome	65	1.747212e-12	4.6448959015384615e-11	2.42941	81	0.01645672	52	0.0000171440064	1.852699	53	112	0.01105088	
GO Cellular Component	nuclear chromosome, telomeric region	69	1.008807e-10	2.5264036173913042e-9	2.32749	74	0.01503454	63	0.004341742628571429	1.571987	53	132	0.01105088	
GO Cellular Component	chromosome, telomeric region	72	2.238071e-10	5.3713704e-9	2.1227	87	0.01767574	68	0.008347368282352942	1.476968	63	167	0.01313595	
GO Cellular Component	endoplasmic reticulum quality control compartment	87	8.338945e-8	0.0000016562870068965518	3.233865	29	0.005891914	86	0.022960016372093023	2.192477	14	25	0.002919099	
GO Cellular Component	catalytic step 2 spliceosome	94	2.144702e-7	0.000003942601123404255	2.118658	58	0.01178383	76	0.01915791536842105	1.590525	39	96	0.008131776	
GO Cellular Component	spliceosomal snRNP complex	98	4.457694e-7	0.000007860097175510203	2.60878	36	0.0073141	91	0.02890404712087912	1.704979	27	62	0.005629691	
GO Cellular Component	cyclin-dependent protein kinase holoenzyme complex	115	0.000005735038	0.00008617517968695651	2.390597	34	0.006907761	75	0.017504886528	1.957569	20	40	0.004170142	
GO Cellular Component	DNA-directed RNA polymerase III complex	129	0.00002405065	0.00032216684651162786	4.485208	12	0.002438033	101	0.04689372831683169	2.266659	11	19	0.002293578	
GO Cellular Component	endopeptidase complex	136	0.00004440687	0.0005642284658823529	2.078535	37	0.007517269	96	0.036349361999999996	1.645493	29	69	0.006046706	
GO Cellular Component	protein phosphatase type 1 complex	184	0.0006202337	0.00582480344347826	2.526893	17	0.003453881	89	0.026799280179775283	2.847373	8	11	0.001668057	
GO Cellular Component	PTW/PP1 phosphatase complex	225	0.003011889	0.023131307519999998	3.775536	7	0.001422186	90	0.029087635200000003	3.355832	6	7	0.001251043	
GO Molecular Function	unfolded protein binding	9	1.432337e-23	6.719252015555555e-21	3.643138	87	0.01767574	60	0.01625125907	1.625151	44	106	0.009174312	
GO Molecular Function	structural constituent of ribosome	20	1.413515e-16	2.983930165e-14	2.558872	101	0.02052011	15	8.868747273333332e-7	1.836731	76	162	0.01584654	
GO Molecular Function	RNA polymerase II repressing transcription factor binding	53	4.661831e-10	3.7136321664150946e-8	3.091696	42	0.008533117	29	0.00016370673972413794	2.700095	20	29	0.004170142	
GO Molecular Function	ribonucleoprotein complex binding	66	1.170378e-8	7.4868726e-7	2.151295	68	0.01381552	88	0.04379314598636364	1.53201	45	115	0.009382819	
GO Molecular Function	ribonuclease activity	70	1.394998e-8	8.413830794285714e-7	2.231991	62	0.01259651	42	0.003350149963333334	1.740061	44	99	0.009174312	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	90	4.181949e-7	0.00001961798742	2.92006	30	0.006095083	56	0.012069423860714286	2.295081	17	29	0.003544621	
GO Molecular Function	5'-3' RNA polymerase activity	102	0.00000254199	0.00010521844882352942	2.839853	27	0.005485575	79	0.033375540627848095	1.914067	22	45	0.004587156	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	109	0.000004224622	0.000163636276	2.824817	26	0.005282406	87	0.040751268110344824	1.912044	21	43	0.004378649	
GO Molecular Function	protein phosphatase activator activity	114	0.000004890974	0.00018113765112280704	3.795358	17	0.003453881	70	0.026493924557142855	3.425745	7	8	0.00145955	
GO Molecular Function	leucine zipper domain binding	123	0.000006983541	0.00023971146424390244	3.260268	20	0.004063389	55	0.011540683472727273	3.203294	9	11	0.001876564	
Human Phenotype	Lipodystrophy	11	2.15678e-16	1.3083811763636365e-13	4.403348	47	0.009548964	40	0.0053639342345	2.669412	15	22	0.003127606	
Human Phenotype	Abnormality of adipose tissue	17	2.802832e-15	1.1001939962352941e-12	3.11618	67	0.01361235	66	0.030640919630303028	1.854539	27	57	0.005629691	
Human Phenotype	Increased serum lactate	51	1.209739e-8	0.0000015828604601960782	2.275864	60	0.01219017	63	0.024767580944444447	1.644358	42	100	0.008757298	
Human Phenotype	Progressive external ophthalmoplegia	136	0.00009126151	0.0044778533546323525	3.43676	14	0.002844372	55	0.017154608683636365	2.871101	11	15	0.002293578	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	43	2.588839e-9	5.513022958837209e-7	2.65197	49	0.009955303	51	0.007215082191960784	1.957569	30	60	0.006255213	
Mouse Phenotype Single KO	increased cellular sensitivity to ionizing radiation	120	0.000005102121	0.000389334349975	2.052561	48	0.009752133	39	0.001463384631102564	1.985939	35	69	0.007297748	
Mouse Phenotype Single KO	abnormal DNA replication	132	0.000008355117	0.0005796045937045455	3.015118	22	0.004469728	80	0.0409027394175	2.383127	14	23	0.002919099	
Mouse Phenotype Single KO	abnormal vitamin A metabolism	226	0.0001970754	0.00798504176017699	3.185627	14	0.002844372	82	0.04588493413780488	2.796527	10	14	0.002085071	
Mouse Phenotype	abnormal hepatocyte physiology	15	2.511798e-17	1.6010200452e-14	2.117424	156	0.03169443	57	0.0005752251524736842	1.656404	66	156	0.01376147	
Mouse Phenotype	abnormal hepatocyte morphology	19	1.105979e-16	5.565402746842105e-14	2.097531	153	0.03108492	95	0.005169044950105263	1.518988	71	183	0.014804	
Mouse Phenotype	pale liver	33	5.71673e-14	1.656292591818182e-11	2.274839	105	0.02133279	187	0.030820982759358292	1.566055	44	110	0.009174312	
Mouse Phenotype	abnormal cellular replicative senescence	64	4.184881e-11	6.25181988140625e-9	2.462093	69	0.01401869	104	0.006438463816730768	1.771134	38	84	0.007923269	
Mouse Phenotype	early cellular replicative senescence	72	2.180832e-10	2.89596316e-8	2.500405	62	0.01259651	136	0.014643733052205885	1.769857	33	73	0.006880734	
Mouse Phenotype	abnormal DNA replication	215	0.000008729324	0.0003881910082046512	2.707672	26	0.005282406	91	0.0047071198503296705	2.465087	17	27	0.003544621	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	256	0.00003030339	0.0011317605929296877	2.692367	23	0.004672897	101	0.006348243675742575	2.349083	18	30	0.003753128	
Mouse Phenotype	abnormal ethanol metabolism	295	0.00008955816	0.0029025951449491525	8.575948	6	0.001219017	218	0.04760329798623853	3.915138	5	5	0.001042535	
Mouse Phenotype	abnormal vitamin A metabolism	458	0.0008782504	0.018333956494323143	2.730271	14	0.002844372	208	0.043663542530769234	2.610092	10	15	0.002085071	
Mouse Phenotype	increased cellular sensitivity to alkylating agents	552	0.002784638	0.04823174622826087	2.082185	19	0.003860219	88	0.004119375320113637	2.740596	14	20	0.002919099